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Article: Reduced-Dose Rivaroxaban Is Associated with Lower All-Cause Mortality in Older Patients with Nonvalvular Atrial Fibrillation.

Chiou, Wei-Ru / Su, Min-I / Lee, Ying-Hsiang / Lin, Po-Lin / Liu, Cheng-Wei

2023 Volume 12, Issue 20

Abstract: Background: Reduced-dose rivaroxaban (10 mg) was used in the J-ROCKET AF trial, demonstrating safety in the Asian population. It remains unclear whether treatment with reduced-dose versus full-dose rivaroxaban (20 mg/15 mg) is associated with all-cause ... ...

Abstract	Background: Reduced-dose rivaroxaban (10 mg) was used in the J-ROCKET AF trial, demonstrating safety in the Asian population. It remains unclear whether treatment with reduced-dose versus full-dose rivaroxaban (20 mg/15 mg) is associated with all-cause mortality in older patients with nonvalvular atrial fibrillation. Proposed: To evaluate the effects of reduced-dose rivaroxaban on all-cause mortality in patients over 85. Methods: We retrospectively enrolled medical records representing the period from October 2012 to November 2016. The 2 × 2 factorial design incorporated age (≥85 vs. <85) and rivaroxaban use (reduced vs. full dose). The primary study outcomes were all-cause and cardiac-related mortality. Results: The study enrolled 2386 patients with a mean age of 76.6 ± 10.4 years; 51.8% were male. In the ≥85 group ( Conclusions: Reduced-dose rivaroxaban was associated with lower risks of all-cause mortality and hospitalization for heart failure in older patients with nonvalvular atrial fibrillation. Future studies can investigate the effect of reduced-dose rivaroxaban on prognoses in elderly individuals ≥85 years in the west.
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206686
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Article ; Online: A Ping Pong Thrombus in the Left Atrium.

Lin, Shu-I / Kuo, Shu-Fan / Tsai, Cheng-Ting / Lee, Ying-Hsiang

The Journal of invasive cardiology

2021 Volume 33, Issue 12, Page(s) E1011

Abstract: In this illustrative case, a transesophageal echocardiographic examination in a 69-year-old woman revealed normally functioning mechanical mitral prosthesis and a 4 cm left atrial heterogenous thrombus moving around her left atrium like a ping pong ball. ...

Abstract	In this illustrative case, a transesophageal echocardiographic examination in a 69-year-old woman revealed normally functioning mechanical mitral prosthesis and a 4 cm left atrial heterogenous thrombus moving around her left atrium like a ping pong ball. Also visible was a thrombus within the left atrial appendage; the left atrial thrombus moved toward the mitral orifice and was bounced away by the mitral regurgitant jet.
MeSH term(s)	Aged ; Echocardiography, Transesophageal ; Female ; Heart Atria/diagnostic imaging ; Heart Diseases/diagnosis ; Heart Diseases/surgery ; Humans ; Prosthesis Implantation ; Thrombosis/diagnostic imaging ; Thrombosis/surgery
Language	English
Publishing date	2021-12-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Differences in patient and physician perspectives on pharmaceutical therapy and renal denervation for the management of hypertension.

Schmieder, Roland E / Kandzari, David E / Wang, Tzung-Dau / Lee, Ying-Hsiang / Lazarus, Gabriel / Pathak, Atul

Journal of hypertension

2020 Volume 39, Issue 1, Page(s) 162–168

Abstract: Objective: To study patient and physician attitudes to pharmaceutical therapy and renal denervation for the management of hypertension.: Methods: Data were analyzed from 19 market research studies in Western Europe and the United States conducted ... ...

