LIVIVO - Search results -

Search results

Result 1 - 10 of total 16

Search options

Article ; Online: The development and impact of an app for a smart drug interaction reminder system.

Lee, Hung-Fu / Liao, Pei-Hung

Technology and health care : official journal of the European Society for Engineering and Medicine

2023 Volume 32, Issue 3, Page(s) 1595–1608

Abstract: Background: Improved access to media and medical knowledge has elicited stronger public health awareness.: Objective: This study developed a smart drug interaction reminder system for patients to increase knowledge and reduce nurse workload.: ... ...

Abstract	Background: Improved access to media and medical knowledge has elicited stronger public health awareness. Objective: This study developed a smart drug interaction reminder system for patients to increase knowledge and reduce nurse workload. Methods: This study used a single-group pre-test/post-test design and applied mining techniques to analyze the weight and probability of interaction among various medicines. Data were collected from 258 participants at a teaching hospital in northern Taiwan using convenience sampling. An app was used to give patients real-time feedback to obtain access to information and remind them of their health issues. In addition to guiding the patients on medications, this app measured the nurses' work satisfaction and patients' knowledge of drug interaction. Results: The results indicate that using information technology products to assist the app's real-time feedback system promoted nurses' work satisfaction, improved their health education skills, and helped patients to better understand drug interactions. Conclusion: Using information technology to provide patients with real-time inquiring functions has a significant effect on nurses' load reduction. Thus, smart drug interaction reminder system apps can be considered suitable nursing health education tools and the SDINRS app can be integrated into quantitative structure-activity relationship intelligence in the future.
MeSH term(s)	Humans ; Mobile Applications ; Reminder Systems ; Female ; Male ; Taiwan ; Adult ; Drug Interactions ; Middle Aged ; Health Knowledge, Attitudes, Practice ; Job Satisfaction ; Patient Education as Topic/methods
Language	English
Publishing date	2023-10-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-230650
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3846: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Effect of S-Allyl L-Cysteine on Retinal Ischemia: The Contributions of MCP-1 and PKM2 in the Underlying Medicinal Properties.

Chao, Windsor Wen-Jin / Chao, Howard Wen-Haur / Lee, Hung-Fu / Chao, Hsiao-Ming

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Retinal ischemia plays a vital role in vision-threatening retinal ischemic disorders, such as diabetic retinopathy, age-related macular degeneration, glaucoma, etc. The aim of this study was to investigate the effects of S-allyl L-cysteine (SAC) and its ... ...

Abstract	Retinal ischemia plays a vital role in vision-threatening retinal ischemic disorders, such as diabetic retinopathy, age-related macular degeneration, glaucoma, etc. The aim of this study was to investigate the effects of S-allyl L-cysteine (SAC) and its associated therapeutic mechanism. Oxidative stress was induced by administration of 500 μM H
MeSH term(s)	Rats ; Animals ; Rats, Wistar ; Cysteine/pharmacology ; Cysteine/therapeutic use ; Hydrogen Peroxide/therapeutic use ; Reperfusion Injury/drug therapy ; Retinal Diseases/drug therapy ; Ischemia/drug therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Glaucoma/drug therapy
Chemical Substances	S-allylcysteine (81R3X99M15) ; Cysteine (K848JZ4886) ; Hydrogen Peroxide (BBX060AN9V) ; Neuroprotective Agents ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021349
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage.

Chen, Chien-Cheng / Ke, Chia-Hua / Wu, Chun-Hu / Lee, Hung-Fu / Chao, Yuan / Tsai, Min-Chien / Shyue, Song-Kun / Chen, Szu-Fu

Brain pathology (Zurich, Switzerland)

2024 , Page(s) e13244

Abstract: Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calcium permeability, ...

