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  1. Article ; Conference proceedings: Association of visceral adiposity and sarcopenia with the risk of colorectal adenoma

    Kim, S. H. / Jeong, J. B. / Kang, H. W. / Kim, J. W. / Lee, K. L.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783531
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  2. Article ; Online: Genetic ablation of the preptin-coding portion of

    Buckels, E J / Hsu, H-L / Buchanan, C M / Matthews, B G / Lee, K L

    American journal of physiology. Endocrinology and metabolism

    2022  Volume 323, Issue 6, Page(s) E467–E479

    Abstract: Preptin is a 34-amino acid peptide derived from the E-peptide of pro-insulin-like growth factor 2 and is co-secreted with insulin from β-cells. Little is understood about the effects of endogenous preptin on whole body glucose metabolism. We developed a ... ...

    Abstract Preptin is a 34-amino acid peptide derived from the E-peptide of pro-insulin-like growth factor 2 and is co-secreted with insulin from β-cells. Little is understood about the effects of endogenous preptin on whole body glucose metabolism. We developed a novel mouse model in which the preptin portion of
    MeSH term(s) Female ; Male ; Mice ; Animals ; Peptide Fragments ; Insulin ; Mice, Knockout ; Glucose/pharmacology
    Chemical Substances preptin ; Peptide Fragments ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00401.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The dynamics of CO production from the photolysis of acetone across the whole S

    Jacob, L S D / Lee, K L K / Schmidt, T W / Nauta, K / Kable, S H

    The Journal of chemical physics

    2022  Volume 156, Issue 9, Page(s) 94303

    Abstract: The unimolecular photodissociation dynamics of acetone spanning the entire ... ...

    Abstract The unimolecular photodissociation dynamics of acetone spanning the entire S
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0080904
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  4. Article: 40 Administration of 0.1μM melatonin during invitro maturation of bovine oocytes regulates autophagy levels in produced embryos

    El-Sheikh, M / Mesalam, A. A / Lee, K.-L / Kong, I.-K

    Reproduction, fertility, and development. 2021, v. 33, no. 2

    2021  

    Abstract: Melatonin, the antioxidant pineal hormone, is a strong regulator for various cellular processes essential for reproduction. Although the protective role of 0.1µM melatonin against the toxicity of different anti-developmental compounds has been elucidated ...

    Abstract Melatonin, the antioxidant pineal hormone, is a strong regulator for various cellular processes essential for reproduction. Although the protective role of 0.1µM melatonin against the toxicity of different anti-developmental compounds has been elucidated in numerous studies, its effect on the autophagy level in invitro-produced blastocysts has not been entirely clarified. In this study, oocytes were incubated for 24h in the presence and absence of melatonin, administered during IVM, to investigate the effect of 0.1µM melatonin on the developmental competence of bovine oocytes and pre-implantation embryos, autophagy, and quality of embryos. The developmental potential of embryos were basically the stages from oocytes fertilization to blastocyst production. Gene expression levels were evaluated in matured oocytes, whereas blastocysts were used for immunofluorescence experiments. The differences between treated and control groups were analysed using Student’s t-test (GraphPad Prism version 6; GraphPad Inc.), where P-values <0.05 were considered significant. Results showed that oocyte maturation, Day-4 total cleavage, and Day-8 blastocyst development rates were not significantly improved (melatonin: 72±2 vs. control: 69±2 for cleavage rate, and melatonin: 33±1 vs. control: 31±2 for control for Day-8 blastocyst; P>0.05), whereas the level of reactive oxygen species (ROS) was reduced (P<0.05) with addition of melatonin. Using RT-qPCR, cumulus cells-related (HAS2) and apoptosis-related (Bcl2 and SOD2) genes were upregulated, whereas BAX was downregulated in melatonin-treated oocytes. Using immunofluorescence, apoptosis (caspase-3) and autophagy (Beclin-1 and LC3) markers were underexpressed, whereas the PI3K survival protein (P<0.05) and matrix metalloproteinases (MMP-2 and MMP-9; P>0.05) were overexpressed, in Day-8 embryos of melatonin-treatment. Additionally, the total number of cells per blastocysts, inspected via nuclei-based 4′,6-diamidino-2-phenylindole (DAPI) staining was higher in the melatonin-treated group (P<0.05). Taken together, our study demonstrates that 0.1µ
    Keywords apoptosis ; autophagy ; blastocyst ; caspase-3 ; cattle ; fluorescent antibody technique ; melatonin ; metalloproteinases ; oocytes ; phosphatidylinositol 3-kinase ; protective effect ; reactive oxygen species ; reproduction ; t-test ; toxicity
    Language English
    Size p. 127.
    Publishing place CSIRO Publishing
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1019913-5
    ISSN 1448-5990 ; 1031-3613
    ISSN (online) 1448-5990
    ISSN 1031-3613
    DOI 10.1071/RDv33n2Ab40
    Database NAL-Catalogue (AGRICOLA)

