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Article ; Online: Effect of socioeconomic disparities on the risk of COVID-19 in 8 metropolitan cities in the Korea: a community-based study.

Hwang, Myung-Jae / Park, Shin Young / Yoon, Tae-Ho / Jang, Jinhwa / Lee, Seon-Young / Yoo, Myeongsu / Kim, Yoo-Yeon / Cheong, Hae-Kwan / Kwon, Donghyok / Kim, Jong-Hun

Epidemiology and health

2022 Volume 44, Page(s) e2022107

Abstract: Objectives: Socioeconomic disparities have been reported as major risk factors contributing to the spread of coronavirus disease 2019 (COVID-19) at the community level. We conducted an epidemiological study on COVID-19 incidence risk using area-based ... ...

Abstract	Objectives: Socioeconomic disparities have been reported as major risk factors contributing to the spread of coronavirus disease 2019 (COVID-19) at the community level. We conducted an epidemiological study on COVID-19 incidence risk using area-based deprivation indices (DIs) reflecting the characteristics of the susceptible population. Methods: A database of the confirmed COVID-19 cases in 8 metropolitan cities in Korea from January 20, 2020 to December 31, 2021 was combined with area-based DI scores and standardized prevalence rates of diabetes and hypertension from the Korean Community Health Survey. Relative risk (RR) levels were estimated using a generalized linear model with a Poisson distribution by age group. Results: The risk of COVID-19 incidence generally increased with increasing age, especially in patients aged ≥75 years. The RR of COVID-19 incidence per interquartile range increment of the composite deprivation index (composite DI) was 1.54 (95% confidence interval [CI], 1.34 to 1.70). Notably, in the first wave, the risk of COVID-19 incidence was approximately 3 times higher in the region with the lowest socioeconomic status than in the region with the highest status (RR, 3.08; 95% CI, 2.42 to 3.78 based on the the composite DI and RR, 3.13; 95% CI, 2.53 to 3.83 based on the social deprivation index). Conclusions: This study provides scientific evidence that socioeconomic deprivation is an important risk factor for the spread of COVID-19. This finding suggests that a mid-term to long-term strategy is needed to protect susceptible populations and reduce the burden of COVID-19 in the community.
MeSH term(s)	Humans ; Aged ; COVID-19/epidemiology ; Cities/epidemiology ; Socioeconomic Disparities in Health ; Socioeconomic Factors ; Republic of Korea/epidemiology
Language	English
Publishing date	2022-11-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590698-7
ISSN	2092-7193 ; 2092-7193
ISSN (online)	2092-7193
ISSN	2092-7193
DOI	10.4178/epih.e2022107
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Article ; Online: EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis.

Park, Jin-Sil / Yang, Seung Cheon / Jeong, Ha Yeon / Lee, Seon-Young / Ryu, Jun-Geol / Choi, Jeong Won / Kang, Hye Yeon / Kim, Sung-Min / Hwang, Sun-Hee / Cho, Mi-La / Park, Sung-Hwan

Arthritis research & therapy

2022 Volume 24, Issue 1, Page(s) 254

Abstract: Background: EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have been no investigations to determine whether EC-18 has preventive potential in ... ...

Abstract	Background: EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have been no investigations to determine whether EC-18 has preventive potential in autoimmune diseases, especially rheumatoid arthritis (RA). Methods: To investigate the efficacy of EC-18 on the development of RA, EC-18 was administered in a collagen-induced arthritis (CIA) murine model and disease severity and the level of inflammatory cytokines in the joint were investigated. The effect of EC-18 on the inflammation-related factors was investigated by flow cytometry, ELISA, western blot, and real-time PCR in splenocytes from mice and in peripheral blood mononuclear cells from healthy and patients with RA. The effect of EC-18 on osteoclastogenesis was investigated. Results: EC-18 effectively reduced the clinical and histological severity of arthritis, similar to Janus kinase inhibitors include tofacitinib and baricitinib, in CIA. Furthermore, EC-18 exhibited a synergistic effect with methotrexate in preventing CIA. Treatment with EC-18 effectively reduced the production of inflammatory cytokines in immune cells and osteoclast differentiation in mice and patients with RA. Conclusion: These results suggest that EC-18 may be an effective strategy for RA.
MeSH term(s)	Mice ; Animals ; Osteogenesis ; Cytokines/pharmacology ; Leukocytes, Mononuclear/pathology ; Arthritis, Experimental ; Arthritis, Rheumatoid/drug therapy
Chemical Substances	Cytokines
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-022-02941-4
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Article ; Online: Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2.

