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Article: Is your endoscopist qualified enough to detect Helicobacter pylori-naive status?

Lee, Sun-Young

2024

Language	English
Publishing date	2024-04-12
Publishing country	Korea (South)
Document type	Editorial
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2024.033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Giant Rugae in Helicobacter pylori-Infected Stomachs.

Lee, Sun-Young

Clinical endoscopy

2021 Volume 54, Issue 1, Page(s) 1–3

Language	English
Publishing date	2021-01-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2021.007
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Article ; Online: Breakthroughs in Cancer Immunotherapy: An Overview of T Cell, NK Cell, Mφ, and DC-Based Treatments.

Lee, Sunyoung / Kim, Tae-Don

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Efforts to treat cancer using chimeric antigen receptor (CAR)-T therapy have made astonishing progress and clinical trials against hematopoietic malignancies have demonstrated their use. However, there are still disadvantages which need to be addressed: ... ...

Abstract	Efforts to treat cancer using chimeric antigen receptor (CAR)-T therapy have made astonishing progress and clinical trials against hematopoietic malignancies have demonstrated their use. However, there are still disadvantages which need to be addressed: high costs, and side effects such as Graft-versus-Host Disease (GvHD) and Cytokine Release Syndrome (CRS). Therefore, recent efforts have been made to harness the properties of certain immune cells to treat cancer-not just T cells, but also natural killer (NK) cells, macrophages (Mφ), dendritic cells (DC), etc. In this paper, we will introduce immune cell-based cellular therapies that use various immune cells and describe their characteristics and their clinical situation. The development of immune cell-based cancer therapy fully utilizing the unique advantages of each and every immune cell is expected to enhance the survival of tumor patients owing to their high efficiency and fewer side effects.
MeSH term(s)	Humans ; T-Lymphocytes ; Killer Cells, Natural ; Immunotherapy ; Neoplasms ; Immunotherapy, Adoptive/adverse effects ; Macrophages
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417634
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Article ; Online: An overview of various methods for in vitro biofilm formation: a review.

Han, Areum / Lee, Sun-Young

Food science and biotechnology

2023 Volume 32, Issue 12, Page(s) 1617–1629

Abstract: Biofilms are widely present in the natural environment and are difficult to remove as they are a survival strategy of microorganisms. Thus, the importance of studying biofilms is being increasingly recognized in food, medical, dental, and water quality- ... ...

Abstract	Biofilms are widely present in the natural environment and are difficult to remove as they are a survival strategy of microorganisms. Thus, the importance of studying biofilms is being increasingly recognized in food, medical, dental, and water quality-related industries. While research on biofilm detection methods is actively progressing, research on biofilm formation is not progressing rapidly. Moreover, there are few standardized methods because biofilm formation is affected by various factors. However, comprehensive knowledge of biofilm formation is essential to select a suitable method for research purposes. To better understand the various in vitro biofilm formation methods, the principles and characteristics of each method are explained in this review by dividing the methods into static and dynamic systems. In addition, the applications of biofilm research based on various assays are also discussed.
Language	English
Publishing date	2023-09-21
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-023-01425-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differences in the prevalence of NAFLD, MAFLD, and MASLD according to changes in the nomenclature in a health check-up using MRI-derived proton density fat fraction.

Park, Hee Jun / Lee, Sunyoung / Lee, Jae Seung

Abdominal radiology (New York)

2024

Abstract: Purpose: International expert panels proposed new nomenclatures, metabolic dysfunction-associated fatty liver disease (MAFLD) in 2020 and metabolic dysfunction-associated steatotic liver disease (MASLD) in 2023, along with revised diagnostic criteria to ...

Abstract	Purpose: International expert panels proposed new nomenclatures, metabolic dysfunction-associated fatty liver disease (MAFLD) in 2020 and metabolic dysfunction-associated steatotic liver disease (MASLD) in 2023, along with revised diagnostic criteria to replace non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the differences in NAFLD, MAFLD, and MASLD prevalence with changing nomenclature in a health check-up using magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) to assess hepatic steatosis. We also examined the prevalence of the sub-classifications of steatotic liver disease (SLD) and the differences in characteristics among the sub-categories. Methods: We included 844 participants who underwent liver MRI-PDFF at our health check-up clinic between January 2020 and November 2022. Hepatic steatosis was defined as MRI-PDFF ≥ 5%. Participants were categorized according to NAFLD, MAFLD, MASLD, and sub-classifications of SLD. Results: The prevalence rates of NAFLD, MAFLD, and MASLD were 25.9%, 29.5%, and 25.2%, respectively. 30.5% of the participants was categorized as SLD. The prevalence rates of the SLD sub-categories were 25.2% for MASLD, 3.7% for MASLD and alcohol-associated liver disease (MetALD), 0.1% for alcohol-associated liver disease, 1.3% for specific etiology SLD, and 0.1% for cryptogenic SLD. Compared with patients in the MASLD group, those in the MetALD group were younger, predominantly male, and exhibited higher levels of serum aspartate aminotransferase, gamma-glutamyl transpeptidase, and triglycerides. Conclusion: The prevalences of NAFLD and MASLD assessed using MRI-PDFF were similar, with MASLD accounting for 97.3% of the patients with NAFLD. The separate MetALD sub-category may have clinical characteristics that differ from those of MASLD.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-024-04285-w
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Article ; Online: Comparison between the GastroPanel test and the serum pepsinogen assay interpreted with the ABC method-A prospective study.

