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Article: A mechanism study on the synergistic effects of rifapentine and fluconazole against fluconazole-resistant

Wang, Yulian / He, Yufei / Cai, Tongkai / Lei, Zhongwei / Lei, Wenzhi / Cao, Yongbing / Wu, Jianhua

2024 Volume 10, Issue 6, Page(s) e27346

Abstract: ... Candida ... ...

Abstract	Candida albicans
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27346
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Article ; Online: Impact of polyphenol-loaded edible starch nanomaterials on antioxidant capacity and gut microbiota.

Lei, Wenzhi / Qi, Maodong / Tan, Pei / Yang, Siqi / Fan, Lingjia / Li, Hongcai / Gao, Zhenpeng

International journal of biological macromolecules

2024 Volume 265, Issue Pt 1, Page(s) 130979

Abstract: Starch nanoparticles (SNPs) have the capability to adsorb polyphenol components from apple pomace efficiently, forming bound polyphenols (P-SNPs). These bound polyphenols may have potential bioactivities to affect human health positively. Therefore, in- ... ...

Abstract	Starch nanoparticles (SNPs) have the capability to adsorb polyphenol components from apple pomace efficiently, forming bound polyphenols (P-SNPs). These bound polyphenols may have potential bioactivities to affect human health positively. Therefore, in-depth in vivo observation of the antioxidant activity and evaluation of its gut microbiota regulatory function are essential. The results revealed that P-SNPs indicated significant scavenging abilities against DPPH, ABTS, and hydroxyl radicals. Furthermore, the nanomaterials exhibited non-toxic properties, devoid of hepatorenal and intestinal damage, while concurrently stimulating the production of short-chain fatty acids (SCFAs) within the gastrointestinal tract. Notably, P-SNPs significantly enhanced antioxidant capacity in serum, liver, and kidney tissues, fostering the proliferation of beneficial bacteria (Lactobacillus, Bacillus, norank_f__Muribaculaceae) while suppressing pathogenic bacterial growth (Helicobacter, Odoribacter). This study proposes a novel research concept for the scientific use of polyphenols in promoting gut health.
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Polyphenols/pharmacology ; Polyphenols/analysis ; Gastrointestinal Microbiome ; Starch/metabolism ; Nanostructures ; Fatty Acids, Volatile/metabolism
Chemical Substances	Antioxidants ; Polyphenols ; Starch (9005-25-8) ; Fatty Acids, Volatile
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130979
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Article ; Online: Post-translational modifications confer amphotericin B resistance in

Zhang, Li / Xiao, Jinzhou / Du, Mingwei / Lei, Wenzhi / Yang, Weiwei / Xue, Xiaochun

Frontiers in immunology

2023 Volume 14, Page(s) 1148681

Abstract: Neutropenia is a common complication in the treatment of hematological diseases and the most common predisposing factor for invasion by fungi, such ... ...

Abstract	Neutropenia is a common complication in the treatment of hematological diseases and the most common predisposing factor for invasion by fungi, such as
MeSH term(s)	Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Lysine/genetics ; Microbial Sensitivity Tests ; Fungi ; Protein Processing, Post-Translational
Chemical Substances	Amphotericin B (7XU7A7DROE) ; Antifungal Agents ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1148681
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Article ; Online: The single-cell modification strategies for probiotics delivery in inflammatory bowel disease: A review.

Han, Mengzhen / Lei, Wenzhi / Liang, Jingjing / Li, Hongcai / Hou, Mengxin / Gao, Zhenpeng

Carbohydrate polymers

2023 Volume 324, Page(s) 121472

Abstract: Oral probiotic therapy has become an increasingly attractive method for treating various diseases, including intestinal barrier dysfunction, inflammatory bowel disease (IBD), and colorectal cancer due to its safety and convenience. However, only a few ... ...

