LIVIVO - Search results -

Search results

Result 1 - 10 of total 98

Search options

Article: Molecular detection and assemblage analysis of the intestinal protozoan

Lee, Haeseung / Kwak, Dongmi

2023 Volume 10, Page(s) 1139060

Abstract: ... Giardia ... ...

Abstract	Giardia duodenalis
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1139060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors.

Kwon, Eun-Ji / Cha, Hyuk-Jin / Lee, Haeseung

iScience

2024 Volume 27, Issue 4, Page(s) 109448

Abstract: Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance. ... ...

Abstract	Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance. Leveraging a multi-omics approach (>1000 cancer cell lines), we explored molecular signatures linked to EGFRi responsiveness and found that expression signatures involved in the estrogen response could recapitulate cancer cell dependency on EGFR, a phenomenon not solely attributable to EGFR-activating mutations. By correlating genome-wide function screening data with EGFRi responses, we identified chemokine receptor 6 (CCR6) as a potential druggable target to mitigate EGFRi resistance. In isogenic cell models, pharmacological inhibition of CCR6 effectively reversed acquired EGFRi resistance, disrupting mitochondrial oxidative phosphorylation, a cellular process commonly associated with therapy resistance. Our data-driven strategy unveils drug-response biomarkers and therapeutic targets for resistance, thus potentially expanding EGFRi applicability and efficacy.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109448
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effect of

Park, Musun / Yi, Jin-Mu / Kim, No Soo / Lee, Seo-Young / Lee, Haeseung

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: We characterized the therapeutic biological modes of action of several terpenes ... ...

Abstract	We characterized the therapeutic biological modes of action of several terpenes in
MeSH term(s)	Molecular Docking Simulation ; Terpenes/pharmacology ; Terpenes/chemistry ; Transcriptome/drug effects ; Humans ; Wolfiporia/chemistry ; Gene Expression Profiling/methods ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics ; Microglia/drug effects ; Microglia/metabolism ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Computational Biology/methods ; Animals
Chemical Substances	Terpenes ; Antioxidants
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094636
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Ginsenoside Rc, an Active Component of

Kim, Aeyung / Park, Sang-Min / Kim, No Soo / Lee, Haeseung

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Loss of skeletal muscle mass and function has detrimental effects on quality of life, morbidity, and mortality, and is particularly relevant in aging societies. The enhancement of mitochondrial function has shown promise in promoting muscle ... ...

Abstract	Loss of skeletal muscle mass and function has detrimental effects on quality of life, morbidity, and mortality, and is particularly relevant in aging societies. The enhancement of mitochondrial function has shown promise in promoting muscle differentiation and function. Ginsenoside Rc (gRc), a major component of ginseng, has various pharmacological activities; however, its effect on muscle loss remains poorly explored. In this study, we examined the effects of gRc on the hydrogen peroxide (H
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081576
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ginsenoside Rc, an Active Component of Panax ginseng, Alleviates Oxidative Stress-Induced Muscle Atrophy via Improvement of Mitochondrial Biogenesis

Kim, Aeyung / Park, Sang-Min / Kim, No Soo / Lee, Haeseung

Antioxidants. 2023 Aug. 07, v. 12, no. 8

2023

Abstract	Loss of skeletal muscle mass and function has detrimental effects on quality of life, morbidity, and mortality, and is particularly relevant in aging societies. The enhancement of mitochondrial function has shown promise in promoting muscle differentiation and function. Ginsenoside Rc (gRc), a major component of ginseng, has various pharmacological activities; however, its effect on muscle loss remains poorly explored. In this study, we examined the effects of gRc on the hydrogen peroxide (H₂O₂)-induced reduction of cell viability in C2C12 myoblasts and myotubes and H₂O₂-induced myotube degradation. In addition, we investigated the effects of gRc on the production of intracellular reactive oxygen species (ROS) and mitochondrial superoxide, ATP generation, and peroxisome proliferator-activated receptor-gamma co-activator 1α (PGC-1α) activity in myoblasts and myotubes under H₂O₂ treatment. Furthermore, to elucidate the mechanism of action of gRc, we conducted a transcriptome analysis of myotubes treated with or without gRc under H₂O₂ treatment. gRc effectively suppressed H₂O₂-induced cytotoxicity, intracellular ROS, and mitochondrial superoxide production, restored PGC-1α promoter activity, and increased ATP synthesis. Moreover, gRc significantly affected the expression levels of genes involved in maintaining mitochondrial mass and biogenesis, while downregulating genes associated with muscle degradation in C2C12 myotubes under oxidative stress. We provide compelling evidence supporting the potential of gRc as a promising treatment for muscle loss and weakness. Further investigations of the pharmacological effects of gRc under various pathological conditions of muscle loss will contribute to the clinical development of gRc as a therapeutic intervention.
Keywords	Panax ginseng ; biogenesis ; cell viability ; cytotoxicity ; ginsenosides ; hydrogen peroxide ; mechanism of action ; mitochondria ; morbidity ; mortality ; muscles ; muscular atrophy ; myoblasts ; myotubes ; oxidative stress ; peroxisome proliferator-activated receptor gamma ; quality of life ; skeletal muscle ; therapeutics ; transcriptomics
Language	English
Dates of publication	2023-0807
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081576
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Enhanced Asymptomatic Systemic Infection Caused by Plesiomonas shigelloides in a Captive Gray Wolf (Canis lupus)

