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Book ; Thesis: Cognitive effects of rhythmic auditory stimulation in Parkinson's disease

Lei, Juan

a P300 study

2021

Institution	Goethe-Universität Frankfurt am Main
Author's details	vorgelegt von Juan Lei aus Anhui, China
Language	English
Size	22 Seiten, Diagramme, 30 cm
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2022
Note	Zusammenfassung auf Deutsch und Englisch ; Literaturverzeichnis: Seite 19-21. - Enthält 1 Sonderabdruck
HBZ-ID	HT021740908
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Retention time prediction and MRM validation reinforce the biomarker identification of LC-MS based phospholipidomics.

Zhang, Jiangang / Zhou, Yu / Lei, Juan / Liu, Xudong / Zhang, Nan / Wu, Lei / Li, Yongsheng

The Analyst

2024 Volume 149, Issue 2, Page(s) 515–527

Abstract: Dysfunctional lipid metabolism plays a crucial role in the development and progression of various diseases. Accurate measurement of lipidomes can help uncover the complex interactions between genes, proteins, and lipids in health and diseases. The ... ...

Abstract	Dysfunctional lipid metabolism plays a crucial role in the development and progression of various diseases. Accurate measurement of lipidomes can help uncover the complex interactions between genes, proteins, and lipids in health and diseases. The prediction of retention time (RT) has become increasingly important in both targeted and untargeted metabolomics. However, the potential impact of RT prediction on targeted LC-MS based lipidomics is still not fully understood. Herein, we propose a simplified workflow for predicting RT in phospholipidomics. Our approach involves utilizing the fatty acyl chain length or carbon-carbon double bond (DB) number in combination with multiple reaction monitoring (MRM) validation. We found that our model's predictive capacity for RT was comparable to that of a publicly accessible program (QSRR Automator). Additionally, MRM validation helped in further mitigating the interference in signal recognition. Using this developed workflow, we conducted phospholipidomics of sorafenib resistant hepatocellular carcinoma (HCC) cell lines, namely MHCC97H and Hep3B. Our findings revealed an abundance of monounsaturated fatty acyl (MUFA) or polyunsaturated fatty acyl (PUFA) phospholipids in these cell lines after developing drug resistance. In both cell lines, a total of 29 lipids were found to be co-upregulated and 5 lipids were co-downregulated. Further validation was conducted on seven of the upregulated lipids using an independent dataset, which demonstrates the potential for translation of the established workflow or the lipid biomarkers.
MeSH term(s)	Humans ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Phospholipids ; Biomarkers ; Carbon
Chemical Substances	Phospholipids ; Biomarkers ; Carbon (7440-44-0)
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an01735d
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Article: [Research Progress of High-intensity Interval Training in Cardiac Rehabilitation of Patients with Acute Coronary Syndrome].

Chi, Lei-Juan / Liu, Hong-Jun / Yang, Chao-Jun / Min, Xiao-Juan

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2023 Volume 45, Issue 1, Page(s) 149–154

Abstract: Acute coronary syndrome (ACS),with increasing mortality year by year,has become a major public health problem in China.Exercise rehabilitation as an important part of the out-of-hospital rehabilitation for the patients with heart diseases can further ... ...

Abstract	Acute coronary syndrome (ACS),with increasing mortality year by year,has become a major public health problem in China.Exercise rehabilitation as an important part of the out-of-hospital rehabilitation for the patients with heart diseases can further reduce the mortality of patients on the basis of drug treatment.The available studies have proved that high-intensity interval training (HIIT) is more effective and efficient than moderate-intensity continuous training (MICT) such as walking and jogging on chronic cardiovascular diseases such as heart failure,stable coronary heart disease,and hypertension and has high security.According to the latest research,HIIT can reduce the platelet response,mitigate myocardial ischemia-reperfusion injury,and increase the exercise compliance of ACS patients more significantly than MICT.Moreover,it does not increase the risk of thrombotic adverse events or malignant arrhythmia.Therefore,HIIT is expected to become an important part of exercise prescription in out-of-hospital cardiac rehabilitation strategy for the patients with ACS.
MeSH term(s)	Humans ; Cardiac Rehabilitation ; High-Intensity Interval Training ; Acute Coronary Syndrome ; Heart Failure ; Blood Platelets
Language	Chinese
Publishing date	2023-02-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000.503X.14527
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Article ; Online: Intestinal microbiota dysbiosis in acute kidney injury: novel insights into mechanisms and promising therapeutic strategies.

