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  1. Article ; Online: Zygomatic implant placement using a robot-assisted flapless protocol: proof of concept.

    Olivetto, M / Bettoni, J / Testelin, S / Lefranc, M

    International journal of oral and maxillofacial surgery

    2022  Volume 52, Issue 6, Page(s) 710–715

    Abstract: Robotic assistance can help in physically guiding the drilling trajectory during zygomatic implant positioning. A new robot-assisted strategy for a flapless zygomatic implant placement protocol is reported here. In this protocol, a preoperative computed ... ...

    Abstract Robotic assistance can help in physically guiding the drilling trajectory during zygomatic implant positioning. A new robot-assisted strategy for a flapless zygomatic implant placement protocol is reported here. In this protocol, a preoperative computed tomography scan is used to plan the surgical path. After surface registration, the ROSA robot (Zimmer Biomet Robotics) guides several steps, which are performed with shared control. The surgeon performs the drilling and tapping, guided by the robotic arm, which is positioned according to the planned trajectory. Placement of the zygomatic implant is done manually. Immediate intraoperative 3D verification is performed by cone beam computed tomography (flat-panel detector, Medtronic O-arm II). Four zygomatic implants were placed in the case patient according to the flapless protocol, with a mean vector error of 1.78 mm (range 0.52-4.70 mm). A screw-retained temporary prosthesis was placed on the same day. No significant complications were observed. The application of this robot-assisted surgical protocol, which guarantees a very high degree of precision, may reduce inaccuracies in the positioning of zygomatic implants that could deviate from the surgeon's plan. This appears to be a potentially safe flapless surgery technique. Drill slipping on the crest or on the maxillary wall is the main source of error in this procedure, emphasizing the usefulness of the assisted surgical guidance with haptic feedback.
    MeSH term(s) Humans ; Dental Implantation, Endosseous/methods ; Dental Implants ; Robotics ; Imaging, Three-Dimensional ; Tomography, X-Ray Computed ; Surgery, Computer-Assisted/methods ; Cone-Beam Computed Tomography
    Chemical Substances Dental Implants
    Language English
    Publishing date 2022-12-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2022.12.002
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    Zs.A 931: Show issues Location:
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    Zs.MO 401: Show issues

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  2. Article ; Online: Robotically assisted deployment of flow diverter stents for the treatment of cerebral and cervical aneurysms.

    Chivot, Cyril / Bouzerar, Roger / Peltier, Johann / Lefranc, Michel / Yzet, Thierry

    Journal of neurointerventional surgery

    2024  Volume 16, Issue 4, Page(s) 412–417

    Abstract: Background: Despite the growing sophistication of robot-assisted surgery, it is necessary to demonstrate that robots can reliably perform complex procedures on site and then remotely. Although a flow diverter stent is one of the most effective and ... ...

    Abstract Background: Despite the growing sophistication of robot-assisted surgery, it is necessary to demonstrate that robots can reliably perform complex procedures on site and then remotely. Although a flow diverter stent is one of the most effective and widely used devices, its placement is sometimes challenging.
    Objective: To evaluate the feasibility and safety of the CorPath GRX robotic platform for the embolization of cerebral and cervical aneurysms using flow diverter stents.
    Methods: We performed a single-center technical study of the first 10 flow diverter stent deployments with the CorPath GRX Robotic System (Corindus Inc, Waltham, Massachusetts, USA) for the treatment of cerebral aneurysms between April and October 2022.
    Results: Ten patients underwent robot-assisted embolization with flow diverter stents: there were nine intracranial aneurysms (paraclinoid n=6; posterior communicating artery aneurysm n=1; anterior communicating artery n=2) and one cervical aneurysm. Four procedures were performed with coils plus a flow diverter stent, one was performed with woven endobridge plus a flow diverter stent and four were performed with flow diverter stents alone. Of these procedures, two were performed with telescoping flow diverters.All flow diverter stents were deployed with robotic assistance, with only one partial conversion to a manual technique (caused by guidewire torquability limitations). No perioperative complications were observed.
    Conclusion: Robot-assisted flow diverter stent deployment using the CorPath GRX platform is feasible and appears to be safe. Larger, in-depth studies of the technique's safety and benefits are now warranted.
    MeSH term(s) Humans ; Robotic Surgical Procedures ; Treatment Outcome ; Endovascular Procedures/methods ; Retrospective Studies ; Stents ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Embolization, Therapeutic/methods ; Cerebral Angiography
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2022-019968
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  3. Article ; Online: Commentary on Robot-assisted all-epiphyseal anterior cruciate ligament reconstruction in skeletally immature patients: a retrospective study.

