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  1. Article ; Online: Asymmetric presentation with a novel RP2 gene mutation in X-Linked retinitis pigmentosa: a case report.

    Lee, Hyun Woo / Lee, Eun Kyoung

    BMC ophthalmology

    2023  Volume 23, Issue 1, Page(s) 221

    Abstract: Background: We present the detailed multimodal imaging analysis in a case of X-linked retinitis pigmentosa (XLRP) exhibiting a markedly asymmetric presentation with a novel RP2 mutation.: Case presentation: A 25-year-old woman complained of decreased ...

    Abstract Background: We present the detailed multimodal imaging analysis in a case of X-linked retinitis pigmentosa (XLRP) exhibiting a markedly asymmetric presentation with a novel RP2 mutation.
    Case presentation: A 25-year-old woman complained of decreased vision in the right eye as well as night blindness. Her visual acuity was 20/100 (OD) and 20/20 (OS). Fundus examination revealed bone spicule pigmentation with tessellated changes in the fundus within the posterior pole. Optical coherence tomography (OCT) showed generalized disruption of foveal microstructures in the OD. No abnormal findings were identified, but localized ellipsoid zone band losses were observed on OCT in the OS. Fundus autofluorescence revealed multiple patchy hypo-autofluorescent lesions in the OD and a tapetal-like radial reflex against a dark background in the OS. Fluorescein angiography and OCT angiography revealed diffuse mottled hyperfluorescence with reduced retinal vessel density in the OD and no evidence of vascular compromise in the OS. Goldmann perimetry demonstrated a constricted visual field, and electrophysiological assessment revealed an extinguished rod response and a severely impaired cone response in the OD. Molecular genetic tests via next-generation sequencing revealed the pathogenic variant to be a heterozygous frameshift mutation in RP2 (RP2, p.Glu269Glyfs*7), resulting in premature termination of the protein.
    Conclusions: Random X-inactivation may be attributed to interocular differences in the severity of XLRP in female carriers. A novel frameshift mutation in the RP2 gene and a comprehensive phenotypic evaluation in the current study may broaden the spectrum of the disease in XLRP carriers.
    MeSH term(s) Humans ; Female ; Adult ; Eye Proteins/genetics ; Visual Fields ; Electroretinography ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/genetics ; Frameshift Mutation ; Pedigree ; Mutation ; Membrane Proteins/genetics ; GTP-Binding Proteins/genetics
    Chemical Substances Eye Proteins ; RP2 protein, human ; Membrane Proteins ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-023-02968-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of vulnerable communities in terms of the benefits and burdens of the energy transition in Pacific Northwest cities

    Min, Yohan / Lee, Hyun Woo

    Elsevier Ltd Journal of Cleaner Production. 20232023 Mar. 05, Jan. 05, v. 393 p.135949-

    2023  

    Abstract: Energy transition to renewable sources has occurred along with the development of various clean energy policies aimed at decarbonization and electrification. However, the transition can inadvertently lead to social inequity resulting in increasing ... ...

    Abstract Energy transition to renewable sources has occurred along with the development of various clean energy policies aimed at decarbonization and electrification. However, the transition can inadvertently lead to social inequity resulting in increasing burdens on vulnerable communities. Although many studies have tried to define and identify vulnerable communities, there has been no study specifically aimed at characterizing vulnerable communities in terms of the benefits and burdens of such energy transition. In response, the objective of this study is to characterize vulnerable communities by examining rooftop solar adoption and energy expenditure using spatial and mixed-effect models. Rooftop solar adoption operationalizes energy resilience and benefits, and energy expenditure operationalizes energy dependence and burdens of the transition. The study also investigates the link between rooftop solar adoption and energy expenditure by considering city-level variability in three Pacific Northwest cities. The results show that Bellevue has 50.4% less rooftop solar adoption than Portland, while Portland has 16.1% or $223 more energy expenditure than Seattle. On average, an increase in annual energy expenditure of $431 is associated with 29% increase in rooftop solar adoption, specifically Bellevue, Seattle, and Portland by 21.4%, 39.1%, and 26.2%, respectively, but not vice versa. Furthermore, the group of communities more vulnerable in housing attributes has 15.2% less rooftop solar adoption than the group of more vulnerable communities in socioeconomic attributes. In addition, the city centers, commercial areas, or mid-rise and high-rise zones are found to have lower rooftop solar adoption and energy expenditure than other areas. The results suggest that policymakers should consider between-city variability when identifying vulnerable communities. Policies should also be tailored to local communities based on their attributes as communities with similar attributes tend to cluster together. Furthermore, policymakers should focus more on housing and built environment attributes to promote resilient communities.
    Keywords annuals ; area ; cities ; clean energy ; cleaning ; energy expenditure ; energy policy ; exhibitions ; journals ; models ; objectives ; solar energy ; Energy dependence ; Energy resilience ; Energy vulnerability ; Rooftop solar adoption ; Spillover effect
    Language English
    Dates of publication 2023-0105
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2023.135949
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Evaluating the HYDRASHIFT 2/4 Daratumumab assay: a powerful approach to assess treatment response in multiple myeloma.