Abstract	Objective: To study patient and physician attitudes to pharmaceutical therapy and renal denervation for the management of hypertension. Methods: Data were analyzed from 19 market research studies in Western Europe and the United States conducted between 2010 and 2019 to obtain quantitative and qualitative perspectives. The analysis incorporated insights from 2768 patients and the experiences of 1902 physicians either actively performing or interested to perform device procedures, or hypertension specialists who would refer patients for a device-based intervention. Results: Referring cardiologists and proceduralists were more likely to recommend the renal denervation procedure to patients with higher BP levels and a greater number of antihypertensive medications. Physicians perceived patient reluctance towards a procedure as an important obstacle to recommending renal denervation as a treatment option for uncontrolled hypertension. Patient interest in the renal denervation procedure did not correlate with BP severity (P = NS), and the highest preference for the procedure was in patients diagnosed with hypertension but not receiving treatment (P < 0.001). Patients who perceived high BP as a major problem (P = 0.029) and those who experienced side effects attributed to their BP medications (P = 0.006) had a higher preference for renal denervation. Conclusion: Patients with hypertension often regard the choice of renal denervation to lower BP differently from physicians. A considerable proportion of hypertensive patients, especially those not taking medications, may prefer a device-based approach to reduce their BP.
MeSH term(s)	Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Denervation ; Humans ; Hypertension/drug therapy ; Hypertension/surgery ; Kidney ; Pharmaceutical Preparations ; Physicians ; Sympathectomy ; Treatment Outcome
Chemical Substances	Antihypertensive Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2020-02-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000002592
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The Removal, Excision, Sterilization, and Quarantine (RESQ) Method is a Feasible Alternative Treatment for Cardiac Implantable Electronic Device Infections.

Liao, Feng-Ching / Chien, Chih-Yin / Lin, Shu-I / Huang, Chun-Che / Tsai, Ming-Feng / Chiou, Wei-Ru / Lin, Po-Lin / Kuo, Jen-Yuan / Tsai, Cheng-Ting / Lee, Ying-Hsiang

Acta Cardiologica Sinica

2023 Volume 39, Issue 1, Page(s) 109–115

Abstract: Background: Current guidelines recommend that all infected cardiac implantable electronic devices (CIEDs) should be removed. However, financial or anatomical concerns can lead to management of infection with simple debridement, as opposed to complete ... ...

Abstract	Background: Current guidelines recommend that all infected cardiac implantable electronic devices (CIEDs) should be removed. However, financial or anatomical concerns can lead to management of infection with simple debridement, as opposed to complete removal. In this observational study, we report the outcomes of our modified procedure for this real-world dilemma. Methods and results: The Quarantine (RESQ) method is characterized as follows: the removal (R) of all non-essential foreign materials, including old sutures and leads; the excision (E) of all non-viable, chronically inflamed, granulation, or scar tissue; the sterilization (S) of the remaining generator; and the quarantine (Q) of a new pocket in the sub-muscular layer for reimplantation. From a review of electronic medical records, 30 patients were selected and divided into three groups according to the intervention used: RESQ (n = 9) in group A, simple debridement (n = 16) in group B, and guideline-recommended replacement (n = 5) in group C. Patient baseline characteristics were similar between the groups. After analyzing the proportion of patients that were free from infection one year following their respective interventions, we found that group A performed better than group B (100% and 31.2% infection-free, respectively, p = 0.001), and was comparable to group C (both 100% infection-free, p = not applicable). Conclusions: The RESQ method is a feasible and beneficial alternative for selected patients with CIED infections who are unable to receive a generator replacement according to the recommended guideline.
Language	English
Publishing date	2023-01-20
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/ACS.202301_39(1).20220603C
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Article ; Online: Optimal Heart Rate Control Improves Long-Term Prognosis of Decompensated Heart Failure with Reduced Ejection Fraction.

Tsai, Ming-Lung / Lin, Shu-I / Kao, Yu-Cheng / Lin, Hsuan-Ching / Lin, Ming-Shyan / Peng, Jian-Rong / Wang, Chao-Yung / Wu, Victor Chien-Chia / Cheng, Chi-Wen / Lee, Ying-Hsiang / Hung, Ming-Jui / Chen, Tien-Hsing

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 2

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Humans ; Stroke Volume/physiology ; Ventricular Function, Left/physiology ; Heart Failure ; Heart Rate ; Ventricular Dysfunction, Left ; Prognosis ; Hospitalization
Language	English
Publishing date	2023-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59020348
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Article ; Online: Early detection of myocardial ischemia in resting ECG: analysis by HHT.

Wang, Chun-Lin / Wei, Chiu-Chi / Tsai, Cheng-Ting / Lee, Ying-Hsiang / Liu, Lawrence Yu-Min / Chen, Kang-Ying / Lin, Yu-Jen / Lin, Po-Lin

Biomedical engineering online

2023 Volume 22, Issue 1, Page(s) 23

Abstract: Background: Exercise electrocardiography (ECG) is a noninvasive test aiming at producing ischemic changes. However, resting ECG cannot be adopted in diagnosing myocardial ischemia till ST-segment depressions. Therefore, this study aimed to detect ... ...