Abstract	Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calcium permeability, has been implicated in neuronal apoptosis and inflammatory responses. This study used a mouse ICH model and neuronal cultures to examine whether TRPV1 activation exacerbates brain damage and neurological deficits by promoting neuronal apoptosis and neuroinflammation. ICH was induced by injecting collagenase in both wild-type (WT) C57BL/6 mice and TRPV1
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1051484-3
ISSN	1750-3639 ; 1015-6305
ISSN (online)	1750-3639
ISSN	1015-6305
DOI	10.1111/bpa.13244
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3585: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation.

Lee, Hung-Fu / Chen, Chih Hung / Chang, Che-Feng

Journal of visualized experiments : JoVE

2020 , Issue 160

Abstract: Cerebral contusion is a severe medical problem affecting millions of people worldwide each year. There is an urgent need to understand the pathophysiological mechanism and to develop effective therapeutic strategy for this devastating neurological ... ...

Abstract	Cerebral contusion is a severe medical problem affecting millions of people worldwide each year. There is an urgent need to understand the pathophysiological mechanism and to develop effective therapeutic strategy for this devastating neurological disorder. Intraparenchymal hemorrhage and post-traumatic inflammatory response induced by initial physical impact can aggravate microglia/macrophage activation and neuroinflammation which subsequently worsen brain pathology. We provide here a controlled cortical impact (CCI) protocol that can reproduce experimental cortical contusion in mice by using a pneumatic impactor system to deliver mechanical force with controllable magnitude and velocity onto the dural surface. This preclinical model allows researchers to induce moderately severe focal cerebral contusion in mice and to investigate a wide range of post-traumatic pathological progressions including hemorrhage contusion, microglia/macrophage activation, iron toxicity, axonal injury, as well as short-term and long-term neurobehavioral deficits. The present protocol can be useful for exploring the long-term effects of and potential interventions for cerebral contusion.
MeSH term(s)	Animals ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/pathology ; Cerebral Cortex/pathology ; Contusions/complications ; Contusions/pathology ; Craniotomy ; Disease Models, Animal ; Hemorrhage/complications ; Hemorrhage/pathology ; Inflammation/complications ; Inflammation/pathology ; Male ; Mice, Inbred C57BL ; Myelin Sheath/metabolism ; Stereotaxic Techniques
Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61393
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits.

Lee, Hung-Fu / Lin, Jhih Syuan / Chang, Che-Feng

Nutrients

2019 Volume 11, Issue 10

Abstract: Traumatic brain injury (TBI) affects millions worldwide with devastating long-term effects on health and cognition. Emerging data suggest that targeting the immune response may offer promising strategies to alleviate TBI outcomes; kahweol, an anti- ... ...

Abstract	Traumatic brain injury (TBI) affects millions worldwide with devastating long-term effects on health and cognition. Emerging data suggest that targeting the immune response may offer promising strategies to alleviate TBI outcomes; kahweol, an anti-inflammatory diterpene that remains in unfiltered coffee, has been shown to be beneficial in neuronal recovery. Here, we examined whether kahweol could alleviate brain trauma-induced injury in a mouse model of TBI and its underlying mechanisms. TBI was induced by controlled cortical impact (CCI) and various doses of kahweol were intraperitoneally administered following injury. Contusion volume, brain edema, neurobehavioral deficits, and protein expression and activity were evaluated in both short-term and long-term recovery. We found that kahweol treatments significantly reduced secondary brain injury and improved neurobehavioral outcomes in TBI mice. These changes were accompanied by the attenuation of proinflammatory cytokine secretion, decreased microglia/macrophage activation, and reduction of neutrophil and leukocyte infiltration. In addition, continuous kahweol treatment further improved short-term TBI outcomes compared to single-dosage. Collectively, our data showed that kahweol protects against TBI by reducing immune responses and may serve as a potential therapeutic intervention for TBI patients.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Brain Injuries, Traumatic/blood ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries, Traumatic/etiology ; Cytokines/drug effects ; Disease Models, Animal ; Diterpenes/pharmacology ; Leukocytes/drug effects ; Macrophages/drug effects ; Mice ; Microglia/drug effects ; Neutrophil Infiltration/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Diterpenes ; kahweol (6894-43-5)
Language	English
Publishing date	2019-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11102301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Evaluation of post-stroke spasticity from the subacute to chronic stages: A clinical and neurophysiologic study of motoneuron pool excitability.

