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  1. Article: Inelastic Responses and Finite Element Predictions of Fiber Cementitious Composite and Concrete Columns.

    Cho, Chang-Geun / Lee, Sun-Ju

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 9

    Abstract: In this research, reinforced concrete (RC) and strain-hardening cementitious composite (SHCC) columns subjected to lateral loads combined with a constant load were investigated, both by experiments and predictions, with two distributed inelastic finite ... ...

    Abstract In this research, reinforced concrete (RC) and strain-hardening cementitious composite (SHCC) columns subjected to lateral loads combined with a constant load were investigated, both by experiments and predictions, with two distributed inelastic finite element models established by the stiffness and flexibility formulations. SHCC applied in the column plastic hinge region could not only enhance the lateral load and displacement capacities of columns but also offer effective advantages in the control of bending and shear cracks induced by multiple microcracks, the prevention of the spalling of cover concrete, and the resistance to buckling of steel bars. With the layered cross-sectional approach using constitutive laws of SHCC considering a proposed model of the post-cracked high-ductile tensile characteristics, as well as concrete and reinforcing steel bars, an inelastic beam-column finite element model was presented with a distributed flexibility formulation. In comparison with experiments concerning the RC and reinforced strain-hardening cementitious composite (R-SHCC) columns, the current flexibility method showed relatively accurate estimations in the lateral load and displacement responses of column systems as well as in localized nonlinear responses of cross-section as estimated in axial strains of longitudinal reinforcing steel bars. In comparison with the stiffness method, the current flexibility method gave more accurate solutions at both element and structural levels, as manifested in the experiments and analysis solutions.
    Language English
    Publishing date 2021-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14092180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: S100 Calcium-Binding Protein A9, a Potential Novel Diagnostic Biomarker for Idiopathic Pulmonary Fibrosis.

    Lee, Jong-Uk / Kim, Min Kyung / Kim, Myung-Shin / Lee, Sun Ju / Park, Seung-Lee / Chang, Hun Soo / Park, Jong-Sook / Park, Choon-Sik

    Journal of Korean medical science

    2024  Volume 39, Issue 1, Page(s) e13

    Abstract: Background: Neutrophilic inflammation is a characteristic feature of idiopathic pulmonary fibrosis (IPF). S100 calcium-binding protein A9 (S100A9) is a neutrophil-derived protein involved in the development of neutrophil-related chronic inflammatory ... ...

    Abstract Background: Neutrophilic inflammation is a characteristic feature of idiopathic pulmonary fibrosis (IPF). S100 calcium-binding protein A9 (S100A9) is a neutrophil-derived protein involved in the development of neutrophil-related chronic inflammatory disorders. However, the role of S100A9 in IPF remains unclear.
    Methods: We used enzyme-linked immunosorbent assays to measure S100A9 levels in bronchoalveolar lavage fluid (BALF) and serum obtained from healthy controls (HCs) and patients with IPF, non-specific interstitial pneumonia, hypersensitivity pneumonitis, and sarcoidosis.
    Results: Compared with HCs, BALF S100A9 levels were significantly higher in IPF patients (
    Conclusion: S100A9 is involved in the development and progression of IPF. Moreover, S100A9 levels in BALF and serum may be surrogate markers for IPF diagnosis and survival prediction, particularly when analyzed in combination with neutrophil percentages.
    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Inflammation ; Alveolitis, Extrinsic Allergic ; Bronchoalveolar Lavage Fluid ; Calgranulin B
    Chemical Substances Calgranulin B
    Language English
    Publishing date 2024-01-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2024.39.e13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect analysis on waste recycling by introducing a new policy, "Environmental Assessment of Recycling," for establishment of the ESG management system in the Republic of Korea.

    Yoo, Heung-Min / Kang, Jang-Hyun / Lee, Sun-Ju / Jang, Su-Han / Yoon, Young-Sam / Kang, Youngyeul

    Integrated environmental assessment and management

    2024  

    Abstract: To move away from linear system mining-manufacture-production-disposal, most countries have been trying to establish a circular economy, by reusing waste as resources. Responding to this paradigm change, the Ministry of Environment of Korea amended the ... ...