Lei, Juan / Xie, Yifan / Sheng, Jingyi / Song, Jiayu

Renal failure

2022 Volume 44, Issue 1, Page(s) 571–580

Abstract: In recent years, the clinical impact of intestinal microbiota-kidney interaction has been emerging. Experimental evidence highlighted a bidirectional evolutionary correlation between intestinal microbiota and kidney diseases. Nonetheless, acute kidney ... ...

Abstract	In recent years, the clinical impact of intestinal microbiota-kidney interaction has been emerging. Experimental evidence highlighted a bidirectional evolutionary correlation between intestinal microbiota and kidney diseases. Nonetheless, acute kidney injury (AKI) is still a global public health concern associated with high morbidity, mortality, healthcare costs, and limited efficient therapy. Several studies on the intestinal microbiome have improved the knowledge and treatment of AKI. Therefore, the present review outlines the concept of the gut-kidney axis and data about intestinal microbiota dysbiosis in AKI to improve the understanding of the mechanisms of the intestinal microbiome on the modification of kidney function and response to kidney injury. We also introduced the future directions and research areas, emphasizing the intervention approaches and recent research advances of intestinal microbiota dysbiosis during AKI, thereby providing a new perspective for future clinical trials.
MeSH term(s)	Acute Kidney Injury/therapy ; Dysbiosis ; Gastrointestinal Microbiome/physiology ; Humans ; Kidney ; Microbiota/physiology
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2022.2056054
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Article ; Online: Mitochondrial Targeted Antioxidant SKQ1 Ameliorates Acute Kidney Injury by Inhibiting Ferroptosis.

Song, Jiayu / Sheng, Jingyi / Lei, Juan / Gan, Weihua / Yang, Yunwen

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 2223957

Abstract: Emerging evidence suggests that ferroptosis is highly correlated with the pathogenesis of acute kidney injury (AKI). Ferroptosis, an iron-dependent form of cell death, is manifested by a toxic accumulation of lipid peroxides and ultrastructural changes ... ...

Abstract	Emerging evidence suggests that ferroptosis is highly correlated with the pathogenesis of acute kidney injury (AKI). Ferroptosis, an iron-dependent form of cell death, is manifested by a toxic accumulation of lipid peroxides and ultrastructural changes in mitochondria. We herein investigated the effect of Visomitin (SKQ1), a novel mitochondria-targeting antioxidant, on several AKI models
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/metabolism ; Animals ; Antioxidants/metabolism ; Cisplatin/adverse effects ; Ferroptosis ; Folic Acid/pharmacology ; Humans ; Iron/metabolism ; Lipid Peroxides/pharmacology ; Mice ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism
Chemical Substances	Antioxidants ; Lipid Peroxides ; Reactive Oxygen Species ; Folic Acid (935E97BOY8) ; Iron (E1UOL152H7) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/2223957
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Article ; Online: Mitochondrial quality control in acute kidney disease.

Sheng, Jingyi / Li, Xian / Lei, Juan / Gan, WeiHua / Song, Jiayu

Journal of nephrology

2023 Volume 36, Issue 5, Page(s) 1283–1291

Abstract: Acute kidney disease (AKD) involves multiple pathogenic mechanisms, including maladaptive repair of renal cells that are rich in mitochondria. Maintenance of mitochondrial homeostasis and quality control is crucial for normal kidney function. ... ...

