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  1. Article ; Online: A commentary on 'Objective measurement of retention of laparoscopic skills: a prospective cohort study'.

    Chiu, Si-Un Frank / Lee, Hui-Ming / Chiu, Chong-Chi

    International journal of surgery (London, England)

    2023  Volume 109, Issue 8, Page(s) 2533–2534

    MeSH term(s) Humans ; Prospective Studies ; Laparoscopy ; Clinical Competence ; Educational Measurement
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6502: Show issues Location:
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  2. Article ; Online: Anti-Cancer Effects of CDK4/6 Inhibitor LEE011 and Chemotherapy Drugs on Lymphocytic Leukemia L1210 Cells.

    Lin, Yu-Cheng / Lin, Yuan-Ho / Chang, Y U / Su, Yu-Chieh / Hsieh, Wen-Chuan / Chen, Wen-Hui / Lee, Hui-Ming

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 1121–1130

    Abstract: Background/aim: Chronic lymphocytic leukemia is a slowly-progressing disease in which symptoms often do not manifest until years after disease onset. In advanced stages, infection and bleeding are common. Past studies have shown that the interaction ... ...

    Abstract Background/aim: Chronic lymphocytic leukemia is a slowly-progressing disease in which symptoms often do not manifest until years after disease onset. In advanced stages, infection and bleeding are common. Past studies have shown that the interaction between CDK4/6 inhibitors and chemotherapy drugs can enhance the anti-tumor efficacy of drugs and limit toxicity. Therefore, in this study, the treatment effects of combining the CDK4/6 inhibitor LEE011 with chemotherapy drugs bendamustine or hydroxyurea were investigated in vitro.
    Materials and methods: The mouse lymphocytic leukemia cell line L1210 was treated with LEE011 combined with hydroxyurea or bendamustine. Western blot and flow cytometry were performed to elucidate the mechanisms behind tumor suppression.
    Results: LEE011 combined with hydroxyurea or bendamustine significantly inhibited proliferation of L1210 cell lines in a concentration- and time-dependent manner as well as increased the arrest of cells in G
    Conclusion: CDK4/6 inhibitor LEE011 treatment alone may not be a suitable treatment option for lymphocytic leukemia; however, our findings in vitro support the combination of LEE011 with chemotherapy drugs to enhance anti-tumor activity in lymphocytic leukemia.
    MeSH term(s) Animals ; Mice ; Cell Proliferation ; Hydroxyurea/pharmacology ; Bendamustine Hydrochloride ; Neoplasms ; Cyclin-Dependent Kinase Inhibitor Proteins ; Cyclin-Dependent Kinase 4 ; Cell Line, Tumor ; Aminopyridines ; Purines
    Chemical Substances ribociclib (TK8ERE8P56) ; Hydroxyurea (X6Q56QN5QC) ; Bendamustine Hydrochloride (981Y8SX18M) ; Cyclin-Dependent Kinase Inhibitor Proteins ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Aminopyridines ; Purines
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 5-Methoxytryptophan enhances the sensitivity of sorafenib on the inhibition of proliferation and metastasis for lung cancer cells.

    Chen, Huang-Chi / Kuo, Chia-Yu / Chang, Yu / Tsai, Dong-Lin / Lee, Mei-Hsuan / Lee, Jui-Ying / Lee, Hui-Ming / Su, Yu-Chieh

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 248

    Abstract: Background: Lung cancer is a leading cause of cancer-related mortality worldwide, and effective therapies are limited. Lung cancer is a leading cause of cancer-related mortality worldwide with limited effective therapy. Sorafenib is a multi-tyrosine ... ...

    Abstract Background: Lung cancer is a leading cause of cancer-related mortality worldwide, and effective therapies are limited. Lung cancer is a leading cause of cancer-related mortality worldwide with limited effective therapy. Sorafenib is a multi-tyrosine kinase inhibitor frequently used to treat numerous types of malignant tumors. However, it has been demonstrated that sorafenib showed moderate antitumor activity and is associated with several side effects in lung cancer, which restricted its clinical application. This study aimed to examine the antitumor effect of the combination treatment of sorafenib and 5-methoxytryptophan (5-MTP) on cell growth and metastasis of Lewis lung carcinoma (LLC) cells.
    Method: The anticancer effect of the combination treatment of sorafenib and 5-MTP was determined through cytotoxicity assay and colony forming assays. The mechanism was elucidated using flow cytometry and western blotting. Wound healing and Transwell assays were conducted to evaluate the impact of the combination treatment on migration and invasion abilities. An in vivo model was employed to analyze the effect of the combination treatment on the tumorigenic ability of LLC cells.
    Result: Our results demonstrated that the sorafenib and 5-MTP combination synergistically reduced viability and proliferation compared to sorafenib or 5-MTP treatment alone. Reduction of cyclin D1 expression was observed in the sorafenib alone or combination treatments, leading to cell cycle arrest. Furthermore, the sorafenib-5-MTP combination significantly increased the inhibitory effect on migration and invasion of LLC cells compared to the single treatments. The combination also significantly downregulated vimentin and MMP9 levels, contributing to the inhibition of metastasis. The reduction of phosphorylated Akt and STAT3 expression may further contribute to the inhibitory effect on proliferation and metastasis. In vivo, the sorafenib-5-MTP combination further reduced tumor growth and metastasis compared to the treatment of sorafenib alone.
    Conclusions: In conclusion, our data indicate that 5-MTP sensitizes the antitumor activity of sorafenib in LLC cells in vitro and in vivo, suggesting that sorafenib-5-MTP has the potential to serve as a therapeutic option for patients with lung cancer.
    MeSH term(s) Humans ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Lung Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Xenograft Model Antitumor Assays ; Phenylurea Compounds/pharmacology ; Phenylurea Compounds/therapeutic use ; Apoptosis ; Tryptophan/analogs & derivatives
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; 5-methoxytryptophan (2504-22-5) ; Phenylurea Compounds ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-024-11986-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A commentary on "Gastrectomy with omentum preservation versus gastrectomy with omentectomy for locally advanced gastric cancer: A systematic review and meta-analysis" (Int J Surg 2021 PMID:34763122).

