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  1. Article ; Online: Toxicity of cerium oxide nanoparticles on neonatal testicular development in mouse organ culture.

    Lee, Won-Yong / Park, Hyun-Jung

    Reproductive toxicology (Elmsford, N.Y.)

    2022  Volume 111, Page(s) 120–128

    Abstract: Cerium oxide nanoparticles ( ... ...

    Abstract Cerium oxide nanoparticles (CeO
    MeSH term(s) Animals ; Cerium ; Female ; Male ; Mice ; Nanoparticles/toxicity ; Organ Culture Techniques ; RNA, Messenger/metabolism ; Sertoli Cells/metabolism ; Spermatogenesis/genetics ; Testis
    Chemical Substances RNA, Messenger ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2022.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2316: Show issues Location:
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  2. Article ; Online: Introducing Nanoscale Electrochemistry in Small-Molecule Detection for Tackling Existing Limitations of Affinity-Based Label-Free Biosensing Applications.

    Lee, Don Hui / Lee, Won-Yong / Kim, Jayoung

    Journal of the American Chemical Society

    2023  Volume 145, Issue 32, Page(s) 17767–17778

    Abstract: Electrochemical sensing techniques for small molecules have progressed in many applications, including disease diagnosis and prevention as well as monitoring of health conditions. However, affinity-based detection for low-abundance small molecules is ... ...

    Abstract Electrochemical sensing techniques for small molecules have progressed in many applications, including disease diagnosis and prevention as well as monitoring of health conditions. However, affinity-based detection for low-abundance small molecules is still challenging due to the imbalance in target-to-receptor size ratio as well as the lack of a highly sensitive signal transducing method. Herein, we introduced nanoscale electrochemistry in affinity-based small molecule detection by measuring the change of quantum electrochemical properties with a nanoscale artificial receptor upon binding. We prepared a nanoscale molecularly imprinted composite polymer (MICP) for cortisol by electrochemically copolymerizing β-cyclodextrin and redox-active methylene blue to offer a high target-to-receptor size ratio, thus realizing "bind-and-read" detection of cortisol as a representative target small molecule, along with extremely high sensitivity. Using the quantum conductance measurement, the present MICP-based sensor can detect cortisol from 1.00 × 10
    MeSH term(s) Humans ; Electrochemistry ; Hydrocortisone ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Limit of Detection ; Molecular Imprinting ; Electrodes
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c04458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Effects of Melatonin on Liver of D-Galactose-Induced Aged Mouse Model.

    Lee, Ran / Lee, Won-Yong / Park, Hyun-Jung

    Current issues in molecular biology

    2023  Volume 45, Issue 10, Page(s) 8412–8426

    Abstract: Melatonin, a hormone secreted by the pineal gland of vertebrates, regulates sleep, blood pressure, and circadian and seasonal rhythms, and acts as an antioxidant and anti-inflammatory agent. We investigated the protective effects of melatonin against ... ...

    Abstract Melatonin, a hormone secreted by the pineal gland of vertebrates, regulates sleep, blood pressure, and circadian and seasonal rhythms, and acts as an antioxidant and anti-inflammatory agent. We investigated the protective effects of melatonin against markers of D-galactose (D-Gal)-induced hepatocellular aging, including liver inflammation, hepatocyte structural damage, and non-alcoholic fatty liver. Mice were divided into four groups: phosphate-buffered saline (PBS, control), D-Gal (200 mg/kg/day), melatonin (20 mg/kg), and D-Gal (200 mg/kg) and melatonin (20 mg) cotreatment. The treatments were administered once daily for eight consecutive weeks. Melatonin treatment alleviated D-Gal-induced hepatocyte impairment. The AST level was significantly increased in the D-Gal-treated groups compared to that in the control group, while the ALT level was decreased compared to the melatonin and D-Gal cotreated group. Inflammatory genes, such as IL1-β, NF-κB, IL-6, TNFα, and iNOS, were significantly increased in the D-Gal aging model, whereas the expression levels of these genes were low in the D-Gal and melatonin cotreated group. Interestingly, the expression levels of hepatic steatosis-related genes, such as LXRα, C/EBPα, PPARα, ACC, ACOX1, and CPT-1, were markedly decreased in the D-Gal and melatonin cotreated group. These results suggest that melatonin suppresses hepatic steatosis and inflammation in a mouse model of D-Gal-induced aging.
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45100530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: One-Step Fabrication of Highly Sensitive Tris(2,2'-bipyridyl)ruthenium(II) Electrogenerated Chemiluminescence Sensor Based on Graphene-Titania-Nafion Composite Film.

    Lee, Sang Jung / Lee, Don Hui / Lee, Won-Yong

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 8

    Abstract: A highly sensitive tris(2,2'-bipyridyl)ruthenium(II) (Ru(bpy) ...

    Abstract A highly sensitive tris(2,2'-bipyridyl)ruthenium(II) (Ru(bpy)
    MeSH term(s) 2,2'-Dipyridyl ; Fluorocarbon Polymers ; Graphite ; Luminescence ; Luminescent Measurements/methods ; Organometallic Compounds ; Ruthenium ; Titanium
    Chemical Substances Fluorocarbon Polymers ; Organometallic Compounds ; tris(2,2'-bipyridyl)ruthenium(II) ; titanium dioxide (15FIX9V2JP) ; perfluorosulfonic acid (39464-59-0) ; 2,2'-Dipyridyl (551W113ZEP) ; Graphite (7782-42-5) ; Ruthenium (7UI0TKC3U5) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22083064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quantitative Detection of Thitsiol and Urushiol as Markers from the

    Lee, Youngseo / Lee, Jihye / Lee, Kang-Bong / Lee, Won-Yong / Lee, Yeonhee

    Molecules (Basel, Switzerland)

    2023  Volume 29, Issue 1

    Abstract: Lacquer sap has been traditionally used in coatings and artwork. Suitable types of lacquer are required to preserve and restore artifacts. Recently, unsuitable cashew nut shell liquid (CNSL) has often been mixed with lacquer sap, so it is necessary to ... ...

