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Artikel: What Is the Diagnostic Accuracy of Chicago Classification Version 4.0 and the Difference From Version 3.0 in Diagnosing Esophageal Motility Disorders?

Lee, Ju Yup

Journal of neurogastroenterology and motility

2023 Band 29, Heft 3, Seite(n) 269–270

Sprache	Englisch
Erscheinungsdatum	2023-07-06
Erscheinungsland	Korea (South)
Dokumenttyp	Editorial
ZDB-ID	2573719-3
ISSN	2093-0887 ; 2093-0879
ISSN (online)	2093-0887
ISSN	2093-0879
DOI	10.5056/jnm23082
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Role of Serum CD26 in the Diagnosis of Gastric Cancer.

Lee, Ju Yup / Park, Mae-Ja

International journal of general medicine

2022 Band 15, Seite(n) 7179–7187

Abstract: Purpose: The value of serum cluster of differentiation 26 (CD26) in gastric cancer remains unknown. We investigated serum CD26 as a non-invasive serological marker for the diagnosis of gastric cancer and its relationship with serum human epidermal ... ...

Abstract	Purpose: The value of serum cluster of differentiation 26 (CD26) in gastric cancer remains unknown. We investigated serum CD26 as a non-invasive serological marker for the diagnosis of gastric cancer and its relationship with serum human epidermal growth factor receptor-2 (HER2) levels. Patients and methods: We enrolled 393 gastric cancer patients treated with endoscopic resection or surgery, and 90 healthy controls. HER2 positivity in tissue was evaluated by immunohistochemistry staining, and the serum CD26 and HER2 levels were measured using an enzyme-linked immunosorbent assay. Results: Serum CD26 levels were significantly lower in gastric cancer patients than in healthy controls (582.2 ± 254.3 vs 862.7 ± 410.6 ng/mL, P<0.001). Serum CD26 levels were significantly lower in advanced gastric cancer compared to early gastric cancer (642.2 ± 333.9 vs 503.4 ± 332.7 ng/mL, P<0.001), and tended to decrease with gastric cancer progression. To diagnose gastric cancer, the optimal cut-off value of serum CD26 was 762.7 ng/mL with 75.6% sensitivity and 64.4% specificity. Serum CD26 levels were weakly correlated with serum HER2 levels (rs=0.363, P<0.001). However, no difference in serum CD26 levels was observed between tissue HER2-negative and HER2-positive gastric cancer groups (586.2 ± 362.1 vs 579.6 ± 264.8 ng/mL, P=0.898). Conclusion: CD26 is a useful non-invasive serological marker for gastric cancer diagnosis; however, its levels do not correlate with HER2 status.
Sprache	Englisch
Erscheinungsdatum	2022-09-12
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S378620
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A case of colonic MALT lymphoma with intra-abdominal abscess and lung metastasis: A case report.

Lee, Kangkook / Lee, Jin Wook / Jung, Hye Ra / Park, Myeongsoon / Cho, Kwang Bum / Lee, Ju Yup

Medicine

2023 Band 102, Heft 43, Seite(n) e35778

Abstract: Rationale: Colonic mucosa-associated lymphoid tissue (MALT) lymphoma is an unusual subtype comprising only 2.5% of all MALT lymphomas. Most cases of colonic MALT lymphoma are diagnosed at an early stage. Therefore, the clinical features of advanced- ... ...

Abstract	Rationale: Colonic mucosa-associated lymphoid tissue (MALT) lymphoma is an unusual subtype comprising only 2.5% of all MALT lymphomas. Most cases of colonic MALT lymphoma are diagnosed at an early stage. Therefore, the clinical features of advanced-stage colonic MALT lymphoma have seldom been reported, and the endoscopic findings are not well established. In this study, we report the clinical and endoscopic characteristics of stage IV colonic MALT lymphoma and highlight the importance of repeat biopsy to figure out this rare disease. Patient concerns: The patient was a 68-year-old male complaining of hematochezia and lower left quadrant abdominal pain for the past 3 days. Diagnoses: The patient had 3 masses and friable mucosal lesions in the colon. With the first colonoscopy and biopsy, he was initially diagnosed as having eosinophilic colitis. However, the first treatment with steroids did not show any response. Because of atypical clinical features and colonoscopic findings, a second colonoscopy and a repeat biopsy were performed, and the results were consistent with colonic MALT lymphoma arising in the colon. The patient was finally diagnosed with stage IV colonic MALT lymphoma accompanied by multiple distant metastases. Interventions and outcomes: The patient started to receive chemotherapy with a combination regimen of cyclophosphamide, vincristine, and prednisolone. The follow-up study after 3 months showed stable disease status based on response evaluation criteria in solid tumors. Lessons: This case report presents atypical clinical characteristics and colonoscopic findings of stage IV colonic MALT lymphoma. Clinical suspicion and repeat biopsy should be considered to diagnose this rare and diagnostically challenging cancer.
Mesh-Begriff(e)	Male ; Humans ; Aged ; Lymphoma, B-Cell, Marginal Zone/complications ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymphoma, B-Cell, Marginal Zone/drug therapy ; Follow-Up Studies ; Colon/pathology ; Lung Neoplasms/complications ; Abdominal Abscess/complications
Sprache	Englisch
Erscheinungsdatum	2023-11-01
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035778
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Identifying Novel Subtypes of Functional Gastrointestinal Disorder by Analyzing Nonlinear Structure in Integrative Biopsychosocial Questionnaire Data.

