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Article ; Online: CRISPR-based identification of N-terminal acetylation in synucleinopathies.

Bae, Eun-Jin / Lee, Seung-Jae

2024

Abstract: A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the ... ...

Abstract	A recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	282488-7
ISSN	1878-108X ; 0378-5912 ; 0166-2236
ISSN (online)	1878-108X
ISSN	0378-5912 ; 0166-2236
DOI	10.1016/j.tins.2024.03.006
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Zs.A 1442: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficient Super-Resolution Method for Targets Observed by Satellite SAR.

Lee, Seung-Jae / Lee, Sun-Gu

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 13

Abstract: This study presents an efficient super-resolution (SR) method for targets observed by satellite synthetic aperture radar (SAR). First, a small target image is extracted from a large-scale SAR image and undergoes proper preprocessing. The preprocessing ... ...

Abstract	This study presents an efficient super-resolution (SR) method for targets observed by satellite synthetic aperture radar (SAR). First, a small target image is extracted from a large-scale SAR image and undergoes proper preprocessing. The preprocessing step is adaptively designed depending on the types of movements of targets. Next, the principal scattering centers of targets are extracted using the compressive sensing technique. Subsequently, an impulse response function (IRF) of the satellite SAR system (IRF-S) is generated using a SAR image of a corner reflector located at the calibration site. Then, the spatial resolution of the IRF-S is improved by the spectral estimation technique. Finally, according to the SAR signal model, the super-resolved IRF-S is combined with the extracted scattering centers to generate a super-resolved target image. In our experiments, the SR capabilities for various targets were investigated using quantitative and qualitative analysis. Compared with conventional SAR SR methods, the proposed scheme exhibits greater robustness towards improvement of the spatial resolution of the target image when the degrees of SR are high. Additionally, the proposed scheme has faster computation time (CT) than other SR algorithms, irrespective of the degree of SR. The novelties of this study can be summarized as follows: (1) the practical design of an efficient SAR SR scheme that has robustness at a high SR degree; (2) the application of proper preprocessing considering the types of movements of targets (i.e., stationary, moderate motion, and complex motion) in SAR SR processing; (3) the effective evaluation of SAR SR capability using various metrics such as peak signal-to-noise ratio (PSNR), structural similarity index (SSIM), focus quality parameters, and CT, as well as qualitative analysis.
MeSH term(s)	Radar ; Algorithms ; Signal-To-Noise Ratio ; Data Compression
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23135893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ant-Agonizing Aging without Tradeoffs in Queens.

Lee, Hanseul / Lee, Seung-Jae V

Molecules and cells

2023 Volume 46, Issue 7, Page(s) 417–419

MeSH term(s)	Animals ; Ants ; Aging ; Female
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2023.0069
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Zs.A 4713: Show issues

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Article: Standardization of the Korean Version of the Acceptance and Action Questionnaire for Obsessions and Compulsions in University Students and Patients With Obsessive-Compulsive Disorder.

Lee, Seung Jae / Lee, Sang Won / Choi, Mina

Psychiatry investigation

2024 Volume 21, Issue 3, Page(s) 275–283

Abstract: Objective: The Acceptance and Action Questionnaire for Obsessions and Compulsions (AAQ-OC) is a version of the Acceptance and Action Questionnaire (AAQ) that specifically measures unwanted intrusive thoughts and responses (e.g., experiential avoidance) ... ...

Abstract	Objective: The Acceptance and Action Questionnaire for Obsessions and Compulsions (AAQ-OC) is a version of the Acceptance and Action Questionnaire (AAQ) that specifically measures unwanted intrusive thoughts and responses (e.g., experiential avoidance) to them. This study aimed to investigate the reliability and validity of the Korean version of the AAQ-OC in clinical and nonclinical Korean samples. Methods: In this study, 561 university students and 121 patients with obsessive-compulsive disorder (OCD) completed the AAQ-OC and several other psychological scales. Descriptive, correlation, and exploratory and confirmatory factor analyses as well as group comparisons were conducted. Results: The results of the exploratory and confirmatory factor analyses indicated a two-factor structure that best fits the data in the university sample: Factors 1 and 2 matched the original Valued Action and Willingness subscales, respectively. The reliability analyses revealed that the AAQ-OC and its factors had excellent internal consistencies. As regards the concurrent validity, the AAQ-OC and its factors had a positive correlation with the AAQ-II and Cognitive Fusion Questionnaire. Compared with the university students, the OCD patients had higher AAQ-OC scores, and their obsessive-compulsive symptoms, particularly the two symptom dimensions of responsibility for harm and mistakes and unacceptable thoughts, were significantly associated with the AAQ-OC and two subscales. Conclusion: The findings of this study confirm the reliability and validity of the Korean version of the AAQ-OC.
Language	English
Publishing date	2024-03-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2414364-9
ISSN	1976-3026 ; 1738-3684
ISSN (online)	1976-3026
ISSN	1738-3684
DOI	10.30773/pi.2023.0240
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Zs.A 6598: Show issues

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Article ; Online: Brief guide to RNA sequencing analysis for nonexperts in bioinformatics.

