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  1. Article ; Online: Evidence-based clinical practice guidelines on postdural puncture headache: infographics.

    Uppal, Vishal / Russell, Robin / Kalagara, Hari / Leffert, Lisa / Narouze, Samer

    Regional anesthesia and pain medicine

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2024-105280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is Insufficient Evidence Sufficient?

    Leffert, Lisa R

    Anesthesia and analgesia

    2019  Volume 129, Issue 5, Page(s) 1202–1204

    MeSH term(s) Female ; Humans ; Obstetrics ; Post-Dural Puncture Headache ; Pregnancy ; Pregnancy Complications ; Retrospective Studies
    Language English
    Publishing date 2019-10-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004437
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  3. Article: What's New in Neuraxial Labor Analgesia.

    Toledano, Roulhac D / Leffert, Lisa

    Current anesthesiology reports

    2021  Volume 11, Issue 3, Page(s) 340–347

    Abstract: Purpose of review: This article provides an update of recent practice trends in neuraxial labor analgesia. It reviews available evidence regarding management of labor pain in obstetric patients with COVID-19, serious adverse events in obstetric ... ...

    Abstract Purpose of review: This article provides an update of recent practice trends in neuraxial labor analgesia. It reviews available evidence regarding management of labor pain in obstetric patients with COVID-19, serious adverse events in obstetric anesthesia to help inform risk/benefit decisions, and increasingly popular neuraxial labor analgesia techniques and adjuvants. State-of-the-art modes of epidural drug delivery are also discussed.
    Recent findings: There has recently been a focus on several considerations specific to obstetric anesthesia, such as anesthetic management of obstetric patients with COVID-19, platelet thresholds for the safe performance of neuraxial analgesia in obstetric patients with thrombocytopenia, and drug delivery modes for initiation and maintenance of neuraxial labor analgesia.
    Summary: Neuraxial labor analgesia (via standard epidural, dural puncture epidural, and combined spinal epidural techniques) is the most effective therapy to alleviate the pain of childbirth. SARS-CoV-2 infection is not, in and of itself, a contraindication to neuraxial labor analgesia or cesarean delivery anesthesia. Early initiation of neuraxial labor analgesia in patients with COVID-19 is recommended if not otherwise contraindicated, as it may reduce the need for general anesthesia should emergency cesarean delivery become necessary. Consensus regarding platelet thresholds for safe initiation of neuraxial procedures has historically been lacking. Recent studies have concluded that the risk of spinal epidural hematoma formation after neuraxial procedures is likely low at or above an imprecise range of platelet count of 70-75,000 × 10
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057373-X
    ISSN 2167-6275 ; 1523-3855
    ISSN (online) 2167-6275
    ISSN 1523-3855
    DOI 10.1007/s40140-021-00453-6
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  4. Article ; Online: #MaternalStroke Trending Now: Time to Cancel It.

    Miller, Eliza C / Leffert, Lisa

    Neurology

    2021  Volume 96, Issue 21, Page(s) 973–974

    MeSH term(s) Factor Analysis, Statistical ; Female ; Finland ; Humans ; Incidence ; Postpartum Period ; Pregnancy ; Stroke/complications ; Stroke/epidemiology
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011995
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  5. Article ; Online: What's New in Obstetric Anesthesia: The 2014 Gerard W. Ostheimer Lecture.

    Leffert, Lisa

    Anesthesia and analgesia

    2015  Volume 120, Issue 5, Page(s) 1065–1073

    MeSH term(s) Anesthesia, Obstetrical/adverse effects ; Anesthesia, Obstetrical/trends ; Delivery, Obstetric/trends ; Female ; Humans ; Hypertension, Pregnancy-Induced/diagnosis ; Hypertension, Pregnancy-Induced/mortality ; Hypertension, Pregnancy-Induced/therapy ; Infant ; Infant, Newborn ; Maternal Health/trends ; Maternal Health Services/trends ; Maternal Mortality/trends ; Neonatology/trends ; Perinatal Mortality/trends ; Perinatology/trends ; Postpartum Hemorrhage/diagnosis ; Postpartum Hemorrhage/mortality ; Postpartum Hemorrhage/therapy ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/mortality ; Pregnancy Complications/therapy ; Pregnancy Outcome ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2015-03-19
    Publishing country United States
    Document type Journal Article ; Lecture ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000000686
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  6. Article ; Online: In Response.