Lee, Weon Sup / Shim, Sang Ryeol / Lee, Seon Young / Yoo, Jin San / Cho, Sung Kweon

Drug design, development and therapy

2018 Volume 12, Page(s) 495–504

Abstract: Background: VEGF is a highly selective mitogen that serves as the central regulator of tumor angiogenesis by mediating endothelial proliferation, permeability, and survival. Tanibirumab (TTAC-0001) is a fully human IgG1 monoclonal antibody derived from ... ...

Abstract	Background: VEGF is a highly selective mitogen that serves as the central regulator of tumor angiogenesis by mediating endothelial proliferation, permeability, and survival. Tanibirumab (TTAC-0001) is a fully human IgG1 monoclonal antibody derived from a fully human naïve single-chain variable fragment (ScFv) phage library that was developed to inhibit the effects of VEGF in the treatment of solid tumors, especially those of the brain. Methods: In the present study, we conducted intravenous pharmacokinetic studies of TTAC-0001 in mice, rats, and cynomolgus monkeys. At the doses studied (3 mg/kg, 10 mg/kg, 30 mg/kg), TTAC-0001 exhibited dose proportionality in mice and monkeys. At a dose of ~10 mg/kg, the clearance of TTAC-0001 from serum was 0.017 mL/h in mice, 0.35 mL/h in rats, and 2.19 mL/h in cynomolgus monkeys, and the terminal half-life ranged from 20-30 h among the three species. Pharmacokinetic data in mice, rats, and cynomolgus monkeys were used to predict the pharmacokinetics of TTAC-0001 in humans using allometric scaling. The predicted serum clearance of TTAC-0001 in humans was 102.45 mL/h and the terminal half-life was 27.52 h. Results: The maximum life span-corrected clearance value was 72.92 mL/h. The observed clearance in humans was more similar to the predicted scaled clearance. Conclusion: We investigated the pharmacokinetics of TTAC-0001 in mice, rats, and cynomolgus monkeys after intravenous administration. At the doses studied, TTAC-0001 exhibited dose proportionality in mice and monkeys. The scaled pharmacokinetics of TTAC-0001 reported here was useful for designing first-in-human studies. Allometric scaling in the therapeutic antibody is feasible.
MeSH term(s)	Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism ; Antibodies, Monoclonal/pharmacokinetics ; Antibodies, Monoclonal, Humanized ; CHO Cells ; Cricetulus ; Dose-Response Relationship, Drug ; Female ; Humans ; K562 Cells ; Macaca fascicularis ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Rats ; Structure-Activity Relationship ; Tissue Distribution ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; olinvacimab (VFH55IZ5VI)
Language	English
Publishing date	2018-03-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S150241
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Article ; Online: Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells.

Kim, Tae Woo / Lee, Seon Young / Kim, Mia / Cheon, Chunhoo / Ko, Seong-Gyu

Cell death & disease

2018 Volume 9, Issue 9, Page(s) 875

Abstract: Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However, detailed mechanisms involved in the treatment of gastric cancer (GC) ... ...