Shen, Heng-Yi / Lin, Jou-Yu / Chen, Chien-Cheng / Lee, Hung-Fu / Chao, Hsien / Lieu, Fu-Kong / Chen, Szu-Fu

The Chinese journal of physiology

2022 Volume 65, Issue 3, Page(s) 109–116

Abstract: Spasticity measured using clinical scales, such as the modified Ashworth scale (MAS), may not sufficiently evaluate the effectiveness of therapeutic interventions and predict prognosis. This study aimed to compare changes in H-reflex excitability in the ... ...

Abstract	Spasticity measured using clinical scales, such as the modified Ashworth scale (MAS), may not sufficiently evaluate the effectiveness of therapeutic interventions and predict prognosis. This study aimed to compare changes in H-reflex excitability in the spastic and unimpaired upper and lower limbs of patients with acute and chronic stroke. We also investigated the relationship between the degree of spasticity as assessed by the MAS and motor neuron pool excitability with by analyzing H-reflex excitability. Sixty adult patients with a first-ever stroke were recruited for this study. MAS scores were recorded in the post-stroke upper and lower limb muscles. H-reflexes and M-responses of the bilateral flexor carpi radialis and soleus were tested by stimulating the median and tibial nerves. The results showed that both the ratio of the maximal size of the H-reflex (Hmax) to the maximal size of the M-response (Mmax) and the ratio of the developmental slope of H-reflex (Hslp) to that of the M-responses (Mslp) were significantly higher on the spastic side than on the unimpaired side for the upper and lower limbs. In contrast, the ratio of the threshold of the H-reflex (Hth) to the threshold of the M-response (Mth) only showed significant differences between the two sides in the upper limbs. The Hslp/Mslp paretic/non-paretic ratio was increased in patients with MAS scores of 2 or 3 compared to MAS scores of 1 for both the upper and lower limbs, whereas the Hmax/Mmax paretic/non-paretic ratio showed significant differences between MAS scores of 2 or 3 and 1 only in the upper limbs. Moreover, in either the spastic or unimpaired sides, there were no significant differences in any of the three motoneuron pool excitability parameters, Hmax/Mmax, Hslp/Mslp, and Hth/Mth, between the shorter chronicity (time post-stroke ≤6 months) and longer chronicity groups (time post-stroke >6 months) for both the upper and lower limbs. These results suggest that Hslp/Mslp could be a potential neurophysiological indicator for evaluating the degree of spasticity in both the upper and lower limbs of patients with hemiplegia. The MAS and Hslp/Mslp characterize clinical and neurophysiologic spasticity, respectively, and could be used as an integrated approach to evaluate and follow up post-stroke spasticity.
MeSH term(s)	Adult ; Humans ; Motor Neurons ; Muscle Spasticity/diagnosis ; Muscle Spasticity/etiology ; Stroke/complications ; Upper Extremity
Language	English
Publishing date	2022-06-30
Publishing country	India
Document type	Journal Article
ZDB-ID	966112-8
ISSN	0304-4920 ; 0300-8525
ISSN	0304-4920 ; 0300-8525
DOI	10.4103/0304-4920.348359
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 309: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits

Lee, Hung-Fu / Lin, Jhih Syuan / Chang, Che-Feng

Nutrients. 2019 Sept. 27, v. 11, no. 10

2019

Abstract	Traumatic brain injury (TBI) affects millions worldwide with devastating long-term effects on health and cognition. Emerging data suggest that targeting the immune response may offer promising strategies to alleviate TBI outcomes; kahweol, an anti-inflammatory diterpene that remains in unfiltered coffee, has been shown to be beneficial in neuronal recovery. Here, we examined whether kahweol could alleviate brain trauma-induced injury in a mouse model of TBI and its underlying mechanisms. TBI was induced by controlled cortical impact (CCI) and various doses of kahweol were intraperitoneally administered following injury. Contusion volume, brain edema, neurobehavioral deficits, and protein expression and activity were evaluated in both short-term and long-term recovery. We found that kahweol treatments significantly reduced secondary brain injury and improved neurobehavioral outcomes in TBI mice. These changes were accompanied by the attenuation of proinflammatory cytokine secretion, decreased microglia/macrophage activation, and reduction of neutrophil and leukocyte infiltration. In addition, continuous kahweol treatment further improved short-term TBI outcomes compared to single-dosage. Collectively, our data showed that kahweol protects against TBI by reducing immune responses and may serve as a potential therapeutic intervention for TBI patients.
Keywords	animal models ; brain ; brain damage ; cognition ; cytokines ; diterpenoids ; edema ; long term effects ; macrophage activation ; mice ; neuroglia ; neurons ; neutrophils ; patients ; protein synthesis ; secretion ; therapeutics
Language	English
Dates of publication	2019-0927
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11102301
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Astaxanthin Ameliorates Ischemic-Hypoxic-Induced Neurotrophin Receptor p75 Upregulation in the Endothelial Cells of Neonatal Mouse Brains.

Kuo, Min-Hsun / Lee, Hung-Fu / Tu, Yi-Fang / Lin, Li-Hsuan / Cheng, Ya-Yun / Lee, Hsueh-Te

International journal of molecular sciences

2019 Volume 20, Issue 24

Abstract: Ischemic stroke is a leading cause of human death in present times. Two phases of pathological impact occur during an ischemic stroke, namely, ischemia and reperfusion. Both periods include individual characteristic effects on cell injury and apoptosis. ... ...

Abstract	Ischemic stroke is a leading cause of human death in present times. Two phases of pathological impact occur during an ischemic stroke, namely, ischemia and reperfusion. Both periods include individual characteristic effects on cell injury and apoptosis. Moreover, these conditions can cause severe cell defects and harm the blood-brain barrier (BBB). Also, the BBB components are the major targets in ischemia-reperfusion injury. The BBB owes its enhanced protective roles to capillary endothelial cells, which maintain BBB permeability. One of the nerve growth factor (NGF) receptors initiating cell signaling, once activated, is the p75 neurotrophin receptor (p75NTR). This receptor is involved in both the survival and apoptosis of neurons. Although many studies have attempted to explain the role of p75NTR in neurons, the mechanisms in endothelial cells remain unclear. Endothelial cells are the first cells to encounter p75NTR stimuli. In this study, we found the upregulated p75NTR expression and reductive expression of tight junction proteins after in vivo and in vitro ischemia-reperfusion injury. Moreover, astaxanthin (AXT), an antioxidant drug, was utilized and was found to reduce p75NTR expression and the number of apoptotic cells. This study verified that p75NTR plays a prominent role in endothelial cell death and provides a novel downstream target for AXT.
MeSH term(s)	Animals ; Animals, Newborn ; Antioxidants/therapeutic use ; Blotting, Western ; Brain/drug effects ; Brain/metabolism ; Cell Survival/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Immunochemistry ; Immunohistochemistry ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Nerve Growth Factor/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Xanthophylls/therapeutic use
Chemical Substances	Antioxidants ; Receptor, Nerve Growth Factor ; Xanthophylls ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2019-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20246168
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats.

Lee, Hung-Fu / Lee, Tzong-Shyuan / Kou, Yu Ru

Respiratory physiology & neurobiology

2012 Volume 182, Issue 1, Page(s) 1–8

Abstract: Traumatic brain injury (TBI) is characterized by neuroinflammation, brain edema, and cerebral damage leading to impairment of neurobehavioral function. Triptolide (PG-490), a diterpenoid component from Tripterygium wilfordii Hook F., has anti- ... ...

