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  1. Article ; Online: MMNet: A Mixing Module Network for Polyp Segmentation.

    Ghimire, Raman / Lee, Sang-Woong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 16

    Abstract: Traditional encoder-decoder networks like U-Net have been extensively used for polyp segmentation. However, such networks have demonstrated limitations in explicitly modeling long-range dependencies. In such networks, local patterns are emphasized over ... ...

    Abstract Traditional encoder-decoder networks like U-Net have been extensively used for polyp segmentation. However, such networks have demonstrated limitations in explicitly modeling long-range dependencies. In such networks, local patterns are emphasized over the global context, as each convolutional kernel focuses on only a local subset of pixels in the entire image. Several recent transformer-based networks have been shown to overcome such limitations. Such networks encode long-range dependencies using self-attention methods and thus learn highly expressive representations. However, due to the computational complexity of modeling the whole image, self-attention is expensive to compute, as there is a quadratic increment in cost with the increase in pixels in the image. Thus, patch embedding has been utilized, which groups small regions of the image into single input features. Nevertheless, these transformers still lack inductive bias, even with the image as a 1D sequence of visual tokens. This results in the inability to generalize to local contexts due to limited low-level features. We introduce a hybrid transformer combined with a convolutional mixing network to overcome computational and long-range dependency issues. A pretrained transformer network is introduced as a feature-extracting encoder, and a mixing module network (MMNet) is introduced to capture the long-range dependencies with a reduced computational cost. Precisely, in the mixing module network, we use depth-wise and 1 × 1 convolution to model long-range dependencies to establish spatial and cross-channel correlation, respectively. The proposed approach is evaluated qualitatively and quantitatively on five challenging polyp datasets across six metrics. Our MMNet outperforms the previous best polyp segmentation methods.
    MeSH term(s) Algorithms ; Benchmarking ; Electric Power Supplies ; Learning
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23167258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oncological relevance of proximal gastrectomy in advanced gastric cancer of upper third of the stomach.

    Imai, Yoshiro / Tanaka, Ryo / Matsuo, Kentaro / Asakuma, Mitsuhiro / Lee, Sang-Woong

    Surgery open science

    2024  Volume 18, Page(s) 23–27

    Abstract: Background: The oncological relevance of proximal gastrectomy in advanced gastric cancer remains unclear. We aimed to examine the frequency of lymph node metastasis in advanced gastric cancer to determine the oncological validity of proximal gastrectomy ...

    Abstract Background: The oncological relevance of proximal gastrectomy in advanced gastric cancer remains unclear. We aimed to examine the frequency of lymph node metastasis in advanced gastric cancer to determine the oncological validity of proximal gastrectomy selection.
    Materials and methods: This study included consecutive 71 patients with locally advanced gastric cancer in the upper third of the stomach who underwent total gastrectomy at our institution between 2001 and 2017. Lymph node metastasis and its therapeutic value index were examined to identify candidates for proximal gastrectomy. Metastatic and 3-year overall survival rates of numbers 3a and 3b lymph nodes were examined from 2010 to 2019.
    Results: The metastatic rate and therapeutic value index of numbers 4d, 5, 6, and 12a lymph nodes were zero or low. The number 3 lymph node had a metastatic rate and therapeutic value index of 36.6 % and 31.1, respectively. The metastatic and 3-year overall survival rates of the number 3a lymph node were 32.7 % and 89 %, respectively, whereas those of the number 3b lymph node were 3.8 % and 100 %, respectively. All patients with positive metastasis to the number 3b lymph node received adjuvant chemotherapy. Histopathological findings of positive metastasis to the number 3b lymph node were located in the lesser curvature, and the tumor diameter exceeded 40 mm.
    Conclusion: For advanced gastric cancer of the upper third of the stomach, the indications of localization to the lesser curvature and a tumor diameter of >40 mm should be considered cautiously.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A commentary on "Laparoscopic vs. open splenectomy and oesophagogastric revascularisation for liver cirrhosis and portal hypertension: A retrospective cohort study".