Lee, Gee-Yoon / Ham, Seokjin / Lee, Seung-Jae V

Molecules and cells

2024 , Page(s) 100060

Abstract: Transcriptome analysis is widely used for current biological research, but remains challenging for many experimental scientists. Here, we present a brief but broad guideline for transcriptome analysis, focusing on RNA sequencing, by providing the list of ...

Abstract	Transcriptome analysis is widely used for current biological research, but remains challenging for many experimental scientists. Here, we present a brief but broad guideline for transcriptome analysis, focusing on RNA sequencing, by providing the list of publicly available datasets, tools, and R packages for practical transcriptome analysis. This work will be useful for biologists to perform key transcriptomic analysis with minimum expertise in bioinformatics.
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Letter
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.1016/j.mocell.2024.100060
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Article ; Online: Super-Resolution Procedure for Target Responses in KOMPSAT-5 Images.

Lee, Seung-Jae / Lee, Sun-Gu

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 19

Abstract: Recently, target analysis using satellite SAR images has received much attention in the area of satellite SAR remote sensing. Because the spatial resolution of the target response in the satellite SAR image is a main factor that has a large effect on ... ...

Abstract	Recently, target analysis using satellite SAR images has received much attention in the area of satellite SAR remote sensing. Because the spatial resolution of the target response in the satellite SAR image is a main factor that has a large effect on target analysis performances, the improvement of the spatial resolution of target response is required to enhance the target analysis capability. However, the spatial resolution is already determined in the satellite SAR system design process. To solve the above problem, the super-resolution techniques that have been applied to radar images can be utilized. However, the application of the super-resolution techniques to the target response in the satellite SAR image is not simple due to the following reasons. First, the target's motion induces severe blurring of the target response, which impedes the successful improvement of spatial resolution. Next, the zero-region in the frequency spectrum of the target image containing the target response also hinders the generation of the super-resolved image. To successfully improve spatial resolution of the satellite SAR image, the super-resolution techniques should be combined with proper preprocessing steps that can cope with the above two issues. In this paper, the whole super-resolution procedure for target responses in KOMPSAT-5 images is described. To the best of the authors' knowledge, the description of the whole super-resolution procedure for target responses is the first ever attempt in the area of satellite SAR. First, a target image containing the target response is extracted from a large-scale KOMPSAT-5 image. Subsequently, the target image is transformed to be appropriate for the utilization of super-resolution techniques by proper preprocessing steps, considering the direction of super resolution and the motion of the target. Then, some super-resolution techniques are utilized to improve the spatial resolutions and qualities of the target images. The super-resolution performances of the proposed scheme are validated using various target images for point static, extended static, and extended moving targets. The novelties of this paper can be summarized as follows: (1) the practical design of whole super-resolution processing for real satellite SAR images; (2) the performance evaluation of super-resolution techniques on real satellite SAR images. The results show that the proposed scheme can led to noticeable improvements of spatial resolution of the target images for various types of targets with reliable computation times. In addition, the proposed scheme also enhanced PSLR, ISLR, and IC, leading to clearer scattering information of the principal scatterers. Consequently, the proposed method can assist in extracting more precise and meaningful information for targets represented in KOMPSAT-5 images, which means great potential for target recognition.
MeSH term(s)	Motion
Language	English
Publishing date	2022-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22197189
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Article ; Online: Multimodal deep learning applied to classify healthy and disease states of human microbiome.

Lee, Seung Jae / Rho, Mina

Scientific reports

2022 Volume 12, Issue 1, Page(s) 824

Abstract: Metagenomic sequencing methods provide considerable genomic information regarding human microbiomes, enabling us to discover and understand microbial diseases. Compositional differences have been reported between patients and healthy people, which could ... ...

