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  1. Article ; Online: Transcriptional Profiling of Muscle in Females With Distal Radius Fracture and Functional Sarcopenia.

    Kang, Jeong-Hyun / Baek, Jeong-Hwa / Lee, Jin Kwang / Hong, Seok Woo

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2024  Volume 79, Issue 4

    Abstract: Skeletal muscle and bone interact with each other in mechanical and biochemical ways. This study aimed to investigate the molecular mechanisms of interaction between muscle and bone by analyzing the transcriptional profiles of total RNA from the muscle ... ...

    Abstract Skeletal muscle and bone interact with each other in mechanical and biochemical ways. This study aimed to investigate the molecular mechanisms of interaction between muscle and bone by analyzing the transcriptional profiles of total RNA from the muscle tissue of females with distal radius fractures. A total of 30 female participants (mean age 71.1 ± 8.9 years) with distal radius fractures were recruited. Participants were categorized into 2 groups: the NORM group consisted of participants with T score of the areal bone mineral density (aBMD) of the femoral neck higher than -1.0, handgrip strength greater than 18 kg, and gait speed faster than 1.0 m/s (n = 10). Otherwise, participants with T score of the aBMD of the femoral neck equal to or less than -1.0, handgrip strength lower than 18 kg, and gait speed slower than 1.0 m/s (n = 20) were categorized into EXP group. Pronator quadratus muscle samples were obtained from all participants. Total RNA was extracted from frozen muscle samples and sequenced. The gene ontology analysis demonstrated that the potential interactions between attached muscle function and the density of the associated bone would be linked with collagen biosynthetic activity and maintenance of extracellular matrix structures. The analysis of the pathway, network, and protein class exhibited that integrin signaling, inflammatory reactions, matrix metalloproteinase (MMP) activity, and extracellular matrix protein structure had possible associations with the molecular background of muscle-bone interaction. Through integrin signaling, MMP activity, inflammatory reactions, and collagen biosynthesis, muscle and bone may mutually interact with one another.
    MeSH term(s) Humans ; Female ; Aged ; Aged, 80 and over ; Sarcopenia ; Wrist Fractures ; Absorptiometry, Photon ; Hand Strength ; Bone Density/genetics ; Muscle, Skeletal ; Integrins ; Collagen ; RNA ; Radius
    Chemical Substances Integrins ; Collagen (9007-34-5) ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glae002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Impact of Patellar Position on Mediolateral Joint Gap in Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty: A Prospective Study.

    Park, Ki Tae / Nam, Tae Seok / Son, Dong Wook / Lee, Jin Kwang / Ahn, Ji Hyun

    The Journal of arthroplasty

    2023  Volume 39, Issue 4, Page(s) 884–890

    Abstract: Background: This prospective study aimed to investigate the influence of patellar position (ie, eversion, lateralization, and reduction) on medial and lateral gap measurements during total knee arthroplasty (TKA) in both cruciate-retaining (CR) and ... ...

    Abstract Background: This prospective study aimed to investigate the influence of patellar position (ie, eversion, lateralization, and reduction) on medial and lateral gap measurements during total knee arthroplasty (TKA) in both cruciate-retaining (CR) and posterior-stabilized (PS) TKA designs.
    Methods: The present work analyzed 50 knees with primary osteoarthritis that underwent TKA between July and November 2019. Medial and lateral gaps were measured at different knee flexion angles (0°, 45°, 90°, and 120°) in 3 patellar positions after sequentially inserting CR type and PS type trial component in the same knee.
    Results: In CR TKA, medial gaps in patellar reduction showed significantly smaller gaps at 90° and 120° of knee flexion compared to those in eversion and lateralization (P < .001). Lateral gaps in patellar reduction were also significantly larger than those in eversion and lateralization (P < .001). The mediolateral gap difference in patellar reduction was significantly greater at all flexion angles compared to those in eversion and lateralization (P < .001). In PS TKA, similar patterns were observed for medial gaps, lateral gaps, and mediolateral gap differences (P < .001).
    Conclusions: The ligament balancing with the patella everted or subluxed may lead to an overly tight medial gap and/or loose lateral gap in the knee with a closed arthrotomy, which has potential consequences for knee function in both CR and PS TKA designs. The results of this study highlight the importance of considering patellar position to ensure optimal soft-tissue balance and joint stability in TKA.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Knee/methods ; Patella/surgery ; Prospective Studies ; Osteoarthritis, Knee/surgery ; Knee Joint/surgery ; Range of Motion, Articular ; Biomechanical Phenomena ; Knee Prosthesis
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2023.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2134: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: [Cyclo-oxygenase-2 and p53 immunoreactivity in superficial early colorectal carcinoma].

    Kim, You Sun / Lim, So Dug / Lee, Jin Kwang / Kim, Seong Eun / Ryu, Soo Hyung / Lee, Jung Whan / Moon, Jeong Seop

    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

    2006  Volume 47, Issue 5, Page(s) 350–356

    Abstract: Background/aims: De novo colorectal carcinoma shows more aggressive behavior including submucosal invasiveness. Both p53 and cyclo-oxygenase-2 (COX-2) have been shown to be involved in colon carcinogenesis, progression from adenoma to carcinoma, and ... ...

