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Article ; Online: Preparation and microwave properties of ZnTiNb2O8/SmTiNbO6 composite dielectric ceramics

Lei Ke

E3S Web of Conferences, Vol 268, p

2021 Volume 01079

Abstract: In order to get a microwave dielectric ceramics having near zero τƒ, different ratio of ZnTiNb2O8 and SmTiNbO6 powders are sintered together at different temperature. XRD and SEM of these composite ceramics are tested to analyze the composition. The ... ...

Abstract	In order to get a microwave dielectric ceramics having near zero τƒ, different ratio of ZnTiNb2O8 and SmTiNbO6 powders are sintered together at different temperature. XRD and SEM of these composite ceramics are tested to analyze the composition. The microwave properties and density of the composite ceramics are measured in order to find the best ratio of ZnTiNb2O8 and SmTiNbO6. For (1-x)ZnTiNb2O8-xSmTiNbO6 ceramics, the ceramics have very good microwave properties(εr = 24.63, Q*ƒ=11846GHz, τƒ = 0.16ppm/℃) when x is 0.35.
Keywords	dielectric property ; microwave ceramics ; x-ray diffraction ; scanning electron microscopy ; zinc titanium niobate ; samarium titanium niobate ; Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Progress in diagnosis and treatment of Leber's hereditary optic neuropathy.

Ma, Qingyue / Sun, Ying / Lei, Ke / Luo, Wenjuan

Journal of molecular medicine (Berlin, Germany)

2023 Volume 102, Issue 1, Page(s) 1–10

Abstract: Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main symptom. It is one of the diseases that cause vision loss and optic atrophy in young and middle-aged people. The mutations of these three ... ...

Abstract	Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main symptom. It is one of the diseases that cause vision loss and optic atrophy in young and middle-aged people. The mutations of these three primary mitochondrial mutations, m.11778G>A, m.14484T>C, and m.3460G>A, are the main molecular basis, but their pathogenesis is also affected by nuclear genes, mitochondrial genetic background, and environmental factors. This article summarizes the research progress on molecular pathogenesis, clinical symptoms, and treatment of LHON in recent years, aiming to summarize the genetic pathogenesis and clinical treatment points of LHON.
MeSH term(s)	Middle Aged ; Humans ; DNA, Mitochondrial/genetics ; Optic Atrophy, Hereditary, Leber/diagnosis ; Optic Atrophy, Hereditary, Leber/genetics ; Optic Atrophy, Hereditary, Leber/therapy ; Mutation ; Mitochondria/genetics ; Mitochondria/pathology
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2023-11-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1223802-8
ISSN	1432-1440 ; 0946-2716
ISSN (online)	1432-1440
ISSN	0946-2716
DOI	10.1007/s00109-023-02389-2
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Article ; Online: Cost-Effectiveness of Elbasvir/Grazoprevir for the Treatment of Chronic Hepatitis C

Jinyu Liu / Min Guo / Lei Ke / Ruxu You

Frontiers in Public Health, Vol

A Systematic Review

2022 Volume 10

Abstract: ObjectiveThis study aims to systematically review recent economic evaluations of elbasvir/grazoprevir (EBR/GZR) for chronic hepatitis C (CHC), to critically appraise the reporting quality and to summarize the results.MethodsA literature search was ... ...

