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Article ; Online: Comparison of the correlation between serum autoantibodies against aldehyde dehydrogenase 2 and thyrotropin receptor in patients with Graves' ophthalmopathy.

Lin, Chia-Ching / Chiu, Li-Wen / Lee, Po-Yen / Chen, Kuo-Jen / Cheng, Kai-Chun

2024 Volume 72, Issue 2, Page(s) 298–299

MeSH term(s)	Humans ; Aldehyde Dehydrogenase ; Autoantibodies ; Graves Ophthalmopathy/diagnosis ; Receptors, Thyrotropin
Chemical Substances	Aldehyde Dehydrogenase (EC 1.2.1.3) ; Autoantibodies ; Receptors, Thyrotropin
Language	English
Publishing date	2024-01-25
Publishing country	India
Document type	Comparative Study ; Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_673_23
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Zs.MO 598: Show issues

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Article: The Role of Long Noncoding RNAs (lncRNAs) in Esophageal Cancer Therapy Resistance and Metastasis.

Weng, Zong-Ping / Hsu, Shen-Kai / Wang, Hui-Min David / Chen, Kuo-Jen / Lee, Po-Yen / Chiu, Chien-Chih / Cheng, Kai-Chun

Biomedicines

2024 Volume 12, Issue 3

Abstract: Esophageal cancer (EC) is one of the most aggressive gastrointestinal cancers. Despite improvements in therapies, the survival rate of patients with EC remains low. Metastasis accounts for up to 90% of cancer-related deaths, and resistance to anti- ... ...

Abstract	Esophageal cancer (EC) is one of the most aggressive gastrointestinal cancers. Despite improvements in therapies, the survival rate of patients with EC remains low. Metastasis accounts for up to 90% of cancer-related deaths, and resistance to anti-neoplastic therapeutics is also a main cause of poor survival. Thus, metastasis and drug resistance are undoubtedly the two main challenges in cancer treatment. Among the different categories of noncoding RNAs, lncRNAs have historically drawn less attention. However, lncRNAs have gradually become a research hotspot, and increasing research has demonstrated that lncRNAs participate in the tumorigenesis of multiple types of cancer, including EC. Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides in length that play important roles in epigenetics, transcription regulation, and posttranscriptional processing. In this review, we elucidated the role of lncRNAs in the metastasis and drug resistance of EC and discussed their potential clinical applications and related limitations. With a better understanding of the underlying mechanisms of lncRNAs, we can identify therapeutic targets for EC in the future.
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12030660
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Article ; Online: An Uncommon Concurrence of Cytomegalovirus Retinitis and Corneal Endotheliitis in an Immunocompromised HIV-Negative Patient.

Kao, Tzu-En / Chang, Yo-Chen / Lee, Po-Yen

Ocular immunology and inflammation

2020 Volume 29, Issue 3, Page(s) 555–557

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Antiviral Agents/therapeutic use ; Azathioprine/therapeutic use ; Cytomegalovirus Retinitis/diagnosis ; Cytomegalovirus Retinitis/drug therapy ; Cytomegalovirus Retinitis/etiology ; Endothelium, Corneal/pathology ; Glomerulonephritis/drug therapy ; HIV Seronegativity/physiology ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/etiology ; Male ; Middle Aged ; Nephrotic Syndrome/drug therapy ; Prednisolone/therapeutic use ; Retrospective Studies ; Valganciclovir/therapeutic use
Chemical Substances	Antiviral Agents ; Immunosuppressive Agents ; Prednisolone (9PHQ9Y1OLM) ; Valganciclovir (GCU97FKN3R) ; Azathioprine (MRK240IY2L)
Language	English
Publishing date	2020-04-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2019.1695859
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Article ; Online: Bilateral radial keratoneuritis resulting from acanthamoeba keratitis.

Lee, Po-Yu / Lin, Chia-Ching / Chiu, Li-Yi / Lee, Po-Yen

The Kaohsiung journal of medical sciences

2021 Volume 38, Issue 1, Page(s) 79–80

MeSH term(s)	Acanthamoeba/isolation & purification ; Acanthamoeba Keratitis/diagnosis ; Acanthamoeba Keratitis/drug therapy ; Acanthamoeba Keratitis/parasitology ; Acanthamoeba Keratitis/pathology ; Adolescent ; Anti-Infective Agents, Local/therapeutic use ; Biguanides/therapeutic use ; Chlorhexidine/therapeutic use ; Contact Lenses/adverse effects ; Cornea/parasitology ; Disinfectants/therapeutic use ; Female ; Humans ; Photophobia/etiology
Chemical Substances	Anti-Infective Agents, Local ; Biguanides ; Disinfectants ; polihexanide (322U039GMF) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2021-09-16
Publishing country	China (Republic : 1949- )
Document type	Case Reports ; Letter
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12446
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Article ; Online: Corneal burn injury in picosecond laser treatment: A potential hazard in cosmetic therapy.

