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  1. Book ; Online ; Thesis: Jugendpolitik in der DDR

    Lehmann, Steffi [Verfasser]

    Anspruch und Auswirkungen

    2018  

    Author's details Steffi Lehmann
    Keywords Öffentliche Verwaltung ; Public administration
    Subject code sg350
    Language German
    Publisher Nomos Verlagsgesellschaft mbH & Co. KG
    Publishing place Baden-Baden
    Document type Book ; Online ; Thesis
    ISBN 978-3-8452-8969-4 ; 3-8452-8969-4
    Database Digital theses on the web

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  2. Book ; Thesis: Die Evaluation der Dispensairebetreuung für die ältesten Bürger der Stadt Grimma durch den Hausarzt in der Poliklinik Grimma

    Lehmann, Steffi

    1988  

    Size 80, [24] Bl. : graph. Darst.
    Publishing country XA-DDDE
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss. A, 1990
    HBZ-ID HT003611844
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    90 E 1006 order for loan Magazin

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  3. Book ; Online ; Thesis: Multimodal in vivo imaging of hypoxic signaling events in a mouse tumor model

    Lehmann, Steffi

    2010  

    Author's details by Steffi Lehmann
    Language English
    Size Online-Ressource (1 Band), Ill
    Publisher ETH
    Publishing place Zürich
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 18983--Zürich, 1898
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections.

    Roehrig, Christian / Huemer, Markus / Lorgé, Dominique / Arn, Fabienne / Heinrich, Nadine / Selvakumar, Lavanja / Gasser, Lynn / Hauswirth, Patrick / Chang, Chun-Chi / Schweizer, Tiziano A / Eichenseher, Fritz / Lehmann, Steffi / Zinkernagel, Annelies S / Schmelcher, Mathias

    mBio

    2024  Volume 15, Issue 2, Page(s) e0254023

    Abstract: Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin- ... ...

    Abstract Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant
    MeSH term(s) Humans ; Animals ; Mice ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Peptidoglycan ; Zebrafish ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcus ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/therapeutic use ; Sepsis/drug therapy
    Chemical Substances Peptidoglycan ; Anti-Bacterial Agents ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02540-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging.

    Sabani, Besmira / Brand, Michael / Albert, Ina / Inderbitzin, Joelle / Eichenseher, Fritz / Schmelcher, Mathias / Rohrer, Jack / Riedl, Rainer / Lehmann, Steffi

    Nanomedicine : nanotechnology, biology, and medicine

    2022  Volume 47, Page(s) 102607

    Abstract: Extracellular vesicles (EVs), nanovesicles released by cells to effectively exchange biological information, are gaining interest as drug delivery system. Yet, analogously to liposomes, they show short blood circulation times and accumulation in the ... ...

    Abstract Extracellular vesicles (EVs), nanovesicles released by cells to effectively exchange biological information, are gaining interest as drug delivery system. Yet, analogously to liposomes, they show short blood circulation times and accumulation in the liver and the spleen. For tissue specific delivery, EV surfaces will thus have to be functionalized. We present a novel platform for flexible modification of EVs with target-specific ligands based on the avidin-biotin system. Genetic engineering of donor cells with a glycosylphosphatidylinositol-anchored avidin (GPI-Av) construct allows the isolation of EVs displaying avidin on their surface, functionalized with any biotinylated ligand. For proof of concept, GPI-Av EVs were modified with i) a biotinylated antibody or ii) de novo designed and synthesized biotinylated ligands binding carbonic anhydrase IX (CAIX), a membrane associated enzyme overexpressed in cancer. Functionalized EVs showed specific binding and uptake by CAIX-expressing cells, demonstrating the power of the system to prepare EVs for cell-specific drug delivery.
    MeSH term(s) Extracellular Vesicles ; Diagnostic Imaging
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2022.102607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Multimodal in vivo imaging of hypoxic signaling events in a mouse tumor model

    Lehmann, Steffi

    2010  

    Abstract: Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 18983, ... ...

    Abstract Diss., Eidgenössische Technische Hochschule ETH Zürich, Nr. 18983, 2010
    Keywords TIERISCHE MODELLE IN DER MEDIZIN ; MEDIZINISCHE IN-VIVO UNTERSUCHUNGEN ; FUNKTIONELLE BILDGEBENDE VERFAHREN (MEDIZINISCHE DIAGNOSTIK) ; CYTOLOGISCHE ASPEKTE DER SIGNALTRANSDUKTION UND SIGNALVERARBEITUNG (BIOKOMMUNIKATION) ; TUMORWACHSTUM ; WACHSTUM UND PROLIFERATION VON KREBSZELLEN (PATHOLOGIE) ; ZELLTOD + ZELLDESINTEGRATION (CYTOLOGIE)
    Language English
    Publisher Zürich, ETH
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Pattern analysis accounts for heterogeneity observed in MRI studies of tumor angiogenesis.

    Dominietto, Marco / Lehmann, Steffi / Keist, Ruth / Rudin, Markus

    Magnetic resonance in medicine

    2013  Volume 70, Issue 5, Page(s) 1481–1490

    Abstract: MRI is a method of choice for assessing anatomical structures or angiogenesis-related parameters noninvasively during tumor progression. Typically, tumor tissue displays a high degree of heterogeneity that can be evaluated using pattern analysis (PA), ... ...

    Abstract MRI is a method of choice for assessing anatomical structures or angiogenesis-related parameters noninvasively during tumor progression. Typically, tumor tissue displays a high degree of heterogeneity that can be evaluated using pattern analysis (PA), which comprises shape and texture analysis. This work aims at implementing PA methods to study angiogenesis in a murine tumor model and testing its sensitivity with regard to detecting changes elicited by administration of a drug. Twelve balb/c-nude mice were injected subcutaneously with 10(6) C51 cells (colon carcinoma). A first group (N = 6) of animals was treated with dimethyloxalylglycine, a drug known to stabilize hypoxia-inducible-factor-α, which among other functions, is involved in angiogenesis. The second group (N = 6) was treated with saline. MRI experiments assessing tumor blood volume and permeability-maps (K(trans) ) were performed immediately before and 6 days after drug treatment. Data have been analyzed using standard histogram analysis and PA. Standard histogram analysis did not reveal any difference between the two groups, neither before nor after the treatment. In contrast, PA revealed significant differences between drug and placebo treated mice in the texture of the TBV and K(trans) maps after drug treatment, but not with regard to tumors shapes. The results indicated that in view of the heterogeneity of tumor tissue, standard histogram analysis appears insensitive in picking-up differences in response to treatment, while PA appears to be particularly sensitive to changes in texture.
    MeSH term(s) Algorithms ; Amino Acids, Dicarboxylic/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Cell Line, Tumor ; Colonic Neoplasms/complications ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/complications ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; Pattern Recognition, Automated/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Treatment Outcome ; Tumor Burden
    Chemical Substances Amino Acids, Dicarboxylic ; Angiogenesis Inhibitors ; oxalylglycine (VVW38EB8YS)
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.24590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1959: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: How specific are risk factors for headache in adolescents? Results from a cross-sectional study in Germany.

    Lehmann, Steffi / Milde-Busch, Astrid / Straube, Andreas / von Kries, Ruediger / Heinen, Florian

    Neuropediatrics

    2013  Volume 44, Issue 1, Page(s) 46–54

    Abstract: Background: The identified preventable risk factors for primary headache in adolescents are smoking; consumption of coffee or alcoholic mixed drinks; physical inactivity; muscle pain in the head, neck, or shoulder region; and chronic stress.: ... ...

    Abstract Background: The identified preventable risk factors for primary headache in adolescents are smoking; consumption of coffee or alcoholic mixed drinks; physical inactivity; muscle pain in the head, neck, or shoulder region; and chronic stress.
    Objective: To investigate the interrelation of headache with other health complaints and the specificity of the above-mentioned risk factors for headache in adolescents.
    Methods: A total of 1,260 students (grades 10 and 11) filled in questionnaires on headache, dietary, and lifestyle factors. The type of headache and health complaints such as dizziness, abdominal pain, musculoskeletal pains, symptoms of possible fatigue syndrome, and psychic complaints were assessed.
    Results: Isolated headache was found in 18% of the headache sufferers; most frequently isolated tension-type headache (78.2%). Only among adolescents with a combination of headache (mainly migraine) and other health complaints, significant associations for almost all analyzed risk factors were found. The strength of the associations with the considered risk factors was very similar in all three analyzed strata except for considerably lower odds ratios for isolated headache.
    Conclusion: All analyzed risk factors are nonspecific for headache in adolescents because they also increase the risk for other health complaints. Interventions, therefore, should consider a holistic approach focusing not only on headache but also on a broader spectrum of health complaints.
    MeSH term(s) Adolescent ; Adult ; Comorbidity ; Cross-Sectional Studies ; Female ; Germany ; Headache/classification ; Headache/epidemiology ; Headache Disorders, Primary/classification ; Headache Disorders, Primary/epidemiology ; Humans ; Male ; Prevalence ; Risk Factors ; Sensitivity and Specificity ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2013-02
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0032-1333432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 728: Show issues Location:
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  9. Article ; Online: Recording intracellular molecular events from the outside: glycosylphosphatidylinositol-anchored avidin as a reporter protein for in vivo imaging.

    Lehmann, Steffi / Garayoa, Elisa Garcia / Blanc, Alain / Keist, Ruth / Schibli, Roger / Rudin, Markus

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2011  Volume 52, Issue 3, Page(s) 445–452

    Abstract: Unlabelled: With the emergence of multimodal imaging strategies, genetically encoded reporters that can be flexibly combined with any imaging modality become highly attractive. Here we describe the use of glycosylphosphatidylinositol (GPI)-anchored ... ...

    Abstract Unlabelled: With the emergence of multimodal imaging strategies, genetically encoded reporters that can be flexibly combined with any imaging modality become highly attractive. Here we describe the use of glycosylphosphatidylinositol (GPI)-anchored avidin, an avidin moiety targeted to the extracellular side of cell membranes via a GPI anchor, as a reporter for in vivo imaging. Being present on the outside of cells, avidin can be visualized with any type of biotinylated imaging agent, without the requirement that the probe be membrane-permeable. We used the avidin-GPI system to monitor the activity of hypoxia-inducible factors (HIFs)-oxygen-sensing transcription factors, which play a major role in regulating cancer progression-in a mouse tumor allograft model.
    Methods: Mouse C51 cells were stably transfected with pH3SVG, a reporter construct driving the expression of avidin-GPI from an HIF-sensitive promoter. The transfected cells were subcutaneously implanted into BALB/c nude mice. At 10 d after tumor inoculation, mice received an intravenous injection of either alexa-594-biocytin or (67)Ga-DOTA-biotin, and tumor HIF activity was imaged using fluorescence reflectance imaging or SPECT.
    Results: In vitro cell experiments demonstrated the functionality and HIF-dependent regulation of the avidin-GPI reporter construct. In vivo, avidin-GPI was targeted specifically in allograft tumors with biotinylated imaging probes using both fluorescence imaging and SPECT. Analysis of the reporter expression pattern on ex vivo tumor tissue sections indicated a good overlap, with areas of hypoxia.
    Conclusion: We have demonstrated the utility of avidin-GPI as a reporter for multimodal in vivo imaging using both a fluorescence and a SPECT approach to assess intracellular oxygen signaling in a mouse tumor model.
    MeSH term(s) Animals ; Avidin/genetics ; Avidin/pharmacokinetics ; Cell Line, Tumor ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Genes, Reporter ; Glycosylphosphatidylinositols/genetics ; Glycosylphosphatidylinositols/pharmacokinetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Glycosylphosphatidylinositols ; Radiopharmaceuticals ; Avidin (1405-69-2)
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.110.082412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  10. Article ; Online: Self-reported neck pain is associated with migraine but not with tension-type headache in adolescents.

    Blaschek, Astrid / Decke, Siona / Albers, Lucia / Schroeder, Andreas Sebastian / Lehmann, Steffi / Straube, Andreas / Landgraf, Mirjam N / Heinen, Florian / von Kries, Rüdiger

    Cephalalgia : an international journal of headache

    2014  Volume 34, Issue 11, Page(s) 895–903

    Abstract: Aim: The aim of the present analysis is to confirm or refute the association of neck pain to migraine or tension-type headache and to assess whether this association is independent of other risk factors for headache.: Methods: Secondary school ... ...

    Abstract Aim: The aim of the present analysis is to confirm or refute the association of neck pain to migraine or tension-type headache and to assess whether this association is independent of other risk factors for headache.
    Methods: Secondary school students were invited to complete a questionnaire on headache and lifestyle factors in a cross-sectional study. Neck pain was assessed via (a) a screening question concerning neck pain and (b) denoting affected areas in schematic drawings of the human body.
    Results: Absolute increment in prevalence of headache with pain in the shoulder-neck region was between 7.5% and 9.6%. Gender, grade, stress and lifestyle factors were assessed as potential confounding factors. Nearly all factors were associated with shoulder-neck pain and most with headache. After adjustment for confounders, the association of neck pain with headache was almost completely confined to migraine (OR 2.39; 95% CI 1.48-3.85) and migraine + tension-type headache (OR 2.12; 95% CI 1.50-2.99), whereas the association with isolated tension-type headache was negligible (OR 1.22, 95% CI 0.87-1.69).
    Conclusion: Neck pain is associated with migraine but not with tension-type headache. A possible link between migraine and neck pain may be the cervico-trigeminal convergence of neck and meningeal sensory afferents or a disturbed descending inhibition in migraine.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Migraine Disorders/complications ; Migraine Disorders/epidemiology ; Neck Pain/complications ; Neck Pain/epidemiology ; Prevalence ; Surveys and Questionnaires ; Tension-Type Headache/complications ; Tension-Type Headache/epidemiology
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102414523338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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