LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 108

Search options

  1. Article ; Online: Testing the Reciprocal Relationship Between Social Networks and Purpose in Life Among Older Adults: Application of a Random Intercept Cross-Lagged Panel Model.

    Lee, Gina / Martin, Peter

    Journal of aging and health

    2023  Volume 35, Issue 9, Page(s) 699–707

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; Male ; Female ; Aged ; Aging ; Social Networking ; Sex Factors ; Longitudinal Studies
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045392-1
    ISSN 1552-6887 ; 0898-2643
    ISSN (online) 1552-6887
    ISSN 0898-2643
    DOI 10.1177/08982643231156721
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3012: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Metabolic Control of m

    Kim, Joohwan / Lee, Gina

    Metabolites

    2021  Volume 11, Issue 2

    Abstract: Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these, ...

    Abstract Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these,
    Language English
    Publishing date 2021-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11020080
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The bidirectional relationship between depressive symptoms and functional limitations among centenarian survivors in their 80s: Testing bivariate latent change score models.

    Lee, Gina / Arieli, Rotem / Ryou, Yeon Ji / Martin, Peter

    Aging & mental health

    2023  Volume 27, Issue 9, Page(s) 1720–1728

    Abstract: Objectives: The purpose of the study was to examine a bivariate latent change score model of depressive symptoms and functional limitations (activities of daily living) among centenarian or near-centenarian survivors over four waves using the Health and ...

    Abstract Objectives: The purpose of the study was to examine a bivariate latent change score model of depressive symptoms and functional limitations (activities of daily living) among centenarian or near-centenarian survivors over four waves using the Health and Retirement Study.
    Method: Four hundred and sixty participants who eventually survived to age 98 or older were included by calculating their death age. Data from the time when the participants were in their 80s were analyzed. The mean age at baseline (1994) was 85.5 years. The observation interval was 2 years, from 1994 to 2000. Including age, gender, and education as a covariate, eight different models were conducted to examine the bivariate effects among depressive symptoms and functional limitations.
    Results: Of the eight models, the bivariate model of depressive symptoms predicting change in functional limitations fitted the data best. The parameter estimates of the final model indicated significant predictive pathways from depressive symptoms to subsequent changes in depressive symptoms and functional limitations.
    Conclusion: This study tested the bidirectional relationship between depressive symptoms and functional limitations among centenarian survivors in their 80s, which uncovered that depressive symptoms is a dominant variable among the two constructs. Our findings add to a lacking number of longitudinal studies with oldest old adults.
    MeSH term(s) Aged, 80 and over ; Humans ; Depression/epidemiology ; Depression/diagnosis ; Activities of Daily Living ; Centenarians ; Longitudinal Studies ; Retirement
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2023.2177830
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5081: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: m

    Jang, Ki-Hong / Heras, Chloe R / Lee, Gina

    Molecules and cells

    2022  Volume 45, Issue 7, Page(s) 435–443

    Abstract: In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. ...

    Abstract In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation.
    MeSH term(s) Adenosine/genetics ; Adenosine/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Methylation ; RNA, Messenger/genetics ; Signal Transduction ; Transforming Growth Factor beta/metabolism
    Chemical Substances RNA, Messenger ; Transforming Growth Factor beta ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2022.0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4713: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Intrapelvic Pseudotumor Presenting with Deep Vein Thrombosis After Hip Replacement with Metal-on-Metal Bearing Surface Implant: A Case Report.

    Jabbouri, Sahir / Lee, Gina / Stonecipher, Thomas / Nawalany, Michal

    JBJS case connector

    2021  Volume 11, Issue 2

    Abstract: Case: A 61-year-old woman with an asymptomatic hip presented acutely with a swollen lower limb 15 years after a metal bearing surface total hip replacement (THR). A large intrapelvic pseudotumor was discovered compressing her femoral and iliac vessels. ... ...

    Abstract Case: A 61-year-old woman with an asymptomatic hip presented acutely with a swollen lower limb 15 years after a metal bearing surface total hip replacement (THR). A large intrapelvic pseudotumor was discovered compressing her femoral and iliac vessels. Collaboration between an orthopaedic and vascular surgeon led to a 2-stage surgical procedure with resection of the pseudotumor, followed by revision of the THR implant 3 months later.
    Conclusion: This case demonstrates the importance of long-term follow-up of patients with metal bearing surface implants, early recognition of an unusual presentation of a common problem, and the utility of collaboration between orthopaedic and vascular surgeons.
    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Female ; Hip Prosthesis/adverse effects ; Humans ; Inflammation/diagnostic imaging ; Inflammation/etiology ; Metal-on-Metal Joint Prostheses ; Middle Aged ; Reoperation ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e20.00866
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Quantitative analysis of m

    Mathur, Lavina / Jung, Sunhee / Jang, Cholsoon / Lee, Gina

    STAR protocols

    2021  Volume 2, Issue 3, Page(s) 100724

    Abstract: ... ...