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    Z 5258: Show issues

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  5. Article: [Investigation of extrauterine growth restriction in very preterm infants in Chinese neonatal intensive care units].

    Lyu, Y Y / Cao, Y / Chen, Y X / Wang, H Y / Zhou, L / Wang, Y / Wang, Y C / Jiang, S Y / Lee, K L E E / Li, L / Sun, J H

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2023  Volume 61, Issue 9, Page(s) 811–819

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Male ; Cohort Studies ; East Asian People ; Infant, Premature ; Infant, Premature, Diseases ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal
    Language Chinese
    Publishing date 2023-08-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20230609-00388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3292: Show issues Location:
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  6. Article: Rotational thromboelastometry as a powerful tool to detect hyperfibrinolysis in a bleeding patient: a case report.

    Kwok, K M / Lee, K L / Lam, S Y / Liong, T / Wong, H M / Lam, P Y / Chow, E Y / Law, K I

    Hong Kong medical journal = Xianggang yi xue za zhi

    2021  Volume 27, Issue 5, Page(s) 370–372

    MeSH term(s) Hemorrhage/etiology ; Humans ; Thrombelastography
    Language English
    Publishing date 2021-10-27
    Publishing country China
    Document type Case Reports
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj208971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Treatment of patent ductus arteriosus in very preterm infants in China].

    Qian, A M / Cheng, R / Gu, X Y / Yin, R / Bai, R M / Du, J / Sun, M Y / Cheng, P / K Lee, K L E E / Du, L Z / Cao, Y / Zhou, W H / Zhao, Y Y / Jiang, S Y

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2023  Volume 61, Issue 10, Page(s) 896–901

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Infant ; Infant, Newborn ; Male ; Humans ; Female ; Ductus Arteriosus, Patent/drug therapy ; Infant, Premature ; Cross-Sectional Studies ; Ibuprofen/therapeutic use ; Infant, Very Low Birth Weight ; Persistent Fetal Circulation Syndrome ; Infant, Premature, Diseases/therapy
    Chemical Substances Ibuprofen (WK2XYI10QM)
    Language Chinese
    Publishing date 2023-09-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20230706-00440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3292: Show issues Location:
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  8. Article ; Conference proceedings: Preceding endoscopic risk factors for the gastric neoplasm in the upper gastrointestinal endoscopy screening

    Huh, J. / Kim, K. W. / Jeong, Y. J. / Oh, D. J. / Jang, H. / Jang, D. K. / Kim, S. H. / Kang, H. W. / Kim, J. W. / Lee, K. L.

    Endoscopy

    2023  Volume 55, Issue S 02

    Event/congress ESGE Days 2023, Dublin, Ireland, 2023-04-20
    Language English
    Publishing date 2023-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0043-1765151
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  9. Article: Lead attenuation characteristics models.