Abstract	Acute kidney disease (AKD) involves multiple pathogenic mechanisms, including maladaptive repair of renal cells that are rich in mitochondria. Maintenance of mitochondrial homeostasis and quality control is crucial for normal kidney function. Mitochondrial quality control serves to maintain mitochondrial function under various conditions, including mitochondrial bioenergetics, mitochondrial biogenesis, mitochondrial dynamics (fusion and fission) and mitophagy. To date, increasing evidence indicates that mitochondrial quality control is disrupted when acute kidney disease develops. This review describes the mechanisms of mitochondria quality control in acute kidney disease, aiming to provide clues to help design new clinical treatments.
MeSH term(s)	Humans ; Mitochondria/pathology ; Kidney Diseases ; Kidney ; Mitophagy ; Acute Disease ; Mitochondrial Dynamics
Language	English
Publishing date	2023-02-17
Publishing country	Italy
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01582-3
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Article: Identification of DELLA gene family in head cabbage and analysis of mRNA transport in the heterograft.

Li, Biyuan / Zhao, Yan-Ting / Yue, Zhi-Chen / Lei, Juan-Li / Hu, Qi-Zan / Tao, Peng

Yi chuan = Hereditas

2023 Volume 45, Issue 2, Page(s) 156–164

Abstract: DELLA gene family is involved in the regulation of signal transduction of plant hormones. mRNAs ... ...

Abstract	DELLA gene family is involved in the regulation of signal transduction of plant hormones. mRNAs of
MeSH term(s)	Brassica/genetics ; Heterografts ; Transcriptome ; Plant Growth Regulators ; RNA, Messenger/genetics ; Gene Expression Regulation, Plant
Chemical Substances	Plant Growth Regulators ; RNA, Messenger
Language	English
Publishing date	2023-03-16
Publishing country	China
Document type	Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.22-330
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Article ; Online: miR‑488‑3p alleviates neuropathic pain by regulating target gene ROCK1.

Fu, Qiang / Deng, Yuanqing / Zhou, Bo / Lei, Juan / Peng, Ke / Feng, Can

Acta neurobiologiae experimentalis

2023 Volume 83, Issue 3, Page(s) 271–279

Abstract: The function of microRNA (miRNA) in neuropathic pain (NP) has received widespread attention. The current research sought to address the contribution of miR‑488‑3p in NP and its downstream mechanisms. The NP rat model was constructed by chronic ... ...

Abstract	The function of microRNA (miRNA) in neuropathic pain (NP) has received widespread attention. The current research sought to address the contribution of miR‑488‑3p in NP and its downstream mechanisms. The NP rat model was constructed by chronic constriction injury (CCI) surgery in rats. Regulation of miR‑488‑3p or Rho‑associated coiled‑coil‑containing protein kinase 1 (ROCK1) in rats by intrathecal injection of lentivirus or plasmid. Real‑time quantitative reverse transcription polymerase chain reaction (RT‑qPCR) to examine the levels of miR‑488‑3p and ROCK1 in the dorsal root ganglion (DRG). Enzyme‑linked immunosorbent assay (ELISA) to monitor the secretion of pro‑inflammatory and anti‑inflammatory factors. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) for the evaluation of mechanosensitive and thermal nociceptive hypersensitivity of NP behaviors. Validation of molecular mechanism between miR‑488‑3p and ROCK1 using RNA immunoprecipitation assay and dual‑luciferase reporter (DLR) assay. miR‑488‑3p was vigorously less expressed in the DRGs of CCI rats, while ROCK1 was upregulated. Elevated miR‑488‑3p alleviated the decrease of PWL and PWT in CCI rats, inhibited the secretion of pro‑inflammatory factors, and enhanced anti‑inflammatory factors levels. Mechanistically, ROCK1 was the target of miR‑488‑3p. Raised ROCK1 partially attenuated the mitigating effect of miR‑488‑3p on NP behavior and the suppression of inflammatory responses in rats. Current research demonstrated that miR‑488‑3p may be a novel therapeutic target for NP.
MeSH term(s)	Animals ; Rats ; Anti-Inflammatory Agents ; Ganglia, Spinal ; MicroRNAs/genetics ; Neuralgia/genetics ; Rats, Sprague-Dawley ; rho-Associated Kinases/genetics ; rho-Associated Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents ; MicroRNAs ; rho-Associated Kinases (EC 2.7.11.1) ; ROCK1 protein, rat (EC 2.7.11.1) ; MIRN484 microRNA, rat
Language	English
Publishing date	2023-09-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	184409-x
ISSN	1689-0035 ; 0065-1400
ISSN (online)	1689-0035
ISSN	0065-1400
DOI	10.55782/ane-2023-2432
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Article ; Online: The intricate role of annexin A2 in kidney: a comprehensive review.

