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  1. Article: Dataset of certified food dye levels in over the counter medicines and vitamins intended for consumption by children and pregnant women

    Lehmkuhler, Arlie L. / Miller, Mark D. / Bradman, Asa / Castorina, Rosemary / Mitchell, Alyson E.

    Data in Brief. 2020 Oct., v. 32

    2020  

    Abstract: Food, Drug, & Cosmetic (FD&C) dyes can be found in various products outside of food that are consumed by children. The amount of FD&C dyes used in commercial products is proprietary. Determining the contribution of dye intake from commercial products ... ...

    Abstract Food, Drug, & Cosmetic (FD&C) dyes can be found in various products outside of food that are consumed by children. The amount of FD&C dyes used in commercial products is proprietary. Determining the contribution of dye intake from commercial products requires direct assessment of FD&C dyes in the products. This dataset contains the raw data of HPLC peak areas, absolute values, averages, SDs and % RSD for FD&C dyes in children's gummy vitamins, children's tablet vitamins, prenatal vitamins, children's cough/cold/allergy tablets & syrups, and children's pain reliever tablets & syrups obtained using high performance liquid chromatography with a photometric diode array detector (HPLC-PDA). The data can be used for further interpretations of dye intake in children, based upon dose levels suggested for distinct age groups, to evaluate the consumption of the FD&C dyes and accepted daily intake (ADIs) suggested for each FD&C dye by the United States Food & Drug Administration (US FDA). The variability associated within each category is critical for understanding how products on the market can differ between lot especially with large gaps between expiration dates. The interpretation of the data is described in “Certified Food Dyes in Over the Counter Medicines and Supplements Marketed for Children and Pregnant Women” in the Journal of Food and Chemical Toxicology [1].
    Keywords Food and Drug Administration ; cold ; cough ; data collection ; diodes ; drugs ; food colorants ; high performance liquid chromatography ; hypersensitivity ; markets ; pain ; photometry ; toxicology
    Language English
    Dates of publication 2020-10
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2020.106073
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Dataset of certified food dye levels in over the counter medicines and vitamins intended for consumption by children and pregnant women.

    Lehmkuhler, Arlie L / Miller, Mark D / Bradman, Asa / Castorina, Rosemary / Mitchell, Alyson E

    Data in brief

    2020  Volume 32, Page(s) 106073

    Abstract: Food, Drug, & Cosmetic (FD&C) dyes can be found in various products outside of food that are consumed by children. The amount of FD&C dyes used in commercial products is proprietary. Determining the contribution of dye intake from commercial products ... ...

    Abstract Food, Drug, & Cosmetic (FD&C) dyes can be found in various products outside of food that are consumed by children. The amount of FD&C dyes used in commercial products is proprietary. Determining the contribution of dye intake from commercial products requires direct assessment of FD&C dyes in the products. This dataset contains the raw data of HPLC peak areas, absolute values, averages, SDs and % RSD for FD&C dyes in children's gummy vitamins, children's tablet vitamins, prenatal vitamins, children's cough/cold/allergy tablets & syrups, and children's pain reliever tablets & syrups obtained using high performance liquid chromatography with a photometric diode array detector (HPLC-PDA). The data can be used for further interpretations of dye intake in children, based upon dose levels suggested for distinct age groups, to evaluate the consumption of the FD&C dyes and accepted daily intake (ADIs) suggested for each FD&C dye by the United States Food & Drug Administration (US FDA). The variability associated within each category is critical for understanding how products on the market can differ between lot especially with large gaps between expiration dates. The interpretation of the data is described in "Certified Food Dyes in Over the Counter Medicines and Supplements Marketed for Children and Pregnant Women" in the Journal of Food and Chemical Toxicology [1].
    Language English
    Publishing date 2020-07-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2020.106073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Certified food dyes in over the counter medicines and supplements marketed for children and pregnant women.

    Lehmkuhler, Arlie L / Miller, Mark D / Bradman, Asa / Castroina, Rosemary / Mitchell, Alyson E

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2020  Volume 143, Page(s) 111499

    Abstract: Food, Drug, & Cosmetic (FD&C) dyes are synthetic color additives used in food, prescription drugs and over-the-counter medicines (OTCs). Consumption of FD&C dyes has been associated with neurobehavioral behavior in some children. The amount of dye used ... ...