    Abstract To move away from linear system mining-manufacture-production-disposal, most countries have been trying to establish a circular economy, by reusing waste as resources. Responding to this paradigm change, the Ministry of Environment of Korea amended the Wastes Control Act in the 2010s. To increase the recycling rate in Korea, the environmental assessment of recycling (EAR) has been introduced to improve the Wastes Control Act. The whole process of new recycling technologies can be assessed in terms of environmental or technical aspects by assessment institutes of the EAR. Finally, the governmental research institute can approve of an application case, which proves environmental friendliness, even if the technology is not defined in the current act. Recently, 17 companies have been coassessed and approved to recycle steel codes in waste tires as resources for iron smelting via assessments of the whole process, such as environmental analysis and quality assessment. The EAR has been enforcing recycling materials for six years, and the total profit of the companies that were approved was estimated to be approximately 55 million USD. However, many amendments to the EAR continue to be requested by stakeholders. In this study, the effect of the EAR was evaluated, and additional tasks were found to enhance the EAR. Integr Environ Assess Manag 2024;00:1-13. © 2024 SETAC.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2234931-5
    ISSN 1551-3793 ; 1551-3777
    ISSN (online) 1551-3793
    ISSN 1551-3777
    DOI 10.1002/ieam.4896
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  4. Article ; Online: Interpretable machine learning to predict adverse perinatal outcomes: examining marginal predictive value of risk factors during pregnancy.

    Lee, Sun Ju / Garcia, Gian-Gabriel P / Stanhope, Kaitlyn K / Platner, Marissa H / Boulet, Sheree L

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 10, Page(s) 101096

    Abstract: Background: The timely identification of nulliparas at high risk of adverse fetal and neonatal outcomes during pregnancy is crucial for initiating clinical interventions to prevent perinatal complications. Although machine learning methods have been ... ...

    Abstract Background: The timely identification of nulliparas at high risk of adverse fetal and neonatal outcomes during pregnancy is crucial for initiating clinical interventions to prevent perinatal complications. Although machine learning methods have been applied to predict preterm birth and other pregnancy complications, many models do not provide explanations of their predictions, limiting the clinical use of the model.
    Objective: This study aimed to develop interpretable prediction models for a composite adverse perinatal outcome (stillbirth, neonatal death, estimated Combined Apgar score of <10, or preterm birth) at different points in time during the pregnancy and to evaluate the marginal predictive value of individual predictors in the context of a machine learning model.
    Study design: This was a secondary analysis of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be data, a prospective cohort study in which 10,038 nulliparous pregnant individuals with singleton pregnancies were enrolled. Here, interpretable prediction models were developed using L1-regularized logistic regression for adverse perinatal outcomes using data available at 3 study visits during the pregnancy (visit 1: 6 0/7 to 13 6/7 weeks of gestation; visit 2: 16 0/7 to 21 6/7 weeks of gestation; visit 3: 22 0/7 to 29 6/7 weeks of gestation). We identified the important predictors for each model using SHapley Additive exPlanations, a model-agnostic method of computing explanations of model predictions, and evaluated the marginal predictive value of each predictor using the DeLong test.
    Results: Our interpretable machine learning model had an area under the receiver operating characteristic curves of 0.617 (95% confidence interval, 0.595-0.639; all predictor variables at visit 1), 0.652 (95% confidence interval, 0.631-0.673; all predictor variables at visit 2), and 0.673 (95% confidence interval, 0.651-0.694; all predictor variables at visit 3). For all visits, the placental biomarker inhibin A was a valuable predictor, as including inhibin A resulted in better performance in predicting adverse perinatal outcomes (P<.001, all visits). At visit 1, endoglin was also a valuable predictor (P<.001). At visit 2, free beta human chorionic gonadotropin (P=.001) and uterine artery pulsatility index (P=.023) were also valuable predictors. At visit 3, cervical length was also a valuable predictor (P<.001).
    Conclusion: Despite various advances in predictive modeling in obstetrics, the accurate prediction of adverse perinatal outcomes remains difficult. Interpretable machine learning can help clinicians understand how predictions are made, but barriers exist to the widespread clinical adoption of machine learning models for adverse perinatal outcomes. A better understanding of the evolution of risk factors for adverse perinatal outcomes throughout pregnancy is necessary for the development of effective interventions.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Pregnancy ; Placenta ; Pregnancy Outcome/epidemiology ; Pregnancy Trimester, Third ; Premature Birth/diagnosis ; Premature Birth/epidemiology ; Premature Birth/etiology ; Prospective Studies ; Risk Factors ; Ultrasonography, Prenatal/methods ; Machine Learning
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Role of Erythrocyte Membrane Protein Band 4.1-like 3 in Idiopathic Pulmonary Fibrosis.

