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  1. Article: Characterization of the TRPV6 calcium channel-specific phenotype by RNA-seq in castration-resistant human prostate cancer cells.

    Cordier, Clément / Haustrate, Aurélien / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Frontiers in genetics

    2023  Volume 14, Page(s) 1215645

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1215645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer.

    Cordier, Clément / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Cancers

    2021  Volume 13, Issue 24

    Abstract: The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it ... ...

    Abstract The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a divalent cations permeant channel but also has intrinsic serine/threonine kinase activity. It is ubiquitously expressed in normal tissues and studies have indicated that it participates in important physiological and pharmacological processes through its channel-kinase activity, such as calcium/magnesium homeostasis, phosphorylation of proteins involved in embryogenesis or the cellular process. Accumulating evidence has shown that TRPM7 is overexpressed in human pathologies including breast cancer. Breast cancer is the second leading cause of cancer death in women with an incidence rate increase of around 0.5% per year since 2004. The overexpression of TRPM7 may be associated with a poor prognosis in breast cancer patients, so more efforts are needed to research a new therapeutic target. TRPM7 regulates the levels of Ca
    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13246322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis.

    Haustrate, Aurélien / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Cells

    2020  Volume 9, Issue 2

    Abstract: It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells. Modulation of TRPV channels activity can modify their physiological function leading to some ... ...

    Abstract It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells. Modulation of TRPV channels activity can modify their physiological function leading to some diseases and disorders like neurodegeneration, pain, cancer, skin disorders, etc. It should be noted that, despite TRPV channels importance, our knowledge of the TRPV channels functions in cells is mostly limited to their plasma membrane location. However, some TRPV channels were shown to be expressed in the endoplasmic reticulum where their modulation by activators and/or inhibitors was demonstrated to be crucial for intracellular signaling. In this review, we have intended to summarize the poorly studied roles and functions of these channels in the endoplasmic reticulum.
    MeSH term(s) Animals ; Calcium/metabolism ; Endoplasmic Reticulum/metabolism ; Homeostasis ; Humans ; Models, Biological ; Transient Receptor Potential Channels/metabolism
    Chemical Substances Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9020317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression.

    Mesquita, Gonçalo / Prevarskaya, Natalia / Schwab, Albrecht / Lehen'kyi, V'yacheslav

    Cells

    2021  Volume 10, Issue 5

    Abstract: The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of ... ...

    Abstract The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represented by nine sub-families that constitute the TRP channel superfamily. From the mid-2000s, several reports have shown the potential role of the TRP channels in cancers of multiple origin. The pancreatic cancer is one of the deadliest cancers worldwide. Its prevalence is predicted to rise further. Disappointingly, the treatments currently used are ineffective. There is an urgency to find new ways to counter this disease and one of the answers may lie in the ion channels belonging to the superfamily of TRP channels. In this review, we analyse the existing knowledge on the role of TRP channels in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The functions of these channels in other cancers are also considered. This might be of interest for an extrapolation to the pancreatic cancer in an attempt to identify potential therapeutic interventions.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cations ; Cell Movement ; Cell Proliferation ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Ion Channels ; Mice ; Neoplasm Invasiveness ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Phylogeny ; Prevalence ; Transient Receptor Potential Channels/physiology ; Tumor Microenvironment
    Chemical Substances Cations ; Ion Channels ; Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: TRPV6 Calcium Channel Targeting by Antibodies Raised against Extracellular Epitopes Induces Prostate Cancer Cell Apoptosis.

    Haustrate, Aurélien / Shapovalov, George / Spriet, Corentin / Cordier, Clément / Kondratskyi, Artem / Noyer, Lucile / Foulquier, François / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Cancers

    2023  Volume 15, Issue 6

    Abstract: The TRPV6 calcium channel is known to be up-regulated in various tumors. The efforts to target the TRPV6 channel in vivo are still ongoing to propose an effective therapy against cancer. Here, we report the generation of two antibodies raised against ... ...

    Abstract The TRPV6 calcium channel is known to be up-regulated in various tumors. The efforts to target the TRPV6 channel in vivo are still ongoing to propose an effective therapy against cancer. Here, we report the generation of two antibodies raised against extracellular epitopes corresponding to the extracellular loop between S1 and S2 (rb79) and the pore region (rb82). These antibodies generated a complex biphasic response with the transient activation of the TRPV6 channel. Store-operated calcium entry was consequently potentiated in the prostate cancer cell line LNCaP upon the treatment. Both rb79 and rb82 antibodies significantly decreased cell survival rate in a dose-dependent manner as compared to the control antibodies of the same isotype. This decrease was due to the enhanced cell death via apoptosis revealed using a sub-G1 peak in a cell cycle assay, TUNEL assay, and a Hoechst staining, having no effects in the PC3M
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: TRPV6 Channel Is Involved in Pancreatic Ductal Adenocarcinoma Aggressiveness and Resistance to Chemotherapeutics.

    Mesquita, Gonçalo / Haustrate, Aurélien / Mihalache, Adriana / Soret, Benjamin / Cordier, Clément / Desruelles, Emilie / Duval, Erika / Pethö, Zoltan / Prevarskaya, Natalia / Schwab, Albrecht / Lehen'kyi, V'yacheslav

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) stands as a highly aggressive and lethal cancer, characterized by a grim prognosis and scarce treatment alternatives. Within this context, TRPV6, a calcium-permeable channel, emerges as a noteworthy candidate due ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) stands as a highly aggressive and lethal cancer, characterized by a grim prognosis and scarce treatment alternatives. Within this context, TRPV6, a calcium-permeable channel, emerges as a noteworthy candidate due to its overexpression in various cancers, capable of influencing the cell behavior in different cancer entities. Nonetheless, the exact expression pattern and functional significance of TRPV6 in the context of PDAC remains enigmatic. This study scrutinizes the expression of TRPV6 in tissue specimens obtained from 46 PDAC patients across distinct stages and grades. We manipulated TRPV6 expression (knockdown, overexpression) in the human PDAC cell lines Panc-1 and Capan-1. Subsequently, we analyzed its impact on multiple facets, encompassing Ca
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Retraction notice to "TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer" [Cell Calcium (2019) 117-124].

    Haustrate, Aurélien / Hantute-Ghesquier, Aline / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Cell calcium

    2020  Volume 86, Page(s) 102126

    Language English
    Publishing date 2020-01-07
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.102126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential.

    Haustrate, Aurélien / Hantute-Ghesquier, Aline / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 606

    Abstract: Monoclonal antibodies (mAbs) represent a rapidly growing pharmaceutical class of protein drugs that becomes an important part of the precision therapy. mAbs are characterized by their high specificity and affinity for the target antigen, which is mostly ... ...

    Abstract Monoclonal antibodies (mAbs) represent a rapidly growing pharmaceutical class of protein drugs that becomes an important part of the precision therapy. mAbs are characterized by their high specificity and affinity for the target antigen, which is mostly present on the cell surface. Ion channels are a large family of transmembrane proteins that control ion transport across the cell membrane. They are involved in almost all biological processes in both health and disease and are widely considered as prospective targets. However, no antibody-based drug targeting ion channel has been developed so far that has progressed to clinical use. Thus, we provide a comprehensive review of the elaborated mAbs against ion channels, describe their mechanisms of action, and discuss their therapeutic potential.
    Language English
    Publishing date 2019-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: RETRACTED: TRPV6 calcium channel regulation, downstream pathways, and therapeutic targeting in cancer.

    Haustrate, Aurélien / Hantute-Ghesquier, Aline / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    publication RETRACTED

    Cell calcium

    2019  Volume 80, Page(s) 117–124

    Language English
    Publishing date 2019-04-22
    Publishing country Netherlands
    Document type Journal Article ; Review ; Retracted Publication
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: TRPM Family Channels in Cancer.

    Hantute-Ghesquier, Aline / Haustrate, Aurélien / Prevarskaya, Natalia / Lehen'kyi, V'yacheslav

    Pharmaceuticals (Basel, Switzerland)

    2018  Volume 11, Issue 2

    Abstract: Members of the TRPM ("Melastatin") family fall into the subclass of the TRP channels having varying permeability to ... ...

    Abstract Members of the TRPM ("Melastatin") family fall into the subclass of the TRP channels having varying permeability to Ca
    Language English
    Publishing date 2018-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph11020058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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