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Article ; Online: COVID-19 Hotlines Provide Links to Services

Lee, Laura

2020

Abstract: News release regarding the establishment of 3 hotlines by the University of Maryland, Baltimore (UMB) and the University of Maryland Medical Center (UMMC) designed to connect people with COVID-19 concerns to critical information. ...

Abstract	News release regarding the establishment of 3 hotlines by the University of Maryland, Baltimore (UMB) and the University of Maryland Medical Center (UMMC) designed to connect people with COVID-19 concerns to critical information.
Keywords	Coronavirus Disease 2019 (COVID-19) ; University of Maryland ; Baltimore ; University of Maryland Medical Center ; COVID-19 (Disease) ; COVID-19 ; covid19
Language	English
Publishing date	2020-04-09
Publishing country	us
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: On the Front Lines

Lee, Laura

UMB Champions of Excellence Center for Health and Homeland Security Team University of Maryland, Baltimore ; Center for Health and Homeland Security Team Center for Health and Homeland Security Team Crisis Consulting: On-Site and On-Task

2020

Abstract: News release describing the work of the Center for Health and Homeland Security Team at the University of Maryland, Baltimore during the COVID-19 Pandemic. The team under the leadership of Michael Greenberger, JD, incuded: Hassan Sheikh, PharmD, JD; ... ...

Abstract	News release describing the work of the Center for Health and Homeland Security Team at the University of Maryland, Baltimore during the COVID-19 Pandemic. The team under the leadership of Michael Greenberger, JD, incuded: Hassan Sheikh, PharmD, JD; Jihane Ambroise, MPH, CPH; Joseph Corona, CEM; Samantha Durbin, MS; Patrick Fleming, MPA, MSL; Ian Hamilton, MS; Netta Squires, JD, MSL, CEM; and Kimberly Stinchcomb, MPH, CPH. The Champions of Excellence campaign is a multiyear branding campaign at the University of Maryland, Baltimore (UMB) in which we highlight individuals and teams that exemplify extraordinary accomplishment and represent excellence at the University. In the 2020 campaign, On the Front Lines: UMB Champions of Excellence, we are featuring UMB’s essential employees, the front-line workers who have continued to fulfill their extraordinary commitment to the University by keeping our important functions and operations running during the COVID-19 pandemic. https://www.umaryland.edu/champions/center-for-health-and-homeland-security-team/ https://elm.umaryland.edu/elm-stories/Elm-Stories-Content/On-the-Front-Lines-UMB-Champions-of-Excellence-Center-for-Health-and-Homeland-Security-Team.php
Keywords	Coronavirus Disease 2019 (COVID-19) ; Homeland Security ; University of Maryland Center for Health and Homeland Security (CHHS) ; Sheikh ; Hassan ; Ambroise ; Jihane ; Corona ; Joseph ; Durbin ; Samantha ; Fleming ; Patrick ; Hamilton ; Ian ; Squires ; Netta ; Stinchcomb ; Kimberly ; University of Maryland ; Baltimore ; COVID-19 (Disease) ; Greenberger ; Michael ; COVID-19 ; covid19
Subject code	290
Language	English
Publishing date	2020-10-14
Publishing country	us
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Audio / Video ; Online: UMB Shines Light on Front-Line Heroes

Lee, Laura

2020

Abstract: As the sun set on downtown Baltimore on April 10, buildings on the campus of the University of Maryland, Baltimore (UMB) and the University of Maryland Medical Center (UMMC) came alive with color to honor the dedicated health care workers, first ... ...

Abstract	As the sun set on downtown Baltimore on April 10, buildings on the campus of the University of Maryland, Baltimore (UMB) and the University of Maryland Medical Center (UMMC) came alive with color to honor the dedicated health care workers, first responders, and other essential employees who are risking their lives every day in the fight against the COVID-19 pandemic. https://www.youtube.com/watch?v=qw5mnPM0oOE
Keywords	Coronavirus Disease 2019 (COVID-19) ; University of Maryland ; Baltimore ; Baltimore. Health Sciences and Human Services Library ; COVID-19 (Disease) ; COVID-19 ; covid19
Language	English
Publishing date	2020-04-14
Publishing country	us
Document type	Article ; Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical Task-Sharing in the Western Canadian Arctic: A Networked Model Between Family Physicians with Enhanced Surgical Skills and Specialist Surgeons.

Falk, Ryan / Topstad, Dawnelle / Lee, Laura

World journal of surgery

2022 Volume 46, Issue 7, Page(s) 1629–1636

Abstract: Background: With the loss of generalism in the surgical specialties, there has been a move in Canada to train family physicians in enhanced surgical skills (FP-ESS) to address the surgical needs of rural and remote populations. This research project ... ...