    Abstract Food, Drug, & Cosmetic (FD&C) dyes are synthetic color additives used in food, prescription drugs and over-the-counter medicines (OTCs). Consumption of FD&C dyes has been associated with neurobehavioral behavior in some children. The amount of dye used in commercial products is proprietary, making it difficult to assess dietary intake and determine exposure in children. To date, no studies have examined FD&C dyes in OTCs or vitamins in the United States. To address this, FD&C Red No. 40, Yellow No. 5, Yellow No. 6, Blue No. 1, and Blue No. 2 levels were measured in prenatal vitamin tablets, children's chewable and gummy vitamins, pain reliever tablets and syrups, and cough/cold/allergy tablets and syrups. Dyes were isolated using solid phase extraction (SPE) and quantified by high performance liquid chromatography (HPLC). Dye levels varied between products with highest levels in pain reliever and cough/cold/allergy syrups. Significant variability was observed within some brands. Degradation of Red No. 40, Blue No. 1, and Yellow No. 6 was observed in the vitamin gummies. Intake of FD&C Red No. 40 is two times the US FDA ADI (accepted daily intake) for some children's pain reliever syrups and almost three times the US FDA ADI for some cough/cold/allergy syrups.
    MeSH term(s) Analgesics/chemistry ; Child ; Chromatography, High Pressure Liquid ; Coloring Agents/chemistry ; Dietary Supplements/analysis ; Female ; Food Additives/chemistry ; Histamine Antagonists/chemistry ; Humans ; Molecular Structure ; No-Observed-Adverse-Effect Level ; Nonprescription Drugs/chemistry ; Pregnancy ; Pregnant Women ; United States ; United States Food and Drug Administration/legislation & jurisprudence ; Vitamins/chemistry
    Chemical Substances Analgesics ; Coloring Agents ; Food Additives ; Histamine Antagonists ; Nonprescription Drugs ; Vitamins
    Language English
    Publishing date 2020-06-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2020.111499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum to "Certified food dyes in over the counter medicines and supplements marketed for children and pregnant women" [Food Chem. Toxicol. 143 (2020) 111499].

    Lehmkuhler, Arlie L / Miller, Mark D / Bradman, Asa / Castorina, Rosemary / Mitchell, Alyson E

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2020  Volume 147, Page(s) 111870

    Language English
    Publishing date 2020-12-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2020.111870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of Saccharin and Resveratrol as Extrinsic Markers of Small-Quantity Lipid-Based Nutrient Supplement Consumption in Healthy Women.

    Zyba, Sarah J / Weinborn, Valerie / Arnold, Charles D / Lehmkuhler, Arlie L / Morel, Fanny B / Zeilani, Mamane / Mitchell, Alyson E / Haskell, Marjorie J

    Current developments in nutrition

    2021  Volume 5, Issue 7, Page(s) nzab089

    Abstract: Background: Dietary supplements, like small-quantity lipid-based nutrient supplements (SQ-LNS), are used in intervention programs to prevent undernutrition among women and young children in low-income countries. An objective marker is needed to track ... ...

    Abstract Background: Dietary supplements, like small-quantity lipid-based nutrient supplements (SQ-LNS), are used in intervention programs to prevent undernutrition among women and young children in low-income countries. An objective marker is needed to track consumption of supplements to evaluate the effectiveness of these programs.
    Objective: The aim of this study was to evaluate saccharin and resveratrol as potential adherence markers for tracking recent consumption of a single serving of SQ-LNS in women.
    Methods: Forty-seven healthy nonpregnant women 18-45 y of age were assigned to consume a single dose of SQ-LNS (20 g) containing either 10 mg sodium saccharin or 5 mg
    Results: Forty-five participants were included in the analysis. Urinary concentrations of saccharin and
    Conclusions: Urinary concentrations of saccharin and
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article
    ISSN 2475-2991
    ISSN (online) 2475-2991
    DOI 10.1093/cdn/nzab089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Measurement of Saccharin and

    Weinborn, Valerie / Lehmkuhler, Arlie L / Zyba, Sarah J / Haskell, Marjorie J / Morel, Fanny B / Zeilani, Mamane / Mitchell, Alyson E

    Journal of agricultural and food chemistry

    2021  Volume 69, Issue 3, Page(s) 1107–1114

    Abstract: Saccharin ... ...

    Abstract Saccharin and
    MeSH term(s) Adolescent ; Adult ; Biomarkers/metabolism ; Biomarkers/urine ; Chromatography, High Pressure Liquid ; Dietary Supplements/analysis ; Female ; Humans ; Resveratrol/chemistry ; Resveratrol/metabolism ; Resveratrol/urine ; Saccharin/analysis ; Saccharin/metabolism ; Young Adult
    Chemical Substances Biomarkers ; Saccharin (FST467XS7D) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.0c06144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against pancreatic cancer.

    Ramachandran, P Veeraraghavan / Helppi, Matthew A / Lehmkuhler, Arlie L / Marchi, Jennifer M / Schmidt, C Max / Yip-Schneider, Michele T

    Bioorganic & medicinal chemistry letters

    2015  Volume 25, Issue 19, Page(s) 4270–4273

    Abstract: A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the ... ...

    Abstract A systematic study to identify the factors influencing the cytotoxicity of α-methylene-γ-hydroxy esters against three pancreatic cancer cell lines (Panc-1, MIA-PaCa-2, and BxPC-3) has established that, in addition to Michael acceptor abilities, the possibility to lactonize to α-methylene-γ-butyrolactones is as important. The substitution pattern and the number of carbons between the hydroxy and ester moieties also influence the bio-activity.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Esters/chemical synthesis ; Esters/chemistry ; Esters/pharmacology ; Humans ; Molecular Structure ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Esters
    Language English
    Publishing date 2015-10-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2015.07.087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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