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Article ; Online: The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers.

Yoon, Ye Eun / Jung, Young Jae / Lee, Sung-Joon

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: The prevalence of two major types of skin cancer, melanoma and non-melanoma skin cancer, has been increasing worldwide. Skin cancer incidence is estimated to rise continuously over the next 20 years due to ozone depletion and an increased life expectancy. ...

Abstract	The prevalence of two major types of skin cancer, melanoma and non-melanoma skin cancer, has been increasing worldwide. Skin cancer incidence is estimated to rise continuously over the next 20 years due to ozone depletion and an increased life expectancy. Chemotherapeutic agents could affect healthy cells, and thus may be toxic to them and cause numerous side effects or drug resistance. Phytochemicals that are naturally occurring in fruits, plants, and herbs are known to possess various bioactive properties, including anticancer properties. Although the effects of phytochemicals are relatively milder than chemotherapeutic agents, the long-term intake of phytochemicals may be effective and safe in preventing tumor development in humans. Diverse phytochemicals have shown anti-tumorigenic activities for either melanoma or non-melanoma skin cancer. In this review, we focused on summarizing recent research findings of the natural and dietary terpenoids (eucalyptol, eugenol, geraniol, linalool, and ursolic acid) that have anticancer activities for both melanoma and non-melanoma skin cancers. These terpenoids may be helpful to protect skin collectively to prevent tumorigenesis of both melanoma and nonmelanoma skin cancers.
MeSH term(s)	Humans ; Skin Neoplasms/drug therapy ; Skin Neoplasms/prevention & control ; Skin Neoplasms/pathology ; Terpenes/pharmacology ; Terpenes/therapeutic use ; Melanoma/drug therapy ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Antineoplastic Agents, Phytogenic/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytochemicals/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
Chemical Substances	Terpenes ; Antineoplastic Agents, Phytogenic ; Phytochemicals ; Antineoplastic Agents
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084423
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Article ; Online: Azelaic acid induces cholecystokinin secretion and reduces fat-rich food preference via activation of Olfr544

Chae, Moonki / Wu, Chunyan / Shin, Jaeeun / Lee, Sung-Joon

Journal of Functional Foods. 2023 June, v. 105 p.105577-

2023

Abstract: Olfactory receptor 544 (Olfr544) is expressed in extra-nasal tissues and has been shown to reduce adiposity and shift fuel preference to fats. Here, we investigated whether Olfr544 regulates feeding behavior. Azelaic acid increased cholecystokinin (CCK) ... ...

Abstract	Olfactory receptor 544 (Olfr544) is expressed in extra-nasal tissues and has been shown to reduce adiposity and shift fuel preference to fats. Here, we investigated whether Olfr544 regulates feeding behavior. Azelaic acid increased cholecystokinin (CCK) secretion ex vivo and in vivo by Olfr544 dependently. In a two-food choice study, oral administration of azelaic acid reduced high fat diet (HFD) intake and increased normal diet (ND) intake, which was abolished in Olfr544-knockout mice. In a two-bottle preference test, the oral administration of azelaic acid reduced the intake of linoleic acid solution while increasing the intake of control solution (xanthan gum) and the effect of azelaic acid disappeared in Olfr544-knockout mice. Intraperitoneal injection of proglumide, a CCK-1/2 receptor antagonist, negated the effect of azelaic acid in reducing fat preference. Collectively, our findings suggested that Olfr544 activation by azelaic acid reduced calorie-rich high-fat food intake mediated, at least in part, by CCK secretion.
Keywords	adiposity ; antagonists ; cholecystokinin ; food choices ; food intake ; fuels ; high fat diet ; high fat foods ; intraperitoneal injection ; linoleic acid ; olfactory receptors ; oral administration ; secretion ; xanthan gum ; Ectopic olfactory receptor ; Olfr544 ; Azelaic acid ; Fat preference
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105577
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Article ; Online: Enhancing Single Photon Emission Purity via Design of van der Waals Heterostructures.

