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  1. Article ; Online: Reproductive performance and sex ratio adjustment of the wild boar (Sus scrofa) in South Korea.

    Lee, Seong-Min

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21774

    Abstract: The wild boar (Sus scrofa), a polygynous species, rapidly expanded its geographical range and increased its population size in South Korea following the extinction of large carnivores and changes to rural environments. Understanding wild boar ... ...

    Abstract The wild boar (Sus scrofa), a polygynous species, rapidly expanded its geographical range and increased its population size in South Korea following the extinction of large carnivores and changes to rural environments. Understanding wild boar reproductive traits and strategies is essential for their effective management; however, studies in this area are lacking. Using samples collected from hunting bags, the relationships between 1) litter size and female weight and 2) fetal sex ratio and female body condition were examined to understand wild boar life-history strategies. Wild boars showed a seasonal breeding pattern that maximized reproduction. Litter size (mean = 5.7 ± 1.7) was correlated with female weight, whereas fetal sex ratio was not explained by female body condition. However, the heaviest ranked fetuses within the litters were male-biased. Wild boars aged three years or less accounted for 90% of the total population, and sexual dimorphism developed from two years of age. Considering that their reproductive strategy is more effective (i.e., early gestation and large litter size) than that of other polygynous species, the Trivers-Willard model was not supported for the wild boars in this study. Instead, females adjusted the sex of the heaviest fetus in the litter to maximize lifetime reproductive success.
    MeSH term(s) Pregnancy ; Male ; Female ; Animals ; Swine ; Reproduction ; Litter Size ; Sex Ratio ; Population Density ; Sus scrofa
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25626-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats.

    Lee, Seong Min / Lee, Sang Mok / Song, Jungbin

    Nutrients

    2024  Volume 16, Issue 8

    Abstract: Benign prostatic hyperplasia (BPH) is the non-malignant enlargement of the prostate, associated with lower urinary tract symptoms (LUTSs). Taraxaci Herba (TH), commonly known as dandelion, has traditionally been utilized in East Asia to treat symptoms ... ...

    Abstract Benign prostatic hyperplasia (BPH) is the non-malignant enlargement of the prostate, associated with lower urinary tract symptoms (LUTSs). Taraxaci Herba (TH), commonly known as dandelion, has traditionally been utilized in East Asia to treat symptoms related to LUTSs. Based on this traditional use, our study aimed to explore the inhibitory effects of TH on BPH progression using a testosterone propionate-induced rat model. To induce BPH, male Sprague Dawley rats were castrated and injected subcutaneously with testosterone propionate (3 mg/kg/day) for 28 days. Concurrently, TH extract was administered orally at doses of 100 and 300 mg/kg/day throughout the four-week period of testosterone propionate injections. The TH extract significantly reduced both the absolute and relative weights of the prostate, along with histopathological changes in the gland. Moreover, it lowered serum levels of testosterone and dihydrotestosterone and reduced the expression of the androgen receptor in the prostate. Additionally, the TH extract modulated the protein expressions of Bax and Bcl-2, which are key regulators of apoptosis in prostate cells. Collectively, our findings suggest that TH inhibits BPH development partially by modulating androgen signaling and inducing apoptosis within the prostate.
    MeSH term(s) Male ; Animals ; Prostatic Hyperplasia/chemically induced ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/pathology ; Testosterone Propionate ; Rats, Sprague-Dawley ; Prostate/drug effects ; Prostate/pathology ; Plant Extracts/pharmacology ; Rats ; Apoptosis/drug effects ; Disease Models, Animal ; Testosterone/blood ; Receptors, Androgen/metabolism ; Dihydrotestosterone/blood ; bcl-2-Associated X Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism
    Chemical Substances Testosterone Propionate (WI93Z9138A) ; Plant Extracts ; Testosterone (3XMK78S47O) ; Receptors, Androgen ; Dihydrotestosterone (08J2K08A3Y) ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16081189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Molecular insights into mineralotropic hormone inter-regulation.

    Pike, J Wesley / Lee, Seong Min / Meyer, Mark B

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1213361

    Abstract: The regulation of mineral homeostasis involves the three mineralotropic hormones PTH, FGF23 and 1,25-dihydroxyvitamin ... ...