    Lee, Sang-Woong / Uchiyama, Kazuhisa

    International journal of surgery (London, England)

    2020  Volume 81, Page(s) 83

    MeSH term(s) Humans ; Hypertension, Portal/etiology ; Hypertension, Portal/surgery ; Laparoscopy ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Retrospective Studies ; Splenectomy
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.07.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: M2GAN

    Nguyen, Duc Manh / Lee, Sang-Woong

    A Multi-Stage Self-Attention Network for Image Rain Removal on Autonomous Vehicles

    2021  

    Abstract: Image deraining is a new challenging problem in applications of autonomous vehicles. In a bad weather condition of heavy rainfall, raindrops, mainly hitting the vehicle's windshield, can significantly reduce observation ability even though the windshield ...

    Abstract Image deraining is a new challenging problem in applications of autonomous vehicles. In a bad weather condition of heavy rainfall, raindrops, mainly hitting the vehicle's windshield, can significantly reduce observation ability even though the windshield wipers might be able to remove part of it. Moreover, rain flows spreading over the windshield can yield the physical effect of refraction, which seriously impede the sightline or undermine the machine learning system equipped in the vehicle. In this paper, we propose a new multi-stage multi-task recurrent generative adversarial network (M2GAN) to deal with challenging problems of raindrops hitting the car's windshield. This method is also applicable for removing raindrops appearing on a glass window or lens. M2GAN is a multi-stage multi-task generative adversarial network that can utilize prior high-level information, such as semantic segmentation, to boost deraining performance. To demonstrate M2GAN, we introduce the first real-world dataset for rain removal on autonomous vehicles. The experimental results show that our proposed method is superior to other state-of-the-art approaches of deraining raindrops in respect of quantitative metrics and visual quality. M2GAN is considered the first method to deal with challenging problems of real-world rains under unconstrained environments such as autonomous vehicles.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 629
    Publishing date 2021-10-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: UnfairGAN

    Nguyen, Duc Manh / Lee, Sang-Woong

    An Enhanced Generative Adversarial Network for Raindrop Removal from A Single Image

    2021  

    Abstract: Image deraining is a new challenging problem in real-world applications, such as autonomous vehicles. In a bad weather condition of heavy rainfall, raindrops, mainly hitting glasses or windshields, can significantly reduce observation ability. Moreover, ... ...

    Abstract Image deraining is a new challenging problem in real-world applications, such as autonomous vehicles. In a bad weather condition of heavy rainfall, raindrops, mainly hitting glasses or windshields, can significantly reduce observation ability. Moreover, raindrops spreading over the glass can yield refraction's physical effect, which seriously impedes the sightline or undermine machine learning systems. In this paper, we propose an enhanced generative adversarial network to deal with the challenging problems of raindrops. UnfairGAN is an enhanced generative adversarial network that can utilize prior high-level information, such as edges and rain estimation, to boost deraining performance. To demonstrate UnfairGAN, we introduce a large dataset for training deep learning models of rain removal. The experimental results show that our proposed method is superior to other state-of-the-art approaches of deraining raindrops regarding quantitative metrics and visual quality.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2021-10-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Trends in the stage distribution of colorectal cancer during the COVID-19 pandemic in Japan: a nationwide hospital-claims data analysis.

    Ota, Masato / Taniguchi, Kohei / Asakuma, Mitsuhiro / Lee, Sang-Woong / Ito, Yuri

    Journal of epidemiology

    2023  

    Abstract: Background: The COVID-19 pandemic has affected cancer care. The aim of this study was to clarify the trend of colorectal cancer (CRC) stage distribution in Japan during the COVID-19 pandemic.: Methods: In this retrospective study, we used an ... ...