Lei, Juan / Sun, Pingping / Sheng, Jingyi / Wang, Hongri / Xie, Yifan / Song, Jiayu

Renal failure

2023 Volume 45, Issue 2, Page(s) 2273427

Abstract: Annexin A2 (Anxa2) is a calcium ( ... ...

Abstract	Annexin A2 (Anxa2) is a calcium (Ca
MeSH term(s)	Humans ; Annexin A2/metabolism ; Calcium/metabolism ; Kidney/pathology ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms
Chemical Substances	Annexin A2 ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2023.2273427
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Article ; Online: Risk factors and prevalence of cognitive impairment in maintenance haemodialysis patients: A systematic review and meta-analysis of observational studies.

Cao, Ting / An, Ran / Wang, Ying / Lei, Juan / Liang, Junqing / Wan, Qiaoqin

Journal of advanced nursing

2023 Volume 79, Issue 10, Page(s) 3691–3706

Abstract: Aims: To systematically identify the risk factors for cognitive impairment in maintenance haemodialysis patients and to assess its prevalence in included studies.: Design: Systematic review and meta-analysis about observational studies.: Data ... ...

Abstract	Aims: To systematically identify the risk factors for cognitive impairment in maintenance haemodialysis patients and to assess its prevalence in included studies. Design: Systematic review and meta-analysis about observational studies. Data sources: Systematic search of seven databases, including PubMed, Web of Science, Scope, Wanfang Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and Weipu Chinese Science and Technology Journal Database, from inception until October 2021. Review methods: Observational studies reporting the risk factors for cognitive impairment in maintenance haemodialysis patients in English and Chinese language were included. Meta-analysis was performed to identify risk factors and prevalence of cognitive impairment in maintenance haemodialysis patients with STATA 15.0 software. Results: Overall, 37 eligible studies encompassing 129,849 cases were included. The risk factors with statistical significance after meta-analysis were older age, female sex, fewer years of education, hypertension, diabetes, cerebrovascular accident, multiple comorbid conditions, systolic blood pressure variability, arterial stiffness and low haemoglobin and albumin level. The overall prevalence of cognitive impairment in maintenance haemodialysis patients was 49.1%. Conclusion: The current analysis indicated a high prevalence of cognitive impairment in maintenance haemodialysis patients. Eleven risk factors for cognitive impairment in maintenance haemodialysis patients were identified, among which more attention should be paid to modifiable factors such as cardiovascular disease risk factors and specific kidney and dialysis-related factors. Impact: This paper provides an updated estimate of the pooled prevalence of cognitive impairment in maintenance haemodialysis patients. Identification of risk factors associated with cognitive impairment may assist in developing targeted prevention strategies for maintenance haemodialysis patients at high risk. No patient or public contribution: This study was a systematic review completed by the authors in accordance with relevant guidelines and processes and did not include the participation of patients, service users, caregivers or the general public.
MeSH term(s)	Humans ; Female ; Prevalence ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Renal Dialysis/adverse effects ; Risk Factors ; Hypertension
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	197634-5
ISSN	1365-2648 ; 0309-2402
ISSN (online)	1365-2648
ISSN	0309-2402
DOI	10.1111/jan.15746
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