    Lee, Hyun-Woo / Kim, Sang-Mi / Park, Hyung-Doo

    Clinical chemistry and laboratory medicine

    2024  

    Abstract: Objectives: This study evaluates the HYDRASHIFT assay's effectiveness in mitigating daratumumab interference on serum protein tests during multiple myeloma (MM) treatment, aiming to ensure an accurate assessment of treatment response.: Methods: We ... ...

    Abstract Objectives: This study evaluates the HYDRASHIFT assay's effectiveness in mitigating daratumumab interference on serum protein tests during multiple myeloma (MM) treatment, aiming to ensure an accurate assessment of treatment response.
    Methods: We analyzed 113 serum samples from 68 MM patients undergoing daratumumab treatment, employing both standard IF and the HYDRASHIFT assay. The assay's precision was determined through intra-day and inter-day variability assessments, while its specificity was verified using serum samples devoid of daratumumab. Comparative analysis of IF results, before and after the application of the HYDRASHIFT assay, facilitated the categorization of treatment responses in alignment with the International Myeloma Working Group's response criteria.
    Results: The precision underscored the assay's consistent repeatability and reproducibility, successfully eliminating interference of daratumumab-induced Gκ bands. Specificity assessments demonstrated the assay's capability to distinguish daratumumab from both isatuximab and naturally occurring M-proteins. Of the analyzed cases, 91 exhibited successful migration of daratumumab-induced Gκ bands, thereby enhancing the accuracy of treatment response classification. The remaining 22 cases did not show a visible migration complex, likely due to the low concentration of daratumumab in the serum. These findings underscore the assay's critical role in distinguishing daratumumab from endogenous M-protein, particularly in samples with a single Gκ band on standard IF, where daratumumab and endogenous M-protein had co-migrated.
    Conclusions: The HYDRASHIFT assay demonstrates high precision, specificity, and utility in the accurate monitoring of treatment responses in MM patients receiving daratumumab. This assay represents a significant advancement in overcoming the diagnostic challenges posed by daratumumab interference.
    Language English
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2024-0416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Magnon Orbital Nernst Effect in Honeycomb Antiferromagnets without Spin-Orbit Coupling.

    Go, Gyungchoon / An, Daehyeon / Lee, Hyun-Woo / Kim, Se Kwon

    Nano letters

    2024  

    Abstract: Recently, topological responses of magnons have emerged as a central theme in magnetism and spintronics. However, resulting Hall responses are typically weak and infrequent, since, according to present understanding, they arise from effective spin-orbit ... ...

    Abstract Recently, topological responses of magnons have emerged as a central theme in magnetism and spintronics. However, resulting Hall responses are typically weak and infrequent, since, according to present understanding, they arise from effective spin-orbit couplings, which are weaker compared to the exchange energy. Here, by investigating transport properties of magnon orbital moments, we predict that the magnon orbital Nernst effect is an intrinsic characteristic of the honeycomb antiferromagnet and therefore, it manifests even in the absence of spin-orbit coupling. For the electric detection, we propose an experimental scheme based on the magnetoelectric effect. Our results break the conventional wisdom that the Hall transport of magnons requires spin-orbit coupling by predicting the magnon orbital Nernst effect in a system without it, which leads us to envision that our work initiates the intensive search for various magnon Hall effects in generic magnetic systems with no reliance on spin-orbit coupling.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prediction of Responsiveness to PD-L1/PD-1 Inhibitors Using miRNA Profiles Associated With PD-L1 Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma.

    Koh, Young Wha / Han, Jae-Ho / Haam, Seokjin / Lee, Hyun Woo

    Anticancer research

    2024  Volume 44, Issue 5, Page(s) 2081–2089

    Abstract: Background/aim: MicroRNAs (miRNAs) regulate programmed cell death ligand 1 (PD-L1) and play a crucial role in tumor immune response. However, the relationship between miRNA expression patterns and PD-L1 remains unclear in both lung adenocarcinoma (LUAD) ...