Abstract	ObjectiveThis study aims to systematically review recent economic evaluations of elbasvir/grazoprevir (EBR/GZR) for chronic hepatitis C (CHC), to critically appraise the reporting quality and to summarize the results.MethodsA literature search was undertaken using Medline, Embase, the Cochrane Library, EconLit, China National Knowledge Infrastructure, Wanfang Data, and Chongqing VIP to identify original articles containing economic evaluations of EBR/GZR for CHC published between 1 January 2000 and 31 December 2020. The Consolidated Health Economic Evaluation Reporting Standards statement was used to assess the quality of reporting of the articles.ResultsOf 93 articles identified, 13 studies fulfilled the inclusion criteria. These studies were conducted in 4 countries, and 8 active interventions were assessed. The target population was patients infected with CHC genotype 1 infection in all studies. Eight out of 13 studies that compared EBR/GZR vs. other direct antiviral agents suggested that EBR/GZR was generally more cost-effective or dominant than daclatasvir/asunaprevir (DCV/ASV), sofosbuvir/velpatasvir (SOF/VEL), ledipasvir/sofosbuvir (LDV/SOF), ombitasvir/paritaprevir/ritonavir + dasabuvir (3D) but not more cost-effective than glecaprevir/pibrentasvir (GLE/PIB). Two studies from China and one study from the USA that compared EBR/GZR vs. pegylated interferon and ribavirin (PegIFN/RBV) consistently indicated that EBR/GZR was generally more cost-effective than PegIFN/RBV. One study from Italy compared EBR/GZR with SOF + PegIFN/RBV and suggested that EBR/GZR had a lower cost and higher effectiveness. One study from France and one study from the USA confirmed that compared with non-therapy for patients with chronic kidney disease, EBR/GZR was cost-effective at commonly accepted current standards. All included studies were of good quality of reporting, with an average score of 21.9 (range 19–23).ConclusionEBR/GZR for CHC genotype 1 might be cost-effective or dominant compared with PegIFN/RBV and other direct ...
Keywords	cost-effectiveness ; elbasvir/grazoprevir ; direct-acting antivirals ; pegylated interferon ; ribavirin ; hepatitis C virus ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Dienedioic acid as a useful diene building block via directed Heck-decarboxylate coupling

Lei Ke / Zhilong Chen

Communications Chemistry, Vol 3, Iss 1, Pp 1-

2020 Volume 12

Abstract: Dienes are useful reagents for cross-couplings in the synthesis of unsaturated natural products, but decarboxylative Heck reactions of dienes are limited by facile E/Z isomerism. Here configurationally stable divinyldicarboxylic acid is used as a ... ...

Abstract	Dienes are useful reagents for cross-couplings in the synthesis of unsaturated natural products, but decarboxylative Heck reactions of dienes are limited by facile E/Z isomerism. Here configurationally stable divinyldicarboxylic acid is used as a coupling reagent in which the carboxylates direct the Heck reaction prior to decarboxylation.
Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Reclassifying BRCA1 c.4358-2A > G and BRCA2 c.475 + 5G > C variants from "Uncertain Significance" to "Pathogenic" based on minigene assays and clinical evidence.

Ning, Ying / Zhang, Yu / Tian, Tian / Chen, Yu / Wang, Jia / Lei, Ke / Cui, Zhumei

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 2, Page(s) 62

Abstract: Background: Pathogenic variants in BRCA genes play a crucial role in the pathogenesis of ovarian cancer. Intronic variants of uncertain significance (VUS) may contribute to pathogenicity by affecting splicing. Currently, the significance of many ... ...

Abstract	Background: Pathogenic variants in BRCA genes play a crucial role in the pathogenesis of ovarian cancer. Intronic variants of uncertain significance (VUS) may contribute to pathogenicity by affecting splicing. Currently, the significance of many intronic variants in BRCA has not been clarified, impacting patient treatment strategies and the management of familial cases. Method: A retrospective study was conducted to analyze BRCA intronic VUS in a cohort of 707 unrelated ovarian cancer patients at a single institution from 2018 to 2023. Three splicing predictors were employed to analyze detected intronic VUS. Variants predicted to have splicing alterations were selected for further validation through minigene assays. Patient and familial investigations were conducted to comprehend cancer incidence within pedigrees and the application of poly (ADP-ribose) polymerase inhibitors (PARPi) by the patients. In accordance with the guidelines of the American College of Medical Genetics and Genomics (ACMG), the intronic VUS were reclassified based on minigene assay results and clinical evidence. Result: Approximately 9.8% (69/707) of patients were identified as carriers of 67 different VUS in BRCA1/2, with four intronic variants accounting for 6% (4/67) of all VUS. Splicing predictors indicated potential splicing alterations in splicing for BRCA1 c.4358-2A>G and BRCA2 c.475+5G>C variants. Minigene assays utilizing the pSPL3 exon trapping vector revealed that these variants induced changes in splicing sites and frameshift, resulting in premature termination of translation (p. Ala1453Glyfs and p. Pro143Glyfs). According to ACMG guidelines, BRCA1 c.4358-2A>G and BRCA2 c.475+5G>C were reclassified as pathogenic variants. Pedigree investigations were conducted on patients with BRCA1 c.4358-2A>G variant, and the detailed utilization of PARPi provided valuable insights into research on PARPi resistance. Conclusion: Two intronic VUS were reclassified as pathogenic variants. A precise classification of variants is crucial for the effective treatment and management of both patients and healthy carriers.
MeSH term(s)	Humans ; Female ; BRCA2 Protein/genetics ; BRCA1 Protein/genetics ; Retrospective Studies ; Ovarian Neoplasms/genetics
Chemical Substances	BRCA2 protein, human ; BRCA2 Protein ; BRCA1 protein, human ; BRCA1 Protein
Language	English
Publishing date	2024-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05597-y
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Article ; Online: Recent Progress on Hydrogen Production from Ammonia Decomposition: Technical Roadmap and Catalytic Mechanism.