Park, Sa-Yoon / Bae, Hyojin / Jeong, Ha-Yeong / Lee, Ju Yup / Kwon, Young-Kyu / Kim, Chang-Eop

Journal of clinical medicine

2024 Band 13, Heft 10

Abstract: Background/Objectives: ...

Abstract	Background/Objectives:
Sprache	Englisch
Erscheinungsdatum	2024-05-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13102821
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: [Gender Difference in Functional Gastrointestinal Disorders].

Lee, Ju Yup / Park, Kyung Sik

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2018 Band 72, Heft 4, Seite(n) 163–169

Abstract: Functional gastrointestinal diseases (FGIDs) are known to be influenced more by a lowering of the quality of life, such as mental health and sleep quality, compared to organic diseases. Genetic, microbiological, molecular biological, and social ... ...

Abstract	Functional gastrointestinal diseases (FGIDs) are known to be influenced more by a lowering of the quality of life, such as mental health and sleep quality, compared to organic diseases. Genetic, microbiological, molecular biological, and social environmental factors are involved in the pathophysiology of FGIDs. In particular, mental factors, such as depression and anxiety, play a major role in the development of FGIDs. The prevalence of most FGIDs is higher in women. Gender needs to be analyzed in patients with FGIDs because it can have a great influence on the onset of FGIDs. Because there are differences in the treatment response according to gender, further research in the development of therapeutic drugs considering this gender difference will be needed, and ultimately it will be possible to lower the prevalence of FGIDs and improve the quality of life of patients.
Mesh-Begriff(e)	Antipsychotic Agents/therapeutic use ; Cytokines/metabolism ; Estrogens/metabolism ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/drug therapy ; Gastrointestinal Diseases/epidemiology ; Humans ; Prevalence ; Proton Pump Inhibitors/therapeutic use ; Sex Factors ; Stress, Psychological
Chemische Substanzen	Antipsychotic Agents ; Cytokines ; Estrogens ; Proton Pump Inhibitors
Sprache	Koreanisch
Erscheinungsdatum	2018-11-13
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article ; Review
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2018.72.4.163
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study.

Lee, Ju Yup / Kim, Nayoung / Yoon, Hyuk / Shin, Cheol Min / Park, Young Soo / Lee, Dong Ho

Journal of neurogastroenterology and motility

2022 Band 28, Heft 2, Seite(n) 265–275

Abstract: Background/aims: To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD).: Methods: FD and IBS-C were diagnosed based on the ... ...

Abstract	Background/aims: To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD). Methods: FD and IBS-C were diagnosed based on the Rome III criteria. Randomized subjects were administered 30 mg of DA-9701 or placebo 3 times a day for 4 weeks. The study endpoints were evaluated the percentage of responders in the overall symptom evaluation of IBS-C and FD. Results: Thirty IBS-C patients and 30 placebos were prospectively enrolled. The proportion of responders with improvement in overall symptoms of IBS-C was 53.33% in the DA-9701 group and 40.00% in the placebo group ( Conclusions: DA-9701 showed trend of treatment efficacy in patients with IBS-C and FD overlap including overall improvement, and safety, compared to placebo but without significance probably due to small numbers. It is suggested the need for a large-scale clinical trial to confirm this preliminary effect of DA-9701.
Sprache	Englisch
Erscheinungsdatum	2022-03-01
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	2573719-3
ISSN	2093-0887 ; 2093-0879
ISSN (online)	2093-0887
ISSN	2093-0879
DOI	10.5056/jnm20236
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Helicobacter pylori Empirical and Tailored Eradication Therapy and Factors Influencing Eradication Rate: a 4-Year Single-Center Study.

