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Article: Research trends in obesity & obesogenic environments in Korea.

Lee, Myoungsook

2019 Volume 13, Issue 6, Page(s) 461–472

Abstract: Background/objectives: Globally, it has been projected that there will be 2 billion overweight and 1 billion obese individuals by 2030. In Korea, the prevalence of adult obesity (BMI>25) increased from 29.7% in 2009 to 32.4% in 2015. Moreover, childhood ...

Abstract	Background/objectives: Globally, it has been projected that there will be 2 billion overweight and 1 billion obese individuals by 2030. In Korea, the prevalence of adult obesity (BMI>25) increased from 29.7% in 2009 to 32.4% in 2015. Moreover, childhood obesity, which leads to adulthood obesity, has increasingly become a social problem. The purpose of this review is to summarize the scientific basis for the development of effective models and policies aimed at preventing obesity over a lifetime based on research modeling obesogenic environments. Materials/methods: The review focuses on the characteristics of obesity prevalence and trends in 3P analysis (papers, patents, and products) as well as government-funded projects in Korean obesity obesogenic environments over the last 10 years. Results and discussion: As a result of the 3P analysis, studies on obesity risk factors were frequently carried out, according to two data bases RISS (4.9%) and PubMed (24.7%). Since there were only 17% patents related to the mechanism of preventing obesity in 7,951 Korean patents related to obesity, new paradigms of technologies to dominate the global obesity markets are needed. After government-funded projects were analyzed, communication and cooperation in multi-governmental departments were suggested to elucidate the characteristics of Korean obesity. Government should also produce short- and long-term road maps to develop a practical, successful outcome. Although the rate of obesity in Korea is currently lower than in other developed countries according to WHO criteria, without adequate governmental intervention, obesity rates will approach those of the top countries with high incidence rates of obesity within the next 10 years.
Language	English
Publishing date	2019-11-22
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2019.13.6.461
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Article ; Online: RMR-Related

Kim, Juhee / Lee, Myoungsook

Cells

2022 Volume 11, Issue 8

Abstract: Obesity causes various complications such as type 2 diabetes, hypertension, fatty liver, cardiovascular diseases, and cancer. In a pilot GWAS study, we screened ... ...

Abstract	Obesity causes various complications such as type 2 diabetes, hypertension, fatty liver, cardiovascular diseases, and cancer. In a pilot GWAS study, we screened the
MeSH term(s)	3T3-L1 Cells ; Adipogenesis/genetics ; Adipokines ; Animals ; Basal Metabolism ; HSP40 Heat-Shock Proteins/genetics ; Insulin/metabolism ; Mice
Chemical Substances	Adipokines ; HSP40 Heat-Shock Proteins ; Insulin
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11081331
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Article ; Online: The Health and Nutritional Status of Children (10-18 years) Belonging to Food Insecure Households: The Korea National Health and Nutrition Examination Survey (2012-2019).

Jung, Sowon / Shin, Jieun / Lee, Myoungsook

International journal of environmental research and public health

2023 Volume 20, Issue 17

Abstract: To research the health and nutritional status in Korean children and adolescents belonging to food insecure households (FI), the preregistered secondary data of 18 items from the Food Security Evaluation in the Korea National Health and Nutrition ... ...

Abstract	To research the health and nutritional status in Korean children and adolescents belonging to food insecure households (FI), the preregistered secondary data of 18 items from the Food Security Evaluation in the Korea National Health and Nutrition Examination Survey (KNHANES; 2012-2019) were used. Comparative analyses (food security group [FS], (
MeSH term(s)	Adolescent ; Male ; Humans ; Child ; Female ; Nutritional Status ; Nutrition Surveys ; Food ; Energy Intake ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20176695
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Article ; Online: Beiging Modulates Inflammatory Adipogenesis in Salt-Treated and

Kang, Songjoo / Lee, Myoungsook

Cells

2021 Volume 10, Issue 5

Abstract: To investigate whether the beiging process changes the interactive effects of salt ... ...

Abstract	To investigate whether the beiging process changes the interactive effects of salt and
MeSH term(s)	3T3-L1 Cells ; Adipocytes, Beige/cytology ; Adipocytes, Beige/metabolism ; Adipocytes, White/cytology ; Adipocytes, White/drug effects ; Adipocytes, White/metabolism ; Adipogenesis ; Animals ; CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Energy Metabolism ; MAP Kinase Kinase 6/genetics ; MAP Kinase Kinase 6/metabolism ; Mice ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Sodium Chloride/pharmacology
Chemical Substances	CCAAT-Enhancer-Binding Proteins ; CEBPA protein, mouse ; PPAR gamma ; Sodium Chloride (451W47IQ8X) ; MAP Kinase Kinase 6 (EC 2.7.12.2) ; Map2k6 protein, mouse (EC 2.7.12.2)
Language	English
Publishing date	2021-05-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10051106
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Article ; Online: MEK6

Lee, Suyeon / Lee, Myoungsook

International journal of molecular sciences

2021 Volume 22, Issue 24

Abstract: Obesity is a state of abnormal fat accumulation caused by an energy imbalance potentially caused by changes in multiple factors. ...

