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  1. Article ; Online: Opti'care protocol: a randomised control trial to evaluate the impact of a mobile antenatal care clinic in isolated rural areas on prenatal follow-up.

    Debost-Legrand, Anne / Legrand, Guillaume / Duclos-Médard, Julie / Thomazet, Juliette / Pranal, Marine / Langlois, Eric / Mourgues, Charline / Vendittelli, Françoise

    BMJ open

    2023  Volume 13, Issue 2, Page(s) e060337

    Abstract: Introduction: Rural residence appears to be a factor of vulnerability among pregnant women with poor clinical antenatal care. Our principal objective is to assess the impact of an infrastructure for a mobile antenatal care clinic on the completion of ... ...

    Abstract Introduction: Rural residence appears to be a factor of vulnerability among pregnant women with poor clinical antenatal care. Our principal objective is to assess the impact of an infrastructure for a mobile antenatal care clinic on the completion of antenatal care for women identified as geographically vulnerable in a perinatal network.
    Methods and analysis: Controlled cluster-randomised study in two parallel arms comparing an intervention group with an open-label control group. This study will concern the population of pregnant women who must live in one of the municipalities covered by the perinatal network and considered to be an area of geographic vulnerability. The cluster randomisation will take place according to the municipality of residence. The intervention will be the implementation of pregnancy monitoring by a mobile antenatal care clinic. The completion of antenatal care between the intervention and control groups will be a binary criterion: 1 will be attributed to each antenatal care that includes all visits and supplementary examinations. Sample size has been estimated to be 330 at least with an 80% participation rate.The univariate analyses will compare the follow-up rates (with Fisher's exact test), and all individual characteristics collected (Fisher's exact test, Student's t-test) between the two groups. The multivariate analysis will use a mixed linear model analysis and consider the cluster effect as random; the initial model will include known confounders from the literature, confounders identified in univariate analyses, and the clinically relevant prognostic factors. All of these factors will be taken into account in the model as a fixed effect.
    Ethics and dissemination: The Patient Protection Committee North-West II approved this study on 4 February 2021 (IRB 2020-A02247-32). The results will be the subject of scientific communications and publications.
    Trial registration number: NCT04823104.
    MeSH term(s) Pregnancy ; Female ; Humans ; Prenatal Care/methods ; Follow-Up Studies ; Parturition ; Pregnant Women ; Research Design ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-060337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Les tumeurs urothéliales, maladies professionnelles.

    Legrand, Guillaume / Guy, Laurent

    La Revue du praticien

    2014  Volume 64, Issue 10, Page(s) 1375–1378

    Title translation Urothelial tumors, occupational diseases.
    MeSH term(s) Age Distribution ; Aged ; Agriculture ; Arsenic/adverse effects ; Chemical Industry ; Early Detection of Cancer ; Female ; France/epidemiology ; Humans ; Incidence ; Male ; Nitrosamines/adverse effects ; Occupational Diseases/chemically induced ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Occupational Exposure/adverse effects ; Polycyclic Aromatic Hydrocarbons/adverse effects ; Prevalence ; Risk Factors ; Sex Distribution ; Smoking/adverse effects ; Urinary Bladder Neoplasms/chemically induced ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/prevention & control ; Urologic Neoplasms/chemically induced ; Urologic Neoplasms/epidemiology
    Chemical Substances Nitrosamines ; Polycyclic Aromatic Hydrocarbons ; Arsenic (N712M78A8G)
    Language French
    Publishing date 2014-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Coût médico-économiqe des cancers de la vessie en France.

    Legrand, Guillaume / Guy, Laurent

    La Revue du praticien

    2014  Volume 64, Issue 10, Page(s) 1381

    Title translation Medical and economic cost of bladder cancer in France.
    MeSH term(s) Cost of Illness ; France/epidemiology ; Health Care Costs ; Humans ; Mass Screening/economics ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/economics ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/therapy
    Language French
    Publishing date 2014-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Organisation and timeline of measures in French psychiatric establishments during the first wave of the COVID-19 epidemic: EvOlu'Psy study.

    Legrand, Guillaume / Boisgard, Catherine / Canac, Bernard / Cardinaud, Zuzana / Gorla, Michela Giugiario / Gregoire, Elisabeth / Jamon, Caroline / Oussal, Tarik / Vaury, Pascal

    BMC psychiatry

    2021  Volume 21, Issue 1, Page(s) 284

    Abstract: Background: The onset of COVID-19 required rapid organisational changes in the mental health domain. Most mental health-care departments appear to have set up infection control measures and also organised planning, coordination and measures that enabled ...