Chuang, Hsun-Jen / Stevens, Christopher E / Rosenberger, Matthew R / Lee, Sung-Joon / McCreary, Kathleen M / Hendrickson, Joshua R / Jonker, Berend T

Nano letters

2024

Abstract: Quantum emitters are essential components of quantum photonic circuitry envisioned beyond the current optoelectronic state-of-the-art. Two dimensional materials are attractive hosts for such emitters. However, the high single photon purity required is ... ...

Abstract	Quantum emitters are essential components of quantum photonic circuitry envisioned beyond the current optoelectronic state-of-the-art. Two dimensional materials are attractive hosts for such emitters. However, the high single photon purity required is rarely realized due to the presence of spectrally degenerate classical light originating from defects. Here, we show that design of a van der Waals heterostructure effectively eliminates this spurious light, resulting in purities suitable for a variety of quantum technological applications. Single photon purity from emitters in monolayer WSe
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.4c00683
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Article ; Online: Epidemiologic and Clinical Features of

Cho, Hyunseok / Lee, Sang Hoon / Lee, Jung Ho / Lee, Sung Joon / Park, Sung Chul

Journal of Korean medical science

2023 Volume 38, Issue 9, Page(s) e67

Abstract: Background: With the increase in meals at home due to coronavirus disease 2019 (COVID-19), the pattern and incidence of enteritis seemed to change. Some types of enteritis, such as : Methods: We analyzed data from the Health Insurance Review and ... ...

Abstract	Background: With the increase in meals at home due to coronavirus disease 2019 (COVID-19), the pattern and incidence of enteritis seemed to change. Some types of enteritis, such as Methods: We analyzed data from the Health Insurance Review and Assessment Service. From 2016 to 2020, the International Classification of Diseases codes related to enteritis were examined to distinguish bacterial and viral enteritis and the trends of each were analyzed. The aspects of enteritis, before and after the COVID-19 outbreak, were compared. Results: Both bacterial and viral enteritis declined in all age groups from 2016 to 2020 ( Conclusion: Although the prevalence of bacterial and viral enteritis have decreased in COVID-19,
MeSH term(s)	Adolescent ; Child ; Humans ; COVID-19/epidemiology ; Gastroenteritis ; Campylobacter Infections/diagnosis ; Campylobacter Infections/epidemiology ; Enterocolitis ; Republic of Korea/epidemiology ; Intraabdominal Infections ; Campylobacter
Language	English
Publishing date	2023-03-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e67
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Article: Effects of dietary fibers and prebiotics in adiposity regulation via modulation of gut microbiota

Rivera-Piza, Adriana / Lee, Sung-Joon

Applied biological chemistry. 2020 Dec., v. 63, no. 1

2020

Abstract: The microbiota is indispensable for human health and the regulation of various body functions, including energy metabolism. The harmonic crosstalk between the microbiota and the intestinal epithelial barrier determines gut homeostasis and health status ... ...

Abstract	The microbiota is indispensable for human health and the regulation of various body functions, including energy metabolism. The harmonic crosstalk between the microbiota and the intestinal epithelial barrier determines gut homeostasis and health status in the healthy subject. Obesity and type 2 diabetes risk are, to some extent, explained by alterations in the microbiota. Since recent data indicate that the population of gut microorganisms can influence nutrient absorption and energy storage thus prevalence on obesity and metabolic disorders. Moreover, metabolic disease conditions, such as obesity, may be stimulated by genetic, environmental factors and by pathways that link metabolism with the immune system. On the basis of the above considerations, this review compiles the current results obtained in recent studies indicating the gut microbiota contribution to obesity development.
Keywords	adiposity ; dietary fiber ; energy ; energy metabolism ; environmental factors ; epithelium ; health status ; homeostasis ; human health ; immune system ; intestinal microorganisms ; intestines ; noninsulin-dependent diabetes mellitus ; nutrient uptake ; obesity ; prebiotics ; risk
Language	English
Dates of publication	2020-12
Size	p. 2.
Publishing place	Springer Singapore
Document type	Article
Note	Review
ZDB-ID	2846955-0
ISSN	2468-0842 ; 2468-0834
ISSN (online)	2468-0842
ISSN	2468-0834
DOI	10.1186/s13765-019-0482-9
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Article ; Online: Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index.