Abstract	Background: Exercise electrocardiography (ECG) is a noninvasive test aiming at producing ischemic changes. However, resting ECG cannot be adopted in diagnosing myocardial ischemia till ST-segment depressions. Therefore, this study aimed to detect myocardial energy defects in resting ECG using the Hilbert-Huang transformation (HHT) in patients with angina pectoris. Methods: Electrocardiographic recordings of positive exercise ECG by performing coronary imaging test (n = 26) and negative exercise ECG (n = 47) were collected. Based on the coronary stenoses severity, patients were divided into three categories: normal, < 50%, and ≥ 50%. During the resting phase of the exercise ECG, all 10-s ECG signals are decomposed by HHT. The RT intensity index, composed of the power spectral density of the P, QRS, and T components, is used to estimate the myocardial energy defect. Results: After analyzing the resting ECG using HHT, the RT intensity index was significantly higher in patients with positive exercise ECG (27.96%) than in those with negative exercise ECG (22.30%) (p < 0.001). In patients with positive exercise ECG, the RT intensity index was gradually increasing with the severity of coronary stenoses: 25.25% (normal, n = 4), 27.14% (stenoses < 50%, n = 14), and 30.75% (stenoses ≥ 50%, n = 8). The RT intensity index of different coronary stenoses was significantly higher in patients with negative exercise ECG, except for the normal coronary imaging test. Conclusions: Patients with coronary stenoses had a higher RT index at the resting stage of exercise ECG. Resting ECG analyzed using HHT could be a method for the early detection of myocardial ischemia.
MeSH term(s)	Humans ; Constriction, Pathologic ; Myocardial Ischemia/diagnosis ; Electrocardiography ; Coronary Artery Disease ; Coronary Stenosis/diagnosis ; Exercise Test
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2084374-4
ISSN	1475-925X ; 1475-925X
ISSN (online)	1475-925X
ISSN	1475-925X
DOI	10.1186/s12938-023-01089-9
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Article ; Online: Author Correction: Rhythm control without catheter ablation may have benefits beyond stroke prevention in rivaroxaban-treated non-permanent atrial fibrillation.

Chiou, Wei-Ru / Lin, Po-Lin / Huang, Chun-Che / Chuang, Jen-Yu / Liu, Lawrence Yu-Min / Su, Min-I / Liao, Feng-Ching / Kuo, Jen-Yuan / Tsai, Cheng-Ting / Wu, Yih-Jer / Wang, Kuang-Te / Lee, Ying-Hsiang

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3961

Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30971-8
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Article ; Online: Iron deficiency in Taiwanese patients with heart failure and reduced ejection fraction.

Sung, Hsiao-Ping / Hsu, Chien-Yi / Lee, Ying-Hsiang / Lin, Po-Lin / Liao, Chia-Te / Chung, Fa-Po / Ko, Shao-Lun / Huang, Chun-Yao / Lin, Kuan-Chia / Chang, Hung-Yu

Journal of the Chinese Medical Association : JCMA

2023 Volume 86, Issue 8, Page(s) 725–731

Abstract: Background: Iron deficiency (ID) is a common comorbidity among patients with heart failure and reduced ejection fraction (HFrEF), and is associated with poorer outcomes independent of anemia. This study aimed to evaluate the prevalence and prognostic ... ...