Abstract	Obesity is a state of abnormal fat accumulation caused by an energy imbalance potentially caused by changes in multiple factors.
MeSH term(s)	Adipose Tissue/pathology ; Animals ; Cytokines/analysis ; Diet, High-Fat/adverse effects ; Fats/analysis ; Inflammation/etiology ; Inflammation/genetics ; Inflammation/pathology ; MAP Kinase Kinase 6/genetics ; Male ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/genetics ; Obesity/pathology ; Up-Regulation ; Mice
Chemical Substances	Cytokines ; Fats ; MAP Kinase Kinase 6 (EC 2.7.12.2) ; Map2k6 protein, mouse (EC 2.7.12.2)
Language	English
Publishing date	2021-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222413559
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Article ; Online: The Effects of C3G and D3G Anthocyanin-Rich Black Soybean on Energy Metabolism in Beige-like Adipocytes.

Lee, Minjee / Lee, Myoungsook

Journal of agricultural and food chemistry

2020 Volume 68, Issue 43, Page(s) 12011–12018

Abstract: Various mechanisms of obesity prevention have been identified; however, the roles of brown or beige fat as regulators of the energy balance are unclear. The effects of anthocyanin-rich black soybean, ...

Abstract	Various mechanisms of obesity prevention have been identified; however, the roles of brown or beige fat as regulators of the energy balance are unclear. The effects of anthocyanin-rich black soybean,
MeSH term(s)	Adipocytes, Beige/metabolism ; Adipocytes, White/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Anthocyanins/analysis ; Anthocyanins/metabolism ; Energy Metabolism ; Male ; Mice ; NAD/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Rats ; Glycine max/chemistry ; Glycine max/metabolism ; Triglycerides/metabolism ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
Chemical Substances	Anthocyanins ; PPAR gamma ; Triglycerides ; Uncoupling Protein 1 ; NAD (0U46U6E8UK)
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c04891
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Article: The Effects of C3G and D3G Anthocyanin-Rich Black Soybean on Energy Metabolism in Beige-like Adipocytes

Lee, Minjee / Lee, Myoungsook

Journal of agricultural and food chemistry. 2020 Oct. 15, v. 68, no. 43

2020

Abstract	Various mechanisms of obesity prevention have been identified; however, the roles of brown or beige fat as regulators of the energy balance are unclear. The effects of anthocyanin-rich black soybean, Glycine max (L.) Merr., testa (ABS) extracts on the energy balance were investigated by comparing beige-like adipocytes (BLA) and white adipocytes (WAT). ABS extracts reduced peroxisome proliferator-activated receptor gamma protein expression and triglyceride accumulation in WAT and BLA without inducing nuclear damage. The biomarkers of fat degradation (phospho-AMPKα and ATGL) or glycerol secretion in the medium and β-oxidation of fatty acids (CPT2) in the ABS-treated BLA were increased compared to those in WAT. ABS extracts significantly increased the expression of thermogenesis markers (UCP1 and CIDEA) and biomarkers related to mitochondrial activation (cytochrome c and NRF1) in BLA. In the primary cell culture of brown adipocytes (BAT) from rats fed ABS, the expression levels of PGC1-α, cytochrome c, and UCP1 proteins were increased compared to those in BAT from nonfed rats. A reduction in the NAD/NADH ratio was consistently associated with an increase in the oxygen consumption rate and basal/maximal respiration rate in ABS-treated BLA. Anthocyanins promote beiging in the body, contribute to the prevention of obesity, and are potentially useful functional materials.
Keywords	Glycine max ; anthocyanins ; biomarkers ; brown adipocytes ; cell culture ; cell respiration ; energy balance ; energy metabolism ; food chemistry ; glycerol ; heat production ; mitochondria ; obesity ; oxygen consumption ; peroxisome proliferator-activated receptor gamma ; protein synthesis ; secretion ; soybeans ; testa ; triacylglycerols ; white adipocytes
Language	English
Dates of publication	2020-1015
Size	p. 12011-12018.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c04891
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Park, Seongmin / Choi, Munji / Lee, Myoungsook

Nutrients. 2021 June 21, v. 13, no. 6

2021

Abstract: Anthocyanins, water-soluble flavonoids that produce red-to-blue pigment in plants, have antioxidant properties and have been developed as a functional food to fight obesity. In randomized controlled trials (RCTs), a systematic review with meta-analysis ( ... ...

