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  1. Book: A Practical Guide to Breast Cancer Treatment

    Lee, Eun Sook

    2023  

    Author's details Eun Sook Lee, MD., PhD, Center for Breast Cancer, Hospital, Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Korea. Current address : President of LiLiU Breast Clinic, 176 Bongeunsa_Ro, Seoul, Korea
    Keywords Personalized treatment ; individualized breast cancer care ; breast cancer prevention ; essential guideline ; Cancer Screening ; personalized treatment ; cancer screening
    Language English
    Size 952 p.
    Edition 1
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_21
    Format 183 x 260 x 53
    ISBN 9789811990434 ; 9811990433
    Database PDA

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  2. Article: Natural-Product-Inspired Approaches for Cancer Diagnosis and Therapy.

    Lee, Eun Sook / Shin, Jung Min

    Pharmaceutics

    2022  Volume 14, Issue 9

    Abstract: In recent years, new methods of cancer diagnosis and therapy have emerged as promising options for fighting cancer [ ... ]. ...

    Abstract In recent years, new methods of cancer diagnosis and therapy have emerged as promising options for fighting cancer [...].
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14091884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic Targeting of DNA Damage Response in Cancer.

    Choi, Wonyoung / Lee, Eun Sook

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells with defective ... ...

    Abstract DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells with defective DDR signaling are directed to rely on compensatory survival pathways, and these vulnerabilities have been exploited for anticancer treatments. Following the impressive success of PARP inhibitors in the treatment of
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Repair/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors ; Signal Transduction/drug effects
    Chemical Substances Antineoplastic Agents ; Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031701
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  4. Article ; Online: The Association between Alcohol Drinking Patterns and Health-Related Quality of Life in the Korean Adult Population: Effects of Misclassification Error on Estimation of Association.

    Lee, Eun Sook / Kim, Boyoung

    International journal of environmental research and public health

    2020  Volume 17, Issue 21

    Abstract: The purpose of this study was to investigate the association between drinking patterns and health-related quality of life (HRQoL) in the Korean general population and to validate the estimation of the association of alcohol use on HRQoL when former ... ...

    Abstract The purpose of this study was to investigate the association between drinking patterns and health-related quality of life (HRQoL) in the Korean general population and to validate the estimation of the association of alcohol use on HRQoL when former drinkers are separated from never drinkers and low-risk drinkers depending on gender. Data were collected from 23,055 adults (over 19 years old) who completed the Korean National Health and Nutritional Examination Survey (2010-2013). Multivariate logistic and linear regression analyses were performed to investigate the association between drinking patterns and HRQoL. When former drinkers were separated from never drinkers and low-risk drinkers to control for misclassification bias, there were gender differences in the associations between alcohol use and HRQoL. Although the estimation of the association of alcohol use was not valid in men, the estimation of association was valid in women, as low-risk women drinkers showed better HRQoL than nondrinkers. Therefore, when conducting research related to alcohol and health, analyses should correct for the various confounding variables and minimize the misclassification bias of drinking patterns. It is also necessary to consider gender characteristics when intervening to improve HRQoL related to drinking.
    MeSH term(s) Adult ; Alcohol Drinking/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Quality of Life ; Republic of Korea/epidemiology
    Language English
    Publishing date 2020-10-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17217758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Could axillary lymph node dissection be omitted in the mastectomy patient with tumor positive sentinel node?

    You, Ji Young / Lee, Eun Sook / Lim, Siew Kuan / Kwon, Youngmee / Jung, So-Youn

    Frontiers in oncology

    2023  Volume 13, Page(s) 1181069

    Abstract: Background: Recent data from the ACOSOG Z0011 trial suggest that axillary lymph node dissection (ALND) may not be necessary for patients with positive sentinel lymph node biopsy (SLNB) receiving breast-conserving surgery (BCS) with irradiation. However, ...