Kim, Seung Wan / Lee, Ju Yup / Park, Myeongsoon / Lee, Jin Wook / Lee, Yoo Jin / Cho, Kwang Bum / Jung, Hye Ra

Clinical laboratory

2023 Band 69, Heft 10

Abstract: Background: The Helicobacter pylori eradication rate with standard triple therapy (STT) is continuously decreasing due to clarithromycin resistance. This study aimed to investigate the eradication rate of empirical and tailored therapy and explore ... ...

Abstract	Background: The Helicobacter pylori eradication rate with standard triple therapy (STT) is continuously decreasing due to clarithromycin resistance. This study aimed to investigate the eradication rate of empirical and tailored therapy and explore various factors affecting this eradication rate using clarithromycin resistance test data for the last 4 years at a single institution in Daegu. Methods: From August 2018 to July 2021, a total of 1,395 patients diagnosed with H. pylori infection based on rapid urea testing and histology at Keimyung University Dongsan Hospital were retrospectively examined. Participants were classified into the empirical and tailored therapy groups according to the results of the clarithromycin resistance test using the polymerase chain reaction. Results: The overall eradication rate of empirical STT was 72.8%, and the eradication rate by year was 71.6% in 2018, 77.4% in 2019, 70.3% in 2020, and 70.6% in 2021; the differences were not statistically significant (p = 0.173). No significant difference was noted in the eradication rate according to gender, age, type of proton pump inhibitors, and use of probiotics. Significant differences were noted in the eradication rate according to the treat-ment period: 69.7% in the 7-day, 67.3% in the 10-day, and 81.4% in the 14-day group (p = 0.001). The eradication rate with STT was 87.4% in the non-resistant group. In the case of clarithromycin resistance, treatment was mainly with bismuth quadruple therapy (BQT), and the eradication rate was 86.1%. The eradication rate was higher with administration of BQT for 10 days or 14 days than for administration of BQT for 7 days, but with no statistical significance (p = 0.364). Conclusions: Extending the treatment period of STT helped in improving the eradication rate, and tailored therapy through clarithromycin resistance testing showed superior results when compared to empirical therapy.
Mesh-Begriff(e)	Humans ; Clarithromycin/therapeutic use ; Clarithromycin/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Helicobacter pylori ; Retrospective Studies ; Drug Therapy, Combination ; Helicobacter Infections/diagnosis ; Helicobacter Infections/drug therapy ; Bismuth/therapeutic use ; Treatment Outcome
Chemische Substanzen	Clarithromycin (H1250JIK0A) ; Anti-Bacterial Agents ; Bismuth (U015TT5I8H)
Sprache	Englisch
Erscheinungsdatum	2023-10-02
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230512
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: [Brain-Gut-Microbiota Axis].

Lee, Ayoung / Lee, Ju Yup / Jung, Sung Won / Shin, Seung Yong / Ryu, Han Seung / Jang, Seung-Ho / Kwon, Joong Goo / Kim, Yong Sung

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2023 Band 81, Heft 4, Seite(n) 145–153

Abstract: Patients frequently report that stress causes or exacerbates gastrointestinal (GI) symptoms, indicating a functional relationship between the brain and the GI tract. The brain and GI tract are closely related embryologically and functionally, interacting ...

Abstract	Patients frequently report that stress causes or exacerbates gastrointestinal (GI) symptoms, indicating a functional relationship between the brain and the GI tract. The brain and GI tract are closely related embryologically and functionally, interacting in various ways. The concept of the brain-gut axis was originally established in the 19th and early 20th centuries based on physiological observations and experiments conducted in animals and humans. In recent years, with the growing recognition that gut microbiota plays a vital role in human health and disease, this concept has been expanded to the brain-gut-microbiota axis. The brain influences the motility, secretion, and immunity of the GI tract, with consequent effects on the composition and function of the gut microbiota. On the other hand, gut microbiota plays an essential role in the development and function of the brain and enteric nervous system. Although knowledge of the mechanisms through which the gut microbiota influences distant brain function is incomplete, studies have demonstrated communication between these organs through the neuronal, immune, and endocrine systems. The brain-gut-microbiota axis is an essential aspect of the pathophysiology of functional GI disorders such as irritable bowel syndrome, and is also involved in other GI diseases, including inflammatory bowel disease. This review summarizes the evolving concept of the brain-gut-microbiota axis and its implications for GI diseases, providing clinicians with new knowledge to apply in clinical practice.
Mesh-Begriff(e)	Animals ; Humans ; Brain-Gut Axis ; Microbiota ; Gastrointestinal Diseases ; Brain
Sprache	Koreanisch
Erscheinungsdatum	2023-04-25
Erscheinungsland	Korea (South)
Dokumenttyp	English Abstract ; Journal Article ; Review
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2023.028
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Masculinity, Rather Than Biological Sex, Is Associated With Psychological Comorbidities in Patients With Irritable Bowel Syndrome.

