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  1. Article: Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson's disease.

    Khan, Arshad H / Lee, Lydia K / Smith, Desmond J

    Translational neuroscience

    2022  Volume 13, Issue 1, Page(s) 255–269

    Abstract: Exposure to pesticides in humans increases the risk of Parkinson's disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we dosed C57BL/6J mice with a combination of the pesticides maneb and paraquat. Behavioral analysis ...

    Abstract Exposure to pesticides in humans increases the risk of Parkinson's disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we dosed C57BL/6J mice with a combination of the pesticides maneb and paraquat. Behavioral analysis revealed motor deficits consistent with PD. Single-cell RNA sequencing of substantia nigra pars compacta revealed both cell-type-specific genes and genes expressed differentially between pesticide and control, including
    Language English
    Publishing date 2022-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0237
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  2. Article ; Online: Challenges in designing and running smouldering myeloma interventional clinical trials.

    Lecat, Catherine / Boyle, Eileen M / Hughes, Daniel / Lee, Lydia / Smith, Dean / Bygrave, Ceri / Ramasamy, Karthik / Yong, Kwee

    EJHaem

    2024  Volume 5, Issue 2, Page(s) 418–420

    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.880
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  3. Article ; Online: A descriptive survey of specialty pharmacy team members' perceptions of interactions with field representatives from pharmaceutical companies.

    Wang, Evelyn Y / Lee, Lydia / Lee, Yehun / Mullen, Maura E / Hill, Aaron W / Rotolo, Shannon M

    Journal of managed care & specialty pharmacy

    2023  Volume 29, Issue 10, Page(s) 1151–1157

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Humans ; Pharmacy ; Pharmaceutical Services ; Pharmacists ; Surveys and Questionnaires ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2376-1032
    ISSN (online) 2376-1032
    DOI 10.18553/jmcp.2023.29.10.1151
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  4. Article ; Online: BCMA CARs in multiple myeloma: room for more?

    Lee, Lydia Sarah Hui / Yong, Kwee L

    Blood

    2021  Volume 137, Issue 21, Page(s) 2859–2860

    MeSH term(s) B-Cell Maturation Antigen ; Humans ; Immunotherapy, Adoptive ; Multiple Myeloma ; Receptors, Chimeric Antigen
    Chemical Substances B-Cell Maturation Antigen ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021010833
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  5. Article ; Online: Adolescent Idiopathic Scoliosis: Common Questions and Answers.

    Kuznia, Angela L / Hernandez, Anita K / Lee, Lydia U

    American family physician

    2020  Volume 101, Issue 1, Page(s) 19–23

    Abstract: Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent idiopathic ... ...

    Abstract Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in the absence of underlying congenital or neuromuscular abnormalities. Adolescent idiopathic scoliosis may be detected via the forward bend test and should be confirmed with scoliometer measurement. Mild scoliosis is usually asymptomatic; it may contribute to musculoskeletal back pain, but there is no evidence that it causes disability or functional impairment. Patients with severe scoliosis (Cobb angle of 40 degrees or more) may have physical pain, cosmetic deformity, psychosocial distress, or, rarely, pulmonary disorders. Several studies have shown modest benefit from bracing and scoliosis-specific physical therapy to limit progression in mild to moderate scoliosis, but there were no effects on quality of life. Because no high-quality studies have proven that surgery is superior to bracing or observation, it should be reserved for severe cases. There is little evidence that treatments improve patient-oriented outcomes. The U.S. Preventive Services Task Force and the American Academy of Family Physicians found insufficient evidence to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents 10 to 18 years of age.
    MeSH term(s) Adolescent ; Child ; Evidence-Based Medicine ; Female ; Humans ; Male ; Physical Examination/methods ; Practice Guidelines as Topic ; Scoliosis/diagnosis ; Scoliosis/therapy
    Language English
    Publishing date 2020-01-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  6. Article: The Use of Mobile-Based Ecological Momentary Assessment (mEMA) Methodology to Assess Dietary Intake, Food Consumption Behaviours and Context in Young People: A Systematic Review.

    Battaglia, Brigitte / Lee, Lydia / Jia, Si Si / Partridge, Stephanie Ruth / Allman-Farinelli, Margaret

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 7

    Abstract: Mobile-based ecological momentary assessment (mEMA) offers a novel method for dietary assessment and may reduce recall bias and participant burden. This review evaluated mEMA methodology and the feasibility, acceptability and validity as a dietary ... ...

    Abstract Mobile-based ecological momentary assessment (mEMA) offers a novel method for dietary assessment and may reduce recall bias and participant burden. This review evaluated mEMA methodology and the feasibility, acceptability and validity as a dietary assessment method in young people. Five databases were searched from January 2008 to September 2021 for studies including healthy young people aged 16-30 years and used mEMA for obtaining dietary intake data, food consumption behaviours and/or contextual factors. Data on the method used to administer mEMA, compliance with recording and validation were extracted. A total of 46 articles from 39 independent studies were included, demonstrating a wide variation in mEMA methods. Signal-contingent prompting (timed notification to record throughout the day) was used in 26 studies, 9 used event-contingent (food consumption triggered recordings), while 4 used both. Monitoring periods varied and most studies reported a compliance rate of 80% or more. Two studies found mEMA to be burdensome and six reported mEMA as easy to use. Most studies (31/39) reported using previously validated questions. mEMA appears to be a feasible and acceptable methodology to assess dietary intake and food consumption in near real time.
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10071329
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  7. Article ; Online: Outcomes of Patients with COPD Treated with ICS/LABA Before and After Initiation of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI).