    Abstract Background/aims: De novo colorectal carcinoma shows more aggressive behavior including submucosal invasiveness. Both p53 and cyclo-oxygenase-2 (COX-2) have been shown to be involved in colon carcinogenesis, progression from adenoma to carcinoma, and submucosal invasion by tumor. We performed this study to evaluate the expression of p53 and COX-2 protein in de novo carcinoma, compared with ex-adenoma carcinoma.
    Methods: Twenty three flat adenomas, 19 ex-adenoma carcinomas, 6 de novo carcinomas were included in this study. The expression of p53, COX-2 and Ki-67 were examined immunohistochemically.
    Results: Both ex- adenoma carcinomas and de novo carcinomas showed similar size and shape. Positive staining for p53 was detected in 3 of 23 (13%) flat adenomas, in 11 of 19 (57.8%) ex-adenoma carcinomas (p < 0.05), and in 1 of 6 (16.6%) de novo carcinomas. Increased numbers of COX-2 positive tumor cells were observed in 1 of 23 (4.3%) flat adenomas, in 2 of 19 (10.5%) ex-adenoma carcinomas, and in 3 of 6 (50%) de novo carcinomas. COX-2 positive expression showed increased tendency in de novo carcinoma (p = 0.073). There was no correlation between COX-2, p53, and Ki-67 expression.
    Conclusion: De novo carcinoma shows increased tendency of COX-2 expression, but decreased p53 expression when compared to ex-adenoma carcinoma. These immunohistochemical findings are in accordance with the fact that de novo carcinoma has no preceding adenoma, with more frequent submucosal invasion despite the small lesion size.
    MeSH term(s) Adenoma/chemistry ; Adenoma/pathology ; Biomarkers, Tumor/analysis ; Carcinoma/chemistry ; Carcinoma/pathology ; Colorectal Neoplasms/chemistry ; Colorectal Neoplasms/pathology ; Cyclooxygenase 2/analysis ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/analysis ; Male ; Middle Aged ; Tumor Suppressor Protein p53/analysis
    Chemical Substances Biomarkers, Tumor ; Ki-67 Antigen ; Tumor Suppressor Protein p53 ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language Korean
    Publishing date 2006-05
    Publishing country Korea (South)
    Document type English Abstract ; Journal Article
    ZDB-ID 2611091-X
    ISSN 1598-9992
    ISSN 1598-9992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6910: Show issues Location:
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  4. Article: A case of spontaneous gallbladder perforation.

    Kim, Hoi Jin / Park, Sang Jong / Lee, Sang Bae / Lee, Jin Kwang / Jung, Hyun Seung / Choi, Chang Kyu / Paik, So Ya

    The Korean journal of internal medicine

    2004  Volume 19, Issue 2, Page(s) 128–131

    Abstract: Gallbladder perforation is an almost exclusive complication of cholecystitis, which accompanies severe inflammation of the gallbladder with or without cholelithiasis. Whether it is of a calculous or acalculous origin, gallbladder perforation, as a ... ...

    Abstract Gallbladder perforation is an almost exclusive complication of cholecystitis, which accompanies severe inflammation of the gallbladder with or without cholelithiasis. Whether it is of a calculous or acalculous origin, gallbladder perforation, as a complication of acute cholecystitis, has common symptoms, signs, laboratory data, radiological findings and treatment modalities. Even though many reports of gallbladder perforation have been published, there are few reports of gallbladder perforation without any clinical and radiological indications. We experienced a case of a 70-year-old woman with acute abdomen, which was found to be peritonitis caused by spontaneous gallbladder perforation that was devoid of clues suggesting this condition. Although rare and unusual, this case shows that this disorder should be considered in elderly patients presenting with peritonitis with an unknown etiology.
    MeSH term(s) Aged ; Female ; Gallbladder Diseases/complications ; Gallbladder Diseases/diagnosis ; Gallbladder Diseases/diagnostic imaging ; Humans ; Peritonitis/diagnosis ; Peritonitis/etiology ; Tomography, X-Ray Computed ; Ultrasonography, Interventional
    Language English
    Publishing date 2004-09-13
    Publishing country Korea (South)
    Document type Case Reports ; Journal Article
    ZDB-ID 639023-7
    ISSN 1226-3303
    ISSN 1226-3303
    DOI 10.3904/kjim.2004.19.2.128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection in relation to CYP2C19 genotype.

    Lee, Sang Bae / Park, Sang Jong / Ryu, Ji Kon / Lee, Jin Kwang / Kim, Hoi Jin / Bae, Jin Soo / Jung, Hyun Seung / Park, Sil Moo

    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

    2003  Volume 42, Issue 6, Page(s) 468–475

    Abstract: Background/aims: Genetic polymorphism of cytochrome P450 CYP2C19 influences the efficacy of proton pump inhibitor (PPI) in Helicobacter pylori (H. pylori) eradication therapy. We investigated the difference in the cure rates of H. pylori infection by ... ...

