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  1. Article ; Online: Mapping Two Decades of Paediatric Down Syndrome Research Literature.

    McKenna, Caoimhe / Schilder, Anne / Lee, Rachel Xue Ning / Manikam, Logan / Venekamp, Roderick / Lakhanpaul, Monica

    The Ulster medical journal

    2023  Volume 92, Issue 2, Page(s) 77–83

    Abstract: Background: While research has led to significant advancements in the health and life expectancy of children with Down Syndrome (DS), there remains a significant burden of disease and health inequity. Further research, focused on areas of greatest need, ...

    Abstract Background: While research has led to significant advancements in the health and life expectancy of children with Down Syndrome (DS), there remains a significant burden of disease and health inequity. Further research, focused on areas of greatest need, is imperative to address this. An understanding of what research has been undertaken, and any existing gaps, helps to guide future academic efforts.
    Methods: We utilised an epistemological approach to summarise two decades of paediatric DS literature. Publications were categorised according to the country of origin, methodology, primary health themes and subcategory research themes.
    Results: Across 5,800 paediatric DS publications we demonstrate a general increase in the number of publications in this field between 2000 and 2014, with a trending decline thereafter. The majority of publications were affiliated with Institutions based in Western countries. The majority of studies utilised a cross-sectional methodology (33.3%), while relatively few were interventional (5.6%), qualitative (2.7%) or mixed-method studies (1.6%). Most publications focused on development & cognition (13.1%), neurology (9.9%) and oncology (9.8%), with fewer focusing on genitourinary health (0.9%), growth (0.9%), mortality (0.9%) and child protection (0.2%).
    Conclusion: These findings highlight areas of relative paucity within the paediatric DS literature which may warrant increased academic attention.
    MeSH term(s) Humans ; Child ; Cross-Sectional Studies ; Down Syndrome ; Neurology
    Language English
    Publishing date 2023-08-29
    Publishing country Northern Ireland
    Document type Journal Article
    ZDB-ID 603342-8
    ISSN 2046-4207 ; 0041-6193
    ISSN (online) 2046-4207
    ISSN 0041-6193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review.

    Lee, Rachel Xue Ning / Cardoso, Maria Joao / Cheung, Kwok Leung / Parks, Ruth M

    The British journal of surgery

    2022  Volume 109, Issue 11, Page(s) 1063–1072

    Abstract: Background: Postmastectomy immediate breast reconstruction (PMIBR) may improve the quality of life of patients with breast cancer, of whom older women (aged 65 years or more) are a growing proportion. This study aimed to assess PMIBR in older women with ...

    Abstract Background: Postmastectomy immediate breast reconstruction (PMIBR) may improve the quality of life of patients with breast cancer, of whom older women (aged 65 years or more) are a growing proportion. This study aimed to assess PMIBR in older women with regard to underlying impediments (if any).
    Methods: MEDLINE, Embase, and PubMed were searched by two independent researchers up to June 2022. Eligible studies compared PMIBR rates between younger and older women with invasive primary breast cancer.
    Results: A total of 10 studies (2012-2020) including 466 134 women were appraised, of whom two-thirds (313 298) were younger and one-third (152 836) older. Only 10.0 per cent of older women underwent PMIBR in contrast to 45.0 per cent of younger women. Two studies explored factors affecting uptake of PMIBR in older women; surgeon-associated (usual practice), patient-associated (socioeconomic status, ethnicity, and co-morbidities), and system-associated (insurance status and hospital location) factors were identified.
    Conclusion: Uptake of PMIBR in older women is low with definable (and some correctable) barriers.
    MeSH term(s) Age Factors ; Aged ; Breast Neoplasms/surgery ; Female ; Humans ; Mammaplasty ; Mastectomy ; Quality of Life
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Barriers and facilitators to breast reconstruction in ethnic minority women-A systematic review.

    Lee, Rachel Xue Ning / Yogeswaran, Gowsika / Wilson, Emma / Oni, Georgette

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 74, Issue 3, Page(s) 463–474

    Abstract: Introduction: Post-mastectomy breast reconstruction (PMBR) is an important component of the multidisciplinary care of breast cancer patients. Despite the improved quality of life, significant racial disparities exist in the receipt of PMBR. Given the ... ...

