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  1. Book ; Conference proceedings: Substance P and related peptides

    Leeman, Susan E.

    cellular and molecular physiology ; [result of a Conference Entitled Substance P and Related Peptides: Cellular and Molecular Physiology, held on July 18 - 21, 1990, in Worcester, Massachusetts]

    (Annals of the New York Academy of Sciences ; 632)

    1991  

    Event/congress International Symposium on Substance P and Related Peptides (1990, WorcesterMass.)
    Author's details ed. by Susan E. Leeman
    Series title Annals of the New York Academy of Sciences ; 632
    Collection
    Keywords Peptides / physiology / congresses ; Substance P / physiology / congresses ; Peptide ; Substanz P
    Language English
    Size XIII, 497 S. : Ill., graph. Darst.
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003957099
    ISBN 0-89766-663-1 ; 0-89766-664-X ; 978-0-89766-663-3 ; 978-0-89766-664-0
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Effect of IL-33 on de novo synthesized mediators from human mast cells.

    Theoharides, Theoharis C / Leeman, Susan E

    The Journal of allergy and clinical immunology

    2018  Volume 143, Issue 1, Page(s) 451

    MeSH term(s) Cells, Cultured ; Humans ; Interleukin-33 ; Mast Cells
    Chemical Substances Interleukin-33
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is substance P a nasal epithelial neuropeptide?

    Douglas, Steven D / Leeman, Susan E

    The Journal of allergy and clinical immunology

    2018  Volume 142, Issue 5, Page(s) 1677

    MeSH term(s) Nasal Mucosa ; Neuropeptides ; Substance P
    Chemical Substances Neuropeptides ; Substance P (33507-63-0)
    Language English
    Publishing date 2018-06-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.05.034
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  4. Article ; Online: IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder.

    Tsilioni, Irene / Pantazopoulos, Harry / Conti, Pio / Leeman, Susan E / Theoharides, Theoharis C

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 28, Page(s) 16475–16480

    Abstract: Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of ... ...

    Abstract Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1β and CXCL8. This process is inhibited by the cytokine IL-37. Another cytokine, IL-38, has been reported to have antiinflammatory actions. In this report, we show that pretreatment of cultured adult human microglia with recombinant IL-38 (aa3-152, 1-100 ng/mL) inhibits (
    MeSH term(s) Adolescent ; Amygdala/immunology ; Autism Spectrum Disorder/blood ; Autism Spectrum Disorder/immunology ; Cells, Cultured ; Child ; Child, Preschool ; Humans ; Interleukin-16/blood ; Interleukin-16/immunology ; Interleukin-1beta/blood ; Interleukin-1beta/immunology ; Interleukin-8/immunology ; Interleukins/blood ; Interleukins/immunology ; Male ; Microglia/immunology ; Neurotensin/blood ; Neurotensin/immunology
    Chemical Substances CXCL8 protein, human ; IL-38 protein, human ; Interleukin-16 ; Interleukin-1beta ; Interleukin-8 ; Interleukins ; Neurotensin (39379-15-2)
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2004666117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diversity of neuropathogenic mechanisms and implications for neuromediation of diseases.

    Leeman, Susan E

    Annals of the New York Academy of Sciences

    2008  Volume 1144, Page(s) 113–115

    MeSH term(s) Adrenocorticotropic Hormone/history ; Adrenocorticotropic Hormone/metabolism ; Animals ; Corticotropin-Releasing Hormone/history ; Corticotropin-Releasing Hormone/metabolism ; Drug Therapy ; History, 20th Century ; Humans ; Neurons/metabolism ; Neuropeptides/history ; Neuropeptides/metabolism ; Substance P/antagonists & inhibitors ; Substance P/history
    Chemical Substances Neuropeptides ; Substance P (33507-63-0) ; Adrenocorticotropic Hormone (9002-60-2) ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1196/annals.1418.017
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  6. Article ; Online: Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin.

    Taracanova, Alexandra / Tsilioni, Irene / Conti, Pio / Norwitz, Errol R / Leeman, Susan E / Theoharides, Theoharis C

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 40, Page(s) E9381–E9390

    Abstract: Mast cells are critical for allergic and inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. SP (0.01-1 μM) administered together with IL-33 (30 ng/mL) to human cultured LAD2 mast cells stimulates a marked ... ...

    Abstract Mast cells are critical for allergic and inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. SP (0.01-1 μM) administered together with IL-33 (30 ng/mL) to human cultured LAD2 mast cells stimulates a marked increase (
    MeSH term(s) Biphenyl Compounds/pharmacology ; Caspase 1/metabolism ; Cell Line, Tumor ; Humans ; Interleukin-1beta/metabolism ; Interleukin-33/pharmacology ; Luteolin/pharmacology ; Mast Cells/cytology ; Mast Cells/metabolism ; Piperidines/pharmacology ; Substance P/pharmacology
    Chemical Substances Biphenyl Compounds ; IL1B protein, human ; IL33 protein, human ; Interleukin-1beta ; Interleukin-33 ; Piperidines ; methoxyluteolin ; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine (148700-85-0) ; Substance P (33507-63-0) ; Caspase 1 (EC 3.4.22.36) ; Luteolin (KUX1ZNC9J2) ; CP 96345 (W22ILA2I52)
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1810133115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism.