    Abstract Background: The COVID-19 pandemic has affected cancer care. The aim of this study was to clarify the trend of colorectal cancer (CRC) stage distribution in Japan during the COVID-19 pandemic.
    Methods: In this retrospective study, we used an inpatient medical claims database established at approximately 400 acute care hospitals. From the database, we searched patients who were identified as having the main disease (using ICD-10codes [C18.0-C20]) between January 2018 and December 2020. A multivariate logistic regression analysis was used to determine the impact of the pandemic on CRC stage distribution each month, and the odds ratio (OR) for late-stage cancer was calculated.
    Results: We analyzed 99,992 CRC patients. Logistic regression analysis, including the interaction term between increased late-stage CRC effect during the pandemic period and by each individual month, showed that the OR for late-stage CRC was highest in July during the pandemic, at 1.31 (95%CI: 1.13- 1.52) and also significantly higher in September at 1.16 (95%CI: 1.00- 1.35).
    Conclusion: We investigated the trend of CRC stage distribution during the COVID-19 pandemic using a nationwide hospital-claims database in Japan, and found that the proportion of early-stage cancers tended to decrease temporarily after the state of emergency declaration due to the COVID-19 pandemic, but the effect was only temporary.
    Language English
    Publishing date 2023-12-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1442118-5
    ISSN 1349-9092 ; 0917-5040
    ISSN (online) 1349-9092
    ISSN 0917-5040
    DOI 10.2188/jea.JE20220347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Polyp segmentation with consistency training and continuous update of pseudo-label.

    Park, Hyun-Cheol / Poudel, Sahadev / Ghimire, Raman / Lee, Sang-Woong

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 14626

    Abstract: Polyp segmentation has accomplished massive triumph over the years in the field of supervised learning. However, obtaining a vast number of labeled datasets is commonly challenging in the medical domain. To solve this problem, we employ semi-supervised ... ...

    Abstract Polyp segmentation has accomplished massive triumph over the years in the field of supervised learning. However, obtaining a vast number of labeled datasets is commonly challenging in the medical domain. To solve this problem, we employ semi-supervised methods and suitably take advantage of unlabeled data to improve the performance of polyp image segmentation. First, we propose an encoder-decoder-based method well suited for the polyp with varying shape, size, and scales. Second, we utilize the teacher-student concept of training the model, where the teacher model is the student model's exponential average. Third, to leverage the unlabeled dataset, we enforce a consistency technique and force the teacher model to generate a similar output on the different perturbed versions of the given input. Finally, we propose a method that upgrades the traditional pseudo-label method by learning the model with continuous update of pseudo-label. We show the efficacy of our proposed method on different polyp datasets, and hence attaining better results in semi-supervised settings. Extensive experiments demonstrate that our proposed method can propagate the unlabeled dataset's essential information to improve performance.
    MeSH term(s) Datasets as Topic/standards ; Datasets as Topic/trends ; Humans ; Image Processing, Computer-Assisted ; Polyps/diagnostic imaging ; Polyps/pathology ; Supervised Machine Learning
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-17843-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Survey on digital dependency, writing by hand, and group learning as learning styles among Japanese medical students: Assessing correlations between various accomplishments.

    Komasawa, Nobuyasu / Takitani, Kimitaka / Lee, Sang-Woong / Terasaki, Fumio / Nakano, Takashi

    Journal of education and health promotion

    2023  Volume 12, Page(s) 204

    Abstract: Background: Although digital learning devices have become increasingly more common in medical education settings, it remains unclear how they influence medical student learning styles and various outcome measures. This study aimed to assess student ... ...

    Abstract Background: Although digital learning devices have become increasingly more common in medical education settings, it remains unclear how they influence medical student learning styles and various outcome measures. This study aimed to assess student learning styles, specifically as they relate to digital dependency, writing habits, and group learning practices among current medical students.
    Materials and methods: This questionnaire study was approved by the Research Ethics Committee of Osaka Medical and Pharmaceutical University. We conducted a questionnaire survey of 109 medical students who were 5
    Results: Of the 109 students targeted, we received responses from 62 (response rate, 56.8%). Among the respondents, digital dependency was 83.4 ± 18.6%, while hand writing ratio 39.8 ± 29.9% and group learning ratio 33.5 ± 30.5%. We also assessed correlations between these learning styles and scores on the CBT, OSCE, CC, and CC Integrative Test. Only writing by hand showed a small positive correlation with CC Integrative Test scores.
    Conclusion: Our questionnaire survey assessed the rates of digital dependency, writing by hand, and group learning practices, and analyzed the correlations between these learning styles and respective outcomes. Current medical students exhibited high digital dependency which was not correlated with performance outcomes.
    Language English
    Publishing date 2023-06-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_912_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Experimental Study of Warburg Effect in Keloid Nodules: Implication for Downregulation of miR-133b.