    Abstract Background/aim: MicroRNAs (miRNAs) regulate programmed cell death ligand 1 (PD-L1) and play a crucial role in tumor immune response. However, the relationship between miRNA expression patterns and PD-L1 remains unclear in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). We investigated PD-L1-related miRNAs that can predict treatment response in patients treated with PD-L1/PD-1 inhibitors.
    Patients and methods: We selected miRNAs that were correlated with PD-L1 expression within the LUAD and LUSC datasets obtained from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC). We validated whether the miRNA profile could be used to predict the prognosis of patients treated with PD-L1/PD-1 inhibitors.
    Results: Based on four public datasets, we selected 66 and 23 miRNAs associated with PD-L1 expression in LUAD and LUSC, respectively. From the above miRNAs, we identified 5 miRNAs in LUSC and 1 miRNA in LUAD that could predict the response to PD-L1/PD-1 inhibitors in a validation set of patients treated with PD-L1/PD-1 inhibitors. In LUSC, the miRNA profile exhibited a high predictive capability for the response to PD-L1/PD-1 treatment [area under the curve (AUC)=0.963] and accurately predicted prognosis (p=0.031). In LUAD, the miRNA profile was relatively less predictive than in LUSC (AUC=0.691 and p=0.213). Additionally, we observed variations in the PD-L1-associated miRNA profiles, as well as in the associated pathways, between LUAD and LUSC.
    Conclusion: The PD-L1-associated miRNA profile may predict treatment response in LUSC patients treated with PD-L1/PD-1 inhibitors and help select the PD-L1/PD-1 inhibitor treatment group.
    MeSH term(s) Humans ; MicroRNAs/genetics ; B7-H1 Antigen/genetics ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lung Neoplasms/metabolism ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/metabolism ; Immune Checkpoint Inhibitors/therapeutic use ; Female ; Male ; Prognosis ; Gene Expression Regulation, Neoplastic ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Middle Aged ; Aged ; Gene Expression Profiling
    Chemical Substances MicroRNAs ; B7-H1 Antigen ; CD274 protein, human ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor ; Biomarkers, Tumor ; PDCD1 protein, human
    Language English
    Publishing date 2024-04-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.17012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Machine learning-driven prediction of brain metastasis in lung adenocarcinoma using miRNA profile and target gene pathway analysis of an mRNA dataset.

    Koh, Young Wha / Han, Jae-Ho / Haam, Seokjin / Lee, Hyun Woo

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2024  

    Abstract: Background: Brain metastasis (BM) is common in lung adenocarcinoma (LUAD) and has a poor prognosis, necessitating predictive biomarkers. MicroRNAs (MiRNAs) promote cancer cell growth, infiltration, and metastasis. However, the relationship between the ... ...

    Abstract Background: Brain metastasis (BM) is common in lung adenocarcinoma (LUAD) and has a poor prognosis, necessitating predictive biomarkers. MicroRNAs (MiRNAs) promote cancer cell growth, infiltration, and metastasis. However, the relationship between the miRNA expression profiles and BM occurrence in patients with LUAD remains unclear.
    Methods: We conducted an analysis to identify miRNAs in tissue samples that exhibited different expression levels between patients with and without BM. Using a machine learning approach, we confirmed whether the miRNA profile could be a predictive tool for BM. We performed pathway analysis of miRNA target genes using a matched mRNA dataset.
    Results: We selected 25 miRNAs that consistently exhibited differential expression between the two groups of 32 samples. The 25-miRNA profile demonstrated a strong predictive potential for BM in both Group 1 and Group 2 and the entire dataset (area under the curve [AUC] = 0.918, accuracy = 0.875 in Group 1; AUC = 0.867, accuracy = 0.781 in Group 2; and AUC = 0.908, accuracy = 0.875 in the entire group). Patients predicted to have BM, based on the 25-miRNA profile, had lower survival rates. Target gene analysis of miRNAs suggested that BM could be induced through the ErbB signaling pathway, proteoglycans in cancer, and the focal adhesion pathway. Furthermore, patients predicted to have BM based on the 25-miRNA profile exhibited higher expression of the epithelial-mesenchymal transition signature, TWIST, and vimentin than those not predicted to have BM. Specifically, there was a correlation between EGFR mRNA levels and BM.
    Conclusions: This 25-miRNA profile may serve as a biomarker for predicting BM in patients with LUAD.
    Language English
    Publishing date 2024-04-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-024-03474-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Volunteers' growth mindset and continuance intention: what are the roles of nostalgia and positive emotions?

    Cho, Heetae / Lee, Hyun-Woo / Kim, Taehee

    Frontiers in psychology

    2023  Volume 14, Page(s) 1169221

    Abstract: This study examined the cognitive and affective aspects of volunteering experiences by focusing on the relationships between volunteers' growth mindset, nostalgia, positive emotions, and their intention to continue volunteering. A total of 364 responses ... ...

