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Article: Noninvasive wearable sensor for the continuous monitoring of human sound and movement signals in real-time.

Choi, Eun Ae / Lee, Jeong Chan / Yu, Mi / Kwak, Hyo Sung / Shrestha, Bishnu Kumar / Park, Chan Hee / Kim, Cheol Sang

2024 Volume 10, Issue 5, Page(s) e26307

Abstract: Recently, with the development of non-invasive human health monitoring technology including wearable devices, a flexible sensor that monitors 'human sound and movement signals' such as human voice and muscle movement is attracting attention. In this ... ...

Abstract	Recently, with the development of non-invasive human health monitoring technology including wearable devices, a flexible sensor that monitors 'human sound and movement signals' such as human voice and muscle movement is attracting attention. In this experiment, electrospun nanofibers were mixed with highly conductive nanoparticles and coated with polyaniline to detect the patient's electrical signals. Due to the high piezoelectric effect, nanofiber-based sensors do not require charging through a separate battery, so they can be used as self-powered devices. In addition, the LCR meter test confirmed that the sensor has a high capacitance due to its high conductivity and high sensitivity to electrical signals. The sensor produced in this study can visually estimate the electrical signal of the actual human body through real-time comparison with electromyography (EMG) measuring equipment, and it was confirmed that the error is small. This sensor is expected to be widely used in the medical field, from simple sound and movement signals to disease monitoring.
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26307
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polyvinylidene fluoride/silk fibroin-based bio-piezoelectric nanofibrous scaffolds for biomedical application.

Lee, Jeong Chan / Suh, Il Won / Park, Chan Hee / Kim, Cheol Sang

Journal of tissue engineering and regenerative medicine

2021 Volume 15, Issue 10, Page(s) 869–877

Abstract: Since the discovery that applying electrical stimulation can promote cell growth, proliferation, and tissue regeneration, research on bio-piezoelectric materials is being actively conducted. In this study, a composite material was prepared by mixing ... ...

Abstract	Since the discovery that applying electrical stimulation can promote cell growth, proliferation, and tissue regeneration, research on bio-piezoelectric materials is being actively conducted. In this study, a composite material was prepared by mixing polyvinylidene fluoride (PVDF), a conventional piezoelectric polymer, and silk fibroin (SF), a natural piezoelectric material that recently attracting attention. These two polymers were fabricated into a composite fiber mat using electrospinning technology. To find optimal conditions, SF was added in various ratios to prepare electrospun PVDF/SF mats. The characteristics of these PVDF/SF composite mats were then analyzed through various evaluations and in vitro studies. It was confirmed that PVDF and SF were successfully mixed through scanning electron microscope images and structural analysis such as x-ray diffractometer and Fourier transform infrared. The results revealed that adding an appropriate amount of SF could improve the tensile strength, enhance cell proliferation rate, and generate a voltage similar to that of a conventional PVDF-only electrospinning mat. Such fabricated electrospun PVDF/SF composite mats are expected to be useful in the bio-piezoelectric field because they can maintain piezoelectricity while compensating for the shortcomings, such as low physical properties, of a PVDF electrospun mat.
MeSH term(s)	Animals ; Cell Proliferation ; Electricity ; Fibroblasts/cytology ; Fibroblasts/ultrastructure ; Fibroins/chemistry ; Fluorocarbon Polymers/chemistry ; Mice ; NIH 3T3 Cells ; Nanofibers/chemistry ; Polyvinyls/chemistry ; Spectroscopy, Fourier Transform Infrared ; Stress, Mechanical ; Tissue Engineering ; Tissue Scaffolds/chemistry ; X-Ray Diffraction
Chemical Substances	Fluorocarbon Polymers ; Polyvinyls ; polyvinylidene fluoride (24937-79-9) ; Fibroins (9007-76-5)
Language	English
Publishing date	2021-08-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2316155-3
ISSN	1932-7005 ; 1932-6254
ISSN (online)	1932-7005
ISSN	1932-6254
DOI	10.1002/term.3232
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Alu cell-free DNA concentration, Alu index, and LINE-1 hypomethylation as a cancer predictor.