    Lee, Yuumi / Ito, Yuko / Taniguchi, Kohei / Nuri, Takashi / Lee, SangWoong / Ueda, Koichi

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 8, Page(s) e5202

    Abstract: Background: A keloid is composed of several nodules, which are divided into two zones: the central zone (CZ; a hypoxic region) and the marginal zone (MZ; a normoxic region). Keloid nodules play a key role in energy metabolic activity for continuous ... ...

    Abstract Background: A keloid is composed of several nodules, which are divided into two zones: the central zone (CZ; a hypoxic region) and the marginal zone (MZ; a normoxic region). Keloid nodules play a key role in energy metabolic activity for continuous growth by increasing in number and total area. In this study, we aimed to investigate the roles of the zones in the execution of the Warburg effect and identify which microRNAs regulate this phenomenon in keloid tissue.
    Methods: Eleven keloids from patients were used. Using immunohistochemical analysis, 179 nodules were randomly chosen from these keloids to identify glycolytic enzymes, autophagic markers, pyruvate kinase M (PKM) 1/2, and polypyrimidine tract binding protein 1 (PTBP1). Western blot and qRT-PCR tests were also performed for PKM, PTBP1, and microRNAs (miR-133b and miR-200b, c).
    Results: Immunohistochemical analysis showed that the expression of the autophagic (LC3, p62) and glycolytic (GLUT1, HK2) were significantly higher in the CZ than in the MZ. PKM2 expression was significantly higher than PKM1 expression in keloid nodules. Furthermore, PKM2 expression was higher in the CZ than in the MZ. However, PKM1 and PTBP1 expression levels were higher in the MZ than in the CZ. The qRT-PCR analysis showed that miR-133b-3p was moderately downregulated in the keloids compared with its expression in the normal skin tissue.
    Conclusions: The Warburg effect occurred individually in nodules. The MZ presented PKM2-positive fibroblasts produced by activated PTBP1. In the CZ, PKM2-positive fibroblasts produced lactate. MiR-133b-3p was predicted to control the Warburg effect in keloids.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Generalized Parking Occupancy Analysis Based on Dilated Convolutional Neural Network.

    Nurullayev, Sherzod / Lee, Sang-Woong

    Sensors (Basel, Switzerland)

    2019  Volume 19, Issue 2

    Abstract: The importance of vacant parking space detection systems is increasing dramatically as the avoidance of traffic congestion and the time-consuming process of searching an empty parking space is a crucial problem for drivers in urban centers. However, the ... ...

    Abstract The importance of vacant parking space detection systems is increasing dramatically as the avoidance of traffic congestion and the time-consuming process of searching an empty parking space is a crucial problem for drivers in urban centers. However, the existing parking space occupancy detection systems are either hardware expensive or not well-generalized for varying images captured from different camera views. As a solution, we take advantage of an affordable visual detection method that is made possible by the fact that camera monitoring is already available in the majority of parking areas. However, the current problem is a challenging vision task because of outdoor lighting variation, perspective distortion, occlusions, different camera viewpoints, and the changes due to the various seasons of the year. To overcome these obstacles, we propose an approach based on Dilated Convolutional Neural Network specifically designed for detecting parking space occupancy in a parking lot, given only an image of a single parking spot as input. To evaluate our method and allow its comparison with previous strategies, we trained and tested it on well-known publicly available datasets, PKLot and CNRPark + EXT. In these datasets, the parking lot images are already labeled, and therefore, we did not need to label them manually. The proposed method shows more reliability than prior works especially when we test it on a completely different subset of images. Considering that in previous studies the performance of the methods was compared with well-known architecture-AlexNet, which shows a highly promising achievement, we also assessed our model in comparison with AlexNet. Our investigations showed that, in comparison with previous approaches, for the task of classifying given parking spaces as vacant or occupied, the proposed approach is more robust, stable, and well-generalized for unseen images captured from completely different camera viewpoints, which has strong indications that it would generalize effectively to other parking lots.
    Language English
    Publishing date 2019-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s19020277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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