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  1. Book ; Online: Actinobacteria: Prolific Producers of Bioactive Metabolites

    Lee, Learn-Han / Goh, Bey-Hing / Chan, Kok-Gan

    2020  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; Actinobacteria ; prolific producers ; Streptomyces ; bioactive metabolites ; bioprospecting
    Size 1 electronic resource (138 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231348
    ISBN 9782889660872 ; 2889660877
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Food Safety and Foodborne Pathogen - A Global Perspective on the Diversity, Combating Multidrug Resistance and Management

    Lee, Learn-Han / Singh, Om V. / Ab Mutalib, Nurul-Syakima / López, Marta

    2020  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; Food safety ; Foodborne pathogen ; multidrug resistance ; Vibrio ; Salmonella ; Listeria ; Campylobacter ; Detection method
    Size 1 electronic resource (441 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230924
    ISBN 9782889662395 ; 288966239X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The Search for Biological Active Agent(s) From Actinobacteria, 2nd Edition

    Lee, Learn-Han / Chan, Kok-Gan / Stach, Jem / Wellington, Elizabeth M. H. / Goh, Bey-Hing

    2020  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; actinobacteria ; drug discovery ; Streptomyces ; bioactive ; next generation ; marine ; terrestrial
    Size 1 electronic resource (312 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230529
    ISBN 9782889636396 ; 2889636399
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: The Search for Biological Active Agent(s) From Actinobacteria

    Goh, Bey-Hing / Chan, Kok-Gan / Stach, Jem / Wellington, Elizabeth M. H. / Lee, Learn-Han

    2018  

    Abstract: There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research ... ...

    Abstract There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today's market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers.

    Actinobacteria are one of the most important and efficient groups of natural metabolite producers.-

    Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities.-

    These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar
    Keywords Science (General) ; Microbiology
    Size 1 electronic resource (312 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101881
    ISBN 9782889455676 ; 288945567X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Editorial: Roles of microbes in esophageal disease.

    Lee, Learn-Han / Gao, Xuefeng / Sun, Gang

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1339579

    MeSH term(s) Humans ; Esophageal Diseases ; Gastroesophageal Reflux
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1339579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Evidence-based on health benefits: probiotics, micronutrients, and edible plants.

    Lee, Learn-Han / Goh, Bey-Hing / Dilokthornsakul, Piyameth / Saokaew, Surasak

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1272456

    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1272456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Can Mindfulness Help to Alleviate Loneliness? A Systematic Review and Meta-Analysis.

    Teoh, Siew Li / Letchumanan, Vengadesh / Lee, Learn-Han

    Frontiers in psychology

    2021  Volume 12, Page(s) 633319

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.633319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Deciphering colorectal cancer immune microenvironment transcriptional landscape on single cell resolution - A role for immunotherapy.

    Tieng, Francis Yew Fu / Lee, Learn-Han / Ab Mutalib, Nurul-Syakima

    Frontiers in immunology

    2022  Volume 13, Page(s) 959705

    Abstract: Single cell RNA sequencing (scRNA-seq) is a novel high-throughput technique that enables the investigation of a single cell's entire transcriptome. It elucidates intricate cellular networks and generates indices that will eventually enable the ... ...

    Abstract Single cell RNA sequencing (scRNA-seq) is a novel high-throughput technique that enables the investigation of a single cell's entire transcriptome. It elucidates intricate cellular networks and generates indices that will eventually enable the development of more targeted and personalized medications. The importance of scRNA-seq has been highlighted in complex biological systems such as cancer and the immune system, which exhibit significant cellular heterogeneity. Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related death globally. Chemotherapy continues to be used to treat these patients. However, 5-FU has been utilized in chemotherapy regimens with oxaliplatin and irinotecan since the 1960s and is still used today. Additionally, chemotherapy-resistant metastatic CRCs with poor prognoses have been treated with immunotherapy employing monoclonal antibodies, immune checkpoint inhibitors, adoptive cell therapy and cancer vaccines. Personalized immunotherapy employing tumor-specific neoantigens allows for treating each patient as a distinct group. Sequencing and multi-omics approaches have helped us identify patients more precisely in the last decade. The introduction of modern methods and neoantigen-based immunotherapy may usher in a new era in treating CRC. The unmet goal is to better understand the cellular and molecular mechanisms that contribute to CRC pathogenesis and resistance to treatment, identify novel therapeutic targets, and make more stratified and informed treatment decisions using single cell approaches. This review summarizes current scRNA-seq utilization in CRC research, examining its potential utility in the development of precision immunotherapy for CRC.
    MeSH term(s) Antibodies, Monoclonal ; Cancer Vaccines ; Colorectal Neoplasms ; Humans ; Immunologic Factors ; Immunotherapy ; Tumor Microenvironment
    Chemical Substances Antibodies, Monoclonal ; Cancer Vaccines ; Immunologic Factors
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.959705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Application of chitosan-based nanoparticles in skin wound healing.

    Loo, Hooi Leong / Goh, Bey Hing / Lee, Learn-Han / Chuah, Lay Hong

    Asian journal of pharmaceutical sciences

    2022  Volume 17, Issue 3, Page(s) 299–332

    Abstract: The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent years. This has prompted research into the development of novel wound dressings with augmented wound healing functions. ... ...

    Abstract The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent years. This has prompted research into the development of novel wound dressings with augmented wound healing functions. Nanoparticle (NP)-based delivery systems have become attractive candidates in constructing such wound dressings due to their various favourable attributes. The non-toxicity, biocompatibility and bioactivity of chitosan (CS)-based NPs make them ideal candidates for wound applications. This review focusses on the application of CS-based NP systems for use in wound treatment. An overview of the wound healing process was presented, followed by discussion on the properties and suitability of CS and its NPs in wound healing. The wound healing mechanisms exerted by CS-based NPs were then critically analysed and discussed in sections, namely haemostasis, infection prevention, inflammatory response, oxidative stress, angiogenesis, collagen deposition, and wound closure time. The results of the studies were thoroughly reviewed, and contradicting findings were identified and discussed. Based on the literature, the gap in research and future prospects in this research area were identified and highlighted. Current evidence shows that CS-based NPs possess superior wound healing effects either used on their own, or as drug delivery vehicles to encapsulate wound healing agents. It is concluded that great opportunities and potentials exist surrounding the use of CSNPs in wound healing.
    Language English
    Publishing date 2022-04-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2650931-3
    ISSN 2221-285X ; 1818-0876 ; 2221-285X
    ISSN (online) 2221-285X
    ISSN 1818-0876 ; 2221-285X
    DOI 10.1016/j.ajps.2022.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strain

    Cui, Ying / Song, Kai / Jin, Zi-Jing / Lee, Learn-Han / Thawai, Chitti / He, Ya-Wen

    Synthetic and systems biotechnology

    2023  Volume 8, Issue 4, Page(s) 618–628

    Abstract: Biocontrol ... ...

    Abstract Biocontrol strain
    Language English
    Publishing date 2023-09-21
    Publishing country China
    Document type Journal Article
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2023.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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