Lee, Jung Ho / Cho, Hyunseok / Lee, Sang Hoon / Lee, Sung Joon / Kang, Chang Don / Choi, Dae Hee / Park, Jin Myung / Nam, Seung-Joo / Kim, Tae Suk / Kim, Ji Hyun / Park, Sung Chul

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

2024 Volume 83, Issue 4, Page(s) 143–149

Abstract: Background/aims: Colorectal adenomas are precancerous lesions that may lead to colorectal cancer. Recent studies have shown that colorectal adenomas are associated with atherosclerosis. The cardio-ankle vascular index (CAVI) and ankle-brachial index ( ... ...

Abstract	Background/aims: Colorectal adenomas are precancerous lesions that may lead to colorectal cancer. Recent studies have shown that colorectal adenomas are associated with atherosclerosis. The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are noninvasive methods for evaluating atherosclerosis. This study examined the association between atherosclerosis and high-risk colorectal adenomas based on the CAVI and ABI. Methods: The data of patients aged ≥50 years who had a colonoscopy and CAVI and ABI measurements from August 2015 to December 2021 at the Kangwon National University Hospital were analyzed retrospectively. After the colonoscopy, subjects were divided into no, overall, and high-risk (size ≥1 cm, high-grade dysplasia or villous adenoma, three or more adenomas) adenoma groups based on the pathology findings. The data were subjected to univariate and multivariate logistic regression analyses. Results: Among the 1,164 subjects, adenomas and high-risk adenomas were found in 613 (52.6%) and 118 (10.1%) patients, respectively. The rate of positive ABI (<0.9) and positive CAVI (≥9.0) were significantly higher in the high-risk adenoma group (22.0% and 55.9%) than in the no adenoma (12.3% and 39.6%) and the overall adenoma group (15.7% and 44.0%) (p=0.008 and p=0.006, respectively). Multivariate analysis revealed a positive CAVI and smoking status to be significantly associated with high-risk adenoma with an odds ratio of 1.595 (95% confidence interval 1.055-2.410, p=0.027) and 1.579 (1.072-2.324, p=0.021), respectively. Conclusions: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.
MeSH term(s)	Humans ; Ankle Brachial Index ; Male ; Middle Aged ; Female ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Adenoma/diagnosis ; Adenoma/pathology ; Aged ; Atherosclerosis/diagnosis ; Colonoscopy ; Logistic Models ; Odds Ratio ; Risk Factors ; ROC Curve
Language	English
Publishing date	2024-04-24
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2611091-X
ISSN	2233-6869 ; 1598-9992
ISSN (online)	2233-6869
ISSN	1598-9992
DOI	10.4166/kjg.2024.003
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Article: Azelaic Acid Induces Mitochondrial Biogenesis in Skeletal Muscle by Activation of Olfactory Receptor 544.

Thach, Trung Thanh / Wu, Chunyan / Hwang, Kwang Yeon / Lee, Sung-Joon

Frontiers in physiology

2020 Volume 11, Page(s) 329

Abstract: Mouse olfactory receptor 544 (Olfr544) is ectopically expressed in varied extra-nasal organs with tissue specific functions. Here, we investigated the functionality of Olfr544 in skeletal muscle cells and tissue. The expression of Olfr544 is confirmed by ...

Abstract	Mouse olfactory receptor 544 (Olfr544) is ectopically expressed in varied extra-nasal organs with tissue specific functions. Here, we investigated the functionality of Olfr544 in skeletal muscle cells and tissue. The expression of Olfr544 is confirmed by RT-PCR and qPCR in skeletal muscle cells and mouse skeletal muscle assessed by RT-PCR and qPCR. Olfr544 activation by its ligand, azelaic acid (AzA, 50 μM), induced mitochondrial biogenesis and autophagy in cultured skeletal myotubes by induction of cyclic adenosine monophosphate-response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)-extracellular signal-regulated kinase-1/2 (ERK1/2) signaling axis. The silencing Olfr544 gene expression abrogated these effects of AzA in cultured myotubes. Similarly, in mice, the acute subcutaneous injection of AzA induced the CREB-PGC-1α-ERK1/2 pathways in mouse skeletal muscle, but these activations were negated in those of Olfr544 knockout mice. These demonstrate that the induction of mitochondrial biogenesis in skeletal muscle by AzA is Olfr544-dependent. Oral administration of AzA to high-fat-diet fed obese mice for 6 weeks increased mitochondrial DNA content in the skeletal muscle as well. Collectively, these findings demonstrate that Olfr544 activation by AzA regulates mitochondrial biogenesis in skeletal muscle. Intake of AzA or food containing AzA may help to improve skeletal muscle function.
Language	English
Publishing date	2020-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.00329
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Article ; Online: Therapeutic potential of ectopic olfactory and taste receptors.

