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  1. AU="Lee-Wing, Matthew"
  2. AU="Dostálová, I"
  3. AU=McCloskey Kayleigh A
  4. AU="Dharmarajan, Arun"
  5. AU="Stebel, Luigi"
  6. AU=Amico Patrizia
  7. AU="Kojev, Aslan"
  8. AU="Zhiyu Wang"
  9. AU="Shannon C Peyton"
  10. AU="Shiltsev, V."
  11. AU="Edward S. Debnam"
  12. AU="Freeston, Sarah L"
  13. AU="Bertolucci, S."
  14. AU="de Barros, Rosires M B"
  15. AU="Carr, Crystal C"
  16. AU="Davies, Mark Lloyd"
  17. AU=St Gelais Corine
  18. AU=Engstrom Malitta
  19. AU="Hongo, Akane"
  20. AU="Krykorková, I"
  21. AU=Yan Bing
  22. AU="Nakos, Konstantinos"
  23. AU="Schreiner, Ryan"
  24. AU=Pltz T
  25. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  26. AU="Goretsky, Anton"
  27. AU="Cordoza, Makayla L"
  28. AU=Midoux Patrick AU=Midoux Patrick
  29. AU="Mundt, H M"
  30. AU=Tsivitse Susan

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  1. Artikel ; Online: Ocular adnexal trauma in the workplace despite the use of protective eyewear.

    Holzer, Elad Y / Lee-Wing, Matthew

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  Band 58, Heft 6, Seite(n) e265–e266

    Mesh-Begriff(e) Humans ; Eye Injuries/diagnosis ; Eye Injuries/etiology ; Eye Injuries/prevention & control ; Workplace ; Working Conditions ; Face ; Eye Protective Devices
    Sprache Englisch
    Erscheinungsdatum 2023-06-27
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.06.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Does cataract surgery in patients with concurrent lower lid malposition increase the risk of postoperative endophthalmitis?

    Yarmak, Pavel / Lee-Wing, Matthew / Rocha, Guillermo

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Band 57, Heft 4, Seite(n) 253–256

    Abstract: Objective: To evaluate the safety of performing cataract surgery prior to eyelid (entropion/ectropion) surgery in patients with concurrent cataract and lower eyelid malposition.: Design: Retrospective case series.: Participants and methods: ... ...

    Abstract Objective: To evaluate the safety of performing cataract surgery prior to eyelid (entropion/ectropion) surgery in patients with concurrent cataract and lower eyelid malposition.
    Design: Retrospective case series.
    Participants and methods: Patients with concurrent lower eyelid malposition and cataract undergoing cataract surgery before lower eyelid repair from 2013 to 2020 were identified from two ophthalmologists (M.L.W., G.R.). Both surgeries were performed by the same ophthalmologist, with eyelid repair completed at least 1 month following cataract extraction. Data analysis was performed with two-parameter estimations. The primary outcome was the postoperative endophthalmitis rate in this cohort.
    Results: 129 cases in 90 patients were found (86 involutional entropion and 43 involutional ectropion). No cases of endophthalmitis were encountered. Statistical analysis using the 95% Jeffreys interval for one-sample binomial proportion revealed an upper limit of 1.9%. The Agresti-Caffo interval of the proportional difference between the study procedure and historical incidence data of postoperative endophthalmitis following cataract surgery alone yielded an estimate of 0.8% with an upper confidence limit of 2.2%.
    Conclusion: We present preliminary evidence on the endophthalmitis risk in patients with concurrent lower eyelid malposition and cataract who undergo cataract surgery prior to eyelid repair. We propose that this strategy may be a viable option to expedite vision restoration and reduce the risk of recurrent lower eyelid malposition in select patients. More data are required to reach statistically significant noninferiority and show that a malpositioned lower eyelid is not a risk factor for postoperative endophthalmitis following cataract surgery.
    Mesh-Begriff(e) Cataract/complications ; Cataract Extraction/adverse effects ; Ectropion/surgery ; Endophthalmitis/epidemiology ; Endophthalmitis/etiology ; Endophthalmitis/surgery ; Entropion/surgery ; Humans ; Postoperative Complications/etiology ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-05-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.04.024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Infection rate following elective oculoplastic surgery in a minor procedure setting: a single-centre retrospective study.