Park, Min-Koo / Lee, Jeong-Chan / Lee, Ji-Won / Hwang, Sung-Joo

Clinical biochemistry

2021 Volume 94, Page(s) 67–73

Abstract: Introduction: The liquid biopsy approach, a less-invasive diagnostic tool, enables the detection of disease-specific genetic and epigenetic aberrations. Approximately 66-69% of the human genome may be composed of transposable repetitive elements, ... ...

Abstract	Introduction: The liquid biopsy approach, a less-invasive diagnostic tool, enables the detection of disease-specific genetic and epigenetic aberrations. Approximately 66-69% of the human genome may be composed of transposable repetitive elements, including Alu and LINE-1. This study aimed to investigate whether Alu-derived cell-free DNA (cfDNA) concentrations, Alu index, and LINE-1 methylation could be used to distinguish patients with cancers from healthy individuals. Methods: Two sets of primers, shorter and longer Alu fragments, were used to amplify Alu elements, followed by the quantitation of Alu DNA concentration and its integrity index. LINE-1 methylation status was then analyzed with quantitative PCR using methylation- and unmethylation-specific TaqMan probes. Results: Both Alu index and LINE-1 methylation level were significantly different in comparison between patients with lung or breast cancer and the healthy controls. The area under the ROC curve of the Alu index and LINE-1 hypomethylation was 0.742 and 0.848 for lung cancer, respectively, and 0.724 and 0.890 for breast cancer, respectively. However, Alu longer fragment DNA concentration was significantly correlated with Alu index in comparison to LINE-1 hypomethylation. Regression analysis suggested that the LINE-1 methylation level, rather than the Alu index, was a good discriminator for lung and breast cancers. Conclusions: This study investigated the genome-wide Alu index and LINE-1 methylation status; their associations with cancers suggested that these combinatory panels could be implemented as a triage test to discriminate cancer patients from healthy individuals.
MeSH term(s)	Cell-Free Nucleic Acids/analysis ; DNA Methylation ; Humans ; Polymerase Chain Reaction ; RNA-Binding Proteins/genetics
Chemical Substances	Cell-Free Nucleic Acids ; RNA-Binding Proteins
Language	English
Publishing date	2021-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2021.04.021
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Article ; Online: Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties.

Lee, Jeong-Chan / Kim, Su Yeong / Song, Jayeon / Jang, Hyowon / Kim, Min / Kim, Hanul / Choi, Siyoung Q / Kim, Sunjoo / Jolly, Pawan / Kang, Taejoon / Park, Steve / Ingber, Donald E

Nature communications

2024 Volume 15, Issue 1, Page(s) 711

Abstract: Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a ...

Abstract	Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a micrometer-thick, porous nanocomposite coating with both antifouling and electroconducting properties that enhances the sensitivity of electrochemical sensors. Nozzle printing of oil-in-water emulsion is used to create a 1 micrometer thick coating composed of cross-linked albumin with interconnected pores and gold nanowires. The layer resists biofouling and maintains rapid electron transfer kinetics for over one month when exposed directly to complex biological fluids, including serum and nasopharyngeal secretions. Compared to a thinner (nanometer thick) antifouling coating made with drop casting or a spin coating of the same thickness, the thick porous nanocomposite sensor exhibits sensitivities that are enhanced by 3.75- to 17-fold when three different target biomolecules are tested. As a result, emulsion-coated, multiplexed electrochemical sensors can carry out simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid, antigen, and host antibody in clinical specimens with high sensitivity and specificity. This thick porous emulsion coating technology holds promise in addressing hurdles currently restricting the application of electrochemical sensors for point-of-care diagnostics, implantable devices, and other healthcare monitoring systems.
MeSH term(s)	Biofouling ; Porosity ; Emulsions ; Antibodies ; Nanocomposites ; Electrochemical Techniques ; Biosensing Techniques
Chemical Substances	Emulsions ; Antibodies
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44822-1
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Article ; Online: Self-Mixed Biphasic Liquid Metal Composite with Ultra-High Stretchability and Strain-Insensitivity for Neuromorphic Circuits.

Lee, Do Hoon / Lim, Taesu / Pyeon, Jeongsu / Park, Hyunmin / Lee, Sang-Won / Lee, Seungkyu / Kim, Wonsik / Kim, Min / Lee, Jeong-Chan / Kim, Do-Wan / Han, Seungmin / Kim, Hyoungsoo / Park, Steve / Choi, Yang-Kyu

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 16, Page(s) e2310956

Abstract: Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/ ... ...

Abstract	Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/R
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310956
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Article ; Online: Microfluidic Screening-Assisted Machine Learning to Investigate Vertical Phase Separation of Small Molecule:Polymer Blend.

Lee, Jeong-Chan / Woo, Jun Hee / Lee, Ho-Jun / Lee, Minho / Woo, Heejin / Baek, Seunghyeok / Nam, Jaewook / Sim, Joo Yong / Park, Steve

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 34, Issue 7, Page(s) e2107596

Abstract: Solution-based thin-film processing is a widely utilized technique for the fabrication of various devices. In particular, the tunability of the ink composition and coating condition allows precise control of thin-film properties and device performance. ... ...

Abstract	Solution-based thin-film processing is a widely utilized technique for the fabrication of various devices. In particular, the tunability of the ink composition and coating condition allows precise control of thin-film properties and device performance. Despite the advantage of having such tunability, the sheer number of possible combinations of experimental parameters render it infeasible to efficiently optimize device performance and analyze the correlation between experimental parameters and device performance. In this work, a microfluidic screening-embedded thin-film processing technique is developed, through which thin-films of varying ratios of small molecule semiconductor:polymer blend are simultaneously generated and screened in a time- and resource-efficient manner. Moreover, utilizing the thin-films of varying combinations of experimental parameters, machine learning models are trained to predict the transistor performance. Gaussian Process Regression (GPR) algorithms tuned by Bayesian optimization shows the best predictive accuracy amongst the trained models, which enables narrowing down of the combinations of experimental parameters and investigation of the degree of vertical phase separation under the predicted parameter space. The technique can serve as a guideline for elucidating the underlying complex parameter-property-performance correlations in solution-based thin-film processing, thereby accelerating the optimization of various thin-film devices in the future.
Language	English
Publishing date	2022-01-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202107596
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Article: Simple conversion of 3D electrospun nanofibrous cellulose acetate into a mechanically robust nanocomposite cellulose/calcium scaffold

Lee, Joshua / Moon, Joon Yeon / Lee, Jeong Chan / Hwang, Tae In / Park, Chan Hee / Kim, Cheol Sang

Carbohydrate polymers. 2021 Feb. 01, v. 253

2021

Abstract: Cellulose and its derivatives are widely used as nanofibrous biomaterials, but obtaining 3D cellulose nanofibers is difficult and relevant research is scarce. In the present study, we propose a simple method for converting electrospun 3D cellulose ... ...

Abstract	Cellulose and its derivatives are widely used as nanofibrous biomaterials, but obtaining 3D cellulose nanofibers is difficult and relevant research is scarce. In the present study, we propose a simple method for converting electrospun 3D cellulose acetate/lactic acid nanofibers via calcium hydroxide treatment into a 3D cellulose/calcium lactate nanocomposite matrix. The conversion resulted in producing a stronger nanofibrous matrix (1.382 MPa vs. 0.112 MPa) that is more hydrophilic and cell-friendly compared to the untreated cellulose acetate/lactic acid group. The successful conversion was verified via FTIR, XPS, TGA, DTG, and XRD. The ability of the scaffolds to provide a suitable environment for cell growth and infiltration was verified by CCK assay and confocal microscopy. The porous nature, mechanical strength, and presence of calcium make the 3D cellulose/calcium lactate matrix a promising material for bone tissue engineering.
Keywords	biocompatible materials ; bones ; calcium ; calcium hydroxide ; calcium lactate ; cell growth ; cellulose ; cellulose acetate ; cellulose nanofibers ; confocal microscopy ; hydrophilicity ; lactic acid ; nanocomposites ; strength (mechanics)
Language	English
Dates of publication	2021-0201
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117191
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fabrication of 3D Electrospun Polycaprolactone Sponge Incorporated with Pt@AuNPs for Biomedical Applications.

Jaswal, Richa / Hwang, Tae In / Kumar, Dinesh / Lee, Jeong Chan / Park, Chan Hee / Kim, Cheol Sang

Journal of nanoscience and nanotechnology

2020 Volume 20, Issue 7, Page(s) 3989–3993

Abstract: Here, we report the synthesis of three-dimensional (3D) polycaprolactone (PCL) nanofiber incorporated with core-satellite platinum nanoparticles (PtNPs, 2-3 nm) coated gold nanospheres (AuNPs, 30 nm) via the simple lactic acid assisted self-assembly ... ...