Chiu, Li-Yi / Lai, Ya-Wei / Hsu, Shiuh-Liang / Chih, Pei-Ling / Lee, Po-Yen

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

2022 Volume 23, Issue 7-8, Page(s) 218–220

Abstract: ... Key ... ...

Abstract	Key Points
MeSH term(s)	Corneal Injuries/etiology ; Eye Burns/chemically induced ; Eye Burns/complications ; Eyelids ; Humans ; Lasers ; Vision Disorders/complications
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2146360-8
ISSN	1476-4180 ; 1476-4172
ISSN (online)	1476-4180
ISSN	1476-4172
DOI	10.1080/14764172.2022.2055077
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Article ; Online: A simple method for preventing graft detachment during phacoemulsification cataract surgery after Descemet stripping automated endothelial keratoplasty: A case report.

Hsu, Shiuh-Liang / Lee, Po-Yen / Chiu, Li-Yi

Medicine

2018 Volume 98, Issue 2, Page(s) e13992

Abstract: Rationale: Graft detachment and endothelial cell damages are 2 major concerns for cataract surgeries in cases after Descemet stripping automated endothelial keratoplasty (DSAEK). We invented a simple but innovative method to anchor the DSAEK graft with ... ...

Abstract	Rationale: Graft detachment and endothelial cell damages are 2 major concerns for cataract surgeries in cases after Descemet stripping automated endothelial keratoplasty (DSAEK). We invented a simple but innovative method to anchor the DSAEK graft with sutures during the surgery to avoid possible graft detachment. Patient concerns: We present a 59-year-old male who had done DSAEK surgery. Due to progressed blurry vision due to cataract, he underwent sequential cataract surgery 1 year after DSAEK surgery. We applied the method to the patient successfully and the result was satisfying. Diagnosis: Cataract post-DSAEK surgery. Interventions: At the beginning of surgery, we made 4 radial fixation sutures with Nylon 10-0 though cornea-DSAEK graft at paracentral point and then through limbus. The sutures were located at 45°, 135°, 225°, and 315°. At the end of surgery, 4 fixation sutures were removed. Outcomes: The DSAEK graft was kept well attached during and after the surgery. Only low-grade corneal edema was found postoperation. Lessons: We provide this special method and applied it to our patient successfully. By using our method, surgeons can reassure graft adhesion during and after surgery, especially for those need cataract surgery after DSAEK surgery.
MeSH term(s)	Descemet Stripping Endothelial Keratoplasty/adverse effects ; Descemet Stripping Endothelial Keratoplasty/methods ; Humans ; Male ; Middle Aged ; Phacoemulsification/methods
Language	English
Publishing date	2018-07-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000013992
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Article ; Online: The Adverse Effects of Air Pollution on the Eye: A Review.

Lin, Chia-Ching / Chiu, Chien-Chih / Lee, Po-Yen / Chen, Kuo-Jen / He, Chen-Xi / Hsu, Sheng-Kai / Cheng, Kai-Chun

International journal of environmental research and public health

2022 Volume 19, Issue 3

Abstract: Air pollution is inevitably the result of human civilization, industrialization, and globalization. It is composed of a mixture of gases and particles at harmful levels. Particulate matter (PM), nitrogen oxides (NOx), and carbon dioxides ( ... ...

Abstract	Air pollution is inevitably the result of human civilization, industrialization, and globalization. It is composed of a mixture of gases and particles at harmful levels. Particulate matter (PM), nitrogen oxides (NOx), and carbon dioxides (CO
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollution, Indoor/adverse effects ; Air Pollution, Indoor/analysis ; Environmental Monitoring ; Humans ; Particulate Matter/analysis ; Particulate Matter/toxicity
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19031186
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Article ; Online: Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia.

Lo, Jung / Wu, Hsin-En / Liu, Ching-Chih / Chang, Kun-Che / Lee, Po-Yen / Liu, Po-Len / Huang, Shu-Pin / Wu, Pei-Chang / Lin, Tzu-Chieh / Lai, Yu-Hung / Chang, Yo-Chen / Chen, Yuan-Ru / Lee, Sheng-I / Huang, Yu-Kai / Wang, Shu-Chi / Li, Chia-Yang

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect of ... ...