    Pearson, Amy C S / Leffert, Lisa R / Kain, Zeev N

    Anesthesia and analgesia

    2022  Volume 135, Issue 1, Page(s) e3–e4

    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006014
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  7. Article ; Online: Gloving up for the fight against racial and ethnic disparities in obstetric anesthesia care.

    Lee, Allison / Leffert, Lisa

    Journal of clinical anesthesia

    2020  Volume 67, Page(s) 109988

    MeSH term(s) Anesthesia, Obstetrical/adverse effects ; Anesthetics ; Continental Population Groups ; Delivery, Obstetric ; Ethnic Groups ; Female ; Humans ; Pregnancy
    Chemical Substances Anesthetics
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2020.109988
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  8. Article ; Online: Preeclampsia and platelet count: How much is enough?

    Bauer, Melissa E / Leffert, Lisa

    Journal of clinical anesthesia

    2020  Volume 64, Page(s) 109798

    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2020.109798
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  9. Article ; Online: Stroke in Pregnancy: A Focused Update.

    Miller, Eliza C / Leffert, Lisa

    Anesthesia and analgesia

    2019  Volume 130, Issue 4, Page(s) 1085–1096

    Abstract: Ischemic stroke (IS) and hemorrhagic stroke (HS) can be devastating complications during pregnancy and the puerperium that are thought to occur in approximately 30 in 100,000 pregnancies. In high-risk groups, such as women with preeclampsia, the ... ...

    Abstract Ischemic stroke (IS) and hemorrhagic stroke (HS) can be devastating complications during pregnancy and the puerperium that are thought to occur in approximately 30 in 100,000 pregnancies. In high-risk groups, such as women with preeclampsia, the incidence of both stroke subtypes, combined, is up to 6-fold higher than in pregnant women without these disorders. IS or HS may present in young women with atypical symptoms including headache, seizure, extremity weakness, dizziness, nausea, behavioral changes, and visual symptoms. Obstetric anesthesiologists who recognize these signs and symptoms of pregnancy-related stroke are well positioned to facilitate timely care. Acute stroke of any type is an emergency that should prompt immediate coordination of care between obstetric anesthesiologists, stroke neurologists, high-risk obstetricians, nurses, and neonatologists. Historically, guidelines have not addressed the unique situation of maternal stroke, and pregnant women have been excluded from the large stroke trials. More recently, several publications and professional societies have highlighted that pregnant women suspected of having IS or HS should be evaluated for the same therapies as nonpregnant women. Vaginal delivery is generally preferred unless there are obstetric indications for cesarean delivery. Neuraxial analgesia and anesthesia are frequently safer than general anesthesia for cesarean delivery in the patient with a recent stroke. Potential exceptions include therapeutic anticoagulation or intracranial hypertension with risk of herniation. General anesthesia may be appropriate when cesarean delivery will be combined with intracranial neurosurgery.
    MeSH term(s) Adult ; Brain Ischemia/complications ; Brain Ischemia/epidemiology ; Brain Ischemia/therapy ; Delivery, Obstetric ; Female ; Humans ; Intracranial Hemorrhages/complications ; Intracranial Hemorrhages/epidemiology ; Intracranial Hemorrhages/therapy ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/therapy ; Stroke/complications ; Stroke/epidemiology ; Stroke/therapy
    Language English
    Publishing date 2019-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004203
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  10. Article ; Online: In Response.

    Bauer, Melissa E / Rajasekhar, Anita / Leffert, Lisa

    Anesthesia and analgesia

    2021  Volume 133, Issue 5, Page(s) e60–e61

    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005726
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