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  1. Article ; Online: CNS tuberculomas.

    Lee, Ruth D / Atencio, Adrienne

    Journal of general internal medicine

    2023  Volume 38, Issue 11, Page(s) 2621

    MeSH term(s) Humans ; Tuberculoma ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08264-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Immunocytoprotection after reperfusion with Kv1.3 inhibitors has an extended treatment window for ischemic stroke.

    Lee, Ruth D / Chen, Yi-Je / Singh, Latika / Nguyen, Hai M / Wulff, Heike

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1190476

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1190476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABA

    Pressly, Brandon / Lee, Ruth D / Singh, Vikrant / Pessah, Isaac N / Wulff, Heike

    Annals of clinical and translational neurology

    2022  Volume 9, Issue 5, Page(s) 600–609

    Abstract: Objective: Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption. During the Vietnam War, RDX intoxication was the most common cause of generalized seizures in ... ...

    Abstract Objective: Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption. During the Vietnam War, RDX intoxication was the most common cause of generalized seizures in US service personnel, and in some sections of the armed forces, eating of RDX has continued as "a dare" to this day. After its mechanism of action was long unknown, RDX was recently shown to be a GABA
    Methods: We used whole-cell patch-clamp to determine the potency of RDX on 10 recombinantly expressed GABA
    Results: RDX was found to reversibly inhibit the α1β2γ2 GABA
    Interpretation: Our findings characterize the mechanism of action of RDX at the atomistic level and suggest that RDX-induced seizures should be susceptible to treatment with GABA
    MeSH term(s) Humans ; Plastics/metabolism ; Receptors, GABA-A ; Seizures/chemically induced ; Triazines ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Plastics ; Receptors, GABA-A ; Triazines ; gamma-Aminobutyric Acid (56-12-2) ; cyclonite (W91SSV5831)
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.51536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Repurposing the K

    Lee, Ruth D / Chen, Yi-Je / Nguyen, Hai M / Singh, Latika / Dietrich, Connor J / Pyles, Benjamin R / Cui, Yanjun / Weinstein, Jonathan R / Wulff, Heike

    Translational stroke research

    2023  

    Abstract: Senicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition ... ...

    Abstract Senicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-023-01152-6
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  5. Article ; Online: Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the

    Pressly, Brandon / Lee, Ruth D / Barnych, Bogdan / Hammock, Bruce D / Wulff, Heike

    Molecular pharmacology

    2020  Volume 99, Issue 1, Page(s) 78–91

    Abstract: Tetramethylenedisulfotetramine (TETS) is a so-called "caged" convulsant that is responsible for thousands of accidental and malicious poisonings. Similar to the widely used GABA receptor type A ( ... ...

    Abstract Tetramethylenedisulfotetramine (TETS) is a so-called "caged" convulsant that is responsible for thousands of accidental and malicious poisonings. Similar to the widely used GABA receptor type A (GABA
    MeSH term(s) Binding Sites/drug effects ; Binding Sites/physiology ; Bridged-Ring Compounds/chemistry ; Bridged-Ring Compounds/metabolism ; Convulsants/chemistry ; Convulsants/metabolism ; Dose-Response Relationship, Drug ; Humans ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, GABA-A/chemistry ; Receptors, GABA-A/metabolism
    Chemical Substances Bridged-Ring Compounds ; Convulsants ; GABRA2 protein, human ; GABRB3 protein, human ; GABRG2 protein, human ; Receptors, GABA-A ; tetramethylenedisulfotetramine (F6TS3WME05)
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/molpharm.120.000090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 525: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Draft Genome Sequence of the Endosymbiont "Candidatus Ruthia magnifica" UCD-CM (Phylum Proteobacteria).

    Lee, Ruth D / Jospin, Guillaume / Coil, David A / Eisen, Jonathan A

    Genome announcements

    2014  Volume 2, Issue 4

    Abstract: Here, we present the draft genome of the endosymbiont "Candidatus Ruthia magnifica" UCD-CM, a member of the phylum Proteobacteria, found from the gills of a deep-sea giant clam, Calyptogena magnifica. The assembly consists of 1,160,249 bp contained in 18 ...