    Deroussen, François / Lefranc, Michel / Gouron, Richard / Klein, Céline

    International orthopaedics

    2023  Volume 47, Issue 7, Page(s) 1881–1882

    MeSH term(s) Humans ; Retrospective Studies ; Robotics ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-023-05821-x
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    Zs.A 1324: Show issues Location:
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  4. Article: Deep brain stimulation programming in Parkinson's disease: Introduction of current issues and perspectives.

    Aubignat, M / Lefranc, M / Tir, M / Krystkowiak, P

    Revue neurologique

    2020  Volume 176, Issue 10, Page(s) 770–779

    Abstract: Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD) leading to a significant reduction in motor and non-motor symptoms. Numerous factors contribute to positive outcomes for DBS including careful patient selection, ... ...

    Abstract Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD) leading to a significant reduction in motor and non-motor symptoms. Numerous factors contribute to positive outcomes for DBS including careful patient selection, lead placement and effective programming. Only DBS programming can be modified after patient implantation, therefore DBS programming plays a crucial role in improving clinical outcomes. In this paper, we review the literature to present current issues and perspectives for DBS programming in PD. Only a few algorithms proposed by experts for the initial programming and management of some adverse effects are available. No guidelines are available for programming sessions and medical treatment management during DBS follow-up. Moreover, emergence of increasingly complex lead designs makes programming more and more complex. Fortunately, in the last few years numerous techniques have emerged for optimization of DBS programming in PD.
    MeSH term(s) Deep Brain Stimulation ; Globus Pallidus ; Humans ; Parkinson Disease/therapy ; Treatment Outcome
    Language English
    Publishing date 2020-04-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2020.02.009
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  5. Article: Entraining Oscillations in the NF-κB Signaling System: With a Little Help from Noise.

    Lefranc, Marc

    Cell systems

    2016  Volume 3, Issue 6, Page(s) 507–508

    Abstract: Two studies show that noise is a key ingredient of new mechanisms for entraining the NF-κB system. ...

    Abstract Two studies show that noise is a key ingredient of new mechanisms for entraining the NF-κB system.
    Language English
    Publishing date 2016-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 2405-4712
    ISSN 2405-4712
    DOI 10.1016/j.cels.2016.12.008
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  6. Article ; Online: Unilateral Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy Thalamotomy for Essential Tremor.

    Aubignat, Mickael / Tir, Mélissa / Ouendo, Martial / Boussida, Salem / Constans, Jean-Marc / Lefranc, Michel

    Movement disorders : official journal of the Movement Disorder Society

    2024  

    Abstract: Background: Essential tremor (ET) affects numerous adults, impacting quality of life (QOL) and often defying pharmacological treatment. Surgical interventions like deep brain stimulation (DBS) and lesional approaches, including radiofrequency, gamma- ... ...

    Abstract Background: Essential tremor (ET) affects numerous adults, impacting quality of life (QOL) and often defying pharmacological treatment. Surgical interventions like deep brain stimulation (DBS) and lesional approaches, including radiofrequency, gamma-knife radiosurgery, and magnetic resonance imaging (MRI)-guided focused ultrasound, offer solutions but are not devoid of limitations.
    Objectives: This retrospective, single-center, single-blinded pilot study aimed to assess the safety and efficacy of unilateral MRI-guided laser interstitial thermal therapy (MRIg-LITT) thalamotomy for medically intractable ET.
    Methods: Nine patients with ET, unresponsive to medications and unsuitable for DBS, underwent unilateral MRIg-LITT thalamotomy. We assessed tremor severity, QOL, cognitive function, and adverse events (AE) over a 12-month period.
    Results: Tremor severity significantly improved, with a reduction of 83.37% at 12 months post-procedure. QOL scores improved by 74.60% at 12 months. Reported AEs predominantly included transient dysarthria, proprioceptive disturbances, and gait balance issues, which largely resolved within a month. At 3 months, 2 patients (22%) exhibited contralateral hemiparesis requiring physiotherapy, with 1 patient (11%) exhibiting persistent hemiparesis at 12 months. No significant cognitive impairment was detected post-procedure.
    Conclusions: Unilateral MRIg-LITT thalamotomy yielded substantial and enduring tremor alleviation and enhanced QOL in patients with ET that is resistant to medication. The AE profile was acceptable. Our findings support the need for additional research with expanded patient cohorts and extended follow-up to corroborate these outcomes and to refine the role of MRIg-LITT as a targeted and minimally invasive approach for ET management. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29790
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    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  7. Article ; Online: Severe kerion Celsi caused by Trichophyton quinckeanum: Severe kerion Celsi due to Trichophyton quinckeanum.