Abstract	Oral probiotic therapy has become an increasingly attractive method for treating various diseases, including intestinal barrier dysfunction, inflammatory bowel disease (IBD), and colorectal cancer due to its safety and convenience. However, only a few probiotics after oral gavage can survive the acidic and bile salt conditions of the gastrointestinal tract and colonize the colon to have a nutritional effect on the host. To address these challenges, encapsulation technology has been applied to protect probiotics from harsh gastrointestinal conditions, improve gut adhesion, and reduce immunogenicity. In addition, some of the functional polysaccharides are used to endow probiotics with exogenous functions as prebiotics. In this review, we systematically introduced the advancements of emerging single-cell modification strategies for probiotics in IBD applications. Additionally, we discussed the limitations and perspectives of single-cell modification strategies for probiotics. This review contributed to the development of probiotic delivery systems with higher therapeutic efficacy against colitis.
MeSH term(s)	Humans ; Inflammatory Bowel Diseases/drug therapy ; Probiotics/therapeutic use ; Prebiotics ; Colitis/drug therapy
Chemical Substances	Prebiotics
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.121472
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Article ; Online: Serum metabolomics combined with 16S rRNA sequencing to reveal the effects of Lycium barbarum polysaccharide on host metabolism and gut microbiota

Liang, Jingjing / Li, Xiaohan / Lei, Wenzhi / Tan, Pei / Han, Mengzhen / Li, Hongcai / Yue, Tianli / Wang, Zhouli / Gao, Zhenpeng

Food Research International. 2023 Mar., v. 165 p.112563-

2023

Abstract: Gut microbes and microbial metabolites derived from polysaccharides mediate beneficial effects related to polysaccharides consumption. Lycium barbarum polysaccharide (LBP) is the main bioactive components in L. barbarum fruits and possesses considerable ... ...

Abstract	Gut microbes and microbial metabolites derived from polysaccharides mediate beneficial effects related to polysaccharides consumption. Lycium barbarum polysaccharide (LBP) is the main bioactive components in L. barbarum fruits and possesses considerable health-promoting effects. In the present study, we aimed to investigate whether LBP supplementation influenced host metabolic responses and gut microbiota in healthy mice, and to identify bacterial taxa associated with the observed beneficial effects. Our results indicated that mice supplied with LBP at 200 mg/kg BW showed lower serum total cholesterol (TC), triglyceride (TG), and liver TG levels. LBP supplementation strengthened the antioxidant capacity of liver, supported the growth of Lactobacillus and Lactococcus, and stimulated short-chain fatty acids (SCFAs) production. Serum metabolomic analysis revealed that fatty acid degradation pathways were enriched, and RT-PCR further confirmed that LBP up-regulated the expression of liver genes involved in fatty acid oxidation. The Spearman’s correlation analysis indicated that some serum and liver lipid profiles and hepatic SOD activity were associated with Lactobacillus, Lactococcus, Ruminococcus, Allobaculum and AF12. Collectively, these findings provide new evidence for the potential preventive effect of LBP consumption on hyperlipidemia and nonalcoholic fatty liver disease.
Keywords	Lactobacillus ; Lactococcus ; Lycium barbarum ; Ruminococcus ; antioxidant activity ; beta oxidation ; blood serum ; cholesterol ; fatty acids ; fatty liver ; food research ; health promotion ; hyperlipidemia ; intestinal microorganisms ; liver ; metabolites ; metabolomics ; polysaccharides ; triacylglycerols ; Lycium barbarum polysaccharide ; Gut microbiota ; Lipid metabolism ; Correlation analysis ; LBP ; TC ; TG ; MDA ; T-AOC ; SOD ; SCFAs ; GPR 41 ; PYY ; GLP-1 ; HDACs ; T2DM ; HDL-C ; LDL-C ; GSH-PX ; CAT ; ALT ; TBA ; H&E ; GC ; RT-PCR ; ROS ; UPGMA ; KEGG ; PCA ; OPLS-DA ; FC ; GPCRs ; PPAR ; NAFLD
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.112563
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Succinylation modification provides new insights for the treatment of immunocompromised individuals with drug-resistant

Chen, Xianzhen / Lei, Wenzhi / Meng, Hui / Jiang, Yi / Zhang, Sanli / Chen, Huyan / Du, Mingwei / Xue, Xiaochun

Frontiers in immunology

2023 Volume 14, Page(s) 1161642

Abstract: ... ...

Abstract	Invasive
MeSH term(s)	Humans ; Animals ; Mice ; Aspergillus fumigatus ; Lysine ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Itraconazole/pharmacology ; Itraconazole/therapeutic use ; Aspergillosis/drug therapy ; Aspergillosis/microbiology ; Triazoles/pharmacology ; Triazoles/therapeutic use
Chemical Substances	Lysine (K3Z4F929H6) ; Antifungal Agents ; Itraconazole (304NUG5GF4) ; Triazoles
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1161642
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Article ; Online: Serum metabolomics combined with 16S rRNA sequencing to reveal the effects of Lycium barbarum polysaccharide on host metabolism and gut microbiota.