    Abstract The regulation of mineral homeostasis involves the three mineralotropic hormones PTH, FGF23 and 1,25-dihydroxyvitamin D
    MeSH term(s) Humans ; Calcitriol/metabolism ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Parathyroid Hormone/metabolism ; Kidney/metabolism ; Calcium/metabolism
    Chemical Substances Calcitriol (FXC9231JVH) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1213361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D

    Lee, Seong Min / Meyer, Mark B / Benkusky, Nancy A / Pike, J Wesley

    The Journal of steroid biochemistry and molecular biology

    2023  Volume 232, Page(s) 106335

    Abstract: Phosphate (P) is an essential element involved in various biological actions, such as bone integrity, energy production, cell signaling and molecular component. P homeostasis is modulated by 4 main tissues; intestine, kidney, bone, and parathyroid gland, ...

    Abstract Phosphate (P) is an essential element involved in various biological actions, such as bone integrity, energy production, cell signaling and molecular component. P homeostasis is modulated by 4 main tissues; intestine, kidney, bone, and parathyroid gland, where 1,25-dihydroxyvitamin D
    MeSH term(s) Mice ; Animals ; Calcitriol/pharmacology ; Calcitriol/metabolism ; Phosphates ; Transcriptome ; Genome-Wide Association Study ; Vitamin D/pharmacology ; Vitamin D/metabolism ; 24,25-Dihydroxyvitamin D 3 ; Calcium/metabolism
    Chemical Substances 1,25-dihydroxyvitamin D (66772-14-3) ; Calcitriol (FXC9231JVH) ; Phosphates ; Vitamin D (1406-16-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-05-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2023.106335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diet of the wild boar (

    Lee, Seong-Min / Lee, Eun-Jae

    PeerJ

    2019  Volume 7, Page(s) e7835

    Abstract: The wild boar is one of the most widely distributed in the world. In South Korea, the wild boar population has rapidly increased and their habitat use has expanded from forests to urban environments. This expansion has led to increased conflicts with ... ...

    Abstract The wild boar is one of the most widely distributed in the world. In South Korea, the wild boar population has rapidly increased and their habitat use has expanded from forests to urban environments. This expansion has led to increased conflicts with humans, such as the severe damaging of crops and the attacking of people in urban areas. We assessed the stomach contents of wild boar killed by hunters in two different environments in Geochang and Seoul, South Korea, from 2012 to 2017. We compared the feeding habits between sites and between seasons and explored the relationship between the number of earthworms and the main diet. The diet of wild boars inhabiting the two environments were found to differ and vary seasonally. Wild boar in Geochang preferred crops, when available, to natural food resources. Although wild boar in Seoul also preferred crops, they had a higher composition of natural food in their diets because of a low availability of crops. The preference of crops and discarded food waste in urban areas is expected to have accelerated the appearance of wild boar in urban areas. The consumption of earthworms did not differ between the two study sites, but it did differ seasonally due to availability. The number of earthworms was significantly negatively correlated with crop availability in both sites. Effective management plans that involve targeted hunting by baiting with food in Seoul and direct hunting in the fall in Geochang should be implemented to resolve the human-wild boar conflicts in these areas.
    Language English
    Publishing date 2019-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.7835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of ceramic material and resin cement systems on the color stability of laminate veneers after accelerated aging.

    Lee, Seong-Min / Choi, Yu-Sung

    The Journal of prosthetic dentistry

    2018  Volume 120, Issue 1, Page(s) 99–106

    Abstract: Statement of problem: Laminate veneers are susceptible to color change during clinical service. Studies that compare the effects of different ceramic and resin cement systems on color stability are lacking.: Purpose: The purpose of this in vitro ... ...

