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  1. Book ; Online: Oriental, Black, and White

    Lee, Josephine

    The Formation of Racial Habits in American Theater

    2022  

    Keywords Black & Asian studies ; Theatre studies ; History of the Americas ; Cross-racial performance ; blackface minstrelsy ; yellowface ; American orientalism ; racial stereotypes ; all-Black musical ; nineteenth-century American theater ; racial habit ; Aladdin ; Shuffle Along ; Ira Aldridge ; Japanese Tommy ; Bert Williams ; George Walker ; In Dahomey ; Abyssinia ; Aida Overton Walker ; Salome ; Chinese laundry ; representations of the Philippine-American War ; Flower Drum Song ; Juanita Long Hall ; Princess Sotanki ; Sissieretta Jones ; Afro-Asian ; chop suey
    Language English
    Size 1 electronic resource (344 pages)
    Publisher The University of North Carolina Press
    Publishing place Chapel Hill
    Document type Book ; Online
    Note English
    HBZ-ID HT030613525
    ISBN 9781469669632 ; 1469669633
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Practical Emergency Resuscitation and Critical Care

    Lee, Jarone / Shah, Kaushal

    2023  

    Size 648 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_25
    Format 158 x 229 x 32
    ISBN 9781009055628 ; 1009055623
    Database PDA

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  3. Book ; Online: Embracing Analytics in the Drinking Water Industry

    Lee, Juneseok

    2022  

    Keywords Environmental science, engineering & technology ; Industrial applications of scientific research & technological innovation ; Mining technology & engineering ; Science ; Environmental Science ; Applied Sciences ; Technology & Engineering ; Mining
    Language 0|e
    Size 1 Online-Ressource
    Publisher IWA Publishing
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021616994
    ISBN 9781789062380 ; 1789062381
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: Model-assisted Bayesian designs for dose finding and optimization

    Yuan, Ying / Lin, Ruitao / Lee, J. Jack

    methods and applications

    (Chapman & Hall/CRC biostatistics series)

    2023  

    Abstract: Bayesian adaptive designs provide a critical approach to improve the efficiency and success rate of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they forms ...

    Author's details Ying Yuan, Ruitao Lin, J. Jack Lee
    Series title Chapman & Hall/CRC biostatistics series
    Abstract "Bayesian adaptive designs provide a critical approach to improve the efficiency and success rate of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they forms the basis for the development and success of subsequent phase II and III trials. The objective of this book is to describes the state-of-the-art model-assisted designs to faciliate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs, yet their decision rules often can be pre-tabulated and included in the protocol-making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design, the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency's support of the use of the novel adaptive design to improve drug development. Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges and issues arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustration of using software to design trials Develops a companion website (www.trialdesign.org) to provide easy-to-use software to assist learning and implementing model-assisted designs Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center, this book shows how model-assisted designs can greatly improve the efficiency and simplify the conduct of early-phase dose finding and optimization trials. It should therefore be a very useful practical reference for biostatisticians, clinicians working in clinical trials, and drug regulatory professionals, as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart!"--
    MeSH term(s) Drug Development/methods ; Drug Design/methods ; Drug Dosage Calculations ; Models, Statistical ; Bayes Theorem ; Clinical Trials, Phase I as Topic
    Keywords Pharmaceutical arithmetic ; Drug development/Statistical methods ; Drug development
    Subject code 615.1/9
    Language English
    Dates of publication 2023-2023
    Size 1 online resource (xiii, 219 pages) :, illustrations.
    Edition First edition.
    Publisher CRC Press
    Publishing place Boca Raton, Florida ; London ; New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-429-05278-2 ; 0-429-62683-5 ; 0-367-14624-X ; 978-0-429-05278-1 ; 978-0-429-62683-8 ; 978-0-367-14624-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: The potential use of bromelain as a natural oral medicine having anticarcinogenic activities

    lee, jungha

    Food Science & Nutrition, 7(5):1656-1667

    2019  

    Abstract: Bromelain (BR), a protease extracted from Ananas comosus, reportedly possesses pharmacological activities including the reduction of thrombogenesis, and antihypertensive, and antimicrobial effects. This study aimed to investigate the potential effects of ...

    Abstract Bromelain (BR), a protease extracted from Ananas comosus, reportedly possesses pharmacological activities including the reduction of thrombogenesis, and antihypertensive, and antimicrobial effects. This study aimed to investigate the potential effects of BR on oral cancer cells. The effect of BR on the viability of Ca9‐22 and SCC25 cells was determined using the MTT assay. These cells were also treated with different doses of BR, and Western blotting was conducted to monitor apoptosis. Finally, flow cytometry analysis was performed to identify sub‐G1 populations of oral cancer cells. After treatment, the viability of both Ca9‐22 and SCC25 cells was markedly reduced, in a dose‐dependent manner. BR induced poly (ADP‐ribose) polymerase (PARP) and lamin A/C degradation, and generated cleavage products. Flow cytometry analysis showed that BR treatment significantly increased the sub‐G1 population. Our findings therefore indicate that BR has potential as a novel, natural anticarcinogenic medicine.
    Keywords anticarcinogenic effect ; bromelain ; oral squamous cell carcinoma ; public oral health
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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  6. Book ; Online: Applications on Ultrasonic Wave

    Lee, Jaesun

    2021  

    Keywords Technology: general issues ; tomographic imaging ; DHB algorithm ; noncontact ; air-coupled transducer ; steel wire rod ; nonlinear ultrasonic ; EMAT ; guided wave ; ultrasonic sensors ; GPS ; surface monitoring ; image processing ; dynamic time warping ; piezoelectric materials ; transversely isotropic material ; IEEE resonance method ; resonant and anti-resonant frequencies ; dynamic non-destructive evaluation ; acoustic wave ; scattering ; random rough surface ; impedance
    Size 1 electronic resource (112 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289584
    ISBN 9783036511214 ; 3036511210
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online: Nazism and Neo-Nazism in Film and Media

    Lee , Jason

    2018  

    Keywords Digital, video and new media arts ; Film history, theory or criticism ; Film theory ; video art
    Language English
    Size 1 electronic resource (264 pages)
    Publisher Amsterdam University Press
    Publishing place Amsterdam
    Document type Book ; Online
    Note English
    HBZ-ID HT030721915
    ISBN 9789089649362 ; 9089649360
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Ventricular arrhythmias in severe cardiac failure - what is the role of radiotherapy?

    Lee, Justin

    Trends in cardiovascular medicine

    2024  

    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3419: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Interventricular Septal Aneurysm: Reconsidering the Risk.

    Lee, Jongmin

    Journal of the Korean Society of Radiology

    2024  Volume 85, Issue 1, Page(s) 215–216

    Language English
    Publishing date 2024-01-22
    Publishing country Korea (South)
    Document type Editorial
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2023.0159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Tetrahydrocannabinol and dopamine D1 receptor.

    Lee, Jiwon

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1360205

    Abstract: Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 ...

    Abstract Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family is known to play a role in motivation and motor control whereas the D2 family is known to affect attention and sleep. THC, a type of cannabinoid, can lead to feelings of euphoria, anxiety, fear, distrust, or panic. THC is known to affect dopamine in regions such as the anterior cingulate cortex (ACC), and plays a role in fundamental cognitive processes. Although there is a vast amount of research between the relationship of THC on dopamine, there continues to be limited research in relation to THC on dopamine receptors. The D1 receptor plays a role in several essential functions, such as memory, attention, impulse control, regulation of renal function, and locomotion. Accordingly, this review is intended to summarize the relationship between THC and D1 receptors, highlighting key gaps in the literature and avenues for future research.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1360205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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