Abstract	Background: With the loss of generalism in the surgical specialties, there has been a move in Canada to train family physicians in enhanced surgical skills (FP-ESS) to address the surgical needs of rural and remote populations. This research project sought to describe one network integrating FP-ESS and specialist surgeons, focusing on the role of FP-ESS and their relationship with specialist surgeons, in the surgical care of the Beaufort Delta Region of the Northwest Territories of Canada. Methods: Using a participatory approach, semi-structured interviews were conducted with 22 stakeholders within the surgical system. Interviews were transcribed and reviewed, then imported into NVivo 12 for analysis. First-level coding was performed based on both deductive and inductive reasoning in an iterative fashion during interview collection to develop and refine the codebook. This was followed by second-level categorizing. Results: The FP-ESS physicians provide cesarean section services to maintain a local obstetrics program, to provide gastrointestinal endoscopy, and to provide emergency on-call support, as described by one stakeholder. FP-ESS work together with specialist surgeons through an informal network keeping surgical care as close to home as possible. FP-ESS within this health regions were seen as "a really big gain to the system." Conclusions: This study deepens our understanding of rural surgical service delivery, in particular where FP-ESS and specialist surgeons function collaboratively. It also contributes to strengthening rural surgical systems in Canada and therefore to addressing the health gap between rural/remote/indigenous and urban populations.
MeSH term(s)	Canada ; Cesarean Section ; Female ; Humans ; Physicians, Family/education ; Pregnancy ; Rural Health Services ; Surgeons
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-022-06524-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The plant stomatal lineage at a glance.

Lee, Laura R / Bergmann, Dominique C

Journal of cell science

2019 Volume 132, Issue 8

Abstract: Stomata are structures on the surfaces of most land plants that are required for gas exchange between plants and their environment. ... ...

Abstract	Stomata are structures on the surfaces of most land plants that are required for gas exchange between plants and their environment. In
MeSH term(s)	Arabidopsis/cytology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/physiology ; Asymmetric Cell Division ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/physiology ; Cell Lineage ; Cell Polarity ; Gases/metabolism ; Gene Expression Regulation, Plant ; Plant Stomata/genetics ; Plant Stomata/physiology ; Signal Transduction ; Stem Cells/metabolism
Chemical Substances	Arabidopsis Proteins ; Basic Helix-Loop-Helix Transcription Factors ; Gases ; SPEECHLESS protein, Arabidopsis
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.228551
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Article: Nuclear GSH import precedes coordinated cell cycle changes during regeneration.

Lee, Laura R / Guillotin, Bruno / Hutchison, Chanel / Desvoyes, Bénédicte / Gutierrez, Crisanto / Birnbaum, Kenneth David

bioRxiv : the preprint server for biology

2023

Abstract: Arabidopsis root tip regeneration requires cell division and cellular reprogramming. Here, we present new datasets that describe the cell cycle in Arabidopsis roots that maintain developmental context and cell-type resolution and provide an expanded set ... ...

Abstract	Arabidopsis root tip regeneration requires cell division and cellular reprogramming. Here, we present new datasets that describe the cell cycle in Arabidopsis roots that maintain developmental context and cell-type resolution and provide an expanded set of cell cycle phase transcriptional markers. Using these data, we provide in vivo confirmation of a longstanding model in plants that glutathione (GSH) and reactive oxygen species (ROS) vary in a cell cycle dependent manner. We then demonstrate using long term time lapse imaging that cells in G1 phase undergo a transient peak of GSH prior to a tissue-wide coordinated entry into S phase. This coordinated S phase entry precedes a period of fast divisions, which we show appears to potentiate cellular reprogramming during regeneration. Taken together, this work demonstrates a role for GSH in coordinating cell cycle regulation and cellular reprogramming during regeneration.
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.28.569014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Buffy Coat Score as a Biomarker of Treatment Response in Neuronal Ceroid Lipofuscinosis Type 2.

Sivananthan, Siyamini / Lee, Laura / Anderson, Glenn / Csanyi, Barbara / Williams, Ruth / Gissen, Paul

Brain sciences

2023 Volume 13, Issue 2

Abstract: The introduction of intracerebroventricular (ICV) enzyme replacement therapy (ERT) for treatment of neuronal ceroid lipofuscinosis type 2 (CLN2) disease has produced dramatic improvements in disease management. However, assessments of therapeutic effect ... ...

Abstract	The introduction of intracerebroventricular (ICV) enzyme replacement therapy (ERT) for treatment of neuronal ceroid lipofuscinosis type 2 (CLN2) disease has produced dramatic improvements in disease management. However, assessments of therapeutic effect for ICV ERT are limited to clinical observational measures, namely the CLN2 Clinical Rating Scale, a subjective measure of motor and language performance. There is a need for an objective biomarker to enable assessments of disease progression and response to treatment. To address this, we investigated whether the proportion of cells with abnormal storage inclusions on electron microscopic examination of peripheral blood buffy coats could act as a biomarker of disease activity in CLN2 disease. We conducted a prospective longitudinal analysis of six patients receiving ICV ERT. We demonstrated a substantial and continuing reduction in the proportion of abnormal cells over the course of treatment, whereas symptomatic scores revealed little or no change over time. Here, we proposed the use of the proportion of cells with abnormal storage as a biomarker of response to therapy in CLN2. In the future, as more tissue-specific biomarkers are developed, the buffy coats may form part of a panel of biomarkers in order to give a more holistic view of a complex disease.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13020209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical, pathologic, and immunohistochemical features of pituitary tumors in 4 chinchillas

Lee, Laura M. / Gasper, David / Szabó, Zoltán / Tse, May / Hawkins, Shawna / Steinberg, Howard / Kiupel, Matti

Veterinary Pathology. 2023 May, v. 60, no. 3 p.320-323

2023

Abstract: Pituitary tumors are rare in chinchillas. This report describes the clinical, gross, histologic, and immunohistochemical characteristics of pituitary tumors in 4 chinchillas. The affected chinchillas were females between 4 and 18 years of age. Clinically, ...