    Abstract Statement of problem: Laminate veneers are susceptible to color change during clinical service. Studies that compare the effects of different ceramic and resin cement systems on color stability are lacking.
    Purpose: The purpose of this in vitro study was to evaluate the color stability of laminate veneers after accelerated aging using different ceramic and resin cement systems.
    Material and methods: Ceramic specimens (N=168; shade A1; thickness, 0.50 ±0.05 mm; diameter, 10.00 ±0.10 mm) were prepared using nanofluorapatite and lithium disilicate (high translucency [HT] to low translucency [LT]) ceramics. Light-polymerizing (LP) cements were classified by brightness (high or low). Dual-polymerizing cements were classified by composition (base-only [DB] or base-catalyst [DC]) for comparison of color stability on the basis of polymerization type. DB cement was light-polymerizing, whereas DC cement was dual-polymerizing. They were further classified by shade (transparent, white, or yellow [n=7, each]). Color difference (ΔE) values were obtained by spectrophotometric quantification of L* (lightness), a* (green-red), and b* (blue-yellow) values before and after aging. The Kruskal-Wallis, Mann-Whitney U, Wilcoxon signed rank, and Bonferroni post hoc tests were used for statistical analysis.
    Results: After specimens were subjected to accelerated aging, HT ceramic specimens luted with yellow-shade DC cement exhibited the greatest color change (ΔE=2.11), whereas HT and LT ceramic specimens luted with low-brightness LP cement exhibited the least color change (ΔE=1.37). In HT ceramic specimens, which exhibited the greatest color change of the 3 ceramic types, transparent shade cement exhibited significantly lower ΔE values than the other shades with DB (P<.001) and DC cements (P=.010). High-brightness cement exhibited significantly higher ΔE values than low-brightness cement when used with NF (P=.017), HT (P<.001), and LT (P<.001) ceramics. The ΔE values of DB cement were not always lower than those of DC cement. For all specimens, the aging of laminate veneers decreased the L* values and increased the a* and b* values.
    Conclusions: Ceramic and resin-cement systems affected the color stability of laminate veneers. Relative to other ceramics, HT lithium disilicate ceramics exhibited greater color changes upon aging. For HT ceramics, the use of transparent shade resin cement is recommended. The lower the brightness of resin cement, the higher the color stability of veneers. For luting of 0.5-mm-thick laminate veneers with dual-polymerizing cement, light polymerization did not yield better color stability than dual polymerization over time.
    MeSH term(s) Apatites/chemistry ; Ceramics/chemistry ; Color ; Dental Porcelain/chemistry ; Dental Veneers ; In Vitro Techniques ; Materials Testing ; Nanostructures/chemistry ; Resin Cements/chemistry ; Spectrophotometry ; Surface Properties
    Chemical Substances Apatites ; Resin Cements ; lithia disilicate ; Dental Porcelain (12001-21-7) ; fluorapatite (M4CM1H238J)
    Language English
    Publishing date 2018-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2017.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Polyion complex micelle formed from tetraphenylethene containing block copolymer.

    Lee, Seong Min / Jang, Woo-Dong

    Biomaterials research

    2017  Volume 21, Page(s) 17

    Abstract: Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block ... ...

    Abstract Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer.
    Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle.
    Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy.
    Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.
    Language English
    Publishing date 2017-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2775188-0
    ISSN 2055-7124 ; 1226-4601
    ISSN (online) 2055-7124
    ISSN 1226-4601
    DOI 10.1186/s40824-017-0103-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Overview of Systematic Reviews: Complementary Therapies for Cancer Patients.

    Lee, Seong Min / Choi, Ho Cheol / Hyun, Min Kyung

    Integrative cancer therapies

    2019  Volume 18, Page(s) 1534735419890029

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) China ; Complementary Therapies/methods ; Humans ; Neoplasms/therapy ; Quality of Life
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2182320-0
    ISSN 1552-695X ; 1534-7354
    ISSN (online) 1552-695X
    ISSN 1534-7354
    DOI 10.1177/1534735419890029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genomic Mechanisms Governing Mineral Homeostasis and the Regulation and Maintenance of Vitamin D Metabolism.

    Pike, J Wesley / Lee, Seong Min / Benkusky, Nancy A / Meyer, Mark B

    JBMR plus

    2020  Volume 5, Issue 1, Page(s) e10433

    Abstract: Our recent genomic studies identified a complex kidney-specific enhancer module located within the introns of ... ...

    Abstract Our recent genomic studies identified a complex kidney-specific enhancer module located within the introns of adjacent
    Language English
    Publishing date 2020-12-05
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D

    Lee, Seong Min / Pike, J Wesley

    The Journal of steroid biochemistry and molecular biology

    2016  Volume 164, Page(s) 265–270

    Abstract: The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin ... ...

    Abstract The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin D
    MeSH term(s) 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/deficiency ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Animals ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Calcitriol/metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Hair/metabolism ; Hair/pathology ; Humans ; Mice ; Mice, Knockout ; Parathyroid Hormone/blood ; Parathyroid Hormone/genetics ; Receptors, Calcitriol/deficiency ; Receptors, Calcitriol/genetics ; Rickets, Hypophosphatemic/genetics ; Rickets, Hypophosphatemic/metabolism ; Rickets, Hypophosphatemic/pathology ; Signal Transduction ; Transcription, Genetic
    Chemical Substances Parathyroid Hormone ; Receptors, Calcitriol ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2015.08.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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