    Abstract This study examined the cognitive and affective aspects of volunteering experiences by focusing on the relationships between volunteers' growth mindset, nostalgia, positive emotions, and their intention to continue volunteering. A total of 364 responses were collected from volunteers who had volunteered within the past 5 years. Results showed that the growth mindset had a positive effect on nostalgia, which in turn positively affected valenced emotions toward volunteering. Nostalgia and volunteers' positive emotions positively influenced their intention to continue volunteering. All indirect effects via nostalgia were significant. This study lays the groundwork to identify the role of nostalgia in volunteerism and contributes to extending the literature on growth mindset and mindset theory.
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1169221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Low-Cost Angle Sensor for Robotics Applications Using Plastic Optical Fiber Based on Optical Loss Mechanism.

    Lee, Hyun-Woo / Kim, Dae-Hyun / Shin, Sangwoo

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 8

    Abstract: Robotic systems and the human body consist of numerous joint structures, all of which require precise angle adjustments. At present, encoder, strain gauge, and electrical resistance-based sensors are commonly used for angle measurement. However, these ... ...

    Abstract Robotic systems and the human body consist of numerous joint structures, all of which require precise angle adjustments. At present, encoder, strain gauge, and electrical resistance-based sensors are commonly used for angle measurement. However, these sensors have limitations when used in underwater or in environments with strong electromagnetic waves. Therefore, we have developed an angle sensor based on step-index profile plastic optical fiber (SI-POF), which is cost-effective and highly durable, in this study in order to overcome the limitations of existing angle measurement sensors. To this end, the amount of light loss according to the gab and angle changes that occur when the POF angle sensor is applied to the robot arm was experimentally measured, and based on the results, a simulation of the amount of light loss when the two losses occurred at the same time was conducted. In addition, the performance of the POF angle sensor was evaluated by measuring sensitivity and resolution, and comparative verification with a commonly used encoder was conducted to verify the reliability of sensors in extreme environments, such as those with electromagnetic fields and those that are underwater. Through this, the reliability and practicality of the POF angle sensor were confirmed. The results obtained in this study suggest that POF-based angle sensors can contribute to the development of the biomimetic robot industry as well as ordinary robots, especially in environments where existing sensors are difficult to apply, such as areas with underwater or electromagnetic interference (EMI).
    Language English
    Publishing date 2023-11-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8080567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Giant Spin-Orbit Torque in Sputter-Deposited Bi Films.

    Kim, Sumin / Lee, Hyun-Woo / Choi, Gyung-Min

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 31, Page(s) e2303831

    Abstract: Bismuth (Bi) has the strongest spin-orbit coupling among non-radioactive elements and is thus a promising material for efficient charge-to-spin conversion. However, previous electrical detections have reported controversial results for the conversion ... ...

    Abstract Bismuth (Bi) has the strongest spin-orbit coupling among non-radioactive elements and is thus a promising material for efficient charge-to-spin conversion. However, previous electrical detections have reported controversial results for the conversion efficiency. In this study, an optical detection of a spin-orbit torque is reported in a Bi/CoFeB bilayer with a polycrystalline texture of (012) and (003). Taking advantage of the optical detection, spin-orbit torque is accurately separated from the Oersted field and achieves a giant damping-like torque efficiency of +0.5, verifying efficient charge-to-spin conversion. This study also demonstrates a field-like torque efficiency of -0.1. For the mechanism of the charge-to-spin conversion, the bulk spin Hall effect and the interface Rashba-Edelstein effect are considered.
    Language English
    Publishing date 2023-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202303831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Medial entorhinal cortex plays a specialized role in learning of flexible, context-dependent interval timing behavior.

    Bigus, Erin R / Lee, Hyun-Woo / Bowler, John C / Shi, Jiani / Heys, James G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Episodic memory requires encoding the temporal structure of experience and relies on brain circuits in the medial temporal lobe, including the medial entorhinal cortex (MEC). Recent studies have identified MEC 'time cells', which fire at specific moments ...

    Abstract Episodic memory requires encoding the temporal structure of experience and relies on brain circuits in the medial temporal lobe, including the medial entorhinal cortex (MEC). Recent studies have identified MEC 'time cells', which fire at specific moments during interval timing tasks, collectively tiling the entire timing period. It has been hypothesized that MEC time cells could provide temporal information necessary for episodic memories, yet it remains unknown whether MEC time cells display learning dynamics required for encoding different temporal contexts. To explore this, we developed a novel behavioral paradigm that requires distinguishing temporal contexts. Combined with methods for cellular resolution calcium imaging, we find that MEC time cells display context-dependent neural activity that emerges with task learning. Through chemogenetic inactivation we find that MEC activity is necessary for learning of context-dependent interval timing behavior. Finally, we find evidence of a common circuit mechanism that could drive sequential activity of both time cells and spatially selective neurons in MEC. Our work suggests that the clock-like firing of MEC time cells can be modulated by learning, allowing the tracking of various temporal structures that emerge through experience.
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.18.524598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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