Abstract	Here, we report the synthesis of three-dimensional (3D) polycaprolactone (PCL) nanofiber incorporated with core-satellite platinum nanoparticles (PtNPs, 2-3 nm) coated gold nanospheres (AuNPs, 30 nm) via the simple lactic acid assisted self-assembly electrospinning technique. The Pt-AuNPs nanoparticle in core-satellite form has been prepared by following solution based methods and characterized with TEM, HR-TEM, UV-Visible, and XRD spectroscopic techniques. The surface morphology and structural analysis of 3D nanofiber scaffolds have been performed with FTIR, TGA, FESEM, and HR-TEM analysis techniques and shown the successful preparation of 3D electrospun fibrous structure composed of Pt-AuNPs loaded PCL (PCL@Pt-AuNPs) as a potential biomaterial for bone tissue engineering applications.
MeSH term(s)	Gold ; Metal Nanoparticles ; Platinum ; Polyesters ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Polyesters ; polycaprolactone (24980-41-4) ; Platinum (49DFR088MY) ; Gold (7440-57-5)
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1533-4899
ISSN (online)	1533-4899
DOI	10.1166/jnn.2020.17563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Numerical Simulations and In Situ Optical Microscopy Connecting Flow Pattern, Crystallization, and Thin-Film Properties for Organic Transistors with Superior Device-to-Device Uniformity.

Lee, Jeong-Chan / Lee, Minho / Lee, Ho-Jun / Ahn, Kwangguk / Nam, Jaewook / Park, Steve

Advanced materials (Deerfield Beach, Fla.)

2020 Volume 32, Issue 48, Page(s) e2004864

Abstract: Currently, due to the lack of precise control of flow behavior and the understanding of how it influences thin-film crystallization, strict tuning of thin-film properties during solution-based coating is difficult. In this work, a continuous-flow ... ...

Abstract	Currently, due to the lack of precise control of flow behavior and the understanding of how it influences thin-film crystallization, strict tuning of thin-film properties during solution-based coating is difficult. In this work, a continuous-flow microfluidic-channel-based meniscus-guided coating (CoMiC) is introduced, which is a system that enables manipulation of flow patterns and analysis connecting flow pattern, crystallization, and thin-film properties. Continuous supply of a solution of an organic semiconductor with various flow patterns is generated using microfluidic channels. 3D numerical simulations and in situ microscopy allow the tracking of the flow pattern along its entire path (from within the microfluidic channel to near the liquid-solid boundary), and enable direct observation of thin-film crystallization process. In particular, the generation of chaotic flow results in unprecedented device-to-device uniformity, with coefficient of variation (CV) of 7.3% and average mobility of 2.04 cm
Language	English
Publishing date	2020-10-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202004864
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Article ; Online: Ultrathin Mixed Ionic-Electronic Conducting Interlayer via the Solution Shearing Technique for High-Performance Lithium-Sulfur Batteries.

Son, Donghyeok / Park, Hyunmin / Lim, Won-Gwang / Baek, Seunghyeok / Kang, Seok Hun / Lee, Jeong-Chan / Maiyalagan, Thandavarayan / Lee, Young-Gi / Park, Steve / Lee, Jinwoo

ACS nano

2023 Volume 17, Issue 24, Page(s) 25507–25518

Abstract: The commercialization of lithium-sulfur (Li-S) batteries has been hampered by diverse challenges, including the shuttle phenomenon and low electrical/ionic conductivity of lithium sulfide and sulfur. To address these issues, extensive research has been ... ...

Abstract	The commercialization of lithium-sulfur (Li-S) batteries has been hampered by diverse challenges, including the shuttle phenomenon and low electrical/ionic conductivity of lithium sulfide and sulfur. To address these issues, extensive research has been devoted to developing multifunctional interlayers. However, interlayers capable of simultaneously suppressing the polysulfide (PS) shuttle and ensuring stable electrical and ionic conductivity are relatively uncommon. Moreover, the use of thick and heavy interlayers results in an unavoidable decline in the energy density of Li-S batteries. We developed an ultrathin (750 nm), lightweight (0.182 mg cm
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09333
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