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Article ; Online: Effects of COVID-19 vaccine type on Guillain-Barré syndrome: Two cases and a literature review.

Lee, Hsin-Yu / Lien, Wan-Ching

2023 Volume 19, Issue 1, Page(s) 2171231

Abstract: Guillain-Barré syndrome (GBS) is a rare but severe complication of COVID-19 vaccination. We report two cases of GBS following vaccination with the adenovirus vector vaccine ChAdOx1 nCoV-19 (Vaxzevria, AstraZeneca) and review the relevant literature. ... ...

Abstract	Guillain-Barré syndrome (GBS) is a rare but severe complication of COVID-19 vaccination. We report two cases of GBS following vaccination with the adenovirus vector vaccine ChAdOx1 nCoV-19 (Vaxzevria, AstraZeneca) and review the relevant literature. Relevant studies published between December 2020 and May 2022 including 881 patients with GBS were reviewed. GBS incidence and the need for mechanical ventilation were reported at a higher level among patients receiving Vaxzevria (n = 400). However, incidence cannot be accurately estimated from case reports. Thus, the true GBS rates following COVID-19 vaccination should be determined by population-based data.
MeSH term(s)	Humans ; Guillain-Barre Syndrome/etiology ; Guillain-Barre Syndrome/epidemiology ; COVID-19 Vaccines/adverse effects ; Influenza Vaccines ; ChAdOx1 nCoV-19 ; COVID-19/prevention & control ; COVID-19/complications ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2171231
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Article ; Online: A man with right flank pain.

Lee, Hsin-Yu / Lien, Wan-Ching / Wang, Hsiu-Po

Emergency medicine journal : EMJ

2023 Volume 40, Issue 7, Page(s) 498–517

MeSH term(s)	Male ; Humans ; Flank Pain/etiology ; Ultrasonography ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2022-212635
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Zs.A 1941: Show issues

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Article ; Online: Lysophosphatidic Acid Receptor 3 Activation Is Involved in the Regulation of Ferroptosis.

Huang, Yi-Xun / Lin, Kuan-Hung / Chiang, Jui-Chung / Chen, Wei-Min / Lee, Hsinyu

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Ferroptosis, a unique form of programmed cell death trigged by lipid peroxidation and iron accumulation, has been implicated in embryonic erythropoiesis and aging. Our previous research demonstrated that lysophosphatidic acid receptor 3 ( ... ...

Abstract	Ferroptosis, a unique form of programmed cell death trigged by lipid peroxidation and iron accumulation, has been implicated in embryonic erythropoiesis and aging. Our previous research demonstrated that lysophosphatidic acid receptor 3 (LPA
MeSH term(s)	Mice ; Animals ; Humans ; Receptors, Lysophosphatidic Acid/genetics ; Receptors, Lysophosphatidic Acid/metabolism ; Ferroptosis ; Apoptosis ; Oxidative Stress ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Iron/metabolism
Chemical Substances	Receptors, Lysophosphatidic Acid ; NF-E2-Related Factor 2 ; Iron (E1UOL152H7)
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042315
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Article: Lysophosphatidic Acid Receptor 3 Promotes Mitochondrial Homeostasis against Oxidative Stress: Potential Therapeutic Approaches for Hutchinson–Gilford Progeria Syndrome

Chiang, Jui-Chung / Chen, Wei-Min / Newman, Ciara / Chen, Benjamin P. C. / Lee, Hsinyu

Antioxidants. 2022 Feb. 10, v. 11, no. 2

2022

Abstract: Lysophosphatidic acid (LPA) is a growth factor-like lipid mediator that regulates various physiological functions via activation of multiple LPA G protein-coupled receptors. We previously reported that LPA suppresses oxidative stress in premature aging ... ...