    McCormack, Meredith / Paczkowski, Rosirene / Gronroos, Noelle N / Noorduyn, Stephen G / Lee, Lydia / Veeranki, Phani / Johnson, Mary G / Igboekwe, Emmeline / Kahle-Wrobleski, Kristin / Panettieri, Reynold

    Advances in therapy

    2024  Volume 41, Issue 3, Page(s) 1245–1261

    Abstract: Introduction: Triple therapy (fluticasone furoate/umeclidinium/vilanterol; FF/UMEC/VI) has been shown to improve symptoms and reduce exacerbations in patients with chronic obstructive pulmonary disease (COPD) and a history of exacerbations. This real- ... ...

    Abstract Introduction: Triple therapy (fluticasone furoate/umeclidinium/vilanterol; FF/UMEC/VI) has been shown to improve symptoms and reduce exacerbations in patients with chronic obstructive pulmonary disease (COPD) and a history of exacerbations. This real-world study compared exacerbation rates and healthcare resource utilization (HCRU) before and after initiation of FF/UMEC/VI in patients with COPD previously treated with inhaled corticosteroid (ICS)/long-acting β
    Methods: This retrospective cohort study included commercial and Medicare Advantage with Part D administrative claims data from September 01, 2016, to March 31, 2020, of patients diagnosed with COPD. The index date was the date of the first FF/UMEC/VI claim (September 2017-March 2019). The 12 months prior to index (baseline) were used to assess patient characteristics and outcomes; the 12 months following index (follow-up) were used to assess study outcomes. All patients had ≥ 30 consecutive days' supply of any ICS/LABA dual therapy during the 12 months prior to FF/UMEC/VI initiation. Subgroup analyses included patients with ≥ 30 consecutive days' supply of budesonide/formoterol (BUD/FORM) during baseline. Analyses of patients with ≥ 1 COPD exacerbation during baseline were reported as well.
    Results: The overall population included 1449 patients (mean age 70.75 years; 54.18% female), of whom 540 were patients in the BUD/FORM subgroup. Significantly fewer patients experienced any exacerbation during follow-up versus baseline (overall population 53.49% vs 62.59%; p < 0.001; BUD/FORM subgroup 55.00% vs 62.41%; p = 0.004). Effects on exacerbation reduction were more pronounced among patients with ≥ 1 exacerbation during baseline. Lower COPD-related HCRU was observed during the follow-up compared with baseline for both the overall population and the BUD/FORM subgroup.
    Conclusion: Patients with COPD treated with ICS/LABA during baseline, including patients specifically treated with BUD/FORM and those with a history of ≥ 1 exacerbation, had fewer COPD exacerbations and lower COPD-related HCRU after initiating FF/UMEC/VI.
    MeSH term(s) United States ; Humans ; Female ; Aged ; Male ; Bronchodilator Agents ; Retrospective Studies ; Administration, Inhalation ; Medicare ; Fluticasone ; Pulmonary Disease, Chronic Obstructive ; Androstadienes ; Benzyl Alcohols ; Chlorobenzenes ; Quinuclidines ; Nebulizers and Vaporizers ; Adrenal Cortex Hormones/therapeutic use ; Drug Combinations
    Chemical Substances fluticasone furoate (JS86977WNV) ; vilanterol (028LZY775B) ; GSK573719 ; Bronchodilator Agents ; Fluticasone (CUT2W21N7U) ; Androstadienes ; Benzyl Alcohols ; Chlorobenzenes ; Quinuclidines ; Adrenal Cortex Hormones ; Drug Combinations
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02776-8
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  8. Article ; Online: Gaining Patient Input on Naming a Novel Patient-Reported Outcome Instrument in Chronic Weight Management.

    Rozjabek, Heather / Fastenau, John / Bennett, Samara / Lee, Lydia Min-Joo

    PharmacoEconomics - open

    2020  Volume 5, Issue 1, Page(s) 133–137

    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2874287-4
    ISSN 2509-4254 ; 2509-4262
    ISSN (online) 2509-4254
    ISSN 2509-4262
    DOI 10.1007/s41669-020-00225-8
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  9. Article: COVID-19 follow-up planning: what will we be missing?

    Lee, Lydia / Iyer, Sriram / Jose, Ricardo J / Manuel, Ari

    ERJ open research

    2020  Volume 6, Issue 2

    Abstract: There is a real need for a discharge plan for COVID-19 survivors in the UK. Follow-up imaging could help assess the resolution of infection, exclude underlying malignancy and identify post-inflammatory fibrosis. ...

    Abstract There is a real need for a discharge plan for COVID-19 survivors in the UK. Follow-up imaging could help assess the resolution of infection, exclude underlying malignancy and identify post-inflammatory fibrosis.
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00198-2020
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  10. Article ; Online: Post COVID-19 bronchiectasis: a potential epidemic within a pandemic.

    José, Ricardo J / Manuel, Ari / Gibson-Bailey, Katie / Lee, Lydia

    Expert review of respiratory medicine

    2020  Volume 14, Issue 12, Page(s) 1183–1184

    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2020.1804366
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