    Abstract Here, we present the draft genome of the endosymbiont "Candidatus Ruthia magnifica" UCD-CM, a member of the phylum Proteobacteria, found from the gills of a deep-sea giant clam, Calyptogena magnifica. The assembly consists of 1,160,249 bp contained in 18 contigs.
    Language English
    Publishing date 2014-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00717-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Draft Genome Sequences of Two Pseudoalteromonas porphyrae Strains Isolated from Seagrass Sediment.

    Lee, Ruth D / Jospin, Guillaume / Lang, Jenna M / Eisen, Jonathan A / Coil, David A

    Genome announcements

    2016  Volume 4, Issue 2

    Abstract: Here, we present the draft genome sequences of Pseudoalteromonas porphyrae UCD-SED9 and UCD-SED14 (phylum Proteobacteria). These strains were isolated from sediment surrounding the roots of the seagrass, Zostera marina, collected near the UC, Davis ... ...

    Abstract Here, we present the draft genome sequences of Pseudoalteromonas porphyrae UCD-SED9 and UCD-SED14 (phylum Proteobacteria). These strains were isolated from sediment surrounding the roots of the seagrass, Zostera marina, collected near the UC, Davis Bodega Marine Laboratory (Bodega Bay, California). The assemblies contain 4,847,456 bp and 4,817,752 bp, respectively.
    Language English
    Publishing date 2016-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00092-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Draft Genome Sequences of Two Vibrio splendidus Strains, Isolated from Seagrass Sediment.

    Lee, Ruth D / Jospin, Guillaume / Lang, Jenna M / Eisen, Jonathan A / Coil, David A

    Genome announcements

    2016  Volume 4, Issue 1

    Abstract: Here, we present the draft genome sequences of Vibrio splendidus UCD-SED7 and UCD-SED10 (phylum Proteobacteria). These strains were isolated from sediment surrounding Zostera marina roots near the UC Davis Bodega Marine Laboratory (Bodega, Bay, ... ...

    Abstract Here, we present the draft genome sequences of Vibrio splendidus UCD-SED7 and UCD-SED10 (phylum Proteobacteria). These strains were isolated from sediment surrounding Zostera marina roots near the UC Davis Bodega Marine Laboratory (Bodega, Bay, California). These assemblies contain 5,334,236 bp and 5,904,824 bp, respectively.
    Language English
    Publishing date 2016-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01769-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Draft Genome Sequence of Pseudoalteromonas tetraodonis Strain UCD-SED8 (Phylum Gammaproteobacteria).

    Lee, Ruth D / Jospin, Guillaume / Lang, Jenna M / Eisen, Jonathan A / Coil, David A

    Genome announcements

    2015  Volume 3, Issue 6

    Abstract: Here, we present the draft genome sequence of Pseudoalteromonas tetraodonis UCD-SED8, a marine bacterium normally associated with the production of tetrodotoxin in pufferfish. This strain was isolated from sediment samples surrounding Zostera marina ... ...

    Abstract Here, we present the draft genome sequence of Pseudoalteromonas tetraodonis UCD-SED8, a marine bacterium normally associated with the production of tetrodotoxin in pufferfish. This strain was isolated from sediment samples surrounding Zostera marina roots collected from Bodega Marine, California. The assembly consists of 4,017,727 bp contained in 35 contigs.
    Language English
    Publishing date 2015-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01276-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Draft Genome Sequence of Bacillus vietnamensis Strain UCD-SED5 (Phylum Firmicutes).

    Lee, Ruth D / Jospin, Guillaume / Lang, Jenna M / Eisen, Jonathan A / Coil, David A

    Genome announcements

    2015  Volume 3, Issue 6

    Abstract: Here, we present the draft genome sequence of Bacillus vietnamensis UCD-SED5 (phylum Firmicutes). This strain was isolated from sediment surrounding Zostera marina roots near the UC Davis Bodega Marine Laboratory (Bodega Bay, California) and represents ... ...

    Abstract Here, we present the draft genome sequence of Bacillus vietnamensis UCD-SED5 (phylum Firmicutes). This strain was isolated from sediment surrounding Zostera marina roots near the UC Davis Bodega Marine Laboratory (Bodega Bay, California) and represents the second genome of this species. The assembly consists of 4,325,707 bp, in 108 contigs.
    Language English
    Publishing date 2015-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01376-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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