Abstract	Lysophosphatidic acid (LPA) is a growth factor-like lipid mediator that regulates various physiological functions via activation of multiple LPA G protein-coupled receptors. We previously reported that LPA suppresses oxidative stress in premature aging Hutchinson-Gilford progeria syndrome (HGPS) patient fibroblasts via its type 3 receptor (LPA₃). Mitochondria have been suggested to be the primary origin of oxidative stress via the overproduction of reactive oxygen species (ROS). Mitochondria are responsible for producing ATP through oxidative phosphorylation (OXPHOS) and have a calcium buffering capacity for the cell. Defects in mitochondria will lead to declined antioxidant capacity and cell apoptosis. Therefore, we aim to demonstrate the regulatory role of LPA₃ in mitochondrial homeostasis. siRNA-mediated depletion of LPA₃ leads to the depolarization of mitochondrial potential (ΔΨm) and cellular ROS accumulation. In addition, the depletion of LPA₃ enhances cisplatin-induced cytochrome C releasing. This indicates that LPA₃ is essential to suppress the mitochondrial apoptosis pathway. LPA₃ is also shown to improve mitochondrial ADP-ATP exchange by enhancing the protein level of ANT2. On the other hand, LPA₃ regulates calcium uptake from the ER to mitochondria via the IP3R1-VDAC1 channel. Moreover, activation of LPA₃ by selective agonist OMPT rescues mitochondrial homeostasis of H₂O₂-induced oxidative stress cells and HGPS patient fibroblasts by improving mitochondrial ΔΨm and OXPHOS. In summary, our findings imply that LPA₃ acts as the gatekeeper for mitochondrial healthiness to maintain cell youth. Furthermore, LPA₃ can be a promising therapeutic target to prevent mitochondrial oxidative stress in aging and HGPS.
Keywords	agonists ; antioxidant activity ; apoptosis ; calcium ; cytochrome c ; fibroblasts ; homeostasis ; lysophospholipids ; mitochondria ; oxidative phosphorylation ; oxidative stress ; patients ; protein content ; reactive oxygen species ; therapeutics ; youth
Language	English
Dates of publication	2022-0210
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11020351
Database	NAL-Catalogue (AGRICOLA)

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Article: Lysophosphatidic Acid Receptor 3 Promotes Mitochondrial Homeostasis against Oxidative Stress: Potential Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome.

Chiang, Jui-Chung / Chen, Wei-Min / Newman, Ciara / Chen, Benjamin P C / Lee, Hsinyu

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 2

Abstract	Lysophosphatidic acid (LPA) is a growth factor-like lipid mediator that regulates various physiological functions via activation of multiple LPA G protein-coupled receptors. We previously reported that LPA suppresses oxidative stress in premature aging Hutchinson-Gilford progeria syndrome (HGPS) patient fibroblasts via its type 3 receptor (LPA
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11020351
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Article ; Online: Polypharmacy and potential drug-drug interactions among people living with HIV in the era of integrase strand transfer inhibitor-based antiretroviral therapy.

Peng, An-Ting / Huang, Sung-Hsi / Lee, Hsin-Yu / Wu, Pei-Ying / Kuo, Han-Yueh / Hung, Chien-Ching

International journal of antimicrobial agents

2023 Volume 63, Issue 2, Page(s) 107067

Abstract: Objectives: To investigate the prevalence of polypharmacy and potential drug-drug interactions (DDIs), and the factors associated with DDIs among people living with human immunodeficiency virus (HIV; PLWH) in the modern era of antiretroviral therapy ( ... ...