Abstract	Traumatic brain injury (TBI) is characterized by neuroinflammation, brain edema, and cerebral damage leading to impairment of neurobehavioral function. Triptolide (PG-490), a diterpenoid component from Tripterygium wilfordii Hook F., has anti-inflammatory properties. Whether triptolide has neuroprotective functions when treating TBI is unclear. To investigate this possibility, Sprague-Dawley rats were treated with triptolide immediately after TBI had been induced by a controlled cortical impact procedure or after a sham procedure. TBI produced neuroinflammation when measured on day 1 after TBI, induced cerebral damage when measured on day 1 and day 3, and impaired neurobehavioral functioning over a 28-day observation period. Triptolide suppressed TBI-induced increases in contusion volume, cell apoptosis, edema and the levels of various pro-inflammatory mediators in the brain. Thriptolide reversed the TBI-induced decrease in brain levels of anti-inflammatory cytokine interleukin-10. Importantly, triptolide improved neurobehavioral outcomes regarding motor, sensory, reflex and balance function. We conclude that triptolide confers neuroprotection against TBI, at least in part, via its anti-inflammatory activity.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Apoptosis/drug effects ; Brain Edema/drug therapy ; Brain Injuries/drug therapy ; Disease Models, Animal ; Diterpenes/therapeutic use ; Epoxy Compounds/therapeutic use ; Inflammation Mediators/physiology ; Male ; Neurons/drug effects ; Neuroprotective Agents/therapeutic use ; Phenanthrenes/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Diterpenes ; Epoxy Compounds ; Inflammation Mediators ; Neuroprotective Agents ; Phenanthrenes ; triptolide (19ALD1S53J)
Language	English
Publishing date	2012-06-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2012.01.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 519: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Increased GABAergic inhibitory function against ischemic long-term potentiation in the CA1 region of the hippocampus

Chu, Ming-Chia / Lee, Jing-Ying / Lee, Hung-Fu / Chu, Kai-Wen / Wu, Han-Fang / Lee, Chi-Wei / Lin, Chia-Hsien / Tang, Chih-Wei / Lin, Hui-Ching

Biochemical and biophysical research communications. 2020 May 28, v. 526, no. 2

2020

Abstract: Potentiation of N-methyl-D-aspartate receptor (NMDAR)-mediated excitatory synaptic plasticity around 1 h after brief exposure to anoxia/aglycemia is called ischemic long-term potentiation (iLTP), which is considered a pathological form of synaptic ... ...

Abstract	Potentiation of N-methyl-D-aspartate receptor (NMDAR)-mediated excitatory synaptic plasticity around 1 h after brief exposure to anoxia/aglycemia is called ischemic long-term potentiation (iLTP), which is considered a pathological form of synaptic response during the early phase of ischemic stroke. It is known that GABAergic inhibitory transmission is also an important molecular process involved in synaptic plasticity and learning memory. However, whether GABAergic transmission is involved in iLTP and early-phase plasticity in ischemic stroke remains unknown. In this study, iLTP was found to be induced in the hippocampal Schaffer-collateral pathway by exposure to oxygen glucose deprivation (OGD). Western blot analysis was conducted to analyze excitatory synaptic receptors and inhibitory synaptic receptors following OGD. The β3 subunit of the GABAA receptor (GABAAR) was markedly reduced, whereas the GluN2B subunit of the NMDAR was increased in the hippocampal area in the OGD group. Using extracellular recording, we demonstrated that application of GABAAR agonist midazolam could abolish the hippocampal iLTP. Moreover, midazolam had no significant effect on the increase in NMDAR subunit GluN2B, but ameliorated the reduction in the β3 subunit of GABAAR after OGD. In summary, our results indicated that hippocampal GABAAR reduction promoted synaptic potentiation after OGD. Activation of GABAergic inhibitory transmission function could inhibit iLTP; thus, modulation of GABAergic function is a protective treatment method in the acute phase of synaptic plasticity in ischemic stroke.
Keywords	Western blotting ; agonists ; glucose ; hippocampus ; hypoxia ; memory ; neuroplasticity ; oxygen ; plasticity ; research ; stroke
Language	English
Dates of publication	2020-0528
Size	p. 491-496.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.03.111
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 71/706: Show issues
Z 3.8: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED