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  1. Article ; Online: The Obesity Pandemic and the Search for Solutions.

    Lee, Jeongmin

    Journal of medicinal food

    2020  Volume 23, Issue 3, Page(s) 205

    MeSH term(s) Humans ; Obesity/complications ; Obesity/epidemiology ; Pandemics ; Public Health ; Research
    Language English
    Publishing date 2020-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2020.29006.lee
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia.

    Lee, Jeongmin / Lee, Seung-Hwan

    The Korean journal of internal medicine

    2023  Volume 38, Issue 6, Page(s) 797–809

    Abstract: Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve ... ...

    Abstract Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetimibe, a cholesterol absorption inhibitor, offers a potential non-statin therapy to optimize LDL-C management. Key clinical trials, such as IMPROVE-IT and RACING, have demonstrated that the addition of ezetimibe to statin therapy leads to further decreases in LDL-C or significant decreases in major adverse cardiovascular events (MACEs), particularly in patients with high ASCVD risk. Subsequent meta-analyses and clinical trials have further supported the beneficial effect of ezetimibe, suggesting additive decreases in LDL-C and MACEs, as well as pleiotropic effects. This review provides a comprehensive analysis of the clinical implications of ezetimibe for managing dyslipidemia; it also evaluates the available evidence that supports the role of ezetimibe as an adjunct non-statin therapy for long-term use. However, the long-term pleiotropic effects of ezetimibe remain controversial because of limited clinical data. Therefore, additional research is needed to clarify its potential benefits beyond LDL-C reduction. Nonetheless, an understanding of the role of ezetimibe in dyslipidemia management will help clinicians to develop effective treatment strategies.
    MeSH term(s) Humans ; Ezetimibe/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholesterol, LDL ; Anticholesteremic Agents/adverse effects ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Drug Therapy, Combination ; Treatment Outcome
    Chemical Substances Ezetimibe (EOR26LQQ24) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol, LDL ; Anticholesteremic Agents
    Language English
    Publishing date 2023-10-20
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2023.243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict CYP3A-Mediated Drug Interaction between Saxagliptin and Nicardipine: Bridging Rat-to-Human Extrapolation.

    Lee, Jeong-Min / Yoon, Jin-Ha / Maeng, Han-Joo / Kim, Yu Chul

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug-drug interactions (DDIs) between saxagliptin and nicardipine using a physiologically based pharmacokinetic (PBPK) model. Initially, in silico and in vitro parameters were ... ...

    Abstract The aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug-drug interactions (DDIs) between saxagliptin and nicardipine using a physiologically based pharmacokinetic (PBPK) model. Initially, in silico and in vitro parameters were gathered from experiments or the literature to construct PBPK models for each drug in rats. These models were integrated to predict the DDIs between saxagliptin, metabolized via CYP3A2, and nicardipine, exhibiting CYP3A inhibitory activity. The rat DDI PBPK model was completed by optimizing parameters using experimental rat plasma concentrations after co-administration of both drugs. Following co-administration in Sprague-Dawley rats, saxagliptin plasma concentration significantly increased, resulting in a 2.60-fold rise in AUC, accurately predicted by the rat PBPK model. Subsequently, the workflow of the rat PBPK model was applied to humans, creating a model capable of predicting DDIs between the two drugs in humans. Simulation from the human PBPK model indicated that nicardipine co-administration in humans resulted in a nearly unchanged AUC of saxagliptin, with an approximate 1.05-fold change, indicating no clinically significant changes and revealing a lack of direct translation of animal interaction results to humans. The animal-to-human PBPK model extrapolation used in this study could enhance the reliability of predicting drug interactions in clinical settings where DDI studies are challenging.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Beyond Acute COVID-19: Investigating the Incidence of Subacute Thyroiditis in Long COVID-19 in Korea.

    Lee, Jeongmin / Seo, Gi Hyeon / Song, Keeho

    Endocrinology and metabolism (Seoul, Korea)

    2023  Volume 38, Issue 4, Page(s) 455–461

    Abstract: Backgruound: The correlation between acute coronavirus disease 2019 (COVID-19) and subacute thyroiditis (SAT) has not been clearly investigated in "long COVID" patients. We aimed to investigate the incidence of SAT during convalescence and after the ... ...

    Abstract Backgruound: The correlation between acute coronavirus disease 2019 (COVID-19) and subacute thyroiditis (SAT) has not been clearly investigated in "long COVID" patients. We aimed to investigate the incidence of SAT during convalescence and after the acute phase of COVID-19, comparing with that of the general population.
    Methods: Data from a total of 422,779 COVID-19 patients and a control group of 2,113,895 individuals were analyzed. The index date was defined as the date 3 months after confirmation of COVID-19. The incidence rate (IR) of SAT and hazard ratios (HRs) were calculated per 100,000 persons. Subgroup analysis included analysis of HRs 90-179 and 180 days post-COVID-19 diagnosis; and additional analysis was conducted according to hospitalization status, sex, and age group.
    Results: The IR of SAT was 17.28 per 100,000 persons (95% confidence interval [CI], 12.56 to 23.20) in the COVID-19 group and 8.63 (95% CI, 6.37 to 11.45) in the control group. The HR of COVID-19 patients was 1.76 (95% CI, 1.01 to 3.06; P=0.045). The HR of SAT was 1.39 (95% CI, 0.82 to 2.34; P=0.220) up to 6 months after the index date and 2.30 (95% CI, 1.60 to 3.30; P<0.001) beyond 6 months. The HR for SAT among COVID-19 patients was 2.00 (95% CI, 1.41 to 2.83) in hospitalized patients and 1.76 (95% CI, 1.01 to 3.06) in non-hospitalized patients compared to the control group. The IR of SAT was 27.09 (95% CI, 20.04 to 35.82) for females and 6.47 (95% CI, 3.34 to 11.30) for males. In the 19 to 64 age group, the IR of SAT was 18.19 (95% CI, 13.70 to 23.67), while the IR was 9.18 (95% CI, 7.72 to 10.84) in the 65 to 69 age group.
    Conclusion: SAT could be a potential long-term complication of COVID-19. Long-term surveillance for thyroid dysfunction is needed especially in hospitalized, female and young-aged subjects.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Thyroiditis, Subacute/epidemiology ; Thyroiditis, Subacute/diagnosis ; COVID-19/diagnosis ; COVID-19/epidemiology ; Incidence ; COVID-19 Testing ; Republic of Korea/epidemiology
    Language English
    Publishing date 2023-08-08
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2802452-7
    ISSN 2093-5978 ; 2093-5978
    ISSN (online) 2093-5978
    ISSN 2093-5978
    DOI 10.3803/EnM.2023.1711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Relationship Between On-Site Clinical Practice, Nursing Professional Value, and Nursing Clinical Self-Efficacy During COVID-19: A Cross-Sectional Study.

    Lee, Jeongmin / Choi, Junho / Kim, Juyoung / Lee, Kayoung

    Journal of multidisciplinary healthcare

    2023  Volume 16, Page(s) 4163–4172

    Abstract: Background: During COVID-19, nursing students experienced variations in on-site clinical practice, such as a combination of on-site and non-face-to-face clinical practice. Although on-site clinical practice is critical for increasing nurses' clinical ... ...