Abstract	Objectives: To investigate the prevalence of polypharmacy and potential drug-drug interactions (DDIs), and the factors associated with DDIs among people living with human immunodeficiency virus (HIV; PLWH) in the modern era of antiretroviral therapy (ART). Methods: This cross-sectional study included PLWH who had been on ART for ≥3 months at two designated HIV hospitals in Taiwan. All ART and non-ART prescriptions were collected from the NHI-MediCloud System and screened for DDIs using the University of Liverpool HIV drug interactions database. A case-control analysis was conducted to investigate the factors associated with DDIs. Results: In total, 1007 PLWH were included in this study from June 2021 to August 2022. The median age was 40 (interquartile range 33-49) years, and 96.2% were taking integrase strand transfer inhibitor (INSTI)-based ART. The proportions of PLWH with at least one non-communicable disease and polypharmacy were 50.0% and 18.7%, respectively. Seven (0.7%) PLWH had red-flagged DDIs, and 159 (15.8%) had amber-flagged DDIs. In multi-variable models, the prevalence of DDIs was associated with older age [adjusted odds ratio (aOR) per 1-year increase 1.022), number of co-medications (aOR 1.097), use of boosted INSTI-based ART (vs unboosted INSTI, aOR 8.653), and concomitant medications in the alimentary tract and metabolism category (aOR 11.058) and anti-neoplastic and immunomodulating agents (aOR 14.733). Conclusions: In the INSTI era, the prevalence of potential DDIs is lower than noted previously, but remains substantial. Clinicians should monitor DDIs routinely, especially in older PLWH, those taking a higher number of co-medications, and those who are taking booster-containing ART or medications from specific categories.
MeSH term(s)	Humans ; Aged ; Adult ; Middle Aged ; HIV ; Polypharmacy ; Cross-Sectional Studies ; HIV Infections/complications ; Drug Interactions ; Integrases
Chemical Substances	Integrases (EC 2.7.7.-)
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.107067
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article ; Online: E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.

Lin, Kuan-Hung / Lee, Sue Chin / Dacheux, Mélanie A / Norman, Derek D / Balogh, Andrea / Bavaria, Mitul / Lee, Hsinyu / Tigyi, Gabor

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 7, Page(s) e23058

Abstract: Dysregulation of the autotaxin (ATX, Enpp2)-lysophosphatidic acid (LPA) signaling in cancerous cells contributes to tumorigenesis and therapy resistance. We previously found that ATX activity was elevated in p53-KO mice compared to wild-type (WT) mice. ... ...

Abstract	Dysregulation of the autotaxin (ATX, Enpp2)-lysophosphatidic acid (LPA) signaling in cancerous cells contributes to tumorigenesis and therapy resistance. We previously found that ATX activity was elevated in p53-KO mice compared to wild-type (WT) mice. Here, we report that ATX expression was upregulated in mouse embryonic fibroblasts from p53-KO and p53
MeSH term(s)	Humans ; Mice ; Animals ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Fibroblasts/metabolism ; Gene Expression Regulation ; Signal Transduction ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; Chromosomes ; Lysophospholipids/metabolism ; E2F7 Transcription Factor/genetics ; E2F7 Transcription Factor/metabolism
Chemical Substances	Tumor Suppressor Protein p53 ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Lysophospholipids ; E2F7 protein, human ; E2F7 Transcription Factor
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202300838R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.

Chen, Wei-Min / Chiang, Jui-Chung / Shang, Zengfu / Palchik, Guillermo / Newman, Ciara / Zhang, Yuanyuan / Davis, Anthony J / Lee, Hsinyu / Chen, Benjamin Pc

The EMBO journal

2023 Volume 42, Issue 6, Page(s) e112094

Abstract: DNA-PKcs is a key regulator of DNA double-strand break repair. Apart from its canonical role in the DNA damage response, DNA-PKcs is involved in the cellular response to oxidative stress (OS), but its exact role remains unclear. Here, we report that DNA- ... ...

Abstract	DNA-PKcs is a key regulator of DNA double-strand break repair. Apart from its canonical role in the DNA damage response, DNA-PKcs is involved in the cellular response to oxidative stress (OS), but its exact role remains unclear. Here, we report that DNA-PKcs-deficient human cells display depolarized mitochondria membrane potential (MMP) and reoriented metabolism, supporting a role for DNA-PKcs in oxidative phosphorylation (OXPHOS). DNA-PKcs directly interacts with mitochondria proteins ANT2 and VDAC2, and formation of the DNA-PKcs/ANT2/VDAC2 (DAV) complex supports optimal exchange of ADP and ATP across mitochondrial membranes to energize the cell via OXPHOS and to maintain MMP. Moreover, we demonstrate that the DAV complex temporarily dissociates in response to oxidative stress to attenuate ADP-ATP exchange, a rate-limiting step for OXPHOS. Finally, we found that dissociation of the DAV complex is mediated by phosphorylation of DNA-PKcs at its Thr2609 cluster by ATM kinase. Based on these findings, we propose that the coordination between the DAV complex and ATM serves as a novel oxidative stress checkpoint to decrease ROS production from mitochondrial OXPHOS and to hasten cellular recovery from OS.
MeSH term(s)	Humans ; Adenosine Triphosphate/metabolism ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; DNA/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Mitochondria/metabolism ; Oxidative Stress ; Phosphorylation
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, human (EC 2.7.11.1) ; DNA (9007-49-2) ; DNA-Binding Proteins
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2022112094
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