Abstract	Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect of nordalbergin, a coumarin isolated from the wood bark of
MeSH term(s)	Mice ; Animals ; Lipopolysaccharides/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Inflammasomes/metabolism ; Microglia/metabolism ; Reactive Oxygen Species/metabolism ; Neuroinflammatory Diseases ; Interleukin-6/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Neurodegenerative Diseases/metabolism ; Signal Transduction ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism
Chemical Substances	Lipopolysaccharides ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Reactive Oxygen Species ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; NF-kappa B ; Nlrp3 protein, mouse
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087300
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Article ; Online: Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis.

Yazal, Taha / Lee, Po-Yen / Chen, Pin-Rong / Chen, I-Chen / Liu, Po-Len / Chen, Yuan-Ru / Lin, Tzu-Chieh / Chen, Yi-Ting / Huang, Shu-Pin / Yeh, Hsin-Chih / Liu, Ching-Chih / Lo, Jung / Wu, Hsin-En / Wang, Shu-Chi / Li, Chia-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115619

Abstract: Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on ... ...

Abstract	Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on the activation of NLRP3 inflammasome and the protective effects against sepsis have not been well investigated. In this study, we aimed to investigate the impacts of kurarinone on NLRP3 inflammasome activation in lipopolysaccharide (LPS)-induced macrophages and its protective effects against sepsis in vivo. Secretion of pro-inflammatory cytokines, activation of MAPKs and NF-κB signaling pathways, formation of NLRP3 inflammasome, and production of reactive oxygen species (ROS) by LPS-induced macrophages were examined; additionally, in vivo LPS-induced endotoxemia model was used to investigate the protective effects of kurarinone in sepsis-induced damages. Our experimental results demonstrated that kurarinone inhibited the expression of iNOS and COX-2, suppressed the phosphorylation of MAPKs, attenuated the production of TNF-α, IL-6, nitric oxide (NO) and ROS, repressed the activation of the NLRP3 inflammasome, and impeded the maturation and secretion of IL-1β and caspase-1. Furthermore, the administration of kurarinone attenuated the infiltration of neutrophils in the lung, kidneys and liver, reduced the expression of organ damage markers, and increased the survival rate in LPS-challenged mice. Collectively, our study demonstrated that kurarinone can protect against LPS-induced sepsis damage and exert anti-inflammatory effects via inhibiting MAPK/NF-κB pathways, attenuating NLRP3 inflammasome formation, and preventing intracellular ROS accumulation, suggesting that kurarinone might have potential for treating sepsis and inflammation-related diseases.
MeSH term(s)	Mice ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Lipopolysaccharides/toxicity ; Reactive Oxygen Species/metabolism ; NF-kappa B/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Sepsis/chemically induced ; Sepsis/drug therapy
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Lipopolysaccharides ; kurarinone ; Reactive Oxygen Species ; NF-kappa B ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-10-05
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115619
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Article: Long-Term Follow-Up of Refractory Large Macular Hole with Autologous Neurosensory Retinal Free Flap Transplantation.

Lee, Po-Yen / Chang, Yo-Chen / Liu, Pei-Kang / Kao, Tzu-En / Wu, Horng-Jiun / Chen, Kuo-Jen / Wu, Kwou-Yeung / Cheng, Kai-Chun / Wu, Wen-Chuan

Journal of ophthalmology

2022 Volume 2022, Page(s) 1717366

Abstract: Purpose: To evaluate the long-term anatomic and functional outcomes of autologous neurosensory retinal free flap transplantation (ART) for patients with refractory large macular hole (MH).: Design: Retrospective interventional case series.: Methods! ...

Abstract	Purpose: To evaluate the long-term anatomic and functional outcomes of autologous neurosensory retinal free flap transplantation (ART) for patients with refractory large macular hole (MH). Design: Retrospective interventional case series. Methods: We reviewed 9 patients who underwent ART for their refractory large MH. In this extended follow-up study, postoperative assessment including spectral-domain optical coherence tomography and best-corrected visual acuity (BCVA) were recorded at 12, 15, 18, 21, and 24 months after surgery. Results: The macular hole of all patients appeared successfully closed during the whole follow-up period. The mean logMAR BCVA improved from 1.61 ± 0.44 (preoperative) to 0.72 ± 0.30 (12 months after surgery) ( Conclusion: ART is a good alternative technique for closing large refractory macular holes. Although inner retinal cystic changes were observed in 4 eyes (44.4%), this phenomenon did not significantly affect visual acuity. It provides long-term good anatomical and functional results, especially in cases where insufficient ILM or lens capsule are left.
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2022/1717366
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