Liang, Jingjing / Li, Xiaohan / Lei, Wenzhi / Tan, Pei / Han, Mengzhen / Li, Hongcai / Yue, Tianli / Wang, Zhouli / Gao, Zhenpeng

Food research international (Ottawa, Ont.)

2023 Volume 165, Page(s) 112563

Abstract	Gut microbes and microbial metabolites derived from polysaccharides mediate beneficial effects related to polysaccharides consumption. Lycium barbarum polysaccharide (LBP) is the main bioactive components in L. barbarum fruits and possesses considerable health-promoting effects. In the present study, we aimed to investigate whether LBP supplementation influenced host metabolic responses and gut microbiota in healthy mice, and to identify bacterial taxa associated with the observed beneficial effects. Our results indicated that mice supplied with LBP at 200 mg/kg BW showed lower serum total cholesterol (TC), triglyceride (TG), and liver TG levels. LBP supplementation strengthened the antioxidant capacity of liver, supported the growth of Lactobacillus and Lactococcus, and stimulated short-chain fatty acids (SCFAs) production. Serum metabolomic analysis revealed that fatty acid degradation pathways were enriched, and RT-PCR further confirmed that LBP up-regulated the expression of liver genes involved in fatty acid oxidation. The Spearman's correlation analysis indicated that some serum and liver lipid profiles and hepatic SOD activity were associated with Lactobacillus, Lactococcus, Ruminococcus, Allobaculum and AF12. Collectively, these findings provide new evidence for the potential preventive effect of LBP consumption on hyperlipidemia and nonalcoholic fatty liver disease.
MeSH term(s)	Animals ; Mice ; RNA, Ribosomal, 16S ; Gastrointestinal Microbiome ; Metabolomics ; Lactobacillus ; Fatty Acids
Chemical Substances	RNA, Ribosomal, 16S ; lycium barbarum polysaccharide ; Fatty Acids
Language	English
Publishing date	2023-02-03
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.112563
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Article ; Online: Investigation the nutritional properties of Auricularia auricula pulp fermented with Lactobacillus strains and their effects on gut microbiota.

Li, Hongcai / Tan, Pei / Lei, Wenzhi / Yang, Siqi / Fan, Lingjia / Yang, Taihao / Guo, Chunfeng / Gao, Zhenpeng

Journal of the science of food and agriculture

2023 Volume 104, Issue 4, Page(s) 2502–2517

Abstract: Background: Auricularia auricula is rich in bioactive components, and microbial fermentation can further dramatically increase its content and bioavailability. However, there are few studies on the relationship between fermented A. auricula pulp (FAAP) ... ...

Abstract	Background: Auricularia auricula is rich in bioactive components, and microbial fermentation can further dramatically increase its content and bioavailability. However, there are few studies on the relationship between fermented A. auricula pulp (FAAP) and gut microbiota. In this study, standard strains Lactobacillus plantarum 21801 and 21805 purchased from the China Center of Industrial Culture Collection were used to ferment A. auricula pulp at a ratio of 2:1, with an inoculum of 5%, a fermentation temperature of 31 °C, and a fermentation time of 22 h. The nutritional properties, aroma, and color of FAAP and their effects on the body characteristics of mice and the structure and abundance of gut microbiota are discussed. Results: The results showed that, compared with A. auricula pulp, FAAP significantly increased the nutritional properties while maintaining favorable sensory quality and flavor profiles. Among them, the content of total polyphenols and total flavonoids reached 22.04 μg mL Conclusion: These findings demonstrate that FAAP is rich in nutrients and has unique functional properties that promote host health and regulate the gut microbiota. © 2023 Society of Chemical Industry.
MeSH term(s)	Lactobacillus/metabolism ; Gastrointestinal Microbiome ; Antioxidants/metabolism ; Polyphenols/pharmacology ; Bacteria ; Fermentation ; Auricularia
Chemical Substances	Antioxidants ; Polyphenols
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13150
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Article ; Online: Preparation of edible starch nanomaterials for the separation of polyphenols from fruit pomace extract and determination of their adsorption properties.