    Abstract N
    MeSH term(s) Adenine/analogs & derivatives ; Adenine/analysis ; Adenine/chemistry ; Adenosine/analogs & derivatives ; Adenosine/chemistry ; Adenosine/metabolism ; Biochemical Phenomena ; Chromatography, Liquid/methods ; Methylation ; Nucleosides/analysis ; RNA/chemistry ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Tandem Mass Spectrometry/methods
    Chemical Substances Nucleosides ; RNA, Messenger ; RNA (63231-63-0) ; Adenine (JAC85A2161) ; Adenosine (K72T3FS567) ; 6-methyladenine (W7IBY2BGAX)
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100724
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.

    Park, Jin H / Lee, Gina / Blenis, John

    Trends in biochemical sciences

    2020  Volume 45, Issue 5, Page(s) 367–369

    Abstract: Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of ... ...

    Abstract Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.
    MeSH term(s) Amino Acids ; Cryoelectron Microscopy ; Lysosomes/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction
    Chemical Substances Amino Acids ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2020-02-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2020.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Neuropathogenesis of HIV and emerging therapeutic targets.

    Siddiqui, Alina / He, Celestine / Lee, Gina / Figueroa, Alex / Slaughter, Alexander / Robinson-Papp, Jessica

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 7, Page(s) 603–615

    Abstract: Introduction: HIV infection causes a wide range of neurological complications, many of which are among the most common complications of chronic HIV infection in the era of combined antiretroviral therapy. These neurological conditions arise due to ... ...

    Abstract Introduction: HIV infection causes a wide range of neurological complications, many of which are among the most common complications of chronic HIV infection in the era of combined antiretroviral therapy. These neurological conditions arise due to complex interactions between HIV viral proteins and neuronal and glial cells that lead to the activation of various inflammatory and neurotoxic pathways across the nervous system.
    Areas covered: This review summarizes the current literature on the pathogenesis and clinical manifestations of neurological injuries associated with HIV in the brain, spinal cord, and peripheral nervous system. Molecular pathways relevant for possible therapeutic targets or advancements are emphasized. Gaps in knowledge and current challenges in therapeutic design are also discussed.
    Expert opinion: Several challenges exist in the development of therapeutic targets for HIV-associated cognitive impairments. However, recent developments in drug delivery systems and treatment strategies are encouraging. Treatments for HIV-associated pain and peripheral sensory neuropathies currently consist of symptomatic management, but a greater understanding of their pathogenesis can lead to the development of targeted molecular therapies and disease-modifying therapies. HIV-associated autonomic dysfunction may affect the course of systemic disease via disrupted neuro-immune interactions; however, more research is needed to facilitate our understanding of how these processes present clinically.
    MeSH term(s) Brain ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Nervous System Diseases/complications ; Neuroimmunomodulation ; Peripheral Nervous System Diseases
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2100253
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cognitive Reserve and Cognitive Functioning among Oldest Old Adults: Findings from the Georgia Centenarian Study.

    Martin, Peter / Gondo, Yasuyuki / Lee, Gina / Woodard, John L / Miller, L Steven / Poon, Leonard W

    Experimental aging research

    2022  Volume 49, Issue 4, Page(s) 334–346

    Abstract: Objectives: Living a long life does not guarantee the maintenance of optimal cognitive functioning; however, similar to older adults in general, cognitive reserve may also protect oldest-old adults from cognitive decline. The purpose of this study was ... ...

    Abstract Objectives: Living a long life does not guarantee the maintenance of optimal cognitive functioning; however, similar to older adults in general, cognitive reserve may also protect oldest-old adults from cognitive decline. The purpose of this study was to assess cognitive reserve among centenarians and octogenarians and to evaluate a process model of cognitive reserve.
    Methods: A total of 321 centenarians and octogenarians from the Georgia Centenarian Study were included in this study. Cognitive reserve components included level of education, occupational responsibility, current social engagement, past engaged lifestyle, and activity. Cognitive functioning was measured with the Mini-Mental Status Examination.
    Results: Structural equation modeling was computed, and the overall model fit well, χ2 (df = 3) = 5.02, p = .17; CFI = .99, RMSEA = .05. Education is directly and indirectly related to cognitive functioning through occupational responsibility and past engaged lifestyle. Current social engagement is related to cognitive functioning directly and indirectly through current activities. The four direct predictors (i.e., education, current social engagement, current activity, and past engaged lifestyle) explained 35% of the variance in cognitive functioning.
    Conclusion: The results provide important information for cognitive reserve theories with implications for interventions that build cognitive reserve.
    MeSH term(s) Aged, 80 and over ; Humans ; Aged ; Cognitive Reserve ; Centenarians ; Georgia ; Aging/psychology ; Cognition ; Cognitive Dysfunction/epidemiology
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 753202-7
    ISSN 1096-4657 ; 0361-073X
    ISSN (online) 1096-4657
    ISSN 0361-073X
    DOI 10.1080/0361073X.2022.2106717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1405: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: MAPK13 stabilization via m

    Kim, Joohwan / Chun, Yujin / Ramirez, Cuauhtemoc B / Hoffner, Lauren A / Jung, Sunhee / Jang, Ki-Hong / Rubtsova, Varvara I / Jang, Cholsoon / Lee, Gina

    The Journal of biological chemistry

    2023  Volume 299, Issue 9, Page(s) 105175

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top