    Doucet, Véronique / McKenzie, Marna / Lee-Wing, Matthew / Bellan, Lorne

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Band 58, Heft 1, Seite(n) 34–38

    Abstract: Objective: A surgical site infection after oculoplastic surgery is a serious complication that can lead to endophthalmitis and vision loss. Although performing these procedures in a minor-surgery setting is common, there is a lack of evidence in the ... ...

    Abstract Objective: A surgical site infection after oculoplastic surgery is a serious complication that can lead to endophthalmitis and vision loss. Although performing these procedures in a minor-surgery setting is common, there is a lack of evidence in the literature regarding the incidence of postoperative infections. The objective of this study was to determine the infection rate associated with elective outpatient oculoplastic procedures performed in a minor-surgery setting.
    Methods: A retrospective review was completed for all patients who underwent elective oculoplastic surgery in the minor-procedure room at the Misericordia Health Centre in Winnipeg between April and December 2018. Operations were performed by 2 senior oculoplastic surgeons. Data collected included the type of procedure, number of surgical incisions, type and number of sutures, use of prophylactic antibiotics, time to follow-up, complications, and presence of surgical site infection.
    Results: Review of 539 patients showed an infection rate of 0.37% (2 of 539). Infection cases were an exposed orbital implant using a temporalis fascia graft and ptosis repair using a frontalis sling. Thirteen complications were identified, corresponding to a complication rate of 2.41% (13 of 539).
    Conclusion: Study results show an infection rate of 0.37% for elective oculoplastic surgery in a minor-procedure setting.
    Mesh-Begriff(e) Humans ; Retrospective Studies ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Blepharoplasty/adverse effects ; Blepharoplasty/methods ; Plastic Surgery Procedures ; Elective Surgical Procedures/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2021-08-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.07.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Eyelid ptosis.

    McInnes, Colin W / Lee-Wing, Matthew

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2015  Band 187, Heft 14, Seite(n) 1074

    Mesh-Begriff(e) Blepharoptosis/diagnosis ; Blepharoptosis/etiology ; Blepharoptosis/physiopathology ; Blepharoptosis/surgery ; Canada ; Humans ; National Health Programs ; Physical Examination
    Sprache Englisch
    Erscheinungsdatum 2015-05-25
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Video-Audio Media
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.140579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Manufacturing autologous myoblast for regenerative medicine applications.

    Lee-Wing, Matthew / Szwajcer, David / Lockwood, Anthony / Flynn, Alanna / Anjos, Karla / Tulloch, Marie / Giftakis, Angeline / Guan, Qingdong

    Cytotechnology

    2020  Band 72, Heft 5, Seite(n) 605–614

    Abstract: Background: Autologous myoblasts have been tested in the treatment of muscle-related diseases. However, the standardization of manufacturing myoblasts is still not established. Here we report a flask and animal-free medium-based method of manufacturing ... ...

    Abstract Background: Autologous myoblasts have been tested in the treatment of muscle-related diseases. However, the standardization of manufacturing myoblasts is still not established. Here we report a flask and animal-free medium-based method of manufacturing clinical-grade myoblast together with establishing releasing criteria for myoblast products under Good Manufacturing Practice (GMP).
    Methods: Quadriceps muscle biopsy samples were donated from three patients with myogenic ptosis. After biopsy samples were digested through enzymatic dissociation, the cells were grown in T175 flasks (passage 0) and hyperflasks (passage 1) in the animal-free SkGM
    Results: 400 to 500 million myoblast cells were manufactured within 15 to 17 days by the end of passage 1, which met pre-determined releasing criteria. The manufactured myoblast cells could differentiate and fuse into myotubes in vitro, with the possible trend that the donor age may impact the differentiation ability of myoblasts.
    Conclusions: The present study establishes a flask-based method of manufacturing myoblast in the animal-free medium together with releasing criteria, which is simple, robust, inexpensive and easily reproducible. This study will serve as the validation for a planned phase 1 clinical trial to assess the use of autologous myoblast transplants for the treatment of myogenic ptosis and other myogenic diseases.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-020-00420-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Amniotic membrane for repair of exposed hydroxyapatite orbital implant.