    Abstract Background: During COVID-19, nursing students experienced variations in on-site clinical practice, such as a combination of on-site and non-face-to-face clinical practice. Although on-site clinical practice is critical for increasing nurses' clinical self-efficacy and developing professional nursing values, there is a lack of knowledge that reflects the current clinical practice environment.
    Aim: To examine the relationship between on-site clinical practice, nursing professional values, and nursing clinical self-efficacy during the COVID-19 pandemic.
    Methods: This study is a cross-sectional correlational study design. Demographic characteristics, on-site clinical practice, nursing professional values, and nursing clinical self-efficacy were assessed using an online survey from October 3, 2022, to November 6, 2022. Data were analyzed using descriptive statistics, ANOVA,
    Results: Of the 86 participants, 18 (20.9%) were male and 68 (79.1%) were female. The duration of the participants' average participation in on-site clinical practice was 39.67 days (61.04%). Nursing professional values significantly influenced clinical self-efficacy (β=0.379, p<0.001). However, on-site clinical practice was not significantly related to clinical self-efficacy (β=0.051, p=0.611). In terms of nursing clinical self-efficacy, measuring blood glucose had the highest score. On the other hand, establishing and maintaining intravenous catheters had the lowest scores.
    Conclusion: Nursing students' professional values were significantly associated with nursing clinical self-efficacy; however, the extent of involvement in on-site clinical practice during the pandemic did not have a significant impact on nursing clinical self-efficacy. Given that this study focused on a single university, it is imperative to replicate this research using diverse samples in the future. In addition, there is a need to establish a range of teaching and learning approaches for clinical practice, including simulation, online learning, and the use of state-of-the-art technology for faculty-student feedback strategies, in anticipation of the need for alternative practices.
    Language English
    Publishing date 2023-12-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S443247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: "I can teach what's in the book": Understanding the why and how behind teachers' implementation of a social-emotional learning (SEL) focused curriculum in rural Malawi.

    Lee, Jeongmin / Simmons Zuilkowski, Stephanie

    The British journal of educational psychology

    2021  Volume 92, Issue 3, Page(s) 974–993

    Abstract: Contextualizing the role of teachers in social-emotional learning (SEL) in Malawi, we examine how teachers' comfort with, commitment to, and perceived school culture toward SEL relate to their actual teaching of it. Using surveys from 432 primary school ... ...

    Abstract Contextualizing the role of teachers in social-emotional learning (SEL) in Malawi, we examine how teachers' comfort with, commitment to, and perceived school culture toward SEL relate to their actual teaching of it. Using surveys from 432 primary school teachers (20-60 years old), we found teacher comfort and supportive school culture were positively related to integration of SEL into classroom instruction, while commitment had no statistically significant relationship with implementation. We explore plausible explanations for these findings by interviewing 42 teachers. Together, our findings highlight the importance of teacher support systems and cultural compatibility of the curriculum for successful SEL implementation.
    MeSH term(s) Adult ; Curriculum ; Emotions ; Humans ; Malawi ; Middle Aged ; School Teachers/psychology ; Social Learning ; Young Adult
    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501130-6
    ISSN 2044-8279 ; 0007-0998
    ISSN (online) 2044-8279
    ISSN 0007-0998
    DOI 10.1111/bjep.12483
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  7. Article ; Online: Variation in the Allergenicity of Scrambled, Boiled, Short-Baked and Long-Baked Egg White Proteins.

    Gantulga, Purevsan / Lee, Jeongmin / Jeong, Kyunguk / Jeon, Se-Ah / Lee, Sooyoung

    Journal of Korean medical science

    2024  Volume 39, Issue 6, Page(s) e54

    Abstract: Background: Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity ... ...

    Abstract Background: Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity using diverse cooking methods commonly used in Korean dishes.
    Methods: Crude extract of raw and 4 types of cooked HEW extracts were produced and used for sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE), enzyme-linked immunosorbent assay (ELISA), and ELISA inhibition assays using 45 serum samples from HEW allergic and tolerant children. Extracts were prepared; scrambled without oil for 20-30 seconds in frying pan without oil, boiled at 100°C for 15 minutes, short-baked at 180°C for 20 minutes, and long-baked at 45°C for 12 hours with a gradual increase in temperature up to 110°C for additional 12 hours, respectively.
    Results: In SDS-PAGE, the intensity of bands of 50-54 kDa decreased by boiling and baking. All bands almost disappeared in long-baked eggs. The intensity of the ovalbumin (OVA) immunoglobulin E (IgE) bands did not change after scrambling; however, an evident decrease was observed in boiled egg white (EW). In contrast, ovomucoid (OM) IgE bands were darker and wider after scrambling and boiling. The IgE binding reactivity to all EW allergens were weakened in short-baked EW and considerably diminished in long-baked EW. In individual ELISA analysis using OVA
    Conclusion: We identified minimally reduced allergenicity in scrambled EW and extensively decreased allergenicity in long-baked EW comparing to boiled and short-baked EW as well as raw EW. By applying the results of this study, we would be able to provide safer dietary guidence with higher quality to egg allergic children.
    MeSH term(s) Child ; Humans ; Female ; Animals ; Egg Hypersensitivity ; Allergens/analysis ; Chickens ; Egg Proteins ; Ovalbumin ; Immunoglobulin E
    Chemical Substances Allergens ; Egg Proteins ; Ovalbumin (9006-59-1) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2024-02-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2024.39.e54
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  8. Article: Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress.

