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  1. Book: Intravital microcirculation imaging

    Lehmann, Christian

    2012  

    Author's details Christian Lehmann (ed.)
    Keywords Mikrozirkulation ; Intravitalmikroskopie
    Language English
    Size 117 S. : Ill., graph. Darst.
    Publisher Pabst
    Publishing place Lengerich u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017709252
    ISBN 978-3-89967-786-7 ; 3-89967-786-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1821 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: Thoughts on grammaticalization

    Lehmann, Christian

    2015  

    Abstract: After a short review of the history of research, the work introduces and delimits the concepts related to grammaticalization. It then provides extensive exemplification of grammaticalization phenomena in diverse languages, ordered by grammatical domains ... ...

    Abstract After a short review of the history of research, the work introduces and delimits the concepts related to grammaticalization. It then provides extensive exemplification of grammaticalization phenomena in diverse languages, ordered by grammatical domains such as the verbal, pronominal and nominal sphere and clause level relations. The final chapter presents a theory of grammaticalization which is based on the autonomy of the linguistic sign with respect to the paradigmatic and syntagmatic axes. This is the basis of the structural parameters that constitute grammaticalization. They are operationalized to the point of rendering degrees of grammaticalization measurable
    Keywords Philology. Linguistics
    Size 1 electronic resource (214+xiii p.)
    Publisher Language Science Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090222
    ISBN 9783946234074 ; 9783946234067 ; 9783946234050 ; 3946234070 ; 3946234062 ; 3946234054
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Dysregulated Iron Homeostasis as Common Disease Etiology and Promising Therapeutic Target.

    Holbein, Bruce E / Lehmann, Christian

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Iron is irreplaceably required for animal and human cells as it provides the activity center for a wide variety of essential enzymes needed for energy production, nucleic acid synthesis, carbon metabolism and cellular defense. However, iron is toxic when ...

    Abstract Iron is irreplaceably required for animal and human cells as it provides the activity center for a wide variety of essential enzymes needed for energy production, nucleic acid synthesis, carbon metabolism and cellular defense. However, iron is toxic when present in excess and its uptake and storage must, therefore, be tightly regulated to avoid damage. A growing body of evidence indicates that iron dysregulation leading to excess quantities of free reactive iron is responsible for a wide range of otherwise discrete diseases. Iron excess can promote proliferative diseases such as infections and cancer by supplying iron to pathogens or cancer cells. Toxicity from reactive iron plays roles in the pathogenesis of various metabolic, neurological and inflammatory diseases. Interestingly, a common underlying aspect of these conditions is availability of excess reactive iron. This underpinning aspect provides a potential new therapeutic avenue. Existing hematologically used iron chelators to take up excess iron have shown serious limitations for use but new purpose-designed chelators in development show promise for suppressing microbial pathogen and cancer cell growth, and also for relieving iron-induced toxicity in neurological and other diseases. Hepcidin and hepcidin agonists are also showing promise for relieving iron dysregulation. Harnessing iron-driven reactive oxygen species (ROS) generation with ferroptosis has shown promise for selective destruction of cancer cells. We review biological iron requirements, iron regulation and the nature of iron dysregulation in various diseases. Current results pertaining to potential new therapies are also reviewed.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lower Urinary Tract Inflammation and Infection: Key Microbiological and Immunological Aspects.

    Dickson, Kayle / Zhou, Juan / Lehmann, Christian

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: The urinary system, primarily responsible for the filtration of blood and waste, is affected by several infectious and inflammatory conditions. Focusing on the lower tract, this review outlines the physiological and immune landscape of the urethra and ... ...

    Abstract The urinary system, primarily responsible for the filtration of blood and waste, is affected by several infectious and inflammatory conditions. Focusing on the lower tract, this review outlines the physiological and immune landscape of the urethra and bladder, addressing key immunological and microbiological aspects of important infectious/inflammatory conditions. The conditions addressed include urethritis, interstitial cystitis/bladder pain syndrome, urinary tract infections, and urosepsis. Key aspects of each condition are addressed, including epidemiology, pathophysiology, and clinical considerations. Finally, therapeutic options are outlined, highlighting gaps in the knowledge and novel therapeutic approaches.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Investigation of the interface of fungal mycelium composite building materials by means of low-vacuum scanning electron microscopy.

    Lehmann, Christian / Schmidt, Bertram / Stephan, Dietmar / Meyer, Vera

    Journal of microscopy

    2024  Volume 294, Issue 2, Page(s) 203–214

    Abstract: Low-vacuum scanning electron microscopy (low-vacuum SEM) is widely used for different applications, such as the investigation of noncoated specimen or the observation of biological materials, which are not stable to high vacuum. In this study, the ... ...

