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  1. Book ; Online: Asian Yearbook of International Law, Volume 25 (2019)

    Lee, Seokwoo / Lee, Hee Eun

    (Asian Yearbook of International Law)

    2022  

    Series title Asian Yearbook of International Law
    Keywords International law ; Law
    Language 0|e
    Size 1 electronic resource (388 pages)
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021615081
    ISBN 9789004501249 ; 900450124X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Asian Yearbook of International Law, Volume 24 (2018)

    Lee, Seokwoo / Lee, Hee Eun

    2020  

    Keywords International law
    Size 1 electronic resource (463 pages)
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021051111
    ISBN 9789004437777 ; 9004437770
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Asian Yearbook of International Law, Volume 23 (2017)

    Lee, Seokwoo / Lee, Hee Eun

    (Asian Yearbook of International Law)

    2019  

    Series title Asian Yearbook of International Law
    Keywords International law ; Law
    Language 0|e
    Size 1 electronic resource (343 pages)
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021614852
    ISBN 9789004415829 ; 9004415823
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Mimickers of immunoglobulin G4-related hepatobiliary disease on biopsy.

    Park, Byoung Uk / Lee, Hee Eun / Zhang, Lizhi

    Seminars in diagnostic pathology

    2024  Volume 41, Issue 2, Page(s) 95–107

    Abstract: With the growing recognition of IgG4-related hepatobiliary disease, establishing a definitive diagnosis relies mainly on a combination of clinical findings, serological markers, and imaging modalities. However, the role of histopathological evaluation ... ...

    Abstract With the growing recognition of IgG4-related hepatobiliary disease, establishing a definitive diagnosis relies mainly on a combination of clinical findings, serological markers, and imaging modalities. However, the role of histopathological evaluation remains indispensable, particularly in cases necessitating differential diagnosis or malignancy exclusion. While diagnosing IgG4-related hepatobiliary disease through surgical resection specimens is often straightforward, pathologists encounter substantial challenges when evaluating biopsies. The increasing rarity of surgical interventions exacerbates this due to improved disease recognition and suspicion. Numerous confounding factors, including the absence of the characteristic histologic features, limited tissue sample size, biopsy artifacts, and the limited value of IgG4 counts, further complicate the diagnostic process. Additionally, many other disorders exhibit clinical and histological features that overlap with IgG4-related disease, intensifying the complexity of interpreting biopsy specimens. This article explores the clinical and histomorphologic features of IgG4-related hepatobiliary disease and its potential mimickers. It offers valuable insights for pathologists and clinicians when confronted with biopsy specimens from hepatobiliary organs.
    MeSH term(s) Humans ; Immunoglobulin G4-Related Disease ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/pathology ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/pathology ; Biopsy ; Immunoglobulin G ; Diagnosis, Differential
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2024.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Understanding User Perception and Intention to Use Smart Homes for Energy Efficiency

    Zharova, Alona / Lee, Hee-Eun

    A Survey

    2022  

    Abstract: The positive impact of Smart Homes on energy efficiency is heavily dependent on how consumers use the system after adoption. While the technical aspects of Smart Home systems and their potential to reduce energy usage is a focus of various studies, there ...

    Abstract The positive impact of Smart Homes on energy efficiency is heavily dependent on how consumers use the system after adoption. While the technical aspects of Smart Home systems and their potential to reduce energy usage is a focus of various studies, there is a limited consideration of behavioral psychology while designing systems for energy management. To investigate users' perception and intention to use Smart Homes to support energy efficiency, we design a research model by combining a theory of planned behavior and the norm activation model. We design a questionnaire and conduct a survey targeting current smart home users (over 350 responses). To analyze the survey results, we extend the partial least squares structural equation modeling (PLS-SEM) by a random forest algorithm. The findings suggest that personal norms have the strongest influence on behavioral intention to use Smart Homes for energy efficiency, followed by the ascription of responsibility. Furthermore, the results support the effects of attitudes, subjective norms, awareness of consequences, as well as the moderating effect of past behavior on the relationship between personal norms and behavioral intentions.
    Keywords Computer Science - Human-Computer Interaction
    Subject code 690
    Publishing date 2022-12-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond.