    Abstract Background: The onset of COVID-19 required rapid organisational changes in the mental health domain. Most mental health-care departments appear to have set up infection control measures and also organised planning, coordination and measures that enabled them to provide psychiatric care in a restrictive environment. Our objective was to assess the organisation by psychiatric facilities in France of their response to COVID-19, during the first wave.
    Methods: In June 2020, a cross-sectional study was performed by an audit with 48 items which was proposed to 331 hospitals in metropolitan France with a capacity for full-time, that is, inpatient psychiatric hospitalisation of adults.
    Results: Of the 331 establishments contacted, 94 (28.4%) agreed to respond to the survey questionnaire. Full-time inpatient hospitalisation was completely or partially maintained by 94.7% (n = 89) of facilities. Specific measures concerning respect for patients' rights were reported by 58% (n = 55) of establishments. Overall, 74.5% (n = 70) had set up a dedicated channel of care for patients at risk of severe COVID-19, and 52.1% (n = 49) a system for routine screening at admission for these risk factors. Nearly half the establishments (48.9%, n = 46) reported they had set up specific training programmes for patients about barrier measures and social distancing.
    Conclusions: French psychiatric establishments on the whole were able to provide a necessary reorganisation of their management of patients and their families, regardless of facility status. Patients' rights nonetheless seem to have not received the attention they merited during the early pandemic period. Somatic management of patients with mental illness must absolutely be improved.
    MeSH term(s) Adult ; COVID-19 ; Cross-Sectional Studies ; France/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-021-03293-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical practice recommendations for nurse-administered intramuscular injections in mental health: A modified Delphi study.

    Guiguet-Auclair, Candy / Bernard, Lise / Boisgard, Stéphane / Cardinaud, Zuzana / Fernandes, Jennifer / Debost-Legrand, Anne / Gregoire, Elisabeth / Lanquetin, Jean Paul / Morin, Nadine / Lopes, Estelle / Noel, Thibault / Guillot, Benjamin / Viennet, Hervé / Reynaud, Dominique / Traore, Ousmane / Legrand, Guillaume

    Journal of advanced nursing

    2023  Volume 79, Issue 10, Page(s) 3956–3980

    Abstract: Aim: To develop clinical practice recommendations for nurse-administered intramuscular injections in mental health.: Background: Intramuscular injection is the main route of long-acting injectable antipsychotics' administration that appear to improve ...

    Abstract Aim: To develop clinical practice recommendations for nurse-administered intramuscular injections in mental health.
    Background: Intramuscular injection is the main route of long-acting injectable antipsychotics' administration that appear to improve the long-term prognosis of mental illness. Specific guidelines related to the nurse administration of intramuscular injections need to be updated and to explore not only the technical aspects of this procedure.
    Design: A modified RAND/University of California Los Angeles (UCLA) appropriateness method Delphi study was conducted between October 2019 and September 2020.
    Methods: A multidisciplinary steering committee conducted a literature review and developed a list of 96 recommendations. These recommendations were submitted in a two-round Delphi electronic survey to a panel of 49 experienced practicing nurses from five mental health hospitals in France. Each recommendation was rated for its appropriateness and applicability in clinical practice on a 9-point Likert scale. Consensus among nurses was evaluated. The steering committee discussed the results after each round and approved the final set of recommendations.
    Results: A final set of 79 specific recommendations were accepted for their appropriateness and applicability in clinical practice. Recommendations were classified in five domains: legal and quality assurance aspects, nurse-patient relationship, hygiene, pharmacology, and injection technique.
    Conclusion: The established recommendations placed patients at the heart of the decisions concerning the intramuscular injection and underlined the need for specific training programs. Future research should focus on the integration of these recommendations in clinical practice, by both before-and-after studies and regular assessments of professional practices with relevant indicators.
    Impact: The recommendations developed for good nursing practices explored not only the technical aspects but integrated the nurse-patient relationship. These recommendations may impact usual practices of administration of long-acting injectable antipsychotics and most of them could be applied in many countries.
    No patient or public contribution: Due to the study design.
    MeSH term(s) Humans ; Mental Health ; Injections, Intramuscular ; Delphi Technique ; Antipsychotic Agents/therapeutic use ; Mental Disorders
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2023-05-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 197634-5
    ISSN 1365-2648 ; 0309-2402
    ISSN (online) 1365-2648
    ISSN 0309-2402
    DOI 10.1111/jan.15709
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  6. Article: Tumeurs de la vessie infiltrant le muscle.