Abstract	Metagenomic sequencing methods provide considerable genomic information regarding human microbiomes, enabling us to discover and understand microbial diseases. Compositional differences have been reported between patients and healthy people, which could be used in the diagnosis of patients. Despite significant progress in this regard, the accuracy of these tools needs to be improved for applications in diagnostics and therapeutics. MDL4Microbiome, the method developed herein, demonstrated high accuracy in predicting disease status by using various features from metagenome sequences and a multimodal deep learning model. We propose combining three different features, i.e., conventional taxonomic profiles, genome-level relative abundance, and metabolic functional characteristics, to enhance classification accuracy. This deep learning model enabled the construction of a classifier that combines these various modalities encoded in the human microbiome. We achieved accuracies of 0.98, 0.76, 0.84, and 0.97 for predicting patients with inflammatory bowel disease, type 2 diabetes, liver cirrhosis, and colorectal cancer, respectively; these are comparable or higher than classical machine learning methods. A deeper analysis was also performed on the resulting sets of selected features to understand the contribution of their different characteristics. MDL4Microbiome is a classifier with higher or comparable accuracy compared with other machine learning methods, which offers perspectives on feature generation with metagenome sequences in deep learning models and their advantages in the classification of host disease status.
MeSH term(s)	Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/microbiology ; Deep Learning ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/microbiology ; Genome, Microbial/genetics ; Healthy Volunteers ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/microbiology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/microbiology ; Metagenome/genetics ; Metagenomics/methods ; Microbiota/genetics
Language	English
Publishing date	2022-01-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-04773-3
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Article ; Online: Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in

Lee, Hanseul / Lee, Seung-Jae V

Molecules and cells

2022 Volume 45, Issue 11, Page(s) 763–770

Abstract: Caenorhabditis ... ...

Abstract	Caenorhabditis elegans
MeSH term(s)	Animals ; Humans ; Caenorhabditis elegans/genetics ; Insulin-Like Growth Factor I/metabolism ; Insulin/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Longevity/genetics ; Aging/metabolism
Chemical Substances	Insulin-Like Growth Factor I (67763-96-6) ; Insulin ; Caenorhabditis elegans Proteins
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2022.0097
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Selective interactions of Co

Hwang, Yunha / Jeong, Jae-Hee / Lee, Dong-Heon / Lee, Seung Jae

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 2, Page(s) 428–433

Abstract: Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained ... ...

Abstract	Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained Co
MeSH term(s)	Concanavalin A/chemistry ; Mannose ; Polysaccharides/chemistry ; Carbohydrates ; Crystallography, X-Ray
Chemical Substances	Concanavalin A (11028-71-0) ; Mannose (PHA4727WTP) ; Polysaccharides ; Carbohydrates
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt03575a
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Article ; Online: Increased risk of dementia after transient global amnesia: a nationwide population-based, longitudinal follow-up study in South Korea.

Lee, Seung-Jae / Lee, Tae-Kyeong / Bae, Yoon-Jong / Kim, Mina

Neuroepidemiology

2024

Abstract: Introduction: The long-term cognitive outcomes after transient global amnesia (TGA) have been contradictory in the literature. Our study aimed to longitudinally investigate the association between TGA and incident dementia using long-term data from a ... ...

Abstract	Introduction: The long-term cognitive outcomes after transient global amnesia (TGA) have been contradictory in the literature. Our study aimed to longitudinally investigate the association between TGA and incident dementia using long-term data from a nationwide population-based cohort in South Korea. Methods: The study population was recruited between 2002 and 2020 using the International Classification of Diseases (tenth revision; ICD-10) codes from the Korean National Health Insurance Service database. The cumulative incidence curve was plotted to compare the incidence of dementia between the TGA (ICD-10 code G45.4; n = 10,276) and non-TGA (n = 27,389) groups, determined using 1:3 propensity score matching. Using Cox proportional hazard regression models, we obtained crude and adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for the incident dementia in patients with TGA compared to non-TGA controls. To examine independent variables determining dementia in the TGA group, logistic regression analysis was performed, and adjusted odds ratios (aORs) and 95% CIs were calculated. Results: The TGA group had a significantly higher cumulative incidence of dementia than the non-TGA group (p <0.001, log-rank test). TGA was significantly associated with incident dementia in the univariate and multivariate Cox models (HR 1.34, 95% CI 1.28-1.39 and aHR 1.40, 95% CI 1.34-1.46, respectively). The adjusted logistic regression for incident dementia in the TGA group showed that age (per 1 year, aOR 1.09, 95% CI 1.09-1.10), female sex (aOR 1.31, 95% CI 1.18-1.45), diabetes (aOR 1.21, 95% CI 1.08-1.35), stroke (aOR 1.30, 95% CI 1.16-1.46), depression (aOR 1.53, 95% CI 1.33-1.76), anxiety (aOR 1.24, 95% CI 1.01-1.39), and rural residence (aOR 1.24, 95% CI 1.10-1.41) were independently associated with incident dementia. Conclusion: Our results suggest a longitudinal association of TGA with incident dementia.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000536529
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