Abstract	Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However, detailed mechanisms involved in the treatment of gastric cancer (GC) using kaempferol are not fully understood. In our study, we investigated the biological activity and molecular mechanism involved in kaempferol-mediated treatment of GC. Kaempferol promoted autophagy and cell death, and increased LC3-I to LC3-II conversion and the downregulation of p62 in GC. Furthermore, our results showed that kaempferol induces autophagic cell death via the activation of the IRE1-JNK-CHOP signaling, indicating ER stress response. Indeed, the inhibition of ER stress suppressed kaempferol-induced autophagy and conferred prolonged cell survival, indicating autophagic cell death. We further showed that kaempferol mediates epigenetic change via the inhibition of G9a (HDAC/G9a axis) and also activates autophagic cell death. Taken together, our findings indicate that kaempferol activates the IRE1-JNK-CHOP signaling from cytosol to nucleus, and G9a inhibition activates autophagic cell death in GC cells.
MeSH term(s)	Antineoplastic Agents, Phytogenic/pharmacology ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/metabolism ; Histocompatibility Antigens/metabolism ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Kaempferols/pharmacology ; MAP Kinase Signaling System/drug effects ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Transcription Factor CHOP/metabolism
Chemical Substances	Antineoplastic Agents, Phytogenic ; DDIT3 protein, human ; Histocompatibility Antigens ; Kaempferols ; Transcription Factor CHOP (147336-12-7) ; kaempferol (731P2LE49E) ; EHMT2 protein, human (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
Language	English
Publishing date	2018-08-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-018-0930-1
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Article ; Online: Compliance of systematic reviews in ophthalmology with the PRISMA statement.

Lee, Seon-Young / Sagoo, Harkiran / Farwana, Reem / Whitehurst, Katharine / Fowler, Alex / Agha, Riaz

BMC medical research methodology

2017 Volume 17, Issue 1, Page(s) 178

Abstract: Background: Systematic reviews and meta-analyses are becoming increasingly important methods to summarize published research. Studies of ophthalmology may present additional challenges because of their potentially complex study designs. The aim of this ... ...

Abstract	Background: Systematic reviews and meta-analyses are becoming increasingly important methods to summarize published research. Studies of ophthalmology may present additional challenges because of their potentially complex study designs. The aim of this study was to evaluate the reporting quality of systematic reviews and meta-analyses on topics in ophthalmology to determine compliance with the PRISMA guidelines. We assessed articles published between 2010 and 2015 in the five major relevant journals with the highest impact factors. Methods: The MEDLINE and EMBASE databases were searched to identify systematic reviews published between January 2010 and December 2015 in the following 5 major ophthalmology journals: Progress in Retinal and Eye Research, Ophthalmology, Archives of Ophthalmology, American Journal of Ophthalmology, and Survey of Ophthalmology. The screening, identification, and scoring of articles were independently performed by two teams, and the results were submitted to statistical analysis to determine medians, ranges, and 95% CIs. Results: A total of 115 articles were included. The median compliance was 15 out of 27 items (56%), the range was 5-26 (26-96%), and the inter-quartile range was 10 (37%). Compliance was highest in items related to the 'description of rationale' (item 3, 100%) and sequentially lower in 'the general interpretation of results' (item 26, 96%) and 'the inclusion of a structured summary in the abstract' (item 2, 90%). Compliance was poorest in the items 'indication of review protocol and registration' (item 5, 9%), 'specification of risk of biases that may affect the cumulative evidence' (item 15, 24%), and 'description of clear objectives in the introduction' (item 4, 26%). Conclusion: The reporting quality of systematic reviews and meta-analyses in ophthalmology should be significantly improved. While we recommend the use of the PRISMA criteria as a guideline before journal submission, additional research aimed at identifying potential barriers to compliance may be required to improve compliance with PRISMA guidelines.
MeSH term(s)	Bias ; Guideline Adherence/standards ; Guidelines as Topic/standards ; Humans ; Meta-Analysis as Topic ; Ophthalmology ; Periodicals as Topic/standards ; Publishing/standards ; Quality Control ; Review Literature as Topic
Language	English
Publishing date	2017--28
Publishing country	England
Document type	Journal Article
ISSN	1471-2288
ISSN (online)	1471-2288
DOI	10.1186/s12874-017-0450-1
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Article ; Online: MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.