    Abstract Background: Recent data from the ACOSOG Z0011 trial suggest that axillary lymph node dissection (ALND) may not be necessary for patients with positive sentinel lymph node biopsy (SLNB) receiving breast-conserving surgery (BCS) with irradiation. However, consensus statements and guidelines have recommended that patients undergoing mastectomy with tumor-positive sentinel node undergo completion ALND. In this study, we compared the locoregional recurrence rate of patients with tumor-positive sentinel nodes among three groups: mastectomy with SLNB, mastectomy with ALND and BCS with SLNB.
    Method: We identified 6,163 women with invasive breast cancer who underwent surgical resection at our institution between January 2000 and December 2011. Clinicopathologic data obtained from the prospectively collected medical database were analyzed retrospectively. Among the patients with sentinel node positive, mastectomy with SLNB was performed in 39 cases, mastectomy with ALND in 181 cases, and BCS with SLNB in 165 cases. The primary end point was the loco-regional recurrence rate.
    Results: Clinicopathologic characteristics were similar among the groups. There were no cases of loco-regional recurrence in the sentinel groups. At a median follow-up of 61.0 months (last follow-up May 2013), the loco-regional recurrence rate of each group was 0% for BCS with SLNB and mastectomy with SLNB only, and 1.7% for mastectomy with ALND (
    Conclusion: In our study, there was no significant difference in loco-regional recurrence rates between groups. This result lends weight to the argument that SLNB without ALND may be a reasonable management for selected patients with appropriate surgery and adjuvant systemic therapy.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1181069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effective Atomic N Doping on CeO

    Paick, Jihun / Hong, Seunghee / Bae, Ji-Young / Jyoung, Jy-Young / Lee, Eun-Sook / Lee, Doohwan

    ACS omega

    2023  Volume 8, Issue 25, Page(s) 22646–22655

    Abstract: Atomic nitrogen doping on ... ...

    Abstract Atomic nitrogen doping on CeO
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01305
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  7. Article ; Online: [Impact of Parents' Problem Drinking on Suicidal Ideation of Their University Student Children: The Multiple Mediating Effects of Childhood Trauma, Experiential Avoidance and Depression].

    Lee, Eun Sook / Bong, Eun Ju

    Journal of Korean Academy of Nursing

    2018  Volume 48, Issue 5, Page(s) 565–577

    Abstract: Purpose: The purpose of this study was to construct and test a hypothetical model about impact of parents' problem drinking on suicidal ideation of their children who are university students and the multiple mediating effects of childhood trauma, ... ...

    Abstract Purpose: The purpose of this study was to construct and test a hypothetical model about impact of parents' problem drinking on suicidal ideation of their children who are university students and the multiple mediating effects of childhood trauma, experiential avoidance, and depression based on stress-vulnerability model.
    Methods: A purposive sample of 400 university students was recruited from three universities in provincial areas and the data were collected between October and November 2016. The collected data were then analyzed using SPSS 20.0 and AMOS 20.0 programs. For data analysis, descriptive statistics, factor analysis, and structural equation modeling were performed. Multiple mediating effects analysis using phantom variable and bootstrapping were implemented to verify the mediating effect of the research model.
    Results: We found no significant direct effect on depression and suicidal ideation of parents' problem drinking, but multiple mediating effects of childhood trauma and experiential avoidance between parents' problem drinking and depression (B=.38,
    Conclusion: Based on the results of this study, it can be suggested that in order to decrease depression and prevent suicide of university students, considering of parents' problem drinking and childhood trauma, intervention methods that decreased chronic use of experiential avoidance and strengthen acceptance should be developed and made available to them.
    MeSH term(s) Adolescent ; Alcoholism/pathology ; Depression/pathology ; Humans ; Models, Theoretical ; Parents ; Stress, Psychological ; Students/psychology ; Suicidal Ideation ; Surveys and Questionnaires ; Universities ; Wounds and Injuries/pathology ; Young Adult
    Language Korean
    Publishing date 2018-11-03
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2619665-7
    ISSN 2093-758X ; 2005-3673 ; 1598-2874
    ISSN (online) 2093-758X
    ISSN 2005-3673 ; 1598-2874
    DOI 10.4040/jkan.2018.48.5.565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Slowly digestible property of highly branched α-limit dextrins produced by 4,6-α-glucanotransferase from Streptococcus thermophilus evaluated in vitro and in vivo