    Pashootan, Pourya / Legrand, Guillaume / Ploussard, Guillaume

    La Revue du praticien

    2014  Volume 64, Issue 10, Page(s) 1391–2, 1395–8

    Abstract: Muscle invasive bladder cancers represent 20 to 30% of bladder tumors and are metastatic at diagnosis in 10% of cases. The diagnosis is based on histological analysis of transuretral resection pieces. An invasion of the detrusor (stage pT2) signs the ... ...

    Title translation Muscle-invasive bladder cancer.
    Abstract Muscle invasive bladder cancers represent 20 to 30% of bladder tumors and are metastatic at diagnosis in 10% of cases. The diagnosis is based on histological analysis of transuretral resection pieces. An invasion of the detrusor (stage pT2) signs the infiltrating nature of the tumor. The local and general staging is based on thoraco-abdominopelvic CT. The standard treatment for localized stages is cystoprostatectomy in men and anterior pelvic exenteration in women. For urinary diversion, the two choices are cutaneous non continent ileal conduit (Bricker) and ileal neobladder. Neoadjuvant chemotherapy can be discussed for locally advanced stages. The concomitant chemoradiotherapy is an alternative to surgical treatment in elderly or frail patients. The management of metastatic bladder cancer is based on systemic chemotherapy.
    MeSH term(s) Carcinoma/mortality ; Carcinoma/pathology ; Carcinoma/therapy ; Chemoradiotherapy/methods ; Cystectomy/methods ; Humans ; Neoplasm Invasiveness ; Neoplasm Staging ; Patient Selection ; Prognosis ; Urinary Bladder Neoplasms/mortality ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/therapy ; Urinary Diversion/methods
    Language French
    Publishing date 2014-12
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  7. Article ; Online: Efficacy and safety of combined paliperidone palmitate and olanzapine pamoate in resistant schizoaffective disorder.

    Legrand, Guillaume / Andrianarisoa, Méja / Mauvieux, Joëlle / Jalenques, Isabelle

    Journal of clinical psychopharmacology

    2014  Volume 34, Issue 5, Page(s) 652–653

    MeSH term(s) Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/administration & dosage ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Delayed-Action Preparations/adverse effects ; Delayed-Action Preparations/therapeutic use ; Drug Combinations ; Drug Resistance ; Humans ; Male ; Middle Aged ; Paliperidone Palmitate/administration & dosage ; Paliperidone Palmitate/adverse effects ; Paliperidone Palmitate/therapeutic use ; Psychotic Disorders/drug therapy
    Chemical Substances Antipsychotic Agents ; Delayed-Action Preparations ; Drug Combinations ; Benzodiazepines (12794-10-4) ; olanzapine (N7U69T4SZR) ; Paliperidone Palmitate (R8P8USM8FR)
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000000185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Selection and validation of reference genes for quantitative real-time PCR analysis of gene expression in Cichorium intybus.

    Delporte, Marianne / Legrand, Guillaume / Hilbert, Jean-Louis / Gagneul, David

    Frontiers in plant science

    2015  Volume 6, Page(s) 651

    Abstract: Plant polyphenols represent a huge reservoir of bioactive compounds. Industrial chicory, an important crop from northwestern Europe, accumulates an original combination of such compounds, i.e., chlorogenic, isochlorogenic, caftaric, and chicoric acids ... ...

    Abstract Plant polyphenols represent a huge reservoir of bioactive compounds. Industrial chicory, an important crop from northwestern Europe, accumulates an original combination of such compounds, i.e., chlorogenic, isochlorogenic, caftaric, and chicoric acids arising from the phenylpropanoid pathway. For a complete understanding of these biochemical pathways, analyses of gene expression using quantitative real-time PCR (qRT-PCR) should be considered. Because cell cultures are a model of choice for specialized metabolism investigations, this study described for the first time the validation of reference genes for this system in chicory. Eighteen potential reference genes were obtained by mining expressed sequence tag databases of chicory for orthologs of Arabidopsis thaliana genes currently used as reference genes. Twelve genes passed the qRT-PCR standard requirements and their expression stability across different samples was tested using three distinct softwares: geNorm, NormFinder, and BestKeeper. In cell cultures grown under various conditions, TIP41 (TIP41 like protein) was shown to be the most stable gene. Further validation of the proposed reference genes was done by normalization of expression levels of a group of genes of interest. In order to assess the potentiality of the proposed list of candidate reference genes, theses genes were in parallel tested on another experimental design, i.e., chicory seedlings. In this case, the best reference gene identified was Clath (Clathrin adaptator complex subunit). The results highlight the importance of the use of properly validated reference genes to achieve relevant interpretation of qRT-PCR analyses. Here, we provide a list of reference genes suitable for future gene expression studies in chicory.
    Language English
    Publishing date 2015-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2015.00651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Goal-Directed Fluid Therapy Guided by Cardiac Monitoring During High-Risk Abdominal Surgery in Adult Patients: Cost-Effectiveness Analysis of Esophageal Doppler and Arterial Pulse Pressure Waveform Analysis.

    Legrand, Guillaume / Ruscio, Laura / Benhamou, Dan / Pelletier-Fleury, Nathalie

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2015  Volume 18, Issue 5, Page(s) 605–613

    Abstract: Background: Several minimally invasive techniques for cardiac output monitoring such as the esophageal Doppler (ED) and arterial pulse pressure waveform analysis (APPWA) have been shown to improve surgical outcomes compared with conventional clinical ... ...

    Abstract Background: Several minimally invasive techniques for cardiac output monitoring such as the esophageal Doppler (ED) and arterial pulse pressure waveform analysis (APPWA) have been shown to improve surgical outcomes compared with conventional clinical assessment (CCA).
    Objective: To evaluate the cost-effectiveness of these techniques in high-risk abdominal surgery from the perspective of the French public health insurance fund.
    Methods: An analytical decision model was constructed to compare the cost-effectiveness of ED, APPWA, and CCA. Effectiveness data were defined from meta-analyses of randomized clinical trials. The clinical end points were avoidance of hospital mortality and avoidance of major complications. Hospital costs were estimated by the cost of corresponding diagnosis-related groups.
    Results: Both goal-directed therapy strategies evaluated were more effective and less costly than CCA. Perioperative mortality and the rate of major complications were reduced by the use of ED and APPWA. Cost reduction was mainly due to the decrease in the rate of major complications. APPWA was dominant compared with ED in 71.6% and 27.6% and dominated in 23.8% and 20.8% of the cases when the end point considered was "major complications avoided" and "death avoided," respectively. Regarding cost per death avoided, APPWA was more likely to be cost-effective than ED in a wide range of willingness to pay.
    Conclusions: Cardiac output monitoring during high-risk abdominal surgery is cost-effective and is associated with a reduced rate of hospital mortality and major complications, whatever the device used. The two devices evaluated had negligible costs compared with the observed reduction in hospital costs. Our comparative studies suggest a larger effect with APPWA that needs to be confirmed by further studies.
    MeSH term(s) Abdomen/surgery ; Aged ; Arterial Pressure ; Blood Pressure Determination/economics ; Blood Pressure Determination/instrumentation ; Cardiac Output ; Cost Savings ; Cost-Benefit Analysis ; Decision Support Techniques ; Decision Trees ; Echocardiography, Doppler/economics ; Echocardiography, Doppler/instrumentation ; Esophagus/diagnostic imaging ; Fluid Therapy/economics ; France ; Hospital Costs ; Hospital Mortality ; Humans ; Middle Aged ; Models, Economic ; Monitoring, Intraoperative/economics ; Monitoring, Intraoperative/instrumentation ; Monitoring, Intraoperative/methods ; Monte Carlo Method ; National Health Programs/economics ; Postoperative Complications/economics ; Postoperative Complications/mortality ; Postoperative Complications/prevention & control ; Predictive Value of Tests ; Public Sector/economics ; Treatment Outcome
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2015.04.005
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  10. Article: Blues et dépression du post-partum.

    Jalenques, Isabelle / Legrand, Guillaume

    La Revue du praticien

    2009  Volume 59, Issue 4, Page(s) 499–506

    Abstract: Post-partum time is an eventful period with modifications of somatic but also biological and psychological status of women, leading to increased risk of anxious and depressive disorders. Diagnosis of post-partum blues (PPB) or post-partum depression (PPD) ...

    Title translation Post-partum blues and depression.
    Abstract Post-partum time is an eventful period with modifications of somatic but also biological and psychological status of women, leading to increased risk of anxious and depressive disorders. Diagnosis of post-partum blues (PPB) or post-partum depression (PPD) is sometimes difficult. PPB is usually benign; thus a punctual help is usually sufficient. A severe or long duration PPB is associated with an increased risk of PPD which has to be taken into account. PPD can be difficult to diagnose because of multiple clinical forms and specially variations in intensity. During prenatal period, the aim is to look for women who are at risk for PPB or PPD. So it is necessary that the different practitioners can exchange informations. A treatment of PPD is essential because it has an important impact on mother and child's health. General practitioner involves from prenatal period (deflection of risk factors) to the diagnosis, the look out and the following of mothers and children in collaboration with obstetric, pediatric and psychiatric teams.
    MeSH term(s) Depression, Postpartum/diagnosis ; Depression, Postpartum/therapy ; Female ; Humans ; Risk Factors
    Language French
    Publishing date 2009-04-20
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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