    Abstract Introduction: Post-mastectomy breast reconstruction (PMBR) is an important component of the multidisciplinary care of breast cancer patients. Despite the improved quality of life, significant racial disparities exist in the receipt of PMBR. Given the increasing population of Black, Asian and minority ethnic (BAME) women in UK, it is important to address this disparity. Our review aims to identify the barriers and facilitators influencing the uptake of PMBR in BAME women and raise awareness for physicians on interventions that could improve uptake of PMBR in BAME women.
    Methods: The methodology outlined by the Cochrane guidelines was used to structure this systematic review. Systematic searches for qualitative studies on barriers and/or facilitators to PMBR in ethnic women published in English were conducted. The following databases were searched from their inception up to June 2019: MEDLINE, EMBASE, PubMed, Cochrane Library, Google Scholar and Scopus. Reference lists of all included articles and relevant systematic reviews were also hand-searched for possible additional publications. Publication year or status restrictions were not applied. Only full text articles published in English and by peer reviewed journals are included. Exclusion criteria were as follows: quantitative studies on barriers and/or facilitators to PMBR, abstracts, conference proceedings, non-English language and non-specific to BAME women. A thematic synthesis approach was used through the development of sub-themes and themes from the findings of the included qualitative studies.
    Results: Five studies satisfied the inclusion and exclusion criteria. Three overarching themes emerged from our review: physician-associated factors (physician recommendations), patient-associated factors (knowledge, language, community and cultural, emotions, logistics, patient characteristics) and system-associated factors (insurance coverage, income status).
    Conclusion: Our systematic review suggests that there is a paucity of data in the literature on the barriers and facilitators to PMBR in BAME women. Considering the expanding population of BAME women and increasing breast cancer incidence, it is imperative that future research in this field is carried out. Physician and patient-associated factors were identified as the most important yet modifiable factors. Adopting a combination of culturally tailored interventions targeting these factors may help improve the access of PMBR in BAME women.
    Registration: Prospero ID: CRD42019133233.
    MeSH term(s) Breast Neoplasms/ethnology ; Breast Neoplasms/psychology ; Breast Neoplasms/surgery ; Culturally Competent Care/ethnology ; Ethnic Groups ; Female ; Humans ; Mammaplasty/methods ; Mammaplasty/psychology ; Mastectomy/methods ; Patient Acceptance of Health Care/ethnology ; Quality of Life
    Language English
    Publishing date 2020-11-05
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.10.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surgical Management of Gastro-oesophageal Reflux Disease After One Anastomosis Gastric Bypass - a Systematic Review.

    Lee, Rachel Xue Ning / Rizkallah, Nayer / Chiappetta, Sonja / Stier, Christine / Pouwels, Sjaak / Sakran, Nasser / Singhal, Rishi / Mahawar, Kamal / Madhok, Brijesh

    Obesity surgery

    2022  Volume 32, Issue 12, Page(s) 4057–4065

    Abstract: Gastro-oesophageal reflux disease (GORD) after one anastomosis gastric bypass (OAGB) remains a concern. We reviewed the current literature on revisional surgery after OAGB for GORD. MEDLINE, EMBASE, and PubMed databases were searched. We identified 21 ... ...

    Abstract Gastro-oesophageal reflux disease (GORD) after one anastomosis gastric bypass (OAGB) remains a concern. We reviewed the current literature on revisional surgery after OAGB for GORD. MEDLINE, EMBASE, and PubMed databases were searched. We identified 21 studies, appraising 13,658 OAGB patients. A total of 230 (1.6%) patients underwent revisional surgery for GORD. Revision to Roux-en-Y configuration was performed in 211 (91.7%) patients. Six (2.6%) patients had a Braun entero-enterostomy added to the OAGB. Thirteen (5.6%) patients underwent excluded stomach fundoplication (ESF). Reflux symptoms resolved in 112 (48.6%) patients, persisted in 13 (5.6%) patients, and were not reported in 105 (45.6%) patients. Revisional surgery after OAGB for GORD appears to be rare, and when required, conversion to Roux-en-Y configuration is the commonest choice.
    MeSH term(s) Humans ; Gastric Bypass ; Obesity, Morbid/surgery ; Anastomosis, Roux-en-Y ; Gastroesophageal Reflux/surgery ; Stomach/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-022-06301-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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