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Article: Microcrater-Arrayed Chemiluminescence Cell Chip to Boost Anti-Cancer Drug Administration in Zebrafish Tumor Xenograft Model

Kuo, Ching-Te / Lai, Yu-Sheng / Lu, Siang-Rong / Lee, Hsinyu / Chang, Hsiu-Hao

Biology. 2021 Dec. 21, v. 11, no. 1

2021

Abstract: Purpose: The aim of this study was to develop a rapid and automatic drug screening platform using microcrater-arrayed (µCA) cell chips. Methods: The µCA chip was fabricated using a laser direct writing technique. The fabrication time required for one 9 × ...

Abstract	Purpose: The aim of this study was to develop a rapid and automatic drug screening platform using microcrater-arrayed (µCA) cell chips. Methods: The µCA chip was fabricated using a laser direct writing technique. The fabrication time required for one 9 × 9 microarray wax chip was as quick as 1 min. On a nanodroplet handling platform, the chip was pre-coated with anti-cancer drugs, including cyclophosphamide, cisplatin, doxorubicin, oncovin, etoposide, and 5-fluorouracil, and their associated mixtures. Cell droplets containing 100 SK-N-DZ or MCF-7 cells were then loaded onto the chip. Cell viability was examined directly through a chemiluminescence assay on the chip using the CellTiter-Glo assay. Results: The time needed for the drug screening assay was demonstrated to be less than 30 s for a total of 81 tests. The prediction of optimal drug synergy from the µCA chip was found by matching it to that of the zebrafish MCF-7 tumor xenograft model, instead of the conventional 96-well plate assay. In addition, the critical reagent volume and cell number for each µCA chip test were 200 nL and 100 cells, respectively, which were significantly lower than 100 µL and 4000 cells, which were achieved using the 96-well assay. Conclusion: Our study for the µCA chip platform could improve the high-throughput drug synergy screening targeting the applications of tumor cell biology.
Keywords	Danio rerio ; cell viability ; chemiluminescence ; cisplatin ; cyclophosphamide ; doxorubicin ; drug synergism ; etoposide ; fluorouracil ; luminescent assay ; microarray technology ; models ; neoplasm cells ; neoplasms ; prediction ; xenotransplantation
Language	English
Dates of publication	2021-1221
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11010004
Database	NAL-Catalogue (AGRICOLA)

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Article: Toward COVID-19 Information: Infodemic or Fear of Missing Out?

Yu, Sen-Chi / Chen, Hong-Ren / Liu, An-Chia / Lee, Hsin-Yu

Healthcare (Basel, Switzerland)

2020 Volume 8, Issue 4

Abstract: Coronavirus disease 2019 (COVID-19) has caused a global pandemic and exerted a profound physiological and mental impact on the public. Due to anxiety from being bombarded by information from the news and social media, people may constantly read and ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has caused a global pandemic and exerted a profound physiological and mental impact on the public. Due to anxiety from being bombarded by information from the news and social media, people may constantly read and repost, with a fear of missing out (FOMO), information about COVID-19 on social media. So far, there has been little research on COVID-19 FOMO. We therefore compiled the COVID-19 information fear of missing out scale (CIFS) and administered it to 1178 adults in Taiwan to identify the possible factors influencing CIFS scores. We demonstrated that the CIFS had good reliability, factor validity, and criterion validity. With regard to demographic variables, we found that gender, marital status, travel time to the nearest hospital, and educational background influenced CIFS scores. In contrast, the participant age and whether he or she lived in an urban area did not affect the CIFS scores. With regard to social media usage, social media usage time (
Language	English
Publishing date	2020-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare8040550
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