Kim, Kyoo-Tae / Lee, Haeseung / Kwak, Dongmi

Veterinary sciences. 2021 Nov. 19, v. 8, no. 11

2021

Abstract: A 7-year-old male gray wolf was found dead at a zoo during exhibition. To determine the cause of death, histological and gross necropsy diagnoses and a molecular analysis were performed. The gross necropsy revealed a swollen abdomen, hemorrhagic exudates ...

Abstract	A 7-year-old male gray wolf was found dead at a zoo during exhibition. To determine the cause of death, histological and gross necropsy diagnoses and a molecular analysis were performed. The gross necropsy revealed a swollen abdomen, hemorrhagic exudates around the mouth, splenomegaly, a discolored liver, a congested kidney, hemorrhagic ascites, and dark gray-colored membranes and air bubbles in the fundus of the stomach. Rod-shaped bacteria were found in the liver parenchyma and hemorrhagic ascites using Giemsa staining. The nucleotide sequencing of the cultured bacteria identified the causative agent as Plesiomonas shigelloides, which is rarely responsible for systemic infections. This study describes a rare case and the first reported systemic gastrointestinal infection due to P. shigelloides in a zoo animal.
Keywords	Canis lupus ; Plesiomonas shigelloides ; abdomen ; air ; ascites ; death ; etiological agents ; gastrointestinal diseases ; histology ; kidneys ; liver ; males ; mouth ; necropsy ; parenchyma (animal tissue) ; splenomegaly ; stomach ; zoo animals ; zoos
Language	English
Dates of publication	2021-1119
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2768971-2
ISSN	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci8110280
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Overexpression of Interleukin-8 Promotes the Progression of Fatty Liver to Nonalcoholic Steatohepatitis in Mice.

Cho, Ye Eun / Kim, Yeonsoo / Kim, Seung-Jin / Lee, Haeseung / Hwang, Seonghwan

International journal of molecular sciences

2023 Volume 24, Issue 20

Abstract: Nonalcoholic steatohepatitis (NASH) is an advanced stage of fatty liver disease characterized by liver damage, inflammation, and fibrosis. Although neutrophil infiltration is consistently observed in the livers of patients with NASH, the precise role of ... ...

Abstract	Nonalcoholic steatohepatitis (NASH) is an advanced stage of fatty liver disease characterized by liver damage, inflammation, and fibrosis. Although neutrophil infiltration is consistently observed in the livers of patients with NASH, the precise role of neutrophil-recruiting chemokines and infiltrating neutrophils in NASH pathogenesis remains poorly understood. Here, we aimed to elucidate the role of neutrophil infiltration in the transition from fatty liver to NASH by examining hepatic overexpression of interleukin-8 (IL8), a major chemokine responsible for neutrophil recruitment in humans. Mice fed a high-fat diet (HFD) for 3 months developed fatty liver without concurrent liver damage, inflammation, and fibrosis. Subsequent infection with an adenovirus overexpressing human IL8 for an additional 2 weeks increased IL8 levels, neutrophil infiltration, and liver injury in mice. Mechanistically, IL8-induced liver injury was associated with the upregulation of components of the NADPH oxidase 2 complex, which participate in neutrophil oxidative burst. IL8-driven neutrophil infiltration promoted macrophage aggregate formation and upregulated the expression of chemokines and inflammatory cytokines. Notably, IL8 overexpression amplified factors associated with fibrosis, including collagen deposition and hepatic stellate cell activation, in HFD-fed mice. Collectively, hepatic overexpression of human IL8 promotes neutrophil infiltration and fatty liver progression to NASH in HFD-fed mice.
MeSH term(s)	Animals ; Mice ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Inflammation/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Liver/metabolism ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism
Chemical Substances	Interleukin-8
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242015489
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Enhanced Asymptomatic Systemic Infection Caused by

Kim, Kyoo-Tae / Lee, Haeseung / Kwak, Dongmi

Veterinary sciences

2021 Volume 8, Issue 11

Abstract	A 7-year-old male gray wolf was found dead at a zoo during exhibition. To determine the cause of death, histological and gross necropsy diagnoses and a molecular analysis were performed. The gross necropsy revealed a swollen abdomen, hemorrhagic exudates around the mouth, splenomegaly, a discolored liver, a congested kidney, hemorrhagic ascites, and dark gray-colored membranes and air bubbles in the fundus of the stomach. Rod-shaped bacteria were found in the liver parenchyma and hemorrhagic ascites using Giemsa staining. The nucleotide sequencing of the cultured bacteria identified the causative agent as
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci8110280
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Non-Invasive Evaluation of a Carotid Arterial Pressure Waveform Using Motion-Tolerant Ultrasound Measurements During the Valsalva Maneuver.