Huang, Xiangyong / Lei, Ke / Mi, Yan / Fang, Wenjian / Li, Xiaochuan

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Ammonia decomposition has attracted significant attention in recent years due to its ability to produce hydrogen without emitting carbon dioxide and the ease of ammonia storage. This paper reviews the recent developments in ammonia decomposition ... ...

Abstract	Ammonia decomposition has attracted significant attention in recent years due to its ability to produce hydrogen without emitting carbon dioxide and the ease of ammonia storage. This paper reviews the recent developments in ammonia decomposition technologies for hydrogen production, focusing on the latest advances in catalytic materials and catalyst design, as well as the research progress in the catalytic reaction mechanism. Additionally, the paper discusses the advantages and disadvantages of each method and the importance of finding non-precious metals to reduce costs and improve efficiency. Overall, this paper provides a valuable reference for further research on ammonia decomposition for hydrogen production.
MeSH term(s)	Ammonia ; Catalysis ; Metals ; Hydrogen
Chemical Substances	Ammonia (7664-41-7) ; Metals ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28135245
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Article ; Online: Transcriptome-based network analysis related to M2-like tumor-associated macrophage infiltration identified VARS1 as a potential target for improving melanoma immunotherapy efficacy.

Wu, Zhengquan / Lei, Ke / Li, Huaizhi / He, Jiali / Shi, Enxian

Journal of translational medicine

2022 Volume 20, Issue 1, Page(s) 489

Abstract: Rationale: The M2-like tumor-associated macrophages (TAMs) are independent prognostic factors in melanoma.: Methods: We performed weighted gene co-expression network analysis (WGCNA) to identify the module most correlated with M2-like TAMs. The ... ...

Abstract	Rationale: The M2-like tumor-associated macrophages (TAMs) are independent prognostic factors in melanoma. Methods: We performed weighted gene co-expression network analysis (WGCNA) to identify the module most correlated with M2-like TAMs. The Cancer Genome Atlas (TCGA) patients were classified into two clusters that differed based on prognosis and biological function, with consensus clustering. A prognostic model was established based on the differentially expressed genes (DEGs) of the two clusters. We investigated the difference in immune cell infiltration and immune response-related gene expression between the high and low risk score groups. Results: The risk score was defined as an independent prognostic value in melanoma. VARS1 was a hub gene in the M2-like macrophage-associated WGCNA module that the DepMap portal demonstrated was necessary for melanoma growth. Overexpressing VARS1 in vitro increased melanoma cell migration and invasion, while downregulating VARS1 had the opposite result. VARS1 overexpression promoted M2 macrophage polarization and increased TGF-β1 concentrations in tumor cell supernatant in vitro. VARS1 expression was inversely correlated with immune-related signaling pathways and the expression of several immune checkpoint genes. In addition, the VARS1 expression level helped predict the response to anti-PD-1 immunotherapy. Pan-cancer analysis demonstrated that VARS1 expression negatively correlated with CD8 T cell infiltration and the immune response-related pathways in most cancers. Conclusion: We established an M2-like TAM-related prognostic model for melanoma and explored the role of VARS1 in melanoma progression, M2 macrophage polarization, and the development of immunotherapy resistance.
MeSH term(s)	Humans ; Tumor-Associated Macrophages ; Transcriptome/genetics ; Melanoma/genetics ; Melanoma/therapy ; Immunotherapy ; Macrophages/metabolism ; Prognosis
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03686-z
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Article ; Online: Establishing a Prognostic Model Based on Ulceration and Immune Related Genes in Melanoma Patients and Identification of EIF3B as a Therapeutic Target.

Wu, Zhengquan / Lei, Ke / Xu, Sheng / He, Jiali / Shi, Enxian

Frontiers in immunology

2022 Volume 13, Page(s) 824946

Abstract: Ulceration and immune status are independent prognostic factors for survival in melanoma patients. Herein univariate Cox regression analysis revealed 53 ulcer-immunity-related DEGs. We performed consensus clustering to divide The Cancer Genome Atlas ( ... ...