    Lee-Wing, Matthew W

    Ophthalmic plastic and reconstructive surgery

    2003  Band 19, Heft 5, Seite(n) 401–402

    Abstract: Exposure of a hydroxyapatite orbital implant measuring 10 x 3 mm developed in a 25-year-old man. The exposure was repaired with an amniotic membrane graft. Follow-up examinations at 5 days, 2 weeks, 2.5 months, and 5 months after surgery demonstrated ... ...

    Abstract Exposure of a hydroxyapatite orbital implant measuring 10 x 3 mm developed in a 25-year-old man. The exposure was repaired with an amniotic membrane graft. Follow-up examinations at 5 days, 2 weeks, 2.5 months, and 5 months after surgery demonstrated closure of the conjunctival defect. The author concludes that amniotic membrane may be useful for the treatment of hydroxyapatite orbital implant exposures.
    Mesh-Begriff(e) Adult ; Amnion/transplantation ; Biological Dressings ; Durapatite ; Eye Enucleation ; Humans ; Male ; Orbital Implants/adverse effects ; Postoperative Complications ; Surgical Wound Dehiscence/etiology ; Surgical Wound Dehiscence/surgery ; Treatment Outcome ; Wound Healing
    Chemische Substanzen Durapatite (91D9GV0Z28)
    Sprache Englisch
    Erscheinungsdatum 2003-09
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 632830-1
    ISSN 1537-2677 ; 0740-9303
    ISSN (online) 1537-2677
    ISSN 0740-9303
    DOI 10.1097/01.IOP.0000087029.00333.C2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Primary leptomeningeal lymphoma masquerading as pseudotumor cerebri.

    Manusow, Joshua Solomon / Lee-Wing, Matthew / Rahman, Jennifer / Mis, Andrew

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2009  Band 44, Heft 3, Seite(n) e19–20

    Mesh-Begriff(e) Adolescent ; Antineoplastic Agents/therapeutic use ; Diagnosis, Differential ; Eye Neoplasms/diagnosis ; Eye Neoplasms/drug therapy ; Eye Neoplasms/physiopathology ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Meningeal Neoplasms/diagnosis ; Meningeal Neoplasms/drug therapy ; Optic Disk/pathology ; Pseudotumor Cerebri/diagnosis ; Visual Acuity ; Visual Fields
    Chemische Substanzen Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2009-06
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.3129/i09-063
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Metastatic large-cell lung carcinoma to the orbit in a 25-year-old nonsmoker.

    Jordan, David R / Lee-Wing, Matthew W

    Ophthalmic surgery and lasers

    2002  Band 33, Heft 6, Seite(n) 488–490

    Abstract: Lung cancer commonly affects middle-aged and elderly smokers. Metastatic disease involving the orbit is uncommon. We report the unusual occurrence of a 25-year-old male nonsmoker with an aggressive form of lung cancer who developed metastatic orbital ... ...

    Abstract Lung cancer commonly affects middle-aged and elderly smokers. Metastatic disease involving the orbit is uncommon. We report the unusual occurrence of a 25-year-old male nonsmoker with an aggressive form of lung cancer who developed metastatic orbital disease involving the medial rectus.
    Mesh-Begriff(e) Adult ; Carcinoma, Large Cell/diagnostic imaging ; Carcinoma, Large Cell/secondary ; Humans ; Lung Neoplasms/pathology ; Male ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/secondary ; Tomography, X-Ray Computed
    Sprache Englisch
    Erscheinungsdatum 2002-11
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1291060-0
    ISSN 1082-3069
    ISSN 1082-3069
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Neural network and logistic regression diagnostic prediction models for giant cell arteritis: development and validation.