Lee, Sun-Young / Ahn, Yeon-Sun / Moon, Hee-Won

Helicobacter

2024 Volume 29, Issue 1, Page(s) e13056

Abstract: Background and aims: This study aimed to validate Helicobacter pylori serological and pepsinogen (PG) assays for detecting infection and gastric neoplasm.: Methods: Individuals who underwent serum Chorus H. pylori and HBI PG assays were included from ...

Abstract	Background and aims: This study aimed to validate Helicobacter pylori serological and pepsinogen (PG) assays for detecting infection and gastric neoplasm. Methods: Individuals who underwent serum Chorus H. pylori and HBI PG assays were included from May to September 2023. The GastroPanel test was performed using the same blood sample. HBI assay findings were interpreted with the ABC method using the criteria of corpus atrophy (PG I ≤ 70 ng/mL & I/II ≤3) and advanced corpus atrophy (PG I ≤ 30 ng/mL & I/II ≤2). Results: A total of 144 H. pylori-infected and 184 non-infected Koreans were analyzed. The Chorus test (sensitivity 97.2%, specificity 89.1%) showed higher area under the curve (0.993 vs. 0.972, p = 0.003) than the GastroPanel test (sensitivity 95.8%, specificity 86.4%). Using the GastroSoft application, the incidence of gastric neoplasms was highest in the corpus atrophy group (50%), followed by the low acid-output (25.8%), H. pylori infection (11.6%), and antral atrophy (9.1%) groups. There were no gastric neoplasms in the normal and high acid output groups. Using the ABC method, the incidence of gastric neoplasms was highest in the corpus atrophy groups (23.8% in Groups C and D), followed by Group B (12.3%) and Group A (2.4%). Corpus atrophy interpreted with the GastroSoft showed poor agreement (k = 0.225) with corpus atrophy interpreted with the ABC method, whereas it showed excellent agreement (k = 0.854) with advanced corpus atrophy. Conclusions: Although the Chorus test was more accurate than the GastroPanel test, both assays discriminated high-risk individuals by detecting atrophy or infection. There were no gastric neoplasms in the normal or high acid-output groups (GastroSoft application), and gastric neoplasm incidence was lowest in Group A (ABC method). Corpus atrophy determined by GastroSoft application is more consistent with advanced corpus atrophy determined by the ABC method than is corpus atrophy.
MeSH term(s)	Humans ; Pepsinogen A ; Prospective Studies ; Stomach Neoplasms ; Helicobacter Infections/diagnosis ; Helicobacter pylori ; Atrophy
Chemical Substances	Pepsinogen A (9001-10-9)
Language	English
Publishing date	2024-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1330665-0
ISSN	1523-5378 ; 1083-4389
ISSN (online)	1523-5378
ISSN	1083-4389
DOI	10.1111/hel.13056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Korean Nursing Students' Experiences of Virtual Simulation Programs Replacing In-Person Mental Health Nursing Practicum during the COVID-19 Pandemic.

Lee, Sunyoung / Park, Eunyoung / Yeom, Hyun-E

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 6

Abstract: This qualitative study explored the experiences of nursing students whose clinical practice in mental health nursing had been substituted with virtual simulation programs due to the COVID-19 pandemic. The participants were ten nursing students who had ... ...