    Abstract Lacquer sap has been traditionally used in coatings and artwork. Suitable types of lacquer are required to preserve and restore artifacts. Recently, unsuitable cashew nut shell liquid (CNSL) has often been mixed with lacquer sap, so it is necessary to identify the characteristics of lacquer sap by the production area. However, research is still focused on urushiol and laccol. In this study, Myanmarese lacquer sap collected from
    Language English
    Publishing date 2023-12-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29010149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Effect of Electrochemically Active Top Electrode Materials on Nanoionic Conductive Bridge Y

    Cho, Yoonjin / Lee, Sangwoo / Heo, Seongwon / Bae, Jin-Hyuk / Kang, In-Man / Kim, Kwangeun / Lee, Won-Yong / Jang, Jaewon

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 6

    Abstract: Herein, sol-gel-processed ... ...

    Abstract Herein, sol-gel-processed Y
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14060532
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  7. Article ; Online: Brownian Motion Paving the Way for Molecular Translocation in Nanopores.

    Lee, Won-Yong / Wen, Chenyu / Pham, Ngan Hoang / Khaksaran, Mohammad Hadi / Lee, Sang-Kwon / Zhang, Shi-Li

    Small methods

    2024  , Page(s) e2400042

    Abstract: Tracing fast nanopore-translocating analytes requires a high-frequency measurement system that warrants a temporal resolution better than 1 µs. This constraint may practically shift the challenge from increasing the sampling bandwidth to dealing with the ...

    Abstract Tracing fast nanopore-translocating analytes requires a high-frequency measurement system that warrants a temporal resolution better than 1 µs. This constraint may practically shift the challenge from increasing the sampling bandwidth to dealing with the rapidly growing noise with frequencies typically above 10 kHz, potentially making it still uncertain if all translocation events are unambiguously captured. Here, a numerical simulation model is presented as an alternative to discern translocation events with different experimental settings including pore dimension, bias voltage, the charge state of the analyte, salt concentration, and electrolyte viscosity. The model allows for simultaneous analysis of forces exerting on a large analyte cohort along their individual trajectories; these forces are responsible for the analyte movement leading eventually to the nanopore translocation. Through tracing the analyte trajectories, the Brownian force is found to dominate the analyte movement in electrolytes until the last moment at which the electroosmotic force determines the final translocation act. The mean dwell time of analytes mimicking streptavidin decreases from ≈6 to ≈1 µs with increasing the bias voltage from ±100 to ±500 mV. The simulated translocation events qualitatively agree with the experimental data with streptavidin. The simulation model is also helpful for the design of new solid-state nanopore sensors.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202400042
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  8. Article ; Online: Severity-based fault diagnostic method for polymer electrolyte membrane fuel cell systems

    Young Park, Jin / Seop Lim, In / Ho Lee, Yeong / Lee, Won-Yong / Oh, Hwanyeong / Soo Kim, Min

    Applied Energy. 2023 Feb., v. 332 p.120486-

    2023  

    Abstract: This research suggests a severity-based multi-stage fault diagnostic method for polymer electrolyte membrane fuel cell systems. By separating the diagnostic stage depending on the fault severity, robustness and sensitivity of the diagnosis algorithm on ... ...

    Abstract This research suggests a severity-based multi-stage fault diagnostic method for polymer electrolyte membrane fuel cell systems. By separating the diagnostic stage depending on the fault severity, robustness and sensitivity of the diagnosis algorithm on each stage can be designed with flexibility. The details of the fault diagnosis algorithm development process are described and validated with fault experimental data using a 1 kW class fuel cell system. First, a nominal model is developed to generate a residual between the predicted normal state and the observed state. Second, expected fault responses of the system are organized in the form of residual patterns. These residual patterns are used for training neural networks that diagnose critical faults, significant faults, and minor faults. Third, the generated residuals are standardized and moving averaged to be used as inputs for the neural networks at each stage. Lastly, diagnosis results from the neural network-based algorithm are compared with the fault experimental data. As a result, 17 different faults are all successfully diagnosed. More specifically, five critical faults, seven significant faults, and 13 minor faults are diagnosed. In addition, a diagnosis method for multi-faults is suggested. Double faults and triple faults are experimentally simulated and diagnosed with the diagnosis algorithm.
    Keywords algorithms ; diagnostic techniques ; electrolytes ; energy ; fuel cells ; models ; polymers ; Polymer electrolyte membrane fuel cell ; Balance of plant ; Fault diagnosis ; Residual ; Health management
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2022.120486
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Sol-Gel-Processed Y

    Kim, Hae-In / Lee, Taehun / Cho, Yoonjin / Lee, Sangwoo / Lee, Won-Yong / Kim, Kwangeun / Jang, Jaewon

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 17

    Abstract: Herein, sol-gel-processed ... ...

    Abstract Herein, sol-gel-processed Y
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13172462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Anti-Inflammatory Effects of Broccoli (

    Sim, Hyeon Woo / Lee, Won-Yong / Lee, Ran / Yang, Seo Young / Ham, Youn-Kyung / Lim, Sung Don / Park, Hyun-Jung

    Current issues in molecular biology

    2023  Volume 45, Issue 11, Page(s) 9117–9131

    Abstract: ... Brassica ... ...

    Abstract Brassica oleracea
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45110572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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