Lei, Wenzhi / Liang, Jingjing / Tan, Pei / Yang, Siqi / Fan, Lingjia / Han, Mengzhen / Li, Hongcai / Gao, Zhenpeng

International journal of biological macromolecules

2022 Volume 222, Issue Pt B, Page(s) 2054–2064

Abstract: Apple polyphenols are abundantly present in apple pomace, and their applications are limited by the low efficiency of traditional extraction methods and the tendency to pollute the environment. Starch nanoparticles (SNPs) have received much attention due ...

Abstract	Apple polyphenols are abundantly present in apple pomace, and their applications are limited by the low efficiency of traditional extraction methods and the tendency to pollute the environment. Starch nanoparticles (SNPs) have received much attention due to their renewable, low cost and biocompatibility. The aim of this study was to prepare SNPs of different sizes from corn starch using ultrasonic-assisted chemical precipitation with adsorption of apple polyphenols, investigate the relationship between particle size and adsorption, while experiments were performed to assess antioxidant activity, simulate in vivo digestion and polyphenol release. The results showed that the smaller the particle size of SNPs the higher the adsorption of polyphenols, and the combination of characterization and adsorption kinetics showed that this adsorption was a physicochemical binding process. DPPH radical scavenging activity showed that polyphenols bound to SNPs were more stable than free polyphenols. In vitro simulation of digestion and release processes, SNPs loaded with polyphenols showed better anti-digestive properties, polyphenols are released in small amounts in gastric juices and continuously in intestinal juices. Our results provide a theoretical basis for the direct separation of polyphenols from fruit pomace polyphenol extracts using nanomaterials and the industrial utilization of polyphenol products.
MeSH term(s)	Polyphenols/chemistry ; Starch/metabolism ; Fruit/chemistry ; Adsorption ; Plant Extracts/chemistry ; Nanostructures
Chemical Substances	Polyphenols ; Starch (9005-25-8) ; Plant Extracts
Language	English
Publishing date	2022-10-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.10.004
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Article: XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway.

Zhu, Xin-Lin / Hu, Dong-Ying / Zeng, Zhao-Xiang / Jiang, Wei-Wei / Chen, Tian-Yang / Chen, Tian-Cheng / Liao, Wan-Qing / Lei, Wen-Zhi / Fang, Wen-Jie / Pan, Wei-Hua

World journal of diabetes

2023 Volume 14, Issue 9, Page(s) 1369–1384

Abstract: Background: Diabetic skin ulcers, a significant global healthcare burden, are mainly caused by the inhibition of cell proliferation and impaired angiogenesis. XB130 is an adaptor protein that regulates cell proliferation and migration. However, the role ...

Abstract	Background: Diabetic skin ulcers, a significant global healthcare burden, are mainly caused by the inhibition of cell proliferation and impaired angiogenesis. XB130 is an adaptor protein that regulates cell proliferation and migration. However, the role of XB130 in the development of diabetic skin ulcers remains unclear. Aim: To investigate whether XB130 can regulate the inhibition of proliferation and vascular damage induced by high glucose. Additionally, we aim to determine whether XB130 is involved in the healing process of diabetic skin ulcers, along with its molecular mechanisms. Methods: We conducted RNA-sequencing analysis to identify the key genes involved in diabetic skin ulcers. We investigated the effects of XB130 on wound healing using histological analyses. In addition, we used reverse transcription-quantitative polymerase chain reaction, Western blot, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, immunofluorescence, wound healing, and tubule formation experiments to investigate their effects on cellular processes in human umbilical vein endothelial cells (HUVECs) stimulated with high glucose. Finally, we performed functional analysis to elucidate the molecular mechanisms underlying diabetic skin ulcers. Results: RNA-sequencing analysis showed that the expression of XB130 was up-regulated in the tissues of diabetic skin ulcers. Knockdown of XB130 promoted the healing of skin wounds in mice, leading to an accelerated wound healing process and shortened wound healing time. At the cellular level, knockdown of XB130 alleviated high glucose-induced inhibition of cell proliferation and angiogenic impairment in HUVECs. Inhibition of the PI3K/Akt pathway removed the proliferative effects and endothelial protection mediated by XB130. Conclusion: The findings of this study indicated that the expression of XB130 is up-regulated in high glucose-stimulated diabetic skin ulcers and HUVECs. Knockdown of XB130 promotes cell proliferation and angiogenesis
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v14.i9.1369
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