Abstract	This qualitative study explored the experiences of nursing students whose clinical practice in mental health nursing had been substituted with virtual simulation programs due to the COVID-19 pandemic. The participants were ten nursing students who had undergone a virtual simulation program-centered practice, replacing the traditional clinical practice in mental health nursing and previous clinical practice in mental health nursing. The data were collected through in-depth individual interviews from January to February 2021. Following Braun and Clarke's method, the thematic analysis identified five themes and ten sub-themes. The five themes included the following: (1) lack of vibrancy in the actual clinical setting, (2) limited direct and indirect practical experience, (3) performing diverse roles in a virtual setting, (4) learner-directed practicum, and (5) sense of relief due to a safe virtual practicum environment. The participants recognized the limitations of the practice, particularly regarding communication with patients with mental disorders in the virtual simulation program. However, their perception of nursing underwent a positive change through the indirect clinical practice experience. Accordingly, it is necessary to develop a platform for the mental health nursing practicum that can easily interact with clients and to establish a hybrid practice that combines the clinical practice and virtual simulation practice.
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12060685
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Article: Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination.

Kim, Jong-Hun / Shin, Jin-Yong / Lee, Sun-Young

Cancers

2024 Volume 16, Issue 8

Abstract: Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More ... ...

Abstract	Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More recently, hyperthermia (HT) has been applied to complement RT and MeM, and this complex approach has shown promising synergistic results. The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences between RT and mEHT alone; thus, these individual methods were considered equivalent. However, RT + mEHT yielded significantly better results in terms of the above parameters. Clinically, mEHT has a lower risk of adverse thermal effects, and due to its efficacy, mEHT can be used to treat RT-resistant lesions.
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16081604
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Article ; Online: Application of food-grade natural antimicrobials for the control of crop disease caused by phytopathogens.

Kim, Ji-Yeon / Lee, Sun-Young

Food science and biotechnology

2022 Volume 31, Issue 3, Page(s) 275–284

Abstract: Phytopathogens can cause crop disease in agriculture, thus, synthetic pesticides are used to prevent disease. However, this type of pesticide has an adverse effect on human and environmental health. Consequently, it is important to develop natural ... ...

Abstract	Phytopathogens can cause crop disease in agriculture, thus, synthetic pesticides are used to prevent disease. However, this type of pesticide has an adverse effect on human and environmental health. Consequently, it is important to develop natural pesticides for crop protection. The final goal of crop protection is enhancing the quality of fresh products for consumers, suggesting that crop safety is related with food safety. Several studies have investigated the effect of food-grade natural antimicrobials on phytopathogens in vitro and ex vivo. The objective of this review is to provide an overview of bactericidal effects when using natural antimicrobial compounds, including essential oils, plant extracts, and carboxylic acids, and their mechanisms of antibacterial action. However, more studies are needed to investigate the efficacy of natural antimicrobial compounds on phytopathogens in field conditions.
Language	English
Publishing date	2022-01-31
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-022-01030-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electrophysiological evidence for a subject-first strategy in visually situated auditory sentence processing in Korean.

Lee, Sun-Young / Nam, Yunju

Acta psychologica

2022 Volume 231, Page(s) 103799

Abstract: This study investigated a subject-first strategy in prediction mechanism in visually situated sentence processing in Korean, using event-related potentials (ERPs). According to the subject-first strategy, parsers tend to generate sentences conforming to ... ...

Abstract	This study investigated a subject-first strategy in prediction mechanism in visually situated sentence processing in Korean, using event-related potentials (ERPs). According to the subject-first strategy, parsers tend to generate sentences conforming to canonical sentence word order (i.e., SOV in Korean), subject-first sentence, mapping conceptually more prominent referent such as agent of the event on the subject position of the sentence. Therefore, in the predictive mechanism of language comprehension, the subject is pre-activated and anticipated for the first NP of the sentence at the initial phase of bottom-up language processing. This study tested this subject-first strategy in Korean by examining brain responses to object-initial sentences (OV) compared with subject-initial sentences (SV) under the context of clear thematic role relations set by a visual image. The results of an ERP experiment with 30 native Korean speakers identified neural effects for object-initial sentences compared with subject-initial sentences at the NP and Verb, reflecting a conflict between the pre-activated representation in the parser's mind and the encountered bottom-up input. An N400 effect was elicited at the NP, as early as at the noun, not at the following object case marker. Late frontal positivity (LFP) was also found in the sentence-final verb, proving the processing difficulty of non-canonical object-initial sentences compared with canonical subject-initial sentences. These results indicate that Korean native speakers build linguistic representation conforming to a canonical sentence in SOV language in the predictive mechanism supporting subject-first strategy but revise the predicted event structure rapidly upon newly encountering input.
Language	English
Publishing date	2022-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1480049-4
ISSN	1873-6297 ; 0001-6918
ISSN (online)	1873-6297
ISSN	0001-6918
DOI	10.1016/j.actpsy.2022.103799
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