    Chen, Zongming Eric / Lee, Hee Eun / Wu, Tsung-Teh

    Human pathology

    2022  Volume 132, Page(s) 20–30

    Abstract: Celiac disease (CD) is an immunoallergic enteropathy affecting genetically susceptible individuals upon dietary exposure to gluten. In current clinical practice, the diagnosis of CD is based on a combination of clinical, serologic, and histologic factors ...

    Abstract Celiac disease (CD) is an immunoallergic enteropathy affecting genetically susceptible individuals upon dietary exposure to gluten. In current clinical practice, the diagnosis of CD is based on a combination of clinical, serologic, and histologic factors with the possible exception of pediatric patients. Histopathologic evaluation of small intestinal tissue plays a critical role in the disease diagnosis and management, despite many practical challenges. Recently published best practice guidelines help to standardize biopsy sample procurement, tissue preparation, histology interpretation, and reporting, to optimize patient care. In addition, an increasing demand for monitoring the disease course, particularly demonstrating the efficacy of dietary and nondietary interventions for disease management, calls for the use of quantitative histology. With the advent of a gradual transition toward digital pathology in routine diagnostic practice, quantitative histopathologic evaluation in CD shows a promising future.
    MeSH term(s) Humans ; Child ; Celiac Disease/diagnosis ; Celiac Disease/therapy ; Genetic Predisposition to Disease
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2022.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Solitary Involvement of the Liver: A Rare Manifestation of Langerhans Cell Histiocytosis.

    Consing, Margarita / Lee, Hee Eun / Jess, Heidi / Vahidi, Shifteh

    The American journal of case reports

    2022  Volume 23, Page(s) e937628

    Abstract: BACKGROUND Langerhans cell histiocytosis (LCH) is a rare condition caused by a neoplastic proliferation of myeloid cells. It can present as a single-system or multi-system disorder. Worse prognosis is associated with the hematopoietic system (spleen, ... ...

    Abstract BACKGROUND Langerhans cell histiocytosis (LCH) is a rare condition caused by a neoplastic proliferation of myeloid cells. It can present as a single-system or multi-system disorder. Worse prognosis is associated with the hematopoietic system (spleen, liver, bone marrow), which is routinely observed in multi-system disease. Because of the varied presentation of this disorder, diagnosis can be difficult, and therefore suitable treatment can be delayed. CASE REPORT We report a case of hepatic LCH in a 51-year-old man who presented with epigastric abdominal pain, with imaging demonstrating a hepatic nodule. A low ejection fraction on hepatobiliary iminodiacetic acid scan suggested chronic cholecystitis. Therefore, the patient underwent a cholecystectomy for biliary dyskinesia, in which liver nodules were noted, and biopsies were taken. The biopsies demonstrated characteristic findings of LCH along with positive immunohistochemical markers and negative BRAF V600E mutation. Radiologic and pathologic findings were consistent with LCH within the liver, associated with bile duct injury and mild biliary obstruction. The patient was placed on a cladribine regimen. His abdominal pain improved. CONCLUSIONS LCH limited to the liver is uncommon and can appear as chronic biliary disease, as was suspected in this case. Despite the poor prognosis of hematopoietic LCH, early recognition can lead to better outcome and chemotherapy susceptibility. This patient was most likely in the first stage of liver LCH, given his presentation, which could have aided his response to chemotherapy. The lack of BRAF V600E mutation could have contributed to a positive prognosis and more possibilities for treatment.
    MeSH term(s) Male ; Humans ; Middle Aged ; Proto-Oncogene Proteins B-raf/genetics ; Mutation ; Histiocytosis, Langerhans-Cell/diagnosis ; Liver ; Abdominal Pain
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.937628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immunoglobulin G4-related hepatobiliary disease.

    Lee, Hee Eun / Zhang, Lizhi

    Seminars in diagnostic pathology

    2019  Volume 36, Issue 6, Page(s) 423–433

    Abstract: Immunoglobuline G4-related disease (IgG4-RD) is a systemic disease that can involve virtually any organs including the biliary tract and liver. The biliary tract involvement of IgG4-RD is known as IgG4-sclerosing cholangitis (IgG4-SC) and may or may not ... ...

