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  1. Article ; Online: Reply: Consensus subtypes of HCC associated with clinical outcomes and genomic phenotypes.

    Yim, Sun Young / Lee, Ju-Seog

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 2, Page(s) E44

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Consensus ; Genomics ; Phenotype
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: An Overview of the Genomic Characterization of Hepatocellular Carcinoma.

    Yim, Sun Young / Lee, Ju-Seog

    Journal of hepatocellular carcinoma

    2021  Volume 8, Page(s) 1077–1088

    Abstract: Tumor classifications based on alterations in the genome, epigenome, or proteome have revealed distinct tumor subgroups that are associated with clinical outcomes. Several landmark studies have demonstrated that such classifications can significantly ... ...

    Abstract Tumor classifications based on alterations in the genome, epigenome, or proteome have revealed distinct tumor subgroups that are associated with clinical outcomes. Several landmark studies have demonstrated that such classifications can significantly improve patient outcomes by enabling tailoring of therapy to specific alterations in cancer cells. Since cancer cells accumulate numerous alterations in many cancer-related genes, it is a daunting task to find and confirm important cancer-promoting alterations as therapeutic targets or biomarkers that can predict clinical outcomes such as survival and response to treatments. To aid further advances, we provide here an overview of the current understanding of molecular and genomic subtypes of hepatocellular carcinoma (HCC). System-level integration of data from multiple studies and development of new technical platforms for analyzing patient samples hold great promise for the discovery of new targets for treatment and correlated biomarkers, leading to personalized medicine for treatment of HCC patients.
    Language English
    Publishing date 2021-09-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S270533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring cancer genomic data from the cancer genome atlas project.

    Lee, Ju-Seog

    BMB reports

    2016  Volume 49, Issue 11, Page(s) 607–611

    Abstract: The Cancer Genome Atlas (TCGA) has compiled genomic, epigenomic, and proteomic data from more than 10,000 samples derived from 33 types of cancer, aiming to improve our understanding of the molecular basis of cancer development. Availability of these ... ...

    Abstract The Cancer Genome Atlas (TCGA) has compiled genomic, epigenomic, and proteomic data from more than 10,000 samples derived from 33 types of cancer, aiming to improve our understanding of the molecular basis of cancer development. Availability of these genome-wide information provides an unprecedented opportunity for uncovering new key regulators of signaling pathways or new roles of pre-existing members in pathways. To take advantage of the advancement, it will be necessary to learn systematic approaches that can help to uncover novel genes reflecting genetic alterations, prognosis, or response to treatments. This minireview describes the updated status of TCGA project and explains how to use TCGA data. [BMB Reports 2016; 49(11): 607-611].
    MeSH term(s) DNA Copy Number Variations ; DNA Methylation ; Databases, Genetic ; Genes, Neoplasm ; Genomics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Proteomics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
    Chemical Substances MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2016-08-17
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    DOI 10.5483/bmbrep.2016.49.11.145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4202: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Genomic Perspective on Mouse Liver Cancer Models.

    Yim, Sun Young / Lee, Ju-Seog

    Cancers

    2019  Volume 11, Issue 11

    Abstract: Selecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the ... ...

    Abstract Selecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the human HCC genome has allowed categorization of HCC according to molecular subtypes. Despite the variety of mouse models that are available for preclinical research, there is a lack of evidence for mouse models that closely resemble human HCC. Therefore, it is necessary to identify the accurate mouse models that represent human HCC based on molecular subtype as well as histologic aggressiveness. In this review, we summarize the mouse models integrated with human HCC genomic data to provide information regarding the models that recapitulates the distinct aspect of HCC biology and prognosis based on molecular subtypes.
    Language English
    Publishing date 2019-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11111648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The mutational landscape of hepatocellular carcinoma.

    Lee, Ju-Seog

    Clinical and molecular hepatology

    2015  Volume 21, Issue 3, Page(s) 220–229

    Abstract: The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in genomic technologies have revolutionized the ... ...

