LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 665

Search options

  1. Article: Current Status and Future Outlook of Additive Manufacturing Technologies for the Reconstruction of the Trachea.

    Lee, Hwa-Yong / Lee, Jin Woo

    Journal of functional biomaterials

    2023  Volume 14, Issue 4

    Abstract: Tracheal stenosis and defects occur congenitally and in patients who have undergone tracheal intubation and tracheostomy due to long-term intensive care. Such issues may also be observed during tracheal removal during malignant head and neck tumor ... ...

    Abstract Tracheal stenosis and defects occur congenitally and in patients who have undergone tracheal intubation and tracheostomy due to long-term intensive care. Such issues may also be observed during tracheal removal during malignant head and neck tumor resection. However, to date, no treatment method has been identified that can simultaneously restore the appearance of the tracheal skeleton while maintaining respiratory function in patients with tracheal defects. Therefore, there is an urgent need to develop a method that can maintain tracheal function while simultaneously reconstructing the skeletal structure of the trachea. Under such circumstances, the advent of additive manufacturing technology that can create customized structures using patient medical image data provides new possibilities for tracheal reconstruction surgery. In this study, the three-dimensional (3D) printing and bioprinting technologies used in tracheal reconstruction are summarized, and various research results related to the reconstruction of mucous membranes, cartilage, blood vessels, and muscle tissue, which are tissues required for tracheal reconstruction, are classified. The prospects for 3D-printed tracheas in clinical studies are also described. This review serves as a guide for the development of artificial tracheas and clinical trials using 3D printing and bioprinting.
    Language English
    Publishing date 2023-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14040196
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Exploring distinct properties of endometrial stem cells through advanced single-cell analysis platforms.

    Lee, Jin Woo / Lee, Hwa-Yong

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 379

    Abstract: The endometrium is a dynamic tissue that undergoes cyclic changes in response to ovarian hormones during the menstrual cycle. These changes are crucial for pregnancy establishment and maintenance. Endometrial stem cells play a pivotal role in endometrial ...

    Abstract The endometrium is a dynamic tissue that undergoes cyclic changes in response to ovarian hormones during the menstrual cycle. These changes are crucial for pregnancy establishment and maintenance. Endometrial stem cells play a pivotal role in endometrial regeneration and repair by differentiating into various cell types within the endometrium. However, their involvement in endometrial disorders such as endometriosis, infertility, and endometrial cancer is still not fully understood yet. Traditional bulk sequencing methods have limitations in capturing heterogeneity and complexity of endometrial stem cell populations. To overcome these limitations, recent single-cell analysis techniques, including single-cell RNA sequencing (scRNA-Seq), single-cell ATAC sequencing (scATAC-Seq), and spatial transcriptomics, have emerged as valuable tools for studying endometrial stem cells. In this review, although there are still many technical limitations that require improvement, we will summarize the current state-of-the-art single-cell analysis techniques for endometrial stem cells and explore their relevance to related diseases. We will discuss studies utilizing various single-cell analysis platforms to identify and characterize distinct endometrial stem cell populations and investigate their dynamic changes in gene expression and epigenetic patterns during menstrual cycle and differentiation processes. These techniques enable the identification of rare cell populations, capture heterogeneity of cell populations within the endometrium, and provide potential targets for more effective therapies.
    MeSH term(s) Female ; Pregnancy ; Humans ; Endometrium ; Stem Cells ; Uterine Diseases/metabolism ; Menstrual Cycle ; Single-Cell Analysis
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03616-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: 3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage Repair.

    Lee, Seung Yeon / Lee, Jin Woo

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Cartilage is a connective tissue that constitutes the structure of the body and consists of chondrocytes that produce considerable collagenous extracellular matrix and plentiful ground substances, such as proteoglycan and elastin fibers. Self-repair is ... ...

    Abstract Cartilage is a connective tissue that constitutes the structure of the body and consists of chondrocytes that produce considerable collagenous extracellular matrix and plentiful ground substances, such as proteoglycan and elastin fibers. Self-repair is difficult when the cartilage is damaged because of insufficient blood supply, low cellularity, and limited progenitor cell numbers. Therefore, three-dimensional (3D) culture systems, including pellet culture, hanging droplets, liquid overlays, self-injury, and spinner culture, have attracted attention. In particular, 3D spheroid culture strategies can enhance the yield of exosome production of mesenchymal stem cells (MSCs) when compared to two-dimensional culture, and can improve cellular restorative function by enhancing the paracrine effects of MSCs. Exosomes are membrane-bound extracellular vesicles, which are intercellular communication systems that carry RNAs and proteins. Information transfer affects the phenotype of recipient cells. MSC-derived exosomes can facilitate cartilage repair by promoting chondrogenic differentiation and proliferation. In this article, we reviewed recent major advances in the application of 3D culture techniques, cartilage regeneration with stem cells using 3D spheroid culture system, the effect of exosomes on chondrogenic differentiation, and chondrogenic-specific markers related to stem cell derived exosomes. Furthermore, the utilization of MSC-derived exosomes to enhance chondrogenic differentiation for osteoarthritis is discussed. If more mechanistic studies at the molecular level are conducted, MSC-spheroid-derived exosomes will supply a better therapeutic option to improve osteoarthritis.
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12070939
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Design of an IoT-based indoor tracking and condition monitoring system for the safe and transparent management of drums storing low- and intermediate-level radioactive waste.