    Hung, Chao-Ming / Lee, Po-Huang / Lee, Hui-Ming / Chiu, Chong-Chi

    International journal of surgery (London, England)

    2021  Volume 97, Page(s) 106193

    MeSH term(s) Gastrectomy/adverse effects ; Humans ; Omentum/surgery ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2021-12-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2021.106193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comment on: Use of an intraoperative wound protector to prevent surgical-site infection after pancreatoduodenectomy: randomized clinical trial.

    Chiu, Chong-Chi / Lee, Po-Huang / Lee, Hui-Ming / Hung, Chao-Ming

    The British journal of surgery

    2021  Volume 108, Issue 2, Page(s) e88

    MeSH term(s) Humans ; Pancreaticoduodenectomy/adverse effects ; Risk Factors ; Surgical Wound Infection/prevention & control
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znaa084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.66: Show issues Location:
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  6. Article ; Online: Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant.

    Hung, Chao-Ming / Lee, Po-Huang / Lee, Hui-Ming / Chiu, Chong-Chi

    World journal of gastroenterology

    2021  Volume 27, Issue 25, Page(s) 3948–3950

    Abstract: ... ...

    Abstract Yang
    MeSH term(s) Cytomegalovirus ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Humans ; Immunocompetence ; Infant ; Measles/complications ; Measles/diagnosis
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i25.3948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  7. Article ; Online: Synergistic and Antagonistic Antiproliferative Effects of Ribociclib (Lee011) and Irinotecan (SN38) on Colorectal Cancer Cells.

    Huang, Chung-I / Huang, Yi-Kai / Lee, Hui-Ming / Chen, Jian-Han / Su, Yu-Chieh / Lin, Pai-Mei

    Anticancer research

    2023  Volume 43, Issue 5, Page(s) 1933–1941

    Abstract: Background/aim: Colorectal cancer (CRC) is one of the most common malignancies and cause of cancer-related deaths worldwide. The combination of chemotherapeutics working with different mechanisms enhances the therapeutic effects and delays the ... ...

    Abstract Background/aim: Colorectal cancer (CRC) is one of the most common malignancies and cause of cancer-related deaths worldwide. The combination of chemotherapeutics working with different mechanisms enhances the therapeutic effects and delays the development of resistance. This study investigated the anticancer effect of the combination of ribociclib (LEE011) and irinotecan (SN38) on CRC cells.
    Materials and methods: HT-29 and SW480 cells were treated with LEE011, SN38, or the combination of LEE011 and SN38. Cell viability and cell cycle distribution were analyzed. The expression of cell cycle- and apoptosis-related proteins was determined using western blot.
    Results: The combination of LEE011 and SN38 elicited a synergistic antiproliferative effect on HT-29 (PIK3CA
    Conclusion: The effects of the combination of LEE011 and conventional chemotherapy drugs on CRC depend on the chemotherapy drug and the specific gene mutation harbored by tumor cells.
    MeSH term(s) Humans ; Irinotecan/pharmacology ; Caspase 8 ; Cell Proliferation ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Camptothecin/pharmacology ; Apoptosis
    Chemical Substances Irinotecan (7673326042) ; ribociclib (TK8ERE8P56) ; Caspase 8 (EC 3.4.22.-) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2023-04-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Show issues Location:
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  8. Article ; Online: A commentary on "acute appendicitis management during the COVID-19 pandemic: A prospective cohort study from a large UK centre".

    Hung, Chao-Ming / Lee, Hui-Ming / Tsai, Kuen-Jang / Yang, Ming-Chieh / Chiu, Chong-Chi

    International journal of surgery (London, England)

    2021  Volume 87, Page(s) 105902

    MeSH term(s) Appendectomy ; Appendicitis/epidemiology ; Appendicitis/surgery ; COVID-19 ; Humans ; Pandemics ; Prospective Studies ; SARS-CoV-2 ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2021.105902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on: Tranexamic acid for safer surgery: the time is now.

    Hung, Chao-Ming / Hung, Kuo-Chuan / Lee, Po-Huang / Tsai, I Ting / Lee, Hui-Ming / Chiu, Chong-Chi

    The British journal of surgery

    2022  Volume 109, Issue 12, Page(s) e130

    Language English
    Publishing date 2022-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comment on: Histopathological assessment of the gallbladder after routine cholecystectomy is essential for high-quality healthcare.

    Hung, Chao-Ming / Hung, Kuo-Chuan / Lin, Jaw-Town / Rau, Kun-Ming / Lee, Hui-Ming / Chiu, Chong-Chi

    The British journal of surgery

    2022  Volume 109, Issue 12, Page(s) e129

    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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