    Abstract The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in genomic technologies have revolutionized the search for genetic alterations in cancer genomes. Recent studies in which all coding exons in HCC were sequenced have shed new light on the genomic landscape of this malignant disease. Catalogues of these somatic mutations and systematic analysis of catalogued mutations will lead us to uncover candidate HCC driver genes, although further functional validation is needed to determine whether these genes play a causal role in the development of HCC. This review provides an overview of previously known oncogenes and new oncogene candidates in HCC that were uncovered from recent exome or whole-genome sequencing studies. This knowledge provides direction for future personalized treatment approaches for patients with HCC.
    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Mutation ; Oxidative Stress ; Precision Medicine ; Telomerase/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Transcription Factors ; Tumor Suppressor Protein p53 ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2015-09
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2672560-5
    ISSN 2287-285X ; 2287-2728
    ISSN (online) 2287-285X
    ISSN 2287-2728
    DOI 10.3350/cmh.2015.21.3.220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6769: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Genomic profiling of liver cancer.

    Lee, Ju-Seog

    Genomics & informatics

    2013  Volume 11, Issue 4, Page(s) 180–185

    Abstract: Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the ...

    Abstract Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find and test candidate genes driving tumor development and progression. Systematic studies of the liver cancer genome have become available in recent years. These studies have uncovered new potential driver genes, including those not previously known to be involved in the development of liver cancer. Novel approaches combining multiple datasets from patient tissues have created an unparalleled opportunity to uncover potential new therapeutic targets and prognostic/predictive biomarkers for personalized therapy that can improve clinical outcomes of the patients with liver cancer.
    Language English
    Publishing date 2013-12-31
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2802682-2
    ISSN 2234-0742 ; 1598-866X
    ISSN (online) 2234-0742
    ISSN 1598-866X
    DOI 10.5808/GI.2013.11.4.180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo.

    Kweon, Soo-Mi / Kim, Gayeoun / Jeong, Yunseong / Huang, Wendong / Lee, Ju-Seog / Lai, Keane K Y

    Cancers

    2022  Volume 14, Issue 6

    Abstract: Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of novel genes that contribute to HCC pathogenesis will ... ...

    Abstract Hepatocellular carcinoma (HCC) ranks worldwide as one of the most lethal cancers. In spite of the vast existing knowledge about HCC, the pathogenesis of HCC is not completely understood. Discovery of novel genes that contribute to HCC pathogenesis will provide new insights for better understanding and treating HCC. The relatively obscure gene midnolin has been studied for over two decades; however, its biological roles are largely unknown. Our study is the first to demonstrate the functional significance of midnolin in HCC/cancer: Midnolin expression correlates with poor prognosis in HCC patients, and suppression of midnolin severely inhibits tumorigenicity of HCC cells in vitro and in mice and disrupts retinoic acid/lipid metabolism in these cells.
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14061421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Inhibition of the interaction between Hippo/YAP and Akt signaling with ursolic acid and 3'3-diindolylmethane suppresses esophageal cancer tumorigenesis.

    Meng, Ruo Yu / Li, Cong Shan / Hu, Dan / Kwon, Soon-Gu / Jin, Hua / Chai, Ok Hee / Lee, Ju-Seog / Kim, Soo Mi

    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

    2023  Volume 27, Issue 5, Page(s) 493–511

    Abstract: Hippo/YAP signaling hinders cancer progression. Inactivation of this pathway contributes to the development of esophageal cancer by activation of Akt. However, the possible interaction between Akt and Hippo/YAP pathways in esophageal cancer progression ... ...