    Abstract Immunoglobuline G4-related disease (IgG4-RD) is a systemic disease that can involve virtually any organs including the biliary tract and liver. The biliary tract involvement of IgG4-RD is known as IgG4-sclerosing cholangitis (IgG4-SC) and may or may not present with an inflammatory pseudotumor. Large bile ducts such as extrahepatic, hilar, and perihilar ducts are typically affected and demonstrate marked bile duct wall thickening and develop strictures. Histologically, the involved ducts show transmural dense lymphoplasmacytic infiltrates with storiform fibrosis extending into peribiliary glands and periductal soft tissue. The luminal epithelium is usually preserved. Tissue eosinophilia and obliterative phlebitis are also frequently noted. Liver biopsy findings of IgG4-SC are heterogeneous and rather nonspecific, but two features specific to IgG4-SC have been described: >10 IgG4-positive plasma cell/HPF and small portal-based fibroinflammatory nodules. Secondary changes, due to downstream bile duct obstruction are often appreciated. When considering the differential diagnosis, primary sclerosing cholangitis and cholangiocarcinoma are great clinical and histologic mimics of IgG4-SC. Liver involvement in IgG4-RD has not been well characterized and includes IgG4-hepatopathy and IgG4-related autoimmune hepatitis (AIH). IgG4-hepatopathy is a generic term covering hepatic lesions related to IgG4-RD and /or IgG4-SC. It includes primary liver parenchymal changes inherent to IgG4-RD, liver parenchymal involvement of IgG4-SC, and secondary changes related to IgG4-SC. IgG4-related AIH is characterized by clinical and histologic features of classical AIH but with prominent (>10/HPF) IgG4-positive plasma cells. It is unclear whether this represents a hepatic manifestation of IgG4-RD or a subset of AIH with increased IgG4-positive plasma cells at the present time. Synchronous or metachronous involvement of other organs, offers a clue to make this distinction. IgG4 immunohistochemistry has an important role in diagnosing IgG4-RD. But the diagnosis cannot be made solely based on the number of IgG4-positive plasma cells, and results need to be interpreted with caution as increased IgG4-positive plasma cells can be seen in other inflammatory conditions or even in malignancy.
    MeSH term(s) Autoimmune Diseases/pathology ; Biliary Tract/pathology ; Biopsy ; Cholangiocarcinoma/pathology ; Cholangitis, Sclerosing/pathology ; Diagnosis, Differential ; Granuloma, Plasma Cell/pathology ; Hepatitis, Autoimmune/pathology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G4-Related Disease/pathology ; Liver/pathology ; Liver Diseases/pathology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605834-6
    ISSN 1930-1111 ; 0740-2570
    ISSN (online) 1930-1111
    ISSN 0740-2570
    DOI 10.1053/j.semdp.2019.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bioinformatics Analysis of Evolution and Human Disease Related Transposable Element-Derived microRNAs.

    Lee, Hee-Eun / Huh, Jae-Won / Kim, Heui-Soo

    Life (Basel, Switzerland)

    2020  Volume 10, Issue 6

    Abstract: Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24 ... ...

    Abstract Transposable element (TE) has the ability to insert into certain parts of the genome, and due to this event, it is possible for TEs to generate new factors and one of these factors are microRNAs (miRNA). miRNAs are non-coding RNAs made up of 19 to 24 nucleotides and numerous miRNAs are derived from TE. In this study, to support general knowledge on TE and miRNAs derived from TE, several bioinformatics tools and databases were used to analyze miRNAs derived from TE in two aspects: evolution and human disease. The distribution of TEs in diverse species presents that almost half of the genome is covered with TE in mammalians and less than a half in other vertebrates and invertebrates. Based on selected evolution-related miRNAs studies, a total of 51 miRNAs derived from TE were found and analyzed. For the human disease-related miRNAs, total of 34 miRNAs derived from TE were organized from the previous studies. In summary, abundant miRNAs derived from TE are found, however, the function of miRNAs derived from TE is not informed either. Therefore, this study provides theoretical understanding of miRNAs derived from TE by using various bioinformatics tools.
    Language English
    Publishing date 2020-06-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life10060095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neuroendocrine Cells Are Commonly Absent in the Intestinal Crypts in Autoimmune Enteropathy.