    Kim, Min Kyung / Lee, Jong-Uk / Lee, Sun Ju / Chang, Hun Soo / Park, Jong-Sook / Park, Choon-Sik

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Novel genetic and epigenetic factors involved in the development and prognosis of idiopathic pulmonary fibrosis (IPF) have been identified. We previously observed that erythrocyte membrane protein band 4.1-like 3 ( ...

    Abstract Novel genetic and epigenetic factors involved in the development and prognosis of idiopathic pulmonary fibrosis (IPF) have been identified. We previously observed that erythrocyte membrane protein band 4.1-like 3 (
    MeSH term(s) Humans ; Transforming Growth Factor beta1/metabolism ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung/metabolism ; Fibroblasts/metabolism ; Epithelial-Mesenchymal Transition/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Cadherins/metabolism ; Microfilament Proteins/metabolism
    Chemical Substances erythrocyte membrane band 4.1 protein ; Transforming Growth Factor beta1 ; RNA, Messenger ; Cadherins ; EPB41L3 protein, human ; Microfilament Proteins
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210182
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  6. Article ; Online: Synergistic Effect of Saccharin and Caffeine on Antiproliferative Activity in Human Ovarian Carcinoma Ovcar-3 Cells.

    Lee, Sun Ju / Park, Sang-Yong / Bak, Subin / Lee, Min-Woo / Lim, Dae Jin / Kim, Hyeong-Dong / Kim, Dong-Gil / Kim, Suhng Wook

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: The purpose of this study was to confirm the antiproliferative and apoptotic induction potential of a saccharin and caffeine combination in ovarian cancer cells. The cell line used was Ovcar-3, and the cell viability was measured through a WST-8 assay, ... ...

    Abstract The purpose of this study was to confirm the antiproliferative and apoptotic induction potential of a saccharin and caffeine combination in ovarian cancer cells. The cell line used was Ovcar-3, and the cell viability was measured through a WST-8 assay, while a Chou-Talalay assay was used to confirm the synergistic effect of saccharin and caffeine on the ovarian cancer cells. A clonogenic assay, annexin V-FITC/PI-PE double-staining, and RT-PCR were performed to confirm the expression of genes that induce colony formation, cell viability, and apoptosis in ovarian cancer cells treated with the saccharin-caffeine combination. It was demonstrated that both saccharin and caffeine decreased the viability of Ovcar-3 cells, and the cell viability decreased even more significantly when the cells were treated with the combination of saccharin and caffeine. The clonogenic assay results showed that the number of colonies decreased the most when saccharin and caffeine were combined, and the number of colonies also significantly decreased compared to the single-treatment groups. Based on flow cytometry analysis using annexin V-FITC/PI-PE double-staining, it was confirmed that the decrease in cell viability caused by the combination of saccharin and caffeine was correlated with the induction of apoptosis. The results of the RT-PCR confirmed that the combined treatment of saccharin and caffeine promoted cell apoptosis by regulating the expression of apoptosis-inducing genes. These results demonstrate that the combination of saccharin and caffeine more efficiently inhibits the proliferation of Ovcar-3 cells and induces apoptosis in vitro.
    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Caffeine/pharmacology ; Apoptosis ; Saccharin/pharmacology ; Cell Proliferation ; Cell Line, Tumor ; Carcinoma, Ovarian Epithelial
    Chemical Substances Caffeine (3G6A5W338E) ; Saccharin (FST467XS7D)
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914445
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  7. Article ; Online: Development of a Simple Direct and Hot-Start PCR Using

