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  1. Article: Tamoxifen Upregulates Collagenase Gene Expression in Human Dermal Fibroblasts.

    Wang, Joanne / Lee, Raphael C

    Plastic and reconstructive surgery. Global open

    2024  Volume 12, Issue 2, Page(s) e5609

    Abstract: Background: Tamoxifen is a known inhibitor of fibroblast transforming growth factor beta biosynthesis and wound scar formation. Tamoxifen is also known to be an estrogen antagonist and protein kinase C (PKC) inhibitor. Cells treated with tamoxifen and ... ...

    Abstract Background: Tamoxifen is a known inhibitor of fibroblast transforming growth factor beta biosynthesis and wound scar formation. Tamoxifen is also known to be an estrogen antagonist and protein kinase C (PKC) inhibitor. Cells treated with tamoxifen and other PKC/calmodulin inhibitors depolymerize their membrane focal adhesion complexes and cytoskeletal protein structures. These effects result in substrate detachment, cell shape rounding, and upregulation of collagenase synthesis and extracellular matrix degradation. The purpose of our study was to test the hypothesis that tamoxifen treatment of human foreskin fibroblasts results in alteration of cytoskeletal protein organization, cell detachment and rounding, and increased collagenase synthesis similar to known PKC/calmodulin inhibitors such as H-7.
    Methods: We characterized the effects of PKC/calmodulin inhibitors tamoxifen and H-7 on human dermal fibroblast morphology, cytoskeletal protein organization, and collagenase gene expression in monolayer culture and within collagen gels.
    Results: We found that fibroblasts responded to tamoxifen by initiation of actin filament depolymerization followed by alteration from spindle to spheroidal shapes. This change in cell shape led to increased collagenase synthesis in cells treated with either tamoxifen or H-7 compared with controls. There was also a 23% increase of hydroxyproline release from tamoxifen-treated fibroblast-populated collagen matrices.
    Conclusions: Tamoxifen may reduce scarring by inhibiting fibroblast PKC/calmodulin activity, which down-regulates pro-fibrotic transforming growth factor beta signaling and upregulates collagenase production. These effects mimic those of the known PKC/calmodulin inhibitor H-7. Overall, these findings suggest that tamoxifen and its analogues are promising agents for clinical investigation as small molecule regulators of fibrosis and scarring disorders.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hidden realities of electrical injuries.

    McCollum, Kyle / Gowrishankar, T R / Lee, Raphael C

    The Nurse practitioner

    2023  Volume 48, Issue 11, Page(s) 9–14

    MeSH term(s) Humans ; Electric Injuries
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604085-8
    ISSN 1538-8662 ; 0361-1817
    ISSN (online) 1538-8662
    ISSN 0361-1817
    DOI 10.1097/01.NPR.0000000000000006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Cell injury

    Lee, Raphael Carl

    mechanisms, responses, and repair ; [result of a seminar series entitled Cell injury: responses and repair held between March 31st and June 2nd, 2004 at the University of Chicago, Chicago, Ill.]

    (Annals of the New York Academy of Sciences ; 1066)

    2005  

    Author's details ed. by Raphael C. Lee
    Series title Annals of the New York Academy of Sciences ; 1066
    Collection
    Keywords Cytopathologie
    Subject Zytopathologie ; Zellpathologie ; Zelle ; Zellularpathologie
    Language English
    Size X, 329 S. : Ill., graph. Darst.
    Publisher New York Acad. of Sciences
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014750655
    ISBN 1-573-31616-4 ; 1-573-31617-2 ; 978-1-573-31616-3 ; 978-1-573-31617-0
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Hidden realities of electrical injuries.

    McCollum, Kyle / Gowrishankar, T R / Lee, Raphael C

    Nursing

    2022  Volume 52, Issue 5, Page(s) 39–43

    Abstract: Abstract: The clinical spectrum of electrical injury ranges from the absence of any external physical signs to severe and life-threatening trauma. This article discusses the fundamental concepts and misunderstandings surrounding electrical injuries and ... ...

    Abstract Abstract: The clinical spectrum of electrical injury ranges from the absence of any external physical signs to severe and life-threatening trauma. This article discusses the fundamental concepts and misunderstandings surrounding electrical injuries and the best practices for evaluation and treatment.
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197895-0
    ISSN 1538-8689 ; 0360-4039
    ISSN (online) 1538-8689
    ISSN 0360-4039
    DOI 10.1097/01.NURSE.0000827148.34185.26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vitamin D Clinical Pharmacology: Relevance to COVID-19 Pathogenesis.

    Campbell, Paige-Ashley / Young, Mimi Wu / Lee, Raphael C

    Journal of the National Medical Association

    2020  Volume 113, Issue 2, Page(s) 208–211

    Abstract: ...

    Abstract ▪▪▪.
    MeSH term(s) African Continental Ancestry Group ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; Cholecalciferol/metabolism ; Cholecalciferol/pharmacology ; Hispanic Americans ; Humans ; Inflammation/metabolism ; Risk Factors ; SARS-CoV-2/physiology ; United States/epidemiology ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/ethnology ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/prevention & control ; Vitamins/metabolism ; Vitamins/pharmacology
    Chemical Substances Vitamins ; Cholecalciferol (1C6V77QF41)
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2020.09.152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Obturator Fasciocutaneous Flap: A Novel Approach to Vulvovaginal Reconstruction.