Lee, Sung-Joon / Depoortere, Inge / Hatt, Hanns

Nature reviews. Drug discovery

2018 Volume 18, Issue 2, Page(s) 116–138

Abstract: Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral ... ...

Abstract	Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
MeSH term(s)	Animals ; Humans ; Neural Pathways/physiology ; Olfactory Mucosa/innervation ; Olfactory Mucosa/physiology ; Olfactory Receptor Neurons/physiology ; Taste/physiology ; Taste Buds
Language	English
Publishing date	2018-12-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2062954-0
ISSN	1474-1784 ; 1474-1776
ISSN (online)	1474-1784
ISSN	1474-1776
DOI	10.1038/s41573-018-0002-3
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Article: OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes.

Kim, Ji-Sun / Lee, Ha Lim / Jeong, Ji Hyun / Yoon, Ye Eun / Lee, In-Ryeong / Kim, Ji Min / Wu, Chunyan / Lee, Sung-Joon

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: Olfactory receptors (ORs) are the largest protein superfamily in mammals. Certain ORs are ectopically expressed in extranasal tissues and regulate cell type-specific signal transduction pathways. OR2AT4 is ectopically expressed in skin cells and promotes ...

Abstract	Olfactory receptors (ORs) are the largest protein superfamily in mammals. Certain ORs are ectopically expressed in extranasal tissues and regulate cell type-specific signal transduction pathways. OR2AT4 is ectopically expressed in skin cells and promotes wound healing and hair growth. As the capacities of wound healing and hair growth decline with aging, we investigated the role of OR2AT4 in the aging and senescence of human keratinocytes. OR2AT4 was functionally expressed in human keratinocytes (HaCaT) and exhibited co-expression with G-protein-coupled receptor signaling components, G
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11112180
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Article: Mechanism of Action of Cyanidin 3-O-Glucoside in Gluconeogenesis and Oxidative Stress-Induced Cancer Cell Senescence.

Jia, Yaoyao / Wu, Chunyan / Rivera-Piza, Adriana / Kim, Yeon-Ji / Lee, Ji Hae / Lee, Sung-Joon

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin abundant in fruits and vegetables that interacts and possibly modulates energy metabolism and oxidative stress. This study investigated the effect of C3G on gluconeogenesis and cancer cell senescence. ...

Abstract	Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin abundant in fruits and vegetables that interacts and possibly modulates energy metabolism and oxidative stress. This study investigated the effect of C3G on gluconeogenesis and cancer cell senescence. C3G activates adenosine monophosphate-activated protein kinase (AMPK), a cellular energy sensor involved in metabolism and the aging process. C3G suppressed hepatic gluconeogenesis by reducing the expression of gluconeogenic genes through the phosphorylation inactivation of CRTC2 and HDAC5 coactivators via AMPK. C3G did not directly interact with AMPK but, instead, activated AMPK through the adiponectin receptor signaling pathway, as demonstrated through adiponectin receptor gene knockdown experiments. In addition, C3G increased cellular AMP levels in cultured hepatocytes, and the oral administration of C3G in mice elevated their plasma adiponectin concentrations. These effects collectively contribute to the activation of AMPK. In addition, C3G showed potent antioxidant activity and induced cellular senescence, and apoptosis in oxidative-stress induced senescence in hepatocarcinoma cells. C3G increased senescence-associated β-galactosidase expression, while increasing the expression levels of P16, P21 and P53, key markers of cellular senescence. These findings demonstrate that anthocyanin C3G achieves hypoglycemic effects via AMPK activation and the subsequent suppression of gluconeogenesis and exhibits anti-cancer activity through the induction of apoptosis and cellular senescence.
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040749
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