    Lee, Hee Eun / Yuan, Lin / Wu, Tsung-Teh

    The American journal of surgical pathology

    2020  Volume 44, Issue 8, Page(s) 1130–1136

    Abstract: The absence of neuroendocrine (NE) cells in the intestinal mucosa in autoimmune enteropathy (AIE) has been occasionally reported. However, the status of NE cells has not been studied in detail in AIE. Small bowel and colonic biopsies were retrospectively ...

    Abstract The absence of neuroendocrine (NE) cells in the intestinal mucosa in autoimmune enteropathy (AIE) has been occasionally reported. However, the status of NE cells has not been studied in detail in AIE. Small bowel and colonic biopsies were retrospectively retrieved from 18 AIE patients (26 baseline [18 small bowel and 8 colon]; and 15 follow-up [11 duodenum and 4 colon] biopsies in 11 patients). Thirty-three common variable immunodeficiency (CVID) patients (30 small bowel and 16 colon), 15 inflammatory bowel disease patients (5 duodenum and 10 colon), 13 immunoglobulinA deficiency patients (13 duodenum and 5 colon), and 10 normal controls (5 colon and 5 duodenum) were selected as control groups. Histologic features (villous atrophy, intraepithelial lymphocytosis, acute inflammation, crypt apoptosis, and absence or presence of goblet cells, Paneth cells and plasma cells) were recorded. Chromogranin immunostain was performed and chromogranin-positive NE cells were counted per 10 consecutive, well-oriented crypts. On the basis of the number of chromogranin-positive NE cells, cases were graded as being absent (≤3 NE cells), markedly decreased (≤15), and intact (>15). The NE cell status correlated with histologic features. The median age of 18 AIE patients was 38.5 years (range: 11 to 74 y) and 14 patients were male. Fourteen of 18 (78%) patients showed loss (absent or markedly decreased) of NE cells in the small bowel and/or colon in the baseline biopsies including 12 (of 18) small bowel and 6 (of 8) colon biopsies. Follow-up biopsy was available in 11 patients. Six of 7 (85%) patients who showed loss of NE cells in the baseline biopsies regained NE cells in the follow-up biopsies, and 1 patient continued to show loss of NE cells. Four patients who showed intact NE cells in the baseline remained unchanged in the follow-up. Among the control groups, 3 of 33 (9%) CVID patients showed loss of NE cells. NE cells were not lost in the biopsies of all 15 and 13 patients with inflammatory bowel disease and immunoglobulinA deficiency, respectively, or the 10 normal controls. In all 41 biopsies (26 baseline plus 15 follow-up) with AIE, NE cell loss was significantly associated with increased crypt apoptosis and loss of goblet cells (P=0.001, both) but not with other histologic findings. In conclusion, our study suggests that NE cells may also be the target cells in AIE and commonly lost in the intestinal crypts in AIE, and consequently loss of NE cells can be used as an adjunct histologic feature for diagnosis of AIE.
    MeSH term(s) Adolescent ; Adult ; Aged ; Biomarkers/analysis ; Biopsy ; Child ; Chromogranins/analysis ; Colon/chemistry ; Colon/immunology ; Colon/pathology ; Databases, Factual ; Female ; Humans ; Immunohistochemistry ; Intestinal Mucosa/chemistry ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Intestine, Small/chemistry ; Intestine, Small/immunology ; Intestine, Small/pathology ; Male ; Middle Aged ; Neuroendocrine Cells/chemistry ; Neuroendocrine Cells/immunology ; Neuroendocrine Cells/pathology ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/metabolism ; Polyendocrinopathies, Autoimmune/pathology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Young Adult
    Chemical Substances Biomarkers ; Chromogranins
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/PAS.0000000000001516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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