Oh, Jung-Min / Kang, Yujin / Park, Jumi / Sung, Yubin / Kim, Dayoung / Seo, Yuri / Lee, Eun A / Ra, Jae Sun / Amarsanaa, Enkhzul / Park, Young-Un / Lee, Seon Young / Hwang, Jung Me / Kim, Hongtae / Schärer, Orlando / Cho, Seung Woo / Lee, Changwook / Takata, Kei-Ichi / Lee, Ja Yil / Myung, Kyungjae

Nucleic acids research

2023 Volume 51, Issue 11, Page(s) 5584–5602

Abstract: DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied. However, it is ... ...

Abstract	DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied. However, it is still unclear how the potential DNA structures generated by the initial short resection by MRE11-RAD50-NBS1 are recognized and recruit proteins, such as EXO1, to DSB sites to facilitate long-range resection. We found that the MSH2-MSH3 mismatch repair complex is recruited to DSB sites through interaction with the chromatin remodeling protein SMARCAD1. MSH2-MSH3 facilitates the recruitment of EXO1 for long-range resection and enhances its enzymatic activity. MSH2-MSH3 also inhibits access of POLθ, which promotes polymerase theta-mediated end-joining (TMEJ). Collectively, we present a direct role of MSH2-MSH3 in the initial stages of DSB repair by promoting end resection and influencing the DSB repair pathway by favoring homologous recombination over TMEJ.
MeSH term(s)	DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; DNA Repair ; Exodeoxyribonucleases/metabolism ; Homologous Recombination ; MutS Homolog 2 Protein/metabolism ; Humans ; Cell Line ; DNA Helicases/metabolism ; MutS Homolog 3 Protein/metabolism
Chemical Substances	DNA (9007-49-2) ; Exodeoxyribonucleases (EC 3.1.-) ; MutS Homolog 2 Protein (EC 3.6.1.3) ; MSH2 protein, human (EC 3.6.1.3) ; MSH3 protein, human ; EXO1 protein, human (EC 3.1.-) ; SMARCAD1 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; MutS Homolog 3 Protein
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad308
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Article ; Online: Cover Picture: Macromol. Biosci. 9/2015.

Seo, Seog-Jin / Lee, Seon-Young / Choi, Seong-Jun / Kim, Hae-Won

Macromolecular bioscience

2015 Volume 15, Issue 9, Page(s) 1175

Abstract: Front Cover: Our multifunctional nanocarrier system designed for tumor-targeting co-delivery shows controlled release behaviors of hydrophobic molecules at tumors by a temperature trigger and receptor-mediated gene delivery. In this system, functions of ... ...

Abstract	Front Cover: Our multifunctional nanocarrier system designed for tumor-targeting co-delivery shows controlled release behaviors of hydrophobic molecules at tumors by a temperature trigger and receptor-mediated gene delivery. In this system, functions of temperature-sensitive drug release and tumor's specific receptor-mediated gene delivery originate from Pluronic F127 and polyethylenimine-decorated folic acid, respectively. Thus, this system envisages a promising potential for the cancer treatment in response to hitting temperature to hyperthermia. Further details can be found in the article by S.-J. Seo et al. on page 1198.
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Journal Article
ISSN	1616-5195
ISSN (online)	1616-5195
DOI	10.1002/mabi.201570029
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Article ; Online: Preparation of high-quality YAG:Ce

Kwon, Seok Bin / Yoo, Jung Hyeon / Choi, Seung Hee / Na, MinYoung / Kim, Bo Young / Lee, Seon Young / Jeong, Ho-Jung / Kim, Wan Ho / Park, Seoung Hyok / Yoon, Ho Shin / Kang, Bong Kyun / Song, Young Hyun / Yoon, Dae Ho

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20477

Abstract: This study investigates the characteristics of a ceramic phosphor (CP) for the converter of a high-power laser diode-based automobile headlamp synthesized by high-frequency induction heated press (HFP) sintering. The CP prepared by an HFP method exhibits ...