Abstract	Ulceration and immune status are independent prognostic factors for survival in melanoma patients. Herein univariate Cox regression analysis revealed 53 ulcer-immunity-related DEGs. We performed consensus clustering to divide The Cancer Genome Atlas (TCGA) cohort (n = 467) into three subtypes with different prognosis and biological functions, followed by validation in three merged Gene Expression Omnibus (GEO) cohorts (n = 399). Multiomics approach was used to assess differences among the subtypes. Cluster 3 showed relatively lesser amplification and expression of immune checkpoint genes. Moreover, Cluster 3 lacked immune-related pathways and immune cell infiltration, and had higher proportion of non-responders to immunotherapy. We also constructed a prognostic model based on ulceration and immune related genes in melanoma. EIF3B was a hub gene in the intersection between genes specific to Cluster 3 and those pivotal for melanoma growth (DepMap, https://depmap.org/portal/download/). High EIF3B expression in TCGA and GEO datasets was related to worst prognosis.
MeSH term(s)	Eukaryotic Initiation Factor-3/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Immunotherapy ; Melanoma ; Prognosis ; Ulcer/genetics
Chemical Substances	EIF3B protein, human ; Eukaryotic Initiation Factor-3
Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.824946
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Article: Automated MRI Field of View Prescription from Region of Interest Prediction by Intra-Stack Attention Neural Network.

Lei, Ke / Syed, Ali B / Zhu, Xucheng / Pauly, John M / Vasanawala, Shreyas V

Bioengineering (Basel, Switzerland)

2023 Volume 10, Issue 1

Abstract: Manual prescription of the field of view (FOV) by MRI technologists is variable and prolongs the scanning process. Often, the FOV is too large or crops critical anatomy. We propose a deep learning framework, trained by radiologists' supervision, for ... ...

Abstract	Manual prescription of the field of view (FOV) by MRI technologists is variable and prolongs the scanning process. Often, the FOV is too large or crops critical anatomy. We propose a deep learning framework, trained by radiologists' supervision, for automating FOV prescription. An intra-stack shared feature extraction network and an attention network are used to process a stack of 2D image inputs to generate scalars defining the location of a rectangular region of interest (ROI). The attention mechanism is used to make the model focus on a small number of informative slices in a stack. Then, the smallest FOV that makes the neural network predicted ROI free of aliasing is calculated by an algebraic operation derived from MR sampling theory. The framework's performance is examined quantitatively with intersection over union (IoU) and pixel error on position and qualitatively with a reader study. The proposed model achieves an average IoU of 0.867 and an average ROI position error of 9.06 out of 512 pixels on 80 test cases, significantly better than two baseline models and not significantly different from a radiologist. Finally, the FOV given by the proposed framework achieves an acceptance rate of 92% from an experienced radiologist.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10010092
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Article ; Online: Applications of sulfonyl hydrazides in radical cyclization of alkenes.

Yi, Rongnan / Wang, Ling-Tao / Chen, Junhao / Wei, Wen-Ting / Lei, Ke-Wei

Organic & biomolecular chemistry

2023 Volume 21, Issue 29, Page(s) 5906–5918

Abstract: Radical cyclization is regarded as a powerful and promising strategy for the assembly of diverse important cyclic structures because of its high atom- and step-economy. As excellent radical acceptors, alkenes offer two potential directions, pushing the ... ...

Abstract	Radical cyclization is regarded as a powerful and promising strategy for the assembly of diverse important cyclic structures because of its high atom- and step-economy. As excellent radical acceptors, alkenes offer two potential directions, pushing the research domain of radical cyclization. In this context, as a radical precursor, sulfonyl hydrazide plays an important role in accomplishing radical cyclization of alkenes in a facile and efficient way. This review focuses on the applications of sulfonyl hydrazides in radical cyclization of alkenes, which generally has two radical conversion modes, sulfonyl radicals and sulfoxide radicals. In particular, the section of sulfonyl radicals consists of eight parts containing aromatic rings, alkenes, alkynes, cyanides, aldehydes, carboxylic acids, amides, and small ring compounds, according to the objects of cyclization after addition with alkenes. Within each category, representative instances are presented and discussed in terms of their general mechanistic perspectives when needed.
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob00789h
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