    Ryu, Jae-Jin / Li, Xiaolei / Lee, Eun-Sook / Li, Dan / Lee, Byung-Hoo

    Carbohydrate polymers. 2022 Jan. 01, v. 275

    2022  

    Abstract: Starch molecules are first degraded to slowly digestible α-limit dextrins (α-LDx) and rapidly hydrolyzable linear malto-oligosaccharides (LMOs) by salivary and pancreatic α-amylases. In this study, we designed a slowly digestible highly branched α-LDx ... ...

    Abstract Starch molecules are first degraded to slowly digestible α-limit dextrins (α-LDx) and rapidly hydrolyzable linear malto-oligosaccharides (LMOs) by salivary and pancreatic α-amylases. In this study, we designed a slowly digestible highly branched α-LDx with maximized α-1,6 linkages using 4,6-α-glucanotransferase (4,6-αGT), which creates a short length of α-1,4 side chains with increasing branching points. The results showed that a short length of external chains mainly composed of 1–8 glucosyl units was newly synthesized in different amylose contents of corn starches, and the α-1,6 linkage ratio of branched α-LDx after the chromatographical purification was significantly increased from 4.6% to 22.1%. Both in vitro and in vivo studies confirmed that enzymatically modified α-LDx had improved slowly digestible properties and extended glycemic responses. Therefore, 4,6-αGT treatment enhanced the slowly digestible properties of highly branched α-LDx and promises usefulness as a functional ingredient to attenuate postprandial glucose homeostasis.
    Keywords Streptococcus thermophilus ; amylose ; corn ; dextrins ; glucose ; homeostasis ; ingredients
    Language English
    Dates of publication 2022-0101
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.118685
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs.

    Son, Deok-Soo / Lee, Eun-Sook / Adunyah, Samuel E

    Immune network

    2020  Volume 20, Issue 4, Page(s) e29

    Abstract: The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove ... ...

    Abstract The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both in human and veterinary medicine. In addition to being antiparasitic agents, benzimidazole anthelmintics are known to exert anticancer activities, such as the disruption of microtubule polymerization, the induction of apoptosis, cell cycle (G2/M) arrest, anti-angiogenesis, and blockage of glucose transport. These antitumorigenic effects even extend to cancer cells resistant to approved therapies and when in combination with conventional therapeutics, enhance anticancer efficacy and hold promise as adjuvants. Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as antiparasitic agents. The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. This review provides valuable information on how to improve the quality of life in patients with cancers by increasing the treatment options and decreasing side effects from conventional therapy.
    Language English
    Publishing date 2020-08-04
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2020.20.e29
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  10. Article: Gut microbial change after administration of

    Song, Eun-Ji / Lee, Eun-Sook / Kim, Young In / Shin, Dong-Uk / Eom, Ji-Eun / Shin, Hee Soon / Lee, So-Young / Nam, Young-Do

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1224636

    Abstract: Introduction: The status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and ... ...

    Abstract Introduction: The status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and prevention of obesity and related gut microbial dysbiosis. The anti-obesity effect of
    Methods: Oral administration of
    Results: Oral administration of
    Discussion: This study demonstrated that
    MeSH term(s) Animals ; Mice ; Lacticaseibacillus paracasei ; Gastrointestinal Microbiome ; Lacticaseibacillus ; Dysbiosis ; Obesity/drug therapy ; Disease Models, Animal ; Lactic Acid
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1224636
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