Abstract	Anthocyanins, water-soluble flavonoids that produce red-to-blue pigment in plants, have antioxidant properties and have been developed as a functional food to fight obesity. In randomized controlled trials (RCTs), a systematic review with meta-analysis (SR-MA) was used to investigate these anti-obesity effects. Using search engines (PubMed, EMBASE, Cochrane-library, and CINAHL) and keywords (anthocyanins, BMI, WC, WHR, and inflammatory biomarkers), 11 out of 642 RCTs (28.3–500 mg/day of anthocyanins for 4 to 24 weeks) were included. The results showed a significant reduction in body mass index (BMI) (MD = −0.36, 95% CI = −0.58 to −0.13), but body weight (BW) and waist circumference (WC) did not change. Anthocyanins decreased BMI in the non-obese (non-OB) group in five RCTs (BMI ≤ 25; MD = −0.40 kg/m²; 95% CI = −0.64 to −0.16;) but did not affect BMI in the obese (OB) group. A subgroup analysis of six RCTs showed that fewer than 300 mg/day reduced BMI (MD = −0.37; 95% CI = −0.06 to −0.14), but ≥300 mg/day did not. A treatment duration of four weeks for four RCTs was sufficient to decrease the BMI (MD = −0.41; 95% CI = −0.66 to −0.16) as opposed to a longer treatment (6–8 or ≥12 weeks). An analysis of the effect of anthocyanins on the BMI showed a significant fall among those from the Middle East compared to those from Asia, Europe, South America, or Oceania. In conclusion, the anthocyanin supplementation of 300 mg/day or less for four weeks was sufficient to reduce the BMI and BW compared to the higher-dose and longer-treatment RCTs. However, further studies might be conducted regarding the dose- or period-dependent responses on various obese biomarkers.
Keywords	anthocyanins ; antioxidants ; biomarkers ; body mass index ; functional foods ; meta-analysis ; obesity ; systematic review ; waist circumference ; water solubility ; Asia ; Europe ; Middle East ; Pacific Ocean Islands ; South America
Language	English
Dates of publication	2021-0621
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13062121
Database	NAL-Catalogue (AGRICOLA)

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Article: The association between dietary sodium intake and obesity in adults by sodium intake assessment methods: a review of systematic reviews and re-meta-analysis.

Lee, Jounghee / Sohn, Cheongmin / Kim, Oh-Yoen / Lee, Young-Min / Yoon, Mi Ock / Lee, Myoungsook

Nutrition research and practice

2023 Volume 17, Issue 2, Page(s) 175–191

Abstract: Background/objectives: The scientific evidence of a sodium-obesity association is limited by sodium intake assessments. Our specific aim is to synthesize the association between dietary sodium intake and obesity across the sodium intake assessments as ... ...

Abstract	Background/objectives: The scientific evidence of a sodium-obesity association is limited by sodium intake assessments. Our specific aim is to synthesize the association between dietary sodium intake and obesity across the sodium intake assessments as evidenced by systematic reviews in adults. Subjects/methods: A systematic search identified systematic reviews comparing the association of dietary sodium intakes with obesity-related outcomes such as body mass index (BMI), body weight, waist circumference, and risk of (abdominal) obesity. We searched PubMed on October 24, 2022. To assess the Risk of Bias in Systematic Reviews (ROBIS), we employed the ROBIS tool. Results: This review included 3 systematic reviews, consisting of 39 unique observational studies (35 cross-sectional studies and 4 longitudinal studies) and 15 randomized controlled trials (RCTs). We found consistently positive associations between dietary sodium intake and obesity-related outcomes in cross-sectional studies. Studies that used 24-h urine collection indicated a greater BMI for those with higher sodium intake (mean difference = 2.27 kg/m Conclusions: Quantitative synthesis of the systematic reviews has shown that cross-sectional associations between dietary sodium intake and obesity outcomes were substantially different across the sodium intake assessments. We need more high-quality prospective cohort studies and RCTs using 24-h urine collection to examine the causal effects of sodium intake on obesity.
Language	English
Publishing date	2023-01-20
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2023.17.2.175
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Article: Minor alleles in the

Kim, Oh Yoen / Park, Jihyun / Lee, Jounghee / Sohn, Cheongmin / Yoon, Mi Ock / Lee, Myoungsook

Nutrition research and practice

2023 Volume 17, Issue 1, Page(s) 62–72

Abstract: Background/objectives: Many studies have revealed an association between fat mass and the obesity-related gene (: Subject/methods: Meta-analysis was finally conducted with data extracted from seven datasets of four studies performed on Korean adults ... ...

Abstract	Background/objectives: Many studies have revealed an association between fat mass and the obesity-related gene ( Subject/methods: Meta-analysis was finally conducted with data extracted from seven datasets of four studies performed on Korean adults after the screening passed. Five kinds of Results: The minor alleles of Conclusions: This meta-analysis showed that minor alleles in the
Language	English
Publishing date	2023-01-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2023.17.1.62
Database	MEDical Literature Analysis and Retrieval System OnLINE

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