Article ; Online: Cardioprotective response and senescence in aged sEH null female mice exposed to LPS.
American journal of physiology. Heart and circulatory physiology
2024 Volume 326, Issue 6, Page(s) H1366–H1385
Abstract: Deterioration of physiological systems, like the cardiovascular system, occurs progressively with age impacting an individual's health and increasing susceptibility to injury and disease. Cellular senescence has an underlying role in age-related ... ...
| Abstract | Deterioration of physiological systems, like the cardiovascular system, occurs progressively with age impacting an individual's health and increasing susceptibility to injury and disease. Cellular senescence has an underlying role in age-related alterations and can be triggered by natural aging or prematurely by stressors such as the bacterial toxin lipopolysaccharide (LPS). The metabolism of polyunsaturated fatty acids by CYP450 enzymes produces numerous bioactive lipid mediators that can be further metabolized by soluble epoxide hydrolase (sEH) into diol metabolites, often with reduced biological effects. In our study, we observed age-related cardiac differences in female mice, where young mice demonstrated resistance to LPS injury, and genetic deletion or pharmacological inhibition of sEH using |
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| MeSH term(s) | Animals ; Epoxide Hydrolases/metabolism ; Epoxide Hydrolases/genetics ; Female ; Lipopolysaccharides/toxicity ; Mice, Knockout ; Aging/metabolism ; Mice ; Mice, Inbred C57BL ; Cellular Senescence/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Age Factors ; Sex Factors | |||||
| Chemical Substances | Epoxide Hydrolases (EC 3.3.2.-) ; Lipopolysaccharides ; Ephx2 protein, mouse (EC 3.3.2.10) | |||||
| Language | English | |||||
| Publishing date | 2024-04-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 603838-4 | |||||
| ISSN | 1522-1539 ; 0363-6135 | |||||
| ISSN (online) | 1522-1539 | |||||
| ISSN | 0363-6135 | |||||
| DOI | 10.1152/ajpheart.00706.2023 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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