    Kandi, Lyndsay A / Hammond, Jacob B / Lee, Raphael C / Teven, Chad M

    Plastic and reconstructive surgery. Global open

    2021  Volume 9, Issue 11, Page(s) e3914

    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000003914
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  7. Article ; Online: Convolving engineering and medical pedagogies for training of tomorrow's health care professionals.

    Lee, Raphael C

    IEEE transactions on bio-medical engineering

    2013  Volume 60, Issue 3, Page(s) 599–601

    Abstract: Several fundamental benefits justify why biomedical engineering and medicine should form a more convergent alliance, especially for the training of tomorrow's physicians and biomedical engineers. Herein, we review the rationale underlying the benefits. ... ...

    Abstract Several fundamental benefits justify why biomedical engineering and medicine should form a more convergent alliance, especially for the training of tomorrow's physicians and biomedical engineers. Herein, we review the rationale underlying the benefits. Biological discovery has advanced beyond the era of molecular biology well into today's era of molecular systems biology, which focuses on understanding the rules that govern the behavior of complex living systems. This has important medical implications. To realize cost-effective personalized medicine, it is necessary to translate the advances in molecular systems biology to higher levels of biological organization (organ, system, and organismal levels) and then to develop new medical therapeutics based on simulation and medical informatics analysis. Higher education in biological and medical sciences must adapt to a new set of training objectives. This will involve a shifting away from reductionist problem solving toward more integrative, continuum, and predictive modeling approaches which traditionally have been more associated with engineering science. Future biomedical engineers and MDs must be able to predict clinical response to therapeutic intervention. Medical education will involve engineering pedagogies, wherein basic governing rules of complex system behavior and skill sets in manipulating these systems to achieve a practical desired outcome are taught. Similarly, graduate biomedical engineering programs will include more practical exposure to clinical problem solving.
    MeSH term(s) Biomedical Engineering/education ; Biomedical Engineering/organization & administration ; Education, Medical ; Health Personnel/education ; Health Personnel/organization & administration ; Health Personnel/trends ; Humans ; Medicine/organization & administration ; Models, Educational ; Teaching
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2013.2243911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Peroxidation of tetronic 1107 reduces protein chaperone effect.

    Ling, Michelle X / Nguyen, Michelle / McFaul, Colin A / Lee, Raphael C

    Physical biology

    2022  Volume 19, Issue 4

    Abstract: To enhance the stability of protein therapeutics, pharmaceutical companies have long used various copolymer surfactants as excipients. They act to stabilize proteins by adhering to the hydrophobic surface of the protein preventing denaturation and ... ...

    Abstract To enhance the stability of protein therapeutics, pharmaceutical companies have long used various copolymer surfactants as excipients. They act to stabilize proteins by adhering to the hydrophobic surface of the protein preventing denaturation and aggregation. However, some commonly used excipients possess polyoxyalkylene chains that are susceptible to oxidative degradation while in aqueous solution. We postulate that oxidation reactions involving the hydrophobic domains reduce the surfactant's ability to stabilize the native protein structure. We investigated the effect of UV (λ = 254 nm) radiated poloxamine T1107 (T1107) on its ability to disaggregate DTT denatured hen egg-white lysozyme (HEWL). Peroxidation of UV irradiated T1107 was analyzed using FTIR spectroscopy, the Fe
    MeSH term(s) Ethylenediamines ; Excipients ; Hydrophobic and Hydrophilic Interactions ; Surface-Active Agents
    Chemical Substances Ethylenediamines ; Excipients ; Surface-Active Agents ; Tetronic 1107
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/ac6eaf
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Enhancing Surgical Fitness through Preconditioning.

    Kandi, Lyndsay A / Hammond, Jacob B / Lee, Raphael C / Struve, Sara L / Teven, Chad M

    Plastic and reconstructive surgery

    2022  Volume 151, Issue 1, Page(s) 177e–179e

    MeSH term(s) Humans ; Ischemic Preconditioning
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000009753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: Electrical injury

    Lee, Raphael Carl

    a multidisciplinary approach to therapy, prevention, and rehabilitation

    (Annals of the New York Academy of Sciences ; 720)

    1994  

    Event/congress International Symposium on Electrical Trauma (2, 1993, ChicagoIll.)
    Author's details [Second International Symposium on Electrical Trauma, June 11 - 12, 1993, in Chicago, Illinois]. Ed. by Raphael C. Lee
    Series title Annals of the New York Academy of Sciences ; 720
    Collection
    Keywords Electric Injuries / physiopathology / congresses ; Electric Injuries / therapy / congresses ; Stromverletzung
    Language English
    Size X, 299 S. : Ill., graph. Darst.
    Publisher New York Acad. of Sciences
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006342000
    ISBN 0-89766-864-2 ; 0-89766-865-0 ; 978-0-89766-864-4 ; 978-0-89766-865-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 110 -720- verfügbar in Königswinter Königswinter

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