    Lee, Sun Ju / Park, Sang-Yong / Lee, Kwang-Ho / Lee, Min-Woo / Yu, Chae-Yeon / Maeng, Jaeyoung / Kim, Hyeong-Dong / Kim, Suhng Wook

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: ... ...

    Abstract Taq
    MeSH term(s) Taq Polymerase ; Escherichia coli/metabolism ; Polymerase Chain Reaction/methods ; DNA ; DNA Replication
    Chemical Substances Taq Polymerase (EC 2.7.7.-) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Aspirin Challenge-Induced Genome-Wide DNA Methylation Profile of Peripheral Blood Lymphocytes in Aspirin-Exacerbated Respiratory Disease.

    Lee, Jong-Uk / Chang, Hun Soo / Shim, Ji-Su / Kim, Min-Hye / Cho, Young-Joo / Kim, Min Kyung / Park, Seung-Lee / Lee, Sun Ju / Park, Jong-Sook / Park, Choon-Sik

    DNA and cell biology

    2024  Volume 43, Issue 3, Page(s) 132–140

    Abstract: Genetic variation and epigenetic factors are thought to contribute to the development of hypersensitivity to aspirin. DNA methylation fluctuates dynamically throughout the day. To discover new CpG methylation in lymphocytes associated with aspirin- ... ...

    Abstract Genetic variation and epigenetic factors are thought to contribute to the development of hypersensitivity to aspirin. DNA methylation fluctuates dynamically throughout the day. To discover new CpG methylation in lymphocytes associated with aspirin-exacerbated respiratory disease (AERD), we evaluated changes in global CpG methylation profiles from before to after an oral aspirin challenge in patients with AERD and aspirin-tolerant asthma (ATA). Whole-genome CpG methylation levels of peripheral blood mononuclear cells were quantified with an Illumina 860K Infinium Methylation EPIC BeadChip array and then adjusted for inferred lymphocyte fraction (ILF) with GLINT and Tensor Composition Analysis. Among the 866,091 CpGs in the array, differentially methylated CpGs (DMCs) were found in 6 CpGs in samples from all 12 patients with asthma included in the study (AERD,
    MeSH term(s) Humans ; Aspirin/adverse effects ; Leukocytes, Mononuclear/metabolism ; DNA Methylation ; Asthma, Aspirin-Induced/genetics ; Asthma, Aspirin-Induced/metabolism ; Asthma/genetics ; Lymphocytes/metabolism
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2023.0218
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  9. Article: Decadal Measurements of the First Geostationary Ocean Color Satellite (GOCI) Compared with MODIS and VIIRS Data

    Park, Myung-Sook / Lee, Seonju / Ahn, Jae-Hyun / Lee, Sun-Ju / Choi, Jong-Kuk / Ryu, Joo-Hyung

    Remote Sensing. 2021 Dec. 24, v. 14, no. 1

    2021  

    Abstract: The first geostationary ocean color data from the Geostationary Ocean Color Imager (GOCI) onboard the Communication, Ocean, and Meteorological Satellite (COMS) have been accumulating for more than ten years from 2010. This study performs a multi-year ... ...