    Patel, Arti B / Tsilioni, Irene / Leeman, Susan E / Theoharides, Theoharis C

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 45, Page(s) E7049–E7058

    Abstract: We had reported elevated serum levels of the peptide neurotensin (NT) in children with autism spectrum disorders (ASD). Here, we show that NT stimulates primary human microglia, the resident immune cells of the brain, and the immortalized cell line of ... ...

    Abstract We had reported elevated serum levels of the peptide neurotensin (NT) in children with autism spectrum disorders (ASD). Here, we show that NT stimulates primary human microglia, the resident immune cells of the brain, and the immortalized cell line of human microglia-SV40. NT (10 nM) increases the gene expression and release (
    Language English
    Publishing date 2016-09-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1604992113
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  8. Article ; Online: Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.

    Douglas, Steven D / Leeman, Susan E

    Annals of the New York Academy of Sciences

    2010  Volume 1217, Page(s) 83–95

    Abstract: The G protein-coupled receptor (GPCR), neurokinin-1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune system and selected infections. NK1R and SP are ubiquitous throughout the animal kingdom. This ... ...

    Abstract The G protein-coupled receptor (GPCR), neurokinin-1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune system and selected infections. NK1R and SP are ubiquitous throughout the animal kingdom. This important pathway has unique functions in numerous cells and tissues. The interaction of SP with its preferred receptor, NK1R, leads to the activation of nuclear factor-kappa B (NF-κB) and proinflammatory cytokines. NK1R has two isoforms, both a full-length and a truncated form. These isoforms have different functional significances and differ in cell signaling capability. The proinflammatory signals modulated by SP are important in bacterial, viral, fungal, and parasitic diseases, as well as in immune system function. The SP-NK1R system is a major class 1, rhodopsin-like GPCR ligand-receptor interaction.
    MeSH term(s) Amino Acid Sequence ; Animals ; Humans ; Infections/microbiology ; Infections/parasitology ; Infections/virology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/physiology ; Molecular Sequence Data ; Protein Isoforms/physiology ; Receptors, Neurokinin-1/physiology ; Substance P/physiology
    Chemical Substances Inflammation Mediators ; Protein Isoforms ; Receptors, Neurokinin-1 ; Substance P (33507-63-0)
    Language English
    Publishing date 2010-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2010.05826.x
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  9. Article ; Online: IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin.

    Tsilioni, Irene / Patel, Arti B / Pantazopoulos, Harry / Berretta, Sabina / Conti, Pio / Leeman, Susan E / Theoharides, Theoharis C

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 43, Page(s) 21659–21665

    Abstract: Autism spectrum disorder (ASD) does not have a distinct pathogenesis or effective treatment. Increasing evidence supports the presence of immune dysfunction and inflammation in the brains of children with ASD. In this report, we present data that gene ... ...

    Abstract Autism spectrum disorder (ASD) does not have a distinct pathogenesis or effective treatment. Increasing evidence supports the presence of immune dysfunction and inflammation in the brains of children with ASD. In this report, we present data that gene expression of the antiinflammatory cytokine IL-37, as well as of the proinflammatory cytokines IL-18 and TNF, is increased in the amygdala and dorsolateral prefrontal cortex of children with ASD as compared to non-ASD controls. Gene expression of IL-18R, which is a receptor for both IL-18 and IL-37, is also increased in the same brain areas of children with ASD. Interestingly, gene expression of the NTR3/sortilin receptor is reduced in the amygdala and dorsolateral prefrontal cortex. Pretreatment of cultured human microglia from normal adult brains with human recombinant IL-37 (1 to 100 ng/mL) inhibits neurotensin (NT)-stimulated secretion and gene expression of IL-1β and CXCL8. Another key finding is that NT, as well as the proinflammatory cytokines IL-1β and TNF increase IL-37 gene expression in cultured human microglia. The data presented here highlight the connection between inflammation and ASD, supporting the development of IL-37 as a potential therapeutic agent of ASD.
    MeSH term(s) Adaptor Proteins, Vesicular Transport/metabolism ; Amygdala/metabolism ; Autism Spectrum Disorder/metabolism ; Cells, Cultured ; Child ; Humans ; Interleukin-1/metabolism ; Interleukin-18/metabolism ; Interleukin-18 Receptor alpha Subunit/metabolism ; Interleukin-1beta/biosynthesis ; Interleukin-8/biosynthesis ; Microglia/metabolism ; Neurotensin/metabolism ; Prefrontal Cortex/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Adaptor Proteins, Vesicular Transport ; CXCL8 protein, human ; IL18R1 protein, human ; IL1B protein, human ; IL37 protein, human ; Interleukin-1 ; Interleukin-18 ; Interleukin-18 Receptor alpha Subunit ; Interleukin-1beta ; Interleukin-8 ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Neurotensin (39379-15-2) ; sortilin (Z020Y8WIJ4)
    Language English
    Publishing date 2019-10-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1906817116
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  10. Article ; Online: Reply to Fattori et al.: Action of SP and IL-33 on mast cells.

    Theoharides, Theoharis C / Taracanova, Alexandra / Tsilioni, Irene / Conti, Pio / Leeman, Susan E

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 47, Page(s) E10036

    MeSH term(s) Interleukin-33 ; Mast Cells ; Receptors, Neurokinin-1 ; Substance P
    Chemical Substances Interleukin-33 ; Receptors, Neurokinin-1 ; Substance P (33507-63-0)
    Language English
    Publishing date 2017--21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1716233114
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