    Abstract Background/aims: Genetic polymorphism of cytochrome P450 CYP2C19 influences the efficacy of proton pump inhibitor (PPI) in Helicobacter pylori (H. pylori) eradication therapy. We investigated the difference in the cure rates of H. pylori infection by triple (rabeprazole plus amoxacillin and clarithromycin) therapy in relation to CYP2C19 genotype status.
    Methods: One hundred and sixteen H. pylori infected patients with gastric ulcer and duodenal ulcer completed the triple therapy with 10 mg of rabeprazole b.i.d., 1,000 mg amoxacillin b.i.d. and 500 mg of clarithromycin b.i.d. for one week. The genotype of CYP2C19 was determined by a PCR-restriction fragment length polymorphism method.
    Results: According to the univariate analysis, heterozygous extensive metabolizers (hetero EMs) and poor metabolizers (PMs) showed the highest (87.0%) and the lowest (80.0%) eradication rates, respectively. The difference in the therapeutic efficacy of rabeprazole among the different CYP2C19 genotypes was insignificant. With regard to gender, age and smoking history in relation to eradication rate, a statistical significance was noted only with age with odds ratio of 1.063 and p-value of 0.0202.
    Conclusions: In the eradication therapy of H. pylori, no statistically significant difference in therapeutic efficacy of rabeprazole was found among different CYP2C19 genotypes.
    MeSH term(s) 2-Pyridinylmethylsulfinylbenzimidazoles ; Adult ; Aged ; Amoxicillin/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Anti-Ulcer Agents/administration & dosage ; Aryl Hydrocarbon Hydroxylases/genetics ; Benzimidazoles/administration & dosage ; Clarithromycin/administration & dosage ; Cytochrome P-450 CYP2C19 ; Drug Therapy, Combination ; Duodenal Ulcer/drug therapy ; Duodenal Ulcer/genetics ; Duodenal Ulcer/microbiology ; Female ; Genotype ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Mixed Function Oxygenases/genetics ; Omeprazole/analogs & derivatives ; Proton Pump Inhibitors ; Rabeprazole ; Stomach Ulcer/drug therapy ; Stomach Ulcer/genetics ; Stomach Ulcer/microbiology
    Chemical Substances 2-Pyridinylmethylsulfinylbenzimidazoles ; Anti-Bacterial Agents ; Anti-Ulcer Agents ; Benzimidazoles ; Proton Pump Inhibitors ; Rabeprazole (32828355LL) ; Amoxicillin (804826J2HU) ; Mixed Function Oxygenases (EC 1.-) ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Clarithromycin (H1250JIK0A) ; Omeprazole (KG60484QX9)
    Language English
    Publishing date 2003-12
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2611091-X
    ISSN 1598-9992
    ISSN 1598-9992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Acute acalculous cholecystitis associated with cholecystoduodenal fistula and duodenal bleeding. A case report.

    Lee, Sang Bae / Ryu, Kwang Hyun / Ryu, Ji Kon / Kim, Hoi Jin / Lee, Jin Kwang / Jeong, Hyun Seung / Bae, Jin Soo

    The Korean journal of internal medicine

    2003  Volume 18, Issue 2, Page(s) 109–114

    Abstract: Although acute acalculous cholecystitis (AAC) accounts for less than 10% of acute cholecystitis in the adult population, gangrene and perforation are much more frequent compared to the usual cases of acute cholecystitis (calculus cholecystitis). However, ...

    Abstract Although acute acalculous cholecystitis (AAC) accounts for less than 10% of acute cholecystitis in the adult population, gangrene and perforation are much more frequent compared to the usual cases of acute cholecystitis (calculus cholecystitis). However, spontaneous biliary-enteric fistula is well recognized in AAC, 90% of which are cholecystoduodenal fistula (CDF) though it is an uncommon disorder. The majority of the CDF are caused by cholelithiasis. As patients are usually associated with complicated clinical illness, the diagnosis is often difficult to make and required surgery is often delayed. We have studied a rare complication of acute acalculous cholecystitis which was presented as intermittent upper gastrointestinal bleeding. Ulceration of the superficial branch of the cystic artery has been observed due to acalculous cholecystitis associated with a cholecystoduodenal fistula. We have performed a transfixing ligation of the bleeding vessel, cholecystectomy and simple closure of the CDF. We have finally made a diagnosis of early gallbladder cancer through a frozen section. There was no serious complication after the operation and the patient has achieved an uneventful recovery.
    MeSH term(s) Acute Disease ; Cholecystectomy ; Cholecystitis/diagnosis ; Duodenal Diseases/complications ; Gallbladder Neoplasms/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Humans ; Intestinal Fistula/complications ; Male ; Middle Aged
    Language English
    Publishing date 2003-07-16
    Publishing country Korea (South)
    Document type Case Reports ; Journal Article
    ZDB-ID 639023-7
    ISSN 1226-3303
    ISSN 1226-3303
    DOI 10.3904/kjim.2003.18.2.109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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