    Abstract The first geostationary ocean color data from the Geostationary Ocean Color Imager (GOCI) onboard the Communication, Ocean, and Meteorological Satellite (COMS) have been accumulating for more than ten years from 2010. This study performs a multi-year quality assessment of GOCI chlorophyll-a (Chl-a) and radiometric data for 2012–2021 with an advanced atmospheric correction technique and a regionally specialized Chl-a algorithm. We examine the consistency and stability of GOCI, Moderate Resolution Imaging Spectroradiometer (MODIS), and Visible Infrared Imaging Radiometer Suite (VIIRS) level 2 products in terms of annual and seasonal climatology, two-dimensional frequency distribution, and multi-year time series. Overall, the GOCI agrees well with MODIS and VIIRS on annual and seasonal variability in Chl-a, as the central biological pattern of the most transparent waters over the western North Pacific, productive waters over the East Sea, and turbid waters over the Yellow Sea are reasonably represented. Overall, an excellent agreement is remarkable for western North Pacific oligotrophic waters (with a correlation higher than 0.91 for Chl-a and 0.96 for band-ratio). However, the sporadic springtime overestimation of MODIS Chl-a values compared with others is notable over the Yellow Sea and East Sea due to the underestimation of MODIS blue-green band ratios for moderate-high aerosol optical depth. The persistent underestimation of VIIRS Chl-a values compared with GOCI and MODIS occurs due to inherent sensor calibration differences. In addition, the artificially increasing trends in GOCI Chl-a (+0.48 mg m⁻³ per 9 years) arise by the decreasing trends in the band ratios. However, decreasing Chl-a trends in MODIS and VIIRS (−0.09 and −0.08 mg m⁻³, respectively) are reasonable in response to increasing sea surface temperature. The results indicate GOCI sensor degradation in the late mission period. The long-term application of the GOCI data should be done with a caveat, however; planned adjustments to GOCI calibration (2022) in the following GOCI-II satellite will essentially eliminate the bias in Chl-a trends.
    Keywords aerosols ; algorithms ; chlorophyll ; climatology ; color ; frequency distribution ; radiometry ; satellites ; seasonal variation ; spring ; surface water temperature ; time series analysis ; Yellow Sea
    Language English
    Dates of publication 2021-1224
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs14010072
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Application of material flow analysis for plastic waste management in the Republic of Korea

    Lee, Min-Yong / Cho, Na-Hyeon / Lee, Sun-Ju / Um, Namil / Jeon, Tae-Wan / Kang, Young-Yeul

    Journal of environmental management. 2021 Dec. 01, v. 299

    2021  

    Abstract: The indiscriminate use of plastics and careless management of plastic waste have caused serious environmental challenges globally. The Republic of Korea (ROK) aims to address the issue by reducing plastic waste generation by up to 50%, and increasing ... ...

    Abstract The indiscriminate use of plastics and careless management of plastic waste have caused serious environmental challenges globally. The Republic of Korea (ROK) aims to address the issue by reducing plastic waste generation by up to 50%, and increasing recycling rate by up to 70%, by 2030. To determine the status and future directions for plastic waste management in the ROK, the present study undertook two tasks: (i) a material flow analysis of plastic waste material from industrial sectors to assess the current status of plastic waste recycling and treatment, (ii) an analysis of the material flow of plastic waste based on the “Waste Classification Code.” According to the findings, 6.202 million metric tons of plastic waste were generated in 2018, out of which 69%, 25%, and 0.5% was recycled, incinerated, and landfilled, respectively. The recycling rate of synthetic resin waste, which accounts for 96% of synthetic waste polymers discharged in the industrial sector, was 69%, which is a very high rate. However, the closed-loop recycling rate was only 33%. Therefore, the system of management of synthetic resin waste discharge without classification of raw materials should be improved to increase the closed-loop recycling rate of synthetic waste polymers. Furthermore, to increase the closed-loop recycling rate, we suggest the subdivision of synthetic resin waste (51-03-01) in plastic waste classification to improve the discharge separation system, which has been mismanaged. Furthermore, we suggest the formulation of a new management strategy for plastic waste, in accordance with those of other hazardous substances, as regulated by the Waste Control Act.
    Keywords material flow analysis ; wastes ; South Korea
    Language English
    Dates of publication 2021-1201
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2021.113625
    Database NAL-Catalogue (AGRICOLA)

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