Seo, Joohyun / Lee, Hae-Seung / Sodini, Charles G

IEEE journal of biomedical and health informatics

2021 Volume 25, Issue 1, Page(s) 163–174

Abstract: This work details the non-invasive evaluation of a carotid arterial blood pressure (ABP) waveform during the Valsalva maneuver. Unfocused and wide acoustic beams are insonated on the carotid artery to achieve motion-tolerant measurements with a simple ... ...

Abstract	This work details the non-invasive evaluation of a carotid arterial blood pressure (ABP) waveform during the Valsalva maneuver. Unfocused and wide acoustic beams are insonated on the carotid artery to achieve motion-tolerant measurements with a simple two-element ultrasound scanner. Arterial flow and distension waveforms are reliably estimated from spectral Doppler and M-mode ultrasound images whose qualities are consistently maintained in different phases of the maneuver despite possible displacements of the artery. A local pulse wave velocity is estimated using a flow-area method, and it is then combined with the distension waveform to produce the ABP waveform. Human subject validation on seven healthy subjects shows that the bias in pulse pressure estimates across subjects is 0.47 ± 13.1 mmHg. The average root mean square deviations of the ultrasonically measured waveform across subjects is 10.1 ± 2.43 mmHg, excluding the strain phase of the Valsalva maneuver, and 17.7 ± 6.30 mmHg in all phases. The mean correlation coefficient between the ultrasonically measured and reference waveform is calculated to be 0.92 ± 0.04 across subjects. Detailed morphological features and their changes across different phases are observed as reported. This uninterrupted central ABP waveform monitoring under hemodynamics changes supports the idea of a novel stress test to evaluate the health and dynamics of the cardiovascular system at a spot check in clinical settings.
MeSH term(s)	Arterial Pressure ; Blood Pressure ; Blood Pressure Determination ; Carotid Arteries/diagnostic imaging ; Humans ; Pulse Wave Analysis ; Valsalva Maneuver
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2020.2995344
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5483: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models

Kim, Jihyun / Lee, Changyong / Noh, Sang Gyun / Kim, Seungwoo / Chung, Hae Young / Lee, Haeseung / Moon, Jeon-Ok

Antioxidants. 2023 Aug. 09, v. 12, no. 8

2023

Abstract: Liver fibrosis, defined by the aberrant accumulation of extracellular matrix proteins in liver tissue due to chronic inflammation, represents a pressing global health issue. In this study, we investigated the transcriptomic signatures of three ... ...

Abstract	Liver fibrosis, defined by the aberrant accumulation of extracellular matrix proteins in liver tissue due to chronic inflammation, represents a pressing global health issue. In this study, we investigated the transcriptomic signatures of three independent liver fibrosis models induced by bile duct ligation, carbon tetrachloride, and dimethylnitrosamine (DMN) to unravel the pathological mechanisms underlying hepatic fibrosis. We observed significant changes in gene expression linked to key characteristics of liver fibrosis, with a distinctive correlation to the burn-wound-healing pathway. Building on these transcriptomic insights, we further probed the p53 signaling pathways within the DMN-induced rat liver fibrosis model, utilizing western blot analysis. We observed a pronounced elevation in p53 protein levels and heightened ratios of BAX/BCL2, cleaved/pro-CASPASE-3, and cleaved/full length-PARP in the livers of DMN-exposed rats. Furthermore, we discovered that orally administering oligonol—a polyphenol, derived from lychee, with anti-oxidative properties—effectively countered the overexpressions of pivotal apoptotic genes within these fibrotic models. In conclusion, our findings offer an in-depth understanding of the molecular alterations contributing to liver fibrosis, spotlighting the essential role of the apoptosis pathway tied to the burn-wound-healing process. Most importantly, our research proposes that regulating this pathway, specifically the balance of apoptosis, could serve as a potential therapeutic approach for treating liver fibrosis.
Keywords	Western blotting ; apoptosis ; bile ducts ; carbon tetrachloride ; extracellular matrix ; inflammation ; litchis ; liver ; liver cirrhosis ; models ; polyphenols ; rats ; therapeutics ; transcriptomics
Language	English
Dates of publication	2023-0809
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12081588
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito