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  1. Article: Klinicznie bezobjawowe przeciwciała antyfosfolipidowe--problemy diagnostyczne i terapeutyczne.

    Zawilska, Krystyna / Lehmann-Kopydłowska, Agata

    Polskie Archiwum Medycyny Wewnetrznej

    2008  Volume 118 Suppl, Page(s) 70–74

    Abstract: The presence of asymptomatic antiphospholipid antibodies (aAPA) creates many difficult diagnostic and clinical problems - they might be a cause either of incorrect hemorrhagic diathesis recognition or an unnecessary anticoagulant therapy. Patients with ... ...

    Title translation Clinically asymptomatic antiphospholipid antibodies--diagnostic and therapeutic problems.
    Abstract The presence of asymptomatic antiphospholipid antibodies (aAPA) creates many difficult diagnostic and clinical problems - they might be a cause either of incorrect hemorrhagic diathesis recognition or an unnecessary anticoagulant therapy. Patients with aAPA should be counseled individually regarding potential thrombotic and/or obstetric complications. An increased risk of these complications is particularly high when lupus anticoagulant (LAC) and IgG anti-beta2 glycoprotein antibodies coexist. The approaches to the diagnosis and management of treatment of patients with aAPA are also discussed.
    MeSH term(s) Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/therapy ; Humans
    Language Polish
    Publishing date 2008
    Publishing country Poland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 1897-9483 ; 0032-3772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
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  2. Article: Transient presence of clonal chromosomal aberrations in Ph-negative cells in patients with chronic myeloid leukemia remaining in deep molecular response on tyrosine kinase inhibitor treatment.

    Gniot, Michał / Lewandowski, Krzysztof / Ratajczak, Błażej / Lewandowska, Maria / Lehmann-Kopydłowska, Agata / Jarmuż-Szymczak, Małgorzata / Komarnicki, Mieczysław

    Cancer genetics

    2014  Volume 207, Issue 10-12, Page(s) 503–510

    Abstract: Advancements in treatment of chronic myeloid leukemia (CML) turned this formerly fatal neoplasm into a manageable chronic condition. Therapy with tyrosine kinase inhibitors (TKIs) often leads to significant reduction of disease burden, known as the deep ... ...

    Abstract Advancements in treatment of chronic myeloid leukemia (CML) turned this formerly fatal neoplasm into a manageable chronic condition. Therapy with tyrosine kinase inhibitors (TKIs) often leads to significant reduction of disease burden, known as the deep molecular response (DMR). Herein, we decided to analyze the cohort of CML patients treated in our center with TKIs, who obtain and retain DMR for a period longer than 24 months. The aim of the study was to evaluate the frequency of clonal cytogenetic aberrations in Philadelphia-negative (Ph-) cells in patients with DMR during TKI treatment. The analyzed data was obtained during routine molecular and cytogenetic treatment monitoring, using G-banded trypsin and Giemsa stain (GTG) karyotyping and reverse transcription quantitative PCR. We noticed that approximately 50% of patients (28 of 55) in DMR had, at some follow-up point, transient changes in the karyotype of their Ph- bone marrow cells. In 9.1% of cases (5 of 55), the presence of the same aberrations was observed at different time points. The most frequently appearing aberrations were monosomies of chromosomes 19, 20, 21, and Y. Statistical analysis suggests that the occurrence of such abnormalities in CML patients correlates with the TKI treatment time.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chromosome Aberrations ; Cytogenetic Analysis ; Female ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative ; Male ; Middle Aged ; Philadelphia Chromosome ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2599227-2
    ISSN 2210-7762
    ISSN 2210-7762
    DOI 10.1016/j.cancergen.2014.10.003
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  3. Article: Nawracajacy wieloogniskowy udar mózgu w przebiegu zapalenia wsierdzia Libmana-Sacksa u młodej kobiety z toczniem rumieniowatym układowym.

    Jedliński, Ireneusz / Duszyńska, Małgorzata / Lehmann-Kopydłowska, Agata / Jamrozek-Jedlińska, Maria / Poprawski, Kajetan / Zawilska, Krystyna

    Kardiologia polska

    2009  Volume 67, Issue 1, Page(s) 50–52

    Abstract: Systemic lupus erythromatosus is often associated with an antiphospholipid syndrome (APS). A high prevalence of valvular heart disease in APS leads to increased risk of embolic events, particularly cerebrovascular. We present a patient with cerebral ... ...

    Title translation Recurrent multi-focal cerebral stroke complicating Libman-Sacks endocarditis in a young woman with systemic lupus erythromatosus.
    Abstract Systemic lupus erythromatosus is often associated with an antiphospholipid syndrome (APS). A high prevalence of valvular heart disease in APS leads to increased risk of embolic events, particularly cerebrovascular. We present a patient with cerebral infarction, with positive lupus anticoagulant, anticardiolipin antibodies and factor V Leiden mutation. Echocardiographic examination revealed mitral valve anterior leaflet thickening and verrucous vegetations consistent with Libman-Sacks endocarditis, which is commonly associated with APS.
    MeSH term(s) Adult ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Cerebral Infarction/etiology ; Echocardiography, Doppler ; Endocarditis/complications ; Endocarditis/diagnosis ; Female ; Humans ; Intracranial Embolism/etiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Recurrence
    Language Polish
    Publishing date 2009-01
    Publishing country Poland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 411492-9
    ISSN 0022-9032
    ISSN 0022-9032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  4. Article ; Online: The JAK2 V617F mutational status and allele burden--authors' reply.

    Borowczyk, Martyna / Wojtaszewska, Marzena / Lewandowski, Krzysztof / Gil, Lidia / Lewandowska, Maria / Lehmann-Kopydłowska, Agata / Kroll-Balcerzak, Renata / Balcerzak, Andrzej / Iwoła, Małgorzata / Michalak, Michał / Komarnicki, Mieczysław

    Thrombosis research

    2015  Volume 136, Issue 3, Page(s) 691–692

    MeSH term(s) Female ; Hemorrhage/genetics ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Male ; Myeloproliferative Disorders/genetics ; Venous Thromboembolism/genetics
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2015.07.006
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  5. Article ; Online: The JAK2 V617F mutational status and allele burden may be related with the risk of venous thromboembolic events in patients with Philadelphia-negative myeloproliferative neoplasms.

    Borowczyk, Martyna / Wojtaszewska, Marzena / Lewandowski, Krzysztof / Gil, Lidia / Lewandowska, Maria / Lehmann-Kopydłowska, Agata / Kroll-Balcerzak, Renata / Balcerzak, Andrzej / Iwoła, Małgorzata / Michalak, Michał / Komarnicki, Mieczysław

    Thrombosis research

    2015  Volume 135, Issue 2, Page(s) 272–280

    Abstract: Introduction: Patients with Philadelphia-negative myeloproliferative neoplasms (Ph(-) MPNs) are at increased risk of thromboembolic and hemorrhagic complications. The aim of the study was to determine the relationship between JAK2 V617F mutational ... ...

    Abstract Introduction: Patients with Philadelphia-negative myeloproliferative neoplasms (Ph(-) MPNs) are at increased risk of thromboembolic and hemorrhagic complications. The aim of the study was to determine the relationship between JAK2 V617F mutational status, JAK2 V617F allele burden and the risk of vascular complications occurrence.
    Materials and methods: Analysis was performed in a cohort of 186 patients diagnosed with polycythemia vera (53), essential thrombocythemia (114), primary myelofibrosis (11), and unclassified MPN (8). The risk of vascular complications development was analyzed in 126 JAK2 V617F-positive patients with respect to allele burden assessed with allele-specific 'real-time' quantitative polymerase chain reaction (AS RQ-PCR).
    Results: Overall prevalence of any vascular complications was 44.6%. Arterial thrombosis occurred in 20.4%, venous thromboembolism (VTE) in 11.3%, bleeding episodes in 24.7% of patients. Individuals harboring JAK2 V617F mutation, regardless of MPN type, were at higher risk of VTE (OR=5.15, 95%CI: 1.16-22.90, P=0.024), mainly deep vein thrombosis (DVT). JAK2 allele burden higher than 20% identified patients with 7.4-fold increased risk of VTE (95%CI: 1.6-33.7, P=0.004), but not of arterial thrombosis, neither of bleeding complications, and remained the only significant VTE risk factor in multivariate logistic regression. High allele burdens (over 50%) were strikingly associated with proximal DVT cases, but not with distal DVT.
    Conclusions: The group of MPN patients with JAK2 V617F allele burden higher than 20% may benefit the most from vigilant monitoring and appropriate prophylaxis against vascular events. Inclusion of JAK2 V617F mutant allele burden in new risk stratifications seems to be justified and requires controlled prospective trials.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alleles ; Female ; Hemorrhage/genetics ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Male ; Middle Aged ; Mutation ; Myeloproliferative Disorders/blood ; Myeloproliferative Disorders/genetics ; Real-Time Polymerase Chain Reaction ; Venous Thromboembolism/blood ; Venous Thromboembolism/genetics
    Chemical Substances JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2014.11.006
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  6. Article ; Online: Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives.

    Undas, Anetta / Zawilska, Krystyna / Ciesla-Dul, Mariola / Lehmann-Kopydłowska, Agata / Skubiszak, Agnieszka / Ciepłuch, Katarzyna / Tracz, Wiesława

    Blood

    2009  Volume 114, Issue 19, Page(s) 4272–4278

    Abstract: We tested the hypothesis that fibrin structure/function is unfavorably altered in patients after idiopathic venous thromboembolism (VTE) and their relatives. Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were ... ...

    Abstract We tested the hypothesis that fibrin structure/function is unfavorably altered in patients after idiopathic venous thromboembolism (VTE) and their relatives. Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were investigated in 100 patients with first-ever VTE, including 34 with pulmonary embolism (PE), 100 first-degree relatives, and 100 asymptomatic controls with no history of thrombotic events. Known thrombophilia, cancer, trauma, and surgery were exclusion criteria. VTE patients and their relatives were characterized by lower clot permeability (P < .001), lower compaction (P < .001), higher maximum clot absorbancy (P < .001), and prolonged clot lysis time (P < .001) than controls, with more pronounced abnormalities, except maximum clot absorbance, in the patients versus relatives (all P < .01). Fibrin clots obtained for PE patients were more permeable, less compact, and were lysed more efficiently compared with deep-vein thrombosis patients (all P < .05) with no differences in their relatives. Being VTE relative, fibrinogen, and C-reactive protein were independent predictors of clot permeability and fibrinolysis time in combined analysis of controls and relatives. We conclude that altered fibrin clot features are associated with idiopathic VTE with a different profile of fibrin variables in PE. Similar features can be detected in VTE relatives. Fibrin properties might represent novel risk factors for thrombosis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Coagulation ; Blood Coagulation Tests ; Case-Control Studies ; Factor XIII/genetics ; Female ; Fibrin/chemistry ; Fibrin/physiology ; Fibrinogen/genetics ; Fibrinolysis ; Genotype ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Nephelometry and Turbidimetry ; Pulmonary Embolism/blood ; Pulmonary Embolism/genetics ; Risk Factors ; Venous Thromboembolism/blood ; Venous Thromboembolism/genetics ; Young Adult
    Chemical Substances Fibrin (9001-31-4) ; Fibrinogen (9001-32-5) ; Factor XIII (9013-56-3)
    Language English
    Publishing date 2009-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2009-05-222380
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  7. Article ; Online: Liposomal cytarabine in advanced-stage acute lymphoblastic leukemia and aggressive lymphoma with central nervous system involvement: experience of the Polish Acute Leukemia Group.

    Holowiecka-Goral, Aleksandra / Hołowiecki, Jerzy / Giebel, Sebastian / Stella-Holowiecka, Beata / Krawczyk-Kulis, Małgorzata / Kos, Kinga / Lehmann-Kopydłowska, Agata / Dudzinski, Marek / Hałasz, Magdalena / Preisner, Witold / Cioch, Maria / Piszcz, Jarosław

    Leukemia & lymphoma

    2008  Volume 50, Issue 3, Page(s) 478–480

    MeSH term(s) Adolescent ; Adult ; Aged ; Central Nervous System Neoplasms/drug therapy ; Cytarabine/administration & dosage ; Drug Carriers ; Female ; Humans ; Liposomes ; Lymphoma/drug therapy ; Male ; Middle Aged ; Poland ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Remission Induction ; Treatment Outcome ; Young Adult
    Chemical Substances Drug Carriers ; Liposomes ; Cytarabine (04079A1RDZ)
    Language English
    Publishing date 2008-12-19
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428190802702375
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    Zs.A 2997: Show issues Location:
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