Abstract	Pituitary tumors are rare in chinchillas. This report describes the clinical, gross, histologic, and immunohistochemical characteristics of pituitary tumors in 4 chinchillas. The affected chinchillas were females between 4 and 18 years of age. Clinically, neurologic signs were most commonly reported and included depression, obtundation, seizure, head-pressing, ataxia, and possible blindness. Computed tomography scanning of 2 chinchillas revealed solitary intracranial extra-axial masses in the region of the pituitary gland. Two pituitary tumors were confined to the pars distalis; the other 2 invaded the brain. Based on their microscopic appearances and lack of distant metastases, all 4 tumors were diagnosed as pituitary adenomas. Immunohistochemically, all pituitary adenomas were weakly to strongly positive for growth hormone, most consistent with the diagnosis of somatotropic pituitary adenomas. To the authors' knowledge, this is the first detailed report of the clinical, pathologic, and immunohistochemical features of pituitary tumors in chinchillas.
Keywords	animal pathology ; blindness ; brain ; computed tomography ; immunohistochemistry ; pituitary gland ; somatotropin ; chinchilla ; Chinchilla lanigera ; growth hormone ; pituitary adenoma ; pituitary neuroendocrine tumors
Language	English
Dates of publication	2023-05
Size	p. 320-323.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858231158077
Database	NAL-Catalogue (AGRICOLA)

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Book: Ein Marquess und kein Gentleman?

Lee, Laura

(Historical gold : Extra ; 81)

2015

Title translation	When the Marquess met his match <dt.>
Author's details	Laura Lee
Series title	Historical gold : Extra ; 81
Language	German
Size	399 S
Publisher	Cora-Verl
Publishing place	Hamburg
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Health science research barriers and facilitators in the midst of the COVID-19 crisis: scoping review

Neira-Fernández, Karen Daniela / Gaitán-Lee, Laura / Gómez-Ramírez, Olga Janneth

Revista colombiana de obstetricia y ginecologia

2021 Volume 72, Issue 4, Page(s) 377–395

Abstract: Objective: The COVID-19 pandemic has imposed a great challenge on health research because of the pressing need to respond promptly and effectively to this crisis situation. It is important to offer a high level perspective of the main barriers and ... ...

Title translation	Barreras y facilitadores para la investigación en ciencias de la salud durante la crisis del COVID-19: una revisión de alcance.
Abstract	Objective: The COVID-19 pandemic has imposed a great challenge on health research because of the pressing need to respond promptly and effectively to this crisis situation. It is important to offer a high level perspective of the main barriers and facilitators found when conducting health science studies during the COVID-19 crisis and to discuss the research initiatives suggested by global, regional or local health research authorities. Materials and methods: A systematic scoping review was carried out. A literature search was conducted in the Medline, Cochrane Library, Lilacs and Google Scholar databases. Original research studies, review and opinion articles and editorials available in full text published in Spanish, English or Portuguese between January 2020 and May 2021 were included. Two authors working independently selected the papers and collected the data. The barriers and facilitators identified were described and organized in four categories according to the literature: sociocultural, administrative, organizational and methodological. Official documents and communications from global, regional and local health and research authorities were also included. Results are presented in narrative and table form. Results: Overall, 26 documents were selected for data analysis and synthesis. The barriers most frequently mentioned in the literature include issues with access to participants, ethics committees paperwork, biological risk for the researchers, and lack of inter and intra-institutional coordination. On the other hand, the facilitators identified include the adoption of on-line solutions, cooperative work among research actors, and a more flexible informed consent process. Regarding the initiatives disseminated by health and research authorities, four strategies were identified: prioritization of research questions, cooperation and inclusion promotion, fight against infodemia, and strengthening of the methodological quality of the studies. Conclusions: Continued cooperation and interoperability among institutions, countries and disciplines to facilitate future research processes is a challenge in the context of the pandemic; similarly, it is now important to maintain open science and funding of cooperative studies when other priorities emerge. Likewise, there is an evident need to develop and sustain efficient information management systems to help with decision-making. Ongoing review of the effects of the pandemic on health research practice is needed in order to gain comprehensive insights of what we need to learn as a society from this crisis.
MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2
Language	Spanish
Publishing date	2021-12-30
Publishing country	Colombia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	732034-6
ISSN	2463-0225 ; 0034-7434
ISSN (online)	2463-0225
ISSN	0034-7434
DOI	10.18597/rcog.3788
Database	MEDical Literature Analysis and Retrieval System OnLINE

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