    Lee, K L / Schick, D

    Australasian physical & engineering sciences in medicine

    2010  Volume 32, Issue 4, Page(s) 212–219

    Abstract: Lead attenuation characteristic curves are often consulted in premises radiation shielding assessments employing the non-destructive testing (NDT) method. This study developed lead attenuation characteristics mathematical models for the radionuclide Co- ... ...

    Abstract Lead attenuation characteristic curves are often consulted in premises radiation shielding assessments employing the non-destructive testing (NDT) method. This study developed lead attenuation characteristics mathematical models for the radionuclide Co-57. These models take into account the statistical variation of the attenuation characteristics. The results are a set of equations that a NDT assessor can use to predict the range of transmission factors for the NDT measurement or, using the inverse functions, to gauge the lead equivalence (with the associated uncertainty) of a radiation barrier. This study showed that the combined effect of types of statistical variations can form an uncertainty region on the transmission characteristics such that the relative uncertainty decreases for values of lead mass per unit area up to approximately 20 kg/m2 and 15 kg/m2 for the Ludlum 18 and Ludlum 2241-2 survey meters respectively but thereafter increases.
    MeSH term(s) Computer Simulation ; Dose-Response Relationship, Radiation ; Lead/chemistry ; Models, Chemical ; Radiation Dosage ; Radiation Protection/methods ; Scattering, Radiation
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2010-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 46226-3
    ISSN 1879-5447 ; 0158-9938
    ISSN (online) 1879-5447
    ISSN 0158-9938
    DOI 10.1007/bf03179241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Admission triage tool for adult intensive care unit admission in Hong Kong during the COVID-19 outbreak.

    Joynt, G M / Leung, A K H / Ho, C M / So, D / Shum, H P / Chow, F L / Yeung, A W T / Lee, K L / Tang, G K Y / Yan, W W

    Hong Kong medical journal = Xianggang yi xue za zhi

    2021  Volume 28, Issue 1, Page(s) 64–72

    Abstract: Intensive care is expensive, and the numbers of intensive care unit (ICU) beds and trained specialist medical staff able to provide services in Hong Kong are limited. The most recent increase in coronavirus disease 2019 (COVID-19) infections over July to ...

    Abstract Intensive care is expensive, and the numbers of intensive care unit (ICU) beds and trained specialist medical staff able to provide services in Hong Kong are limited. The most recent increase in coronavirus disease 2019 (COVID-19) infections over July to August 2020 resulted in more than 100 new cases per day for a prolonged period. The increased numbers of critically ill patients requiring ICU admission posed a capacity challenge to ICUs across the territory, and it may be reasonably anticipated that should a substantially larger outbreak occur, ICU services will be overwhelmed. Therefore, a transparent and fair prioritisation process for decisions regarding patient ICU admission is urgently required. This triage tool is built on the foundation of the existing guidelines and framework for admission, discharge, and triage that inform routine clinical practice in Hospital Authority ICUs, with the aim of achieving the greatest benefit for the greatest number of patients from the available ICU resources. This COVID-19 Crisis Triage Tool is expected to provide structured guidance to frontline doctors on how to make triage decisions should ICU resources become overwhelmed by patients requiring ICU care, particularly during the current COVID-19 pandemic. The triage tool takes the form of a detailed decision aid algorithm based on a combination of established prognostic scores, and it should increase objectivity and transparency in triage decision making and enhance decision-making consistency between doctors within and across ICUs in Hong Kong. However, it remains an aid rather than a complete substitute for the carefully considered judgement of an experienced intensive care clinician.
    MeSH term(s) Adult ; COVID-19/epidemiology ; Disease Outbreaks ; Hong Kong/epidemiology ; Hospitalization ; Humans ; Intensive Care Units ; Pandemics ; SARS-CoV-2 ; Triage/methods
    Language English
    Publishing date 2021-01-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj209033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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