    Abstract Hippo/YAP signaling hinders cancer progression. Inactivation of this pathway contributes to the development of esophageal cancer by activation of Akt. However, the possible interaction between Akt and Hippo/YAP pathways in esophageal cancer progression is unclear. In this study, we found that ursolic acid (UA) plus 3'3-diindolylmethane (DIM) efficiently suppressed the oncogenic Akt/Gsk-3β signaling pathway while activating the Hippo tumor suppressor pathway in esophageal cancer cells. Moreover, the addition of the Akt inhibitor LY294002 and the PI3K inhibitor 3-methyladenine enhanced the inhibitory effects of UA plus DIM on Akt pathway activation and further stimulated the Hippo pathway, including the suppression of YAP nuclear translocation in esophageal cancer cells. Silencing YAP under UA plus DIM conditions significantly increased the activation of the tumor suppressor PTEN in esophageal cancer cells, while decreasing p-Akt activation, indicating that the Akt signaling pathway could be down-regulated in esophageal cancer cells by targeting PTEN. Furthermore, in a xenograft nude mice model, UA plus DIM treatment effectively diminished esophageal tumors by inactivating the Akt pathway and stimulating the Hippo signaling pathway. Thus, our study highlights a feedback loop between the PI3K/Akt and Hippo signaling pathways in esophageal cancer cells, implying that a low dose of UA plus DIM could serve as a promising chemotherapeutic combination strategy in the treatment of esophageal cancer.
    Language English
    Publishing date 2023-08-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1387595-4
    ISSN 2093-3827 ; 1226-4512
    ISSN (online) 2093-3827
    ISSN 1226-4512
    DOI 10.4196/kjpp.2023.27.5.493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: 3,3'-Diindolylmethane Augments 5-Fluorouracil-InducedGrowth Suppression in Gastric Cancer Cells through Suppression of the Akt/GSK-3

    Li, Cong Shan / Nguyen, Thi Van / Chai, Ok Hee / Park, Byung Hyun / Lee, Ju-Seog / Kim, Soo Mi

    Journal of oncology

    2023  Volume 2023, Page(s) 8268955

    Abstract: Gastric cancer (GC) is one of the most lethal cancers in South Korea, and it is a cancer of concern worldwide. 5-fluorouracil (5-Fu) is commonly used as the first-line therapy for advanced GC; however, its side effects often limit the dosage range and ... ...

    Abstract Gastric cancer (GC) is one of the most lethal cancers in South Korea, and it is a cancer of concern worldwide. 5-fluorouracil (5-Fu) is commonly used as the first-line therapy for advanced GC; however, its side effects often limit the dosage range and impair patients' quality of life. Due to the limitations of current chemotherapy, new anticancer therapies are urgently needed. 3,3'-diindolylmethane (DIM) has been reported to have the ability to protect against various types of cancer. Our study aimed to elucidate the anticancer effect of DIM in GC when treated with the chemotherapeutic agent 5-Fu. In our results, combined treatment with DIM and 5-Fu resulted in higher apoptosis and lower cell proliferation than treatment with 5-Fu in SNU484 and SNU638 cell lines. Furthermore, when DIM and 5-Fu were administered together, cell invasion was diminished by mediated E-cadherin, MMP-9, and uPA; p-Akt and p-GSK-3
    Language English
    Publishing date 2023-02-04
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2023/8268955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway.

    Hu, Dan / Meng, Ruo Yu / Nguyen, Thi Van / Chai, Ok Hee / Park, Byung Hyun / Lee, Ju-Seog / Kim, Soo Mi

    Molecular medicine reports

    2022  Volume 27, Issue 1

    Abstract: Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product‑derived and chemotherapy agents including curcumin combined with 5‑ ... ...

    Abstract Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product‑derived and chemotherapy agents including curcumin combined with 5‑fluorouracil, resveratrol combined with cisplatin and epigallocatechin‑3‑gallate (EGCG) combined with cisplatin in preventing cancer progression and killing cancer cells has emerged. The Akt and Hippo signaling pathways serve a key role in colorectal tumor growth; however, the exact role of the crosstalk between Akt and Hippo signaling pathways in CRC remains poorly elucidated. The combined effect of UA and DOX on the cell proliferation, apoptosis, migration and cell cycle of CRC cells were investigated by performing Cell proliferation assay, a soft agar colony formation assay, flow cytometry, wound healing assay and western blotting assay. Subsequently, the expression of AKT and Hippo signaling pathway‑associated proteins were also assessed by western blot assay. Moreover, a xenograft nude mouse model was constructed to verify the effects of UA and DOX on the tumorigenesis of HCT116 cell
    MeSH term(s) Humans ; Mice ; Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Hippo Signaling Pathway ; Cisplatin/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Xenograft Model Antitumor Assays ; Signal Transduction ; Carcinogenesis ; Cell Proliferation ; Apoptosis ; Doxorubicin/pharmacology ; Colorectal Neoplasms/drug therapy ; Mammals/metabolism ; Ursolic Acid
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cisplatin (Q20Q21Q62J) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-11-16
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2022.12898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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