    Ing, Edsel B / Miller, Neil R / Nguyen, Angeline / Su, Wanhua / Bursztyn, Lulu L C D / Poole, Meredith / Kansal, Vinay / Toren, Andrew / Albreki, Dana / Mouhanna, Jack G / Muladzanov, Alla / Bernier, Mikaël / Gans, Mark / Lee, Dongho / Wendel, Colten / Sheldon, Claire / Shields, Marc / Bellan, Lorne / Lee-Wing, Matthew /
    Mohadjer, Yasaman / Nijhawan, Navdeep / Tyndel, Felix / Sundaram, Arun N E / Ten Hove, Martin W / Chen, John J / Rodriguez, Amadeo R / Hu, Angela / Khalidi, Nader / Ing, Royce / Wong, Samuel W K / Torun, Nurhan

    Clinical ophthalmology (Auckland, N.Z.)

    2019  Band 13, Seite(n) 421–430

    Abstract: Purpose: To develop and validate neural network (NN) vs logistic regression (LR) diagnostic prediction models in patients with suspected giant cell arteritis (GCA). Design: Multicenter retrospective chart review.: Methods: An audit of consecutive ... ...

    Abstract Purpose: To develop and validate neural network (NN) vs logistic regression (LR) diagnostic prediction models in patients with suspected giant cell arteritis (GCA). Design: Multicenter retrospective chart review.
    Methods: An audit of consecutive patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at 14 international medical centers. The outcome variable was biopsy-proven GCA. The predictor variables were age, gender, headache, clinical temporal artery abnormality, jaw claudication, vision loss, diplopia, erythrocyte sedimentation rate, C-reactive protein, and platelet level. The data were divided into three groups to train, validate, and test the models. The NN model with the lowest false-negative rate was chosen. Internal and external validations were performed.
    Results: Of 1,833 patients who underwent TABx, there was complete information on 1,201 patients, 300 (25%) of whom had a positive TABx. On multivariable LR age, platelets, jaw claudication, vision loss, log C-reactive protein, log erythrocyte sedimentation rate, headache, and clinical temporal artery abnormality were statistically significant predictors of a positive TABx (
    Conclusion: Statistical models can aid in the triage of patients with suspected GCA. Misclassification remains a concern, but cutoff values for 95% and 99% sensitivities are provided (https://goo.gl/THCnuU).
    Sprache Englisch
    Erscheinungsdatum 2019-02-21
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S193460
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Acanthamoeba keratitis: persistent organisms without inflammation after 1 year of topical chlorhexidine.

    Gooi, Patrick / Lee-Wing, Matthew / Brownstein, Seymour / El-Defrawy, Sherif / Jackson, W Bruce / Mintsioulis, George

    Cornea

    2008  Band 27, Heft 2, Seite(n) 246–248

    Abstract: Purpose: To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year.: Methods: A 53-year-old man with Acanthamoeba ... ...

    Abstract Purpose: To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year.
    Methods: A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty.
    Results: Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring.
    Conclusions: The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.
    Mesh-Begriff(e) Acanthamoeba Keratitis/drug therapy ; Acanthamoeba Keratitis/parasitology ; Acanthamoeba Keratitis/surgery ; Administration, Topical ; Antiprotozoal Agents/therapeutic use ; Chlorhexidine/therapeutic use ; Corneal Stroma/parasitology ; Humans ; Keratoplasty, Penetrating ; Male ; Middle Aged ; Time Factors
    Chemische Substanzen Antiprotozoal Agents ; Chlorhexidine (R4KO0DY52L)
    Sprache Englisch
    Erscheinungsdatum 2008-02
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0b013e31815b82a2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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