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  1. Article ; Online: An alarm system of carbamazepine-induced toxic effects highly associated with HLA-B*1502 allele.

    Lu, Ying-Hao / Hsu, Wen-Chin / Lee, Li-Yao / Kuo, Chen-Chun

    The Kaohsiung journal of medical sciences

    2020  Volume 37, Issue 2, Page(s) 156–157

    MeSH term(s) Alleles ; Carbamazepine/adverse effects ; Genetic Testing ; HLA-B Antigens/genetics ; Humans
    Chemical Substances HLA-B Antigens ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2020-11-24
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Establishing Quality of Life in Southern Taiwan COPD Patients Using Long-Acting Bronchodilator.

    Chin, Pik-Qi / Sheu, Chau-Chyun / Tsai, Jong-Rung / Chang, Hsu-Liang / Lee, Li-Yao / Chen, Chung-Yu

    Patient preference and adherence

    2022  Volume 16, Page(s) 875–886

    Abstract: Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these ... ...

    Abstract Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these patients.
    Methods: This cross-sectional study included outpatient participants aged 35 years old and older who were receiving long-acting bronchodilator treatment in one of two hospitals in Southern Taiwan. Participants were categorized according to their Global Initiative for Obstructive Lung Disease (GOLD) classification as either their COPD group, based on symptoms and exacerbation risk, or their COPD stage, based on spirometry results. Patients' HRQoL was assessed using the St. George's Respiratory Questionnaire score (SGRQ), World Health Organization Quality of Life Quality of Life-BREF (WHOQOL-BREF), and EQ-5D-5L. The total scores of the SGRQ, WHOQOL-BREF, EQ-5D utility index, and EQ-VAS were presented as mean ± standard deviation (SD) among different combination treatments. Univariate and multivariate analyses were used to explore the association of patients' baseline characteristics and environmental factors with HRQoL.
    Results: A total of 218 patients were enrolled in the study. The distribution of patients using GOLD group classification were as follows: 73.39% in group A, 20.19% group B, 1.83% group C and 4.59% group D. Triple therapy patients mostly showed a lower quality of life than other combination therapies, regardless of the GOLD classification system. However, only the SGRQ scores of GOLD groups A and B were significantly different when using different drug combinations (p-value = 0.0072 and 0.0430, respectively). The COPD assessment test (CAT) score, a questionnaire to assess impact of COPD on health status, was found to be associated with all the questionnaires.
    Conclusion: The HRQoL is impaired in patients with COPD, and it deteriorates with an increase of severity. The CAT was the strongest predictor of HRQoL.
    Language English
    Publishing date 2022-04-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S355023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Developing an App by Exploiting Web-Based Mobile Technology to Inspect Controlled Substances in Patient Care Units.

    Lu, Ying-Hao / Lee, Li-Yao / Chen, Ying-Lan / Cheng, Hsing-I / Tsai, Wen-Tsung / Kuo, Chen-Chun / Chen, Chung-Yu / Huang, Yaw-Bin

    BioMed research international

    2017  Volume 2017, Page(s) 3195369

    Abstract: We selected iOS in this study as the App operation system, Objective-C as the programming language, and Oracle as the database to develop an App to inspect controlled substances in patient care units. Using a web-enabled smartphone, pharmacist inspection ...

    Abstract We selected iOS in this study as the App operation system, Objective-C as the programming language, and Oracle as the database to develop an App to inspect controlled substances in patient care units. Using a web-enabled smartphone, pharmacist inspection can be performed on site and the inspection result can be directly recorded into HIS through the Internet, so human error of data translation can be minimized and the work efficiency and data processing can be improved. This system not only is fast and convenient compared to the conventional paperwork, but also provides data security and accuracy. In addition, there are several features to increase inspecting quality: (1) accuracy of drug appearance, (2) foolproof mechanism to avoid input errors or miss, (3) automatic data conversion without human judgments, (4) online alarm of expiry date, and (5) instant inspection result to show not meted items. This study has successfully turned paper-based medication inspection into inspection using a web-based mobile device.
    MeSH term(s) Controlled Substances/analysis ; Humans ; Mobile Applications ; Smartphone
    Chemical Substances Controlled Substances
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2017/3195369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Rapid HPLC Quantification Approach for Detection of Active Constituents in Modern Combinatorial Formula, San-Huang-Xie-Xin-Tang (SHXXT).

    Wu, Tung-Ying / Chang, Fang-Rong / Liou, Jing-Ru / Lo, I-Wen / Chung, Tang-Chia / Lee, Li-Yao / Chi, Chun-Chen / Du, Ying-Chi / Wong, Man-Hon / Juo, Suh-Hang Hank / Lee, Chun-Chen / Wu, Yang-Chang

    Frontiers in pharmacology

    2016  Volume 7, Page(s) 374

    Abstract: San-Huang-Xie-Xin-Tang (SHXXT), one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome ... ...

    Abstract San-Huang-Xie-Xin-Tang (SHXXT), one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome of
    Language English
    Publishing date 2016-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2016.00374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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