Abstract	This study investigates the characteristics of a ceramic phosphor (CP) for the converter of a high-power laser diode-based automobile headlamp synthesized by high-frequency induction heated press (HFP) sintering. The CP prepared by an HFP method exhibits remarkable optical properties that are comparable to spark plasma sintering. The effects of post-treatment process for controlling residual pores, as well as sintering temperature, sintering pressure and heating rate for optimization of the HFP sintering method, were studied. The HFP sintering process can be widely used in ceramics and lighting fields because it is designed relatively low cost compared to other techniques and exhibits excellent productivity.
Language	English
Publishing date	2022-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-23094-z
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Article ; Online: Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles.

Seo, Seog-Jin / Lee, Seon-Young / Choi, Seong-Jun / Kim, Hae-Won

Macromolecular bioscience

2015 Volume 15, Issue 9, Page(s) 1198–1204

Abstract: Co-delivery strategy using multifunctional nanocarriers is an attractive option for the synergistic and enhanced effects in cancer treatment, but one system integrating multiple functions for controlled release at the target is still challenging. Herein, ...

Abstract	Co-delivery strategy using multifunctional nanocarriers is an attractive option for the synergistic and enhanced effects in cancer treatment, but one system integrating multiple functions for controlled release at the target is still challenging. Herein, this study shows the synthesis and characterization of our stimulus-responsive co-delivery system for the controlled release into tumors, which is composed of polyethylenimine (PEI)-linked Pluronic F127 (PF127) and folic acid (FA), called PF127-PEI-FA. PF127-PEI-FA system facilitated drug loading and gene complex formation, and showed controlled release behaviors in response to hitting temperature to hyperthermia. PF127-PEI-FA system was demonstrated to be biocompatible and showed receptor-mediated gene delivery. The results of our multifunctional nanocarrier system that enabled co-delivery suggest a promising potential for controlled drug release at targeted areas. However, further in-depth studies on the use of therapeutic drugs and genes in multiple cell types and the animal response are required.
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Combined Modality Therapy ; Drug Carriers ; Folic Acid/analogs & derivatives ; Folic Acid/chemistry ; Gene Transfer Techniques ; HeLa Cells ; Humans ; Micelles ; Neoplasms/drug therapy ; Neoplasms/therapy ; Poloxamer ; Polyethyleneimine/analogs & derivatives ; Polyethyleneimine/chemistry ; Temperature ; Transgenes
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; Micelles ; Pluronic F127-polyethylenimine-folate copolymer ; Poloxamer (106392-12-5) ; Polyethyleneimine (9002-98-6) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.201500137
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Article ; Online: Reporting Quality of Observational Studies in Plastic Surgery Needs Improvement: A Systematic Review.

Agha, Riaz Ahmed / Lee, Seon-Young / Jeong, Kyung Jin Lee / Fowler, Alexander J / Orgill, Dennis P

Annals of plastic surgery

2016 Volume 76, Issue 5, Page(s) 585–589

Abstract: Introduction: Our objective was to determine the compliance of observational studies in plastic surgery with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist.: Methods: All cohort, cross-sectional, ...

Abstract	Introduction: Our objective was to determine the compliance of observational studies in plastic surgery with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist. Methods: All cohort, cross-sectional, and case-control studies published in five major plastic surgery journals in 2013 were assessed for their compliance with the STROBE statement. Results: One hundred thirty-six studies were identified initially and 94 met the inclusion criteria. The average STROBE score was 12.4 (range, 2-20.1) with a standard deviation of 3.36. The most frequent reporting deficiencies were not reporting the study design in the title and abstract 30% compliance; describing the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collection (24%); describing efforts to address sources of bias (20%); reporting numbers of individuals at each stage of the study (20%); and discussing limitations (40%). Conclusions: The reporting quality of observational studies in Plastic Surgery needs improvement. We suggest ways this could be improved including better education, awareness among all stakeholders, and hardwiring compliance through electronic journal submission systems.
MeSH term(s)	Case-Control Studies ; Cohort Studies ; Cross-Sectional Studies ; Observational Studies as Topic/standards ; Periodicals as Topic ; Research Design/standards ; Surgery, Plastic/standards
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000000419
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