    Lee, Jin-Woo / Kim, Tack-Jin / Lee, Hyun-Kyu

    Journal of the Air & Waste Management Association (1995)

    2023  Volume 73, Issue 2, Page(s) 133–145

    Abstract: Regulatory agencies and civil society organizations concerned with radioactive waste management are demanding maximized safety management of radioactive-waste-containing drums using advanced technology for more efficient and safe management. In the ... ...

    Abstract Regulatory agencies and civil society organizations concerned with radioactive waste management are demanding maximized safety management of radioactive-waste-containing drums using advanced technology for more efficient and safe management. In the present paper, we propose a sensor system that can track and monitor drums containing low- and intermediate-level radioactive waste using advanced technology based on the Internet of Things (IoT). The proposed system consists of drum nodes, pallet nodes, and gateways. A drum node and magnetic sensor installed on a drum can be used to remotely check whether the drum lid is open or closed, and the location of the drum can be tracked using a near-field communication reader and an infrared module installed on the pallet node. Considering that radioactive waste is stored for a long time period, the proposed sensors are designed for low power consumption. Moreover, a pilot test involving 48 drums and 12 pallets was conducted to verify the system prototype. Accordingly, from the results of the pilot test, drawbacks were noted and solutions were proposed to improve the system in future work.
    MeSH term(s) Radioactive Waste/prevention & control ; Radioactive Waste/analysis ; Computer Simulation ; Waste Management
    Chemical Substances Radioactive Waste
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003064-5
    ISSN 2162-2906 ; 0894-0630 ; 1047-3289 ; 1096-2247
    ISSN (online) 2162-2906
    ISSN 0894-0630 ; 1047-3289 ; 1096-2247
    DOI 10.1080/10962247.2022.2149636
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Targeting Cancer Stem Cell Markers or Pathways: A Potential Therapeutic Strategy for Oral Cancer Treatment.

    Lee, Jin Woo / Lee, Hwa-Yong

    International journal of stem cells

    2021  Volume 14, Issue 4, Page(s) 386–399

    Abstract: Cancer stem cells (CSCs) are a small subset of cancer cells with stem cell-like properties, self-renewal potential, and differentiation capacity into multiple cell types. Critical genetic alterations or aberrantly activated signaling pathways associated ... ...

    Abstract Cancer stem cells (CSCs) are a small subset of cancer cells with stem cell-like properties, self-renewal potential, and differentiation capacity into multiple cell types. Critical genetic alterations or aberrantly activated signaling pathways associated with drug resistance and recurrence have been observed in multiple types of CSCs. In this context, CSCs are considered to be responsible for tumor initiation, growth, progression, therapeutic resistance, and metastasis. Therefore, to effectively eradicate CSCs, tremendous efforts have been devoted to identify specific target molecules that play a critical role in regulating their distinct functions and to develop novel therapeutics, such as proteins, monoclonal antibodies, selective small molecule inhibitors, and small antisense RNA (asRNA) drugs. Similar to other CSC types, oral CSCs can be characterized by certain pluripotency-associated markers, and oral CSCs can also survive and form 3D tumor spheres in suspension culture conditions. These oral CSC-targeting therapeutics selectively suppress specific surface markers or key signaling components and subsequently inhibit the stem-like properties of oral CSCs. A large number of new therapeutic candidates have been tested, and some products are currently in the pre-clinical or clinical development phase. In the present study, we review new oral CSC-targeted therapeutic strategies and discuss the various specific CSC surface markers and key signaling components involved in the stem-like properties, growth, drug resistance, and tumorigenicity of oral CSCs.
    Language English
    Publishing date 2021-10-29
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2914134-5
    ISSN 2005-5447 ; 2005-3606
    ISSN (online) 2005-5447
    ISSN 2005-3606
    DOI 10.15283/ijsc21084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Author Correction: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.