    Abstract Low-vacuum scanning electron microscopy (low-vacuum SEM) is widely used for different applications, such as the investigation of noncoated specimen or the observation of biological materials, which are not stable to high vacuum. In this study, the combination of mineral building materials (concrete or clay plaster) with a biological composite (fungal mycelium composite) by using low-vacuum SEM was investigated. Fungal biotechnology is increasingly gaining prominence in addressing the challenges of sustainability transformation. The construction industry is one of the biggest contributors to the climate crises and, therefore, can highly profit from applications based on regenerative fungal materials. In this work, a fungal mycelium composite is used as alternative to conventional insulating materials like Styrofoam. However, to adapt bio-based products to the construction industry, investigations, optimisations and adaptations to existing solutions are needed. This paper examines the compatibility between fungal mycelium materials with mineral-based materials to demonstrate basic feasibility. For this purpose, fresh and hardened concrete specimens as well as clay plaster samples are combined with growing mycelium from the tinder fungus Fomes fomentarius. The contact zone between the mycelium composite and the mineral building materials is examined by scanning electron microscopy (SEM). The combination of these materials proves to be feasible in general. The use of hardened concrete or clay with living mycelium composite appears to be the favoured variant, as the hyphae can grow into the surface of the building material and thus a layered structure with a stable connection is formed. In order to work with the combination of low-density organic materials and higher-density inorganic materials simultaneously, low-vacuum SEM offers a suitable method to deliver results with reduced effort in preparation while maintaining high capture and magnification quality. Not only are image recordings possible with SE and BSE, but EDX measurements can also be carried out quickly without the influence of a coating. Depending on the signal used, as well as the magnification, image-recording strategies must be adapted. Especially when using SE, an image-integration method was used to reduce the build-up of point charges from the electron beam, which damages the mycelial hyphae. Additionally using different signals during image capture is recommended to confirm acquired information, avoiding misinterpretations.
    MeSH term(s) Microscopy, Electron, Scanning ; Vacuum ; Clay ; Mycelium/chemistry ; Minerals/analysis ; Construction Materials
    Chemical Substances Clay (T1FAD4SS2M) ; Minerals
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 219263-9
    ISSN 1365-2818 ; 0022-2720
    ISSN (online) 1365-2818
    ISSN 0022-2720
    DOI 10.1111/jmi.13292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 838: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Dysregulated Iron Homeostasis as Common Disease Etiology and Promising Therapeutic Target

    Holbein, Bruce E. / Lehmann, Christian

    Antioxidants. 2023 Mar. 09, v. 12, no. 3

    2023  

    Abstract: Iron is irreplaceably required for animal and human cells as it provides the activity center for a wide variety of essential enzymes needed for energy production, nucleic acid synthesis, carbon metabolism and cellular defense. However, iron is toxic when ...

    Abstract Iron is irreplaceably required for animal and human cells as it provides the activity center for a wide variety of essential enzymes needed for energy production, nucleic acid synthesis, carbon metabolism and cellular defense. However, iron is toxic when present in excess and its uptake and storage must, therefore, be tightly regulated to avoid damage. A growing body of evidence indicates that iron dysregulation leading to excess quantities of free reactive iron is responsible for a wide range of otherwise discrete diseases. Iron excess can promote proliferative diseases such as infections and cancer by supplying iron to pathogens or cancer cells. Toxicity from reactive iron plays roles in the pathogenesis of various metabolic, neurological and inflammatory diseases. Interestingly, a common underlying aspect of these conditions is availability of excess reactive iron. This underpinning aspect provides a potential new therapeutic avenue. Existing hematologically used iron chelators to take up excess iron have shown serious limitations for use but new purpose-designed chelators in development show promise for suppressing microbial pathogen and cancer cell growth, and also for relieving iron-induced toxicity in neurological and other diseases. Hepcidin and hepcidin agonists are also showing promise for relieving iron dysregulation. Harnessing iron-driven reactive oxygen species (ROS) generation with ferroptosis has shown promise for selective destruction of cancer cells. We review biological iron requirements, iron regulation and the nature of iron dysregulation in various diseases. Current results pertaining to potential new therapies are also reviewed.
    Keywords carbon metabolism ; cell growth ; energy ; ferroptosis ; hepcidin ; homeostasis ; humans ; iron ; neoplasm cells ; nucleic acids ; pathogenesis ; pathogens ; reactive oxygen species ; therapeutics ; toxicity
    Language English
    Dates of publication 2023-0309
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030671
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies.

    Khayat, Wujood / Lehmann, Christian

    Metabolites

    2022  Volume 12, Issue 6

    Abstract: Abnormal blood coagulation or coagulopathy is a common manifestation of many pathological conditions. It occurs when there is an imbalance between the activities of the coagulation system and the fibrinolytic system, leading to excessive or impaired ... ...

    Abstract Abnormal blood coagulation or coagulopathy is a common manifestation of many pathological conditions. It occurs when there is an imbalance between the activities of the coagulation system and the fibrinolytic system, leading to excessive or impaired intravascular blood clot formation, which can disturb blood flow causing ischemia or hemorrhage in the affected tissues. A growing body of evidence has demonstrated blood coagulation abnormalities in association with cannabinoid use, suggesting the involvement of the endogenous cannabinoid system (ECS) in modulating blood coagulation. However, the evidence in the literature has been controversial on whether cannabinoids promote or inhibit blood coagulation. The ECS has been extensively studied in recent years for its potential as a therapeutic target for many diseases. This review provides a brief introduction to the ECS and discusses the reported anticoagulatory and procoagulatory effects of various cannabinoids, highlighting some possible mechanisms that might underlie the observed effects. Understanding the coagulatory effects of cannabinoids and the interaction between the coagulation system and the ECS is vital for developing novel therapeutics for coagulopathies.
    Language English
    Publishing date 2022-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12060541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cannabinoid effects in the microvasculature - CB, or not CB? That is the question! A mini-review.

    Lehmann, Christian / Zhou, Juan

    Clinical hemorheology and microcirculation

    2022  Volume 83, Issue 3, Page(s) 287–292

    Abstract: Cannabinoids play critical roles in human pathophysiology through the cannabinoid (CB) receptors and non-CB receptors on variety of cells, tissues, and organs. Microvasculature with the inside bloodstream containing the plasmatic and cellular components ... ...

    Abstract Cannabinoids play critical roles in human pathophysiology through the cannabinoid (CB) receptors and non-CB receptors on variety of cells, tissues, and organs. Microvasculature with the inside bloodstream containing the plasmatic and cellular components exerts multiple functions in maintaining tissue and organ physiology through microcirculation. This review focusses on the impact of cannabinoids on the microvasculature, including mechanisms mediated by both CB receptor-related pathways and CB receptor-independent pathways.
    MeSH term(s) Humans ; Cannabinoids/pharmacology ; Microvessels/drug effects ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Microcirculation/drug effects
    Chemical Substances Cannabinoids ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid
    Language English
    Publishing date 2022-12-27
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-221677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection-A Narrative Review.

    Carter, Caroline / Laviolette, Lindsay / Bietar, Bashir / Zhou, Juan / Lehmann, Christian

    Current issues in molecular biology

    2024  Volume 46, Issue 4, Page(s) 3122–3133

    Abstract: Worldwide, approximately 15 million people per year suffer from stroke. With about 5 million deaths, stroke is the second most common cause of death and a major cause of long-term disability. It is estimated that about 25% of people older than 85 years ... ...

    Abstract Worldwide, approximately 15 million people per year suffer from stroke. With about 5 million deaths, stroke is the second most common cause of death and a major cause of long-term disability. It is estimated that about 25% of people older than 85 years will develop stroke.
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46040196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Cannabinoids and the Endocannabinoid System in Early SARS-CoV-2 Infection and Long COVID-19-A Scoping Review.

    Scott, Cassidy / Hall, Stefan / Zhou, Juan / Lehmann, Christian

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: Coronavirus disease-19 (COVID-19) is a highly contagious illness caused by the SARS-CoV-2 virus. The clinical presentation of COVID-19 is variable, often including symptoms such as fever, cough, headache, fatigue, and an altered sense of smell and taste. ...

    Abstract Coronavirus disease-19 (COVID-19) is a highly contagious illness caused by the SARS-CoV-2 virus. The clinical presentation of COVID-19 is variable, often including symptoms such as fever, cough, headache, fatigue, and an altered sense of smell and taste. Recently, post-acute "long" COVID-19 has emerged as a concern, with symptoms persisting beyond the acute infection. Vaccinations remain one of the most effective preventative methods against severe COVID-19 outcomes and the development of long-term COVID-19. However, individuals with underlying health conditions may not mount an adequate protective response to COVID-19 vaccines, increasing the likelihood of severe symptoms, hospitalization, and the development of long-term COVID-19 in high-risk populations. This review explores the potential therapeutic role of cannabinoids in limiting the susceptibility and severity of infection, both pre- and post-SARS-CoV-19 infection. Early in the SARS-CoV-19 infection, cannabinoids have been shown to prevent viral entry, mitigate oxidative stress, and alleviate the associated cytokine storm. Post-SARS-CoV-2 infection, cannabinoids have shown promise in treating symptoms associated with post-acute long COVID-19, including depression, anxiety, post-traumatic stress injury, insomnia, pain, and decreased appetite. While current research primarily focuses on potential treatments for the acute phase of COVID-19, there is a gap in research addressing therapeutics for the early and post-infectious phases. This review highlights the potential for future research to bridge this gap by investigating cannabinoids and the endocannabinoid system as a potential treatment strategy for both early and post-SARS-CoV-19 infection.
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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