    Goo, Jiyoung / Lee, Yeji / Lee, Jeongmin / Kim, In-San / Jeong, Cherlhyun

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: Small Extracellular Vesicles (sEVs) are typically 30-150 nm in diameter, produced inside cells, and released into the extracellular space. These vesicles carry RNA, DNA, proteins, and lipids that reflect the characteristics of their parent cells, ... ...

    Abstract Small Extracellular Vesicles (sEVs) are typically 30-150 nm in diameter, produced inside cells, and released into the extracellular space. These vesicles carry RNA, DNA, proteins, and lipids that reflect the characteristics of their parent cells, enabling communication between cells and the alteration of functions or differentiation of target cells. Owing to these properties, sEVs have recently gained attention as potential carriers for functional molecules and drug delivery tools. However, their use as a therapeutic platform faces limitations, such as challenges in mass production, purity issues, and the absence of established protocols and characterization methods. To overcome these, researchers are exploring the characterization and engineering of sEVs for various applications. This review discusses the origins of sEVs and their engineering for therapeutic effects, proposing areas needing intensive study. It covers the use of cell-derived sEVs in their natural state and in engineered forms for specific purposes. Additionally, the review details the sources of sEVs and their subsequent purification methods. It also outlines the potential of therapeutic sEVs and the requirements for successful clinical trials, including methods for large-scale production and purification. Finally, we discuss the progress of ongoing clinical trials and the implications for future healthcare, offering a comprehensive overview of the latest research in sEV applications.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030311
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  9. Article: Inhalation of

    Seo, Eunhye / Cho, Yoonah / Lee, Jeong-Min / Seol, Geun Hee

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: Pain in lumbar spinal stenosis (LSS) patients is closely associated with psychological factors, including anxiety, stress, and depression, and is a critical determinant of patient daily functionality and overall quality of life. The present study ... ...

    Abstract Pain in lumbar spinal stenosis (LSS) patients is closely associated with psychological factors, including anxiety, stress, and depression, and is a critical determinant of patient daily functionality and overall quality of life. The present study evaluated the effects of inhalation of
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010001
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  10. Article ; Online: 자기공명영상 유도하 유방의 중재적시술: 조직생검술 및 침위치결정술.

    Park, Ga Eun / Lee, Jeongmin / Kang, Bong Joo / Kim, Sung Hun

    Journal of the Korean Society of Radiology

    2023  Volume 84, Issue 2, Page(s) 345–360

    Abstract: In Korea, the number of institutions providing breast MRI, as well as the number of breast MRIs, has recently increased. However, MRI-guided procedures, including biopsy and needle localization, are rarely performed compared to ultrasound-guided or ... ...

    Title translation MRI-Guided Breast Intervention: Biopsy and Needle Localization.
    Abstract In Korea, the number of institutions providing breast MRI, as well as the number of breast MRIs, has recently increased. However, MRI-guided procedures, including biopsy and needle localization, are rarely performed compared to ultrasound-guided or stereotactic biopsy. As breast MRI has high sensitivity but limited specificity, lesions detected only on MRI require pathologic confirmation through MRI-guided biopsy or surgical excision with MRI-guided needle localization. Thus, we aimed to review MRI-guided procedures, including their indications, techniques, procedural considerations, and limitations.
    Language Korean
    Publishing date 2023-03-28
    Publishing country Korea (South)
    Document type English Abstract ; Journal Article ; Review
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2022.0162
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