    Lefranc, M / Fourmond, S / Jabet, A / Normand, A-C / Girard, D / Accoceberry, I / Gabriel, F / Delhaes, L / Imbert, S

    Journal de mycologie medicale

    2023  Volume 34, Issue 1, Page(s) 101453

    Abstract: We report a severe case of kerion Celsi of the scalp in a previously healthy 13-year-old girl due to Trichophyton quinckeanum, an emerging dermatophyte species in Europe. The species was definitely identified by DNA sequencing and the patient was ... ...

    Abstract We report a severe case of kerion Celsi of the scalp in a previously healthy 13-year-old girl due to Trichophyton quinckeanum, an emerging dermatophyte species in Europe. The species was definitely identified by DNA sequencing and the patient was successfully treated by oral terbinafine for 6 weeks. Kerion Celsi is a severe inflammatory form of tinea capitis, which is characterised by a purulent discharge and alopecia [1]. It typically occurs in children infected with zoophilic dermatophytes, such as Trichophyton mentagrophytes, and an increasing number of cases caused by other Trichophyton species has recently been reported [2]. Herein we report a severe case of kerion Celsi of the scalp caused by the emerging species Trichophyton quinckeanum, which was successfully treated by oral antifungal.
    MeSH term(s) Child ; Female ; Humans ; Adolescent ; Arthrodermataceae ; Tinea Capitis/diagnosis ; Tinea Capitis/drug therapy ; Tinea Capitis/microbiology ; Trichophyton/genetics ; Antifungal Agents/therapeutic use
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-11-17
    Publishing country France
    Document type Case Reports
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2023.101453
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    Zs.A 3148: Show issues Location:
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  8. Article ; Online: Successful Surgical Treatment of an Intracranial Arachnoid Cyst Inducing Holmes' Tremor.

    Aubignat, Mickael / Tir, Mélissa / Vandici, Ovidiu-Florian / Lefranc, Michel

    Movement disorders clinical practice

    2023  Volume 10, Issue 6, Page(s) 998–1000

    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13744
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  9. Article: An Overview of the Circadian Clock in the Frame of Chronotherapy: From Bench to Bedside.

    Vandenberghe, Alan / Lefranc, Marc / Furlan, Alessandro

    Pharmaceutics

    2022  Volume 14, Issue 7

    Abstract: Most living organisms in both the plant and animal kingdoms have evolved processes to stay in tune with the alternation of day and night, and to optimize their physiology as a function of light supply. In mammals, a circadian clock relying on feedback ... ...

    Abstract Most living organisms in both the plant and animal kingdoms have evolved processes to stay in tune with the alternation of day and night, and to optimize their physiology as a function of light supply. In mammals, a circadian clock relying on feedback loops between key transcription factors will thus control the temporally regulated pattern of expression of most genes. Modern ways of life have highly altered the synchronization of human activities with their circadian clocks. This review discusses the links between an altered circadian clock and the rise of pathologies. We then sum up the proofs of concept advocating for the integration of circadian clock considerations in chronotherapy for health care, medicine, and pharmacotherapy. Finally, we discuss the current challenges that circadian biology must face and the tools to address them.
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071424
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  10. Article ; Online: Evaluation of the ROSA™ Spine robot for minimally invasive surgical procedures.

    Lefranc, M / Peltier, J

    Expert review of medical devices

    2016  Volume 13, Issue 10, Page(s) 899–906

    Abstract: The ROSA® robot (Medtech, Montpellier, France) is a new medical device designed to assist the surgeon during minimally invasive spine procedures. The device comprises a patient-side cart (bearing the robotic arm and a workstation) and an optical ... ...

    Abstract The ROSA® robot (Medtech, Montpellier, France) is a new medical device designed to assist the surgeon during minimally invasive spine procedures. The device comprises a patient-side cart (bearing the robotic arm and a workstation) and an optical navigation camera. The ROSA® Spine robot enables accurate pedicle screw placement. Thanks to its robotic arm and navigation abilities, the robot monitors movements of the spine throughout the entire surgical procedure and thus enables accurate, safe arthrodesis for the treatment of degenerative lumbar disc diseases, exactly as planned by the surgeon. Development perspectives include (i) assistance at all levels of the spine, (ii) improved planning abilities (virtualization of the entire surgical procedure) and (iii) use for almost any percutaneous spinal procedures not limited in screw positioning such as percutaneous endoscopic lumbar discectomy, intracorporeal implant positioning, over te top laminectomy or radiofrequency ablation.
    MeSH term(s) Device Approval ; Humans ; Minimally Invasive Surgical Procedures/instrumentation ; Robotics/instrumentation ; Spine/surgery ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2016.1236680
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