Abstract	Background: Iron deficiency (ID) is a common comorbidity among patients with heart failure and reduced ejection fraction (HFrEF), and is associated with poorer outcomes independent of anemia. This study aimed to evaluate the prevalence and prognostic significance of ID in Taiwanese patients with HFrEF. Methods: We included HFrEF patients from two multicenter cohorts at different periods. The multivariate Cox regression analysis was applied to assess the risk of outcomes associated with ID, accounting for the varying risk of death. Results: Of the 3612 patients with HFrEF registered from 2013 to 2018, 665 patients (18.4%) had available baseline iron profile measurements. Of these, 290 patients (43.6%) were iron deficient; 20.2% had ID+/anemia+, 23.4% ID+/anemia-, 21.5% ID-/anemia+, and 34.9% ID-/anemia-. Regardless of anemia status, patients with coexisting ID had a higher risk than those without ID (all-cause mortality: 14.3 vs 9.5 per 100 patient-years, adjusted hazard ratio [HR] 1.33; 95% confidence interval [CI], 0.96-1.85; p = 0.091; cardiovascular mortality: 10.5 per 100 patient-years vs 6.1, adjusted HR 1.54 [95% CI, 1.03-2.30; p = 0.037]; cardiovascular mortality or first unplanned hospitalization for HF: 36.7 vs 19.7 per 100 patient-years, adjusted HR 1.57 [95% CI, 1.22-2.01; p < 0.001]). Among patients eligible for treatment in the IRONMAN trial design (43.9%), parenteral iron therapy was estimated to reduce heart failure hospitalizations and cardiovascular deaths by 13.7 per 100 patient-years. Conclusion: Iron profiles were tested in less than one-fifth of the Taiwanese HFrEF cohort. ID was present in 43.6% of tested patients and was independently associated with poor prognosis in these patients.
MeSH term(s)	Humans ; Heart Failure/complications ; Heart Failure/therapy ; Stroke Volume ; Iron Deficiencies ; Prognosis ; Anemia, Iron-Deficiency/etiology ; Iron ; Ventricular Dysfunction, Left ; Anemia/complications ; Hospitalization
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2023-06-14
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000949
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Zs.A 2699: Show issues

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Article ; Online: Closed loop stimulation helps with weaning from chronotropic incompetence-related ventilator dependence.

Lin, Shu-I / Liao, Feng-Ching / Chiou, Wei-Ru / Lin, Po-Lin / Kuo, Jen-Yuan / Tsai, Cheng-Ting / Lee, Ying-Hsiang

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2021 Volume 63, Issue 2, Page(s) 229–230

MeSH term(s)	Arrhythmias, Cardiac ; Exercise Test ; Heart Rate/physiology ; Humans ; Pacemaker, Artificial ; Ventilators, Mechanical
Language	English
Publishing date	2021-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-021-01074-z
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Zs.A 5214: Show issues

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Article ; Online: Rhythm control without catheter ablation may have benefits beyond stroke prevention in rivaroxaban-treated non-permanent atrial fibrillation.

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3745

Abstract: The current treatment paradigm for atrial fibrillation (AF) prioritizes rate control over rhythm control; however, rhythm control has shown benefits over other AF strategies. This study compares the outcomes of rivaroxaban with and without concomitant ... ...

Abstract	The current treatment paradigm for atrial fibrillation (AF) prioritizes rate control over rhythm control; however, rhythm control has shown benefits over other AF strategies. This study compares the outcomes of rivaroxaban with and without concomitant antiarrhythmic drugs (AADs), using propensity score matching to correct for statistical effects of baseline discrepancies. This multi-center retrospective study included 1,477 patients with non-permanent AF who took rivaroxaban for at least one month between 2011 and 2016 and had not received catheter ablation. Concomitant AAD use was compared against clinical outcome endpoints for effectiveness, safety, and major adverse cardiac events (MACE). Associations with concomitant AAD use were evaluated using multivariate Cox proportional hazard analyses. Patients were divided into two matched groups: rivaroxaban alone (n = 739) and with concomitant AADs (n = 738). The cumulative incidences of safety (p = 0.308), effectiveness (p = 0.583), and MACE (p = 0.754) were similar between the two groups, and multivariate analysis showed no significant differences. The new thromboembolism and all-cause death rates were higher in rivaroxaban alone (2.7% vs 0.8%, p = 0.005; and 10% vs. 6.9%, p = 0.032, respectively). The heart failure readmission rate was higher in the concomitant-AAD group (8.4% vs. 13.3%, p = 0.003). The concomitant use of rivaroxaban with AADs appears to be well-tolerated, with lower rates of thromboembolism and all-cause death, but is associated with more occurrences of congestive heart failure.
MeSH term(s)	Anti-Arrhythmia Agents/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Catheter Ablation/adverse effects ; Heart Failure/drug therapy ; Humans ; Retrospective Studies ; Rivaroxaban/adverse effects ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Thromboembolism/etiology ; Treatment Outcome
Chemical Substances	Anti-Arrhythmia Agents ; Rivaroxaban (9NDF7JZ4M3)
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07466-z
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