    Park, Chulo / Lee, Jin-Woo / Kim, Kiheon / Seen, Dong-Seung / Jeong, Jae-Yeon / Huh, Won-Ki

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9424

    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60108-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: Neural Fourier Shift for Binaural Speech Rendering

    Lee, Jin Woo / Lee, Kyogu

    2022  

    Abstract: We present a neural network for rendering binaural speech from given monaural audio, position, and orientation of the source. Most of the previous works have focused on synthesizing binaural speeches by conditioning the positions and orientations in the ... ...

    Abstract We present a neural network for rendering binaural speech from given monaural audio, position, and orientation of the source. Most of the previous works have focused on synthesizing binaural speeches by conditioning the positions and orientations in the feature space of convolutional neural networks. These synthesis approaches are powerful in estimating the target binaural speeches even for in-the-wild data but are difficult to generalize for rendering the audio from out-of-distribution domains. To alleviate this, we propose Neural Fourier Shift (NFS), a novel network architecture that enables binaural speech rendering in the Fourier space. Specifically, utilizing a geometric time delay based on the distance between the source and the receiver, NFS is trained to predict the delays and scales of various early reflections. NFS is efficient in both memory and computational cost, is interpretable, and operates independently of the source domain by its design. Experimental results show that NFS performs comparable to the previous studies on the benchmark dataset, even with its 25 times lighter memory and 6 times fewer calculations.

    Comment: Accepted by ICASSP 2023
    Keywords Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Artificial Intelligence ; Computer Science - Multimedia ; Computer Science - Sound ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 006
    Publishing date 2022-11-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Limitations of the Barcelona clinic liver cancer staging treatment strategy in hepatocellular carcinoma patients with performance status 1.

    Yu, Jung Hwan / Lee, Jin-Woo

    Annals of translational medicine

    2020  Volume 8, Issue 17, Page(s) 1042

    Language English
    Publishing date 2020-10-29
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-4316
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Online: Inverse Nonlinearity Compensation of Hyperelastic Deformation in Dielectric Elastomer for Acoustic Actuation

    Lee, Jin Woo / An, Gwang Seok / Sun, Jeong-Yun / Lee, Kyogu

    2024  

    Abstract: This paper delves into the analysis of nonlinear deformation induced by dielectric actuation in pre-stressed ideal dielectric elastomers. It formulates a nonlinear ordinary differential equation governing this deformation based on the hyperelastic model ... ...

    Abstract This paper delves into the analysis of nonlinear deformation induced by dielectric actuation in pre-stressed ideal dielectric elastomers. It formulates a nonlinear ordinary differential equation governing this deformation based on the hyperelastic model under dielectric stress. Through numerical integration and neural network approximations, the relationship between voltage and stretch is established. Neural networks are employed to approximate solutions for voltage-to-stretch and stretch-to-voltage transformations obtained via an explicit Runge-Kutta method. The effectiveness of these approximations is demonstrated by leveraging them for compensating nonlinearity through the waveshaping of the input signal. The comparative analysis highlights the superior accuracy of the approximated solutions over baseline methods, resulting in minimized harmonic distortions when utilizing dielectric elastomers as acoustic actuators. This study underscores the efficacy of the proposed approach in mitigating nonlinearities and enhancing the performance of dielectric elastomers in acoustic actuation applications.
    Keywords Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
    Subject code 518
    Publishing date 2024-01-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book ; Online: String Sound Synthesizer on GPU-accelerated Finite Difference Scheme

    Lee, Jin Woo / Choi, Min Jun / Lee, Kyogu

    2023  

    Abstract: This paper introduces a nonlinear string sound synthesizer, based on a finite difference simulation of the dynamic behavior of strings under various excitations. The presented synthesizer features a versatile string simulation engine capable of ... ...

    Abstract This paper introduces a nonlinear string sound synthesizer, based on a finite difference simulation of the dynamic behavior of strings under various excitations. The presented synthesizer features a versatile string simulation engine capable of stochastic parameterization, encompassing fundamental frequency modulation, stiffness, tension, frequency-dependent loss, and excitation control. This open-source physical model simulator not only benefits the audio signal processing community but also contributes to the burgeoning field of neural network-based audio synthesis by serving as a novel dataset construction tool. Implemented in PyTorch, this synthesizer offers flexibility, facilitating both CPU and GPU utilization, thereby enhancing its applicability as a simulator. GPU utilization expedites computation by parallelizing operations across spatial and batch dimensions, further enhancing its utility as a data generator.

    Comment: To be appeared in ICASSP 2024
    Keywords Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 621
    Publishing date 2023-11-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top