Kim, Yong Sung / Lee, Ju Yup / Kim, Jung-Wook / Kang, Seung Joo / Park, Jung Ho / Kim, Hyun Jin / Jang, Seung-Ho / Kim, Ji-Hyeon / Oh, Jung-Hwan

Journal of neurogastroenterology and motility

2024

Abstract: Background/aims: Irritable bowel syndrome (IBS) generally shows sex differences, and psychiatric comorbidities play an important role in its pathogenesis. We aim to measure the levels of gender roles and investigate their relationship with psychiatric ... ...

Abstract	Background/aims: Irritable bowel syndrome (IBS) generally shows sex differences, and psychiatric comorbidities play an important role in its pathogenesis. We aim to measure the levels of gender roles and investigate their relationship with psychiatric factors in patients with IBS versus healthy controls. Methods: Patients diagnosed with IBS by Rome III and whose colonoscopy findings were normal were enrolled at multiple sites in Korea. The participants completed the Korean Sex Role Inventory-Short Form (KSRI-SF) to assess masculinity and femininity, the stress questionnaire, the Hospital Anxiety Depression Scale (HADS), and the 36-item Short Form Health Survey questionnaire to assess the quality of life (QOL). Results: In total, 102 patients with IBS (male:female = 35:67; mean age 42.6 ± 16.7 years) and 55 controls (male:female = 20:35; mean age 42.4 ± 11.1 years) were recruited. IBS patients had higher stress (9.69 ± 8.23 vs 4.56 ± 8.31, Conclusions: IBS patients had higher stress, more psychiatric comorbidities, and lower QOL than controls. Low masculinity, rather than sex, was associated with stress and psychological comorbidities, which deteriorated the QOL in IBS patients.
Sprache	Englisch
Erscheinungsdatum	2024-02-07
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ZDB-ID	2573719-3
ISSN	2093-0887 ; 2093-0879
ISSN (online)	2093-0887
ISSN	2093-0879
DOI	10.5056/jnm23012
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ibuprofen-induced multiorgan malformation during embryogenesis in Xenopus laevis (FETAX).

Park, Mae Ja / Chae, Jeong-Pil / Woo, Dongju / Kim, Ji Yoon / Bae, Yong Chul / Lee, Ju Yup / Lee, Sang Yeon / Nam, Eon Jeong / Nam, Sung-Wook

Biochemical and biophysical research communications

2024 Band 703, Seite(n) 149565

Abstract: Ibuprofen, one of the most commonly prescribed nonsteroidal anti-inflammatory drugs, has not been fully assessed for embryonic toxicity in vertebrates. Here, we systematically assessed the embryotoxicity of ibuprofen in Xenopus laevis at various ... ...

Abstract	Ibuprofen, one of the most commonly prescribed nonsteroidal anti-inflammatory drugs, has not been fully assessed for embryonic toxicity in vertebrates. Here, we systematically assessed the embryotoxicity of ibuprofen in Xenopus laevis at various concentrations during embryogenesis. Embryos were treated with different concentrations of ibuprofen, ranging from 8 to 64 mg/L, at 23 °C for 96 h, and examined daily and evaluated at 72 hpf. Lethal or teratogenic effects were documented. For histological analysis, paraffin embedded embryos were transversely sectioned at a thickness of 10-μm and stained with hematoxylin and eosin. Total RNA was isolated from embryos at stages 6, 12, 22 and 36, and real-time quantitative PCR was performed. Ibuprofen-treated embryos showed delayed or failed dorsal lip formation and its closure at the beginning of gastrulation. This resulted in herniation of the endodermal mass after gastrulation under high concentrations of ibuprofen-treated embryos. Underdeveloped intestines with stage and/or intestinal malrotation, distorted microcephaly, and hypoplastic heart, lungs, and pronephric tubules were observed in ibuprofen-treated embryos. Cephalic, cardiac, and truncal edema were also observed in them. The severity of the deformities was observed in a concentration-dependent manner. The teratogenic index was 2.28. These gross and histological disruptions correlated well with the altered expression of each organ marker gene. In conclusion, ibuprofen induced delayed and disrupted gastrulation in the early developmental stage and multiorgan malformation later in the organogenesis stage of Xenopus laevis embryos.
Mesh-Begriff(e)	Animals ; Xenopus laevis ; Ibuprofen/toxicity ; Teratogens ; Embryonic Development ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Embryo, Nonmammalian
Chemische Substanzen	Ibuprofen (WK2XYI10QM) ; Teratogens ; Anti-Inflammatory Agents, Non-Steroidal
Sprache	Englisch
Erscheinungsdatum	2024-02-07
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149565
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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