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Article ; Online: Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer

Leila Kohan

Journal of Fasa University of Medical Sciences, Vol 7, Iss 2, Pp 217-

2017 Volume 222

Abstract: Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast cancer, it seems ... ...

Abstract	Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast cancer, it seems that resistin may present a molecular link between inflammation and breast carcinogenesis. The aim of this study was to investigate the association of rs1862513 promoter resistin gene variant with breast cancer risk. Material & Methods: For the purpose of this case-control study, 150 breast cancer and 150 healthy control blood samples were collected. After DNA extraction, genotype determination was performed by PCR-RFLP method. Statistical analysis was done using logistic regression model. Results: The case and control groups were in Hardy-Weinberg equilibrium. The subjects with GG genotype had increased risk of breast cancer compared to those with CC genotype (OR: 1.9, 95% CI: 1-3.7, P: 0.04). Also, the G allele indicated a positive association with breast cancer susceptibility (OR: 1.4, 95% CI: 1-1.98, P: 0.03). Conclusion: Results of this study showed possible association of resistin rs1862513 gene variant with breast cancer risk in Iranian women.
Keywords	Resistin ; Breast cancer ; Promoter ; Genetic variant ; Medicine (General) ; R5-920
Subject code	616 ; 610
Language	Persian
Publishing date	2017-09-01T00:00:00Z
Publisher	Fasa University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of 45bp Ins/Del Genetic Variant in UCP-2 Gene as a Risk factor for Bipolar Disorder

Leila Kohan / Fateme Zarei / Ebrahim Moghimi Sarani

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 28, Iss 6, Pp 62-

2021 Volume 69

Abstract: Introduction: Bipolar disorder is a type biphasic disorder of energy availability that indicates increased mitochondrial respiration in episodes of mania, compared to decreased mitochondrial function in the depressive phase of the illness. Mitochondrial ... ...

Abstract	Introduction: Bipolar disorder is a type biphasic disorder of energy availability that indicates increased mitochondrial respiration in episodes of mania, compared to decreased mitochondrial function in the depressive phase of the illness. Mitochondrial dysfunction may lead to an excessive increase in reactive oxygen species (ROS). The UCP-2 proteins act as regulators of ROS in the cell. This study aimed to investigate the association of UCP-2 45bp ins/del genetic variant with susceptibility to bipolar disorder. Materials & Methods: This case-control study was performed on 205 subjects with bipolar disorder and 200 healthy subjects as a control group. After extraction of DNA from peripheral blood samples, genotype determination was performed using the PCR method. Moreover, the logistic regression analysis was used for the comparison of genotypes and allele frequencies between case and control groups. Ethics code: IR.SUMS.REC.1396.S435 Findings: There was a significant association between ID (OR=0.42; 95% CI= 0.27-0.64; P<0.001) and II (OR=0.39; 95% CI=0.20-0.77; P=0.006) genotypes with bipolar disorder. Data analysis showed I allele had a protective effect on susceptibility to bipolar disorder (OR=0.56; 95% CI=0.42-0.75; P<0.001). Discussions & Conclusions: This study investigated, for the first time, the association between UCP-2 45bp ins/del genetic variant and bipolar disorder. The results showed UCP-2 45bp ins/del genetic variant was associated with bipolar disorder; however, more studies are required to be conducted in different ethnicities to confirm these results.
Keywords	bipolar disorder ; genetic variant ; mitochondria ; ucp-2 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	150
Language	Persian
Publishing date	2021-02-01T00:00:00Z
Publisher	Ilam University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening

Mina Niusha / Seyed Ali Rahmani / Leila Kohan / Ladan Sadeghi / Mohammad Nouri / Hamid Reza Nejabati

Asian Pacific Journal of Reproduction, Vol 12, Iss 1, Pp 16-

2023 Volume 22

Abstract: Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 ... ...

Abstract	Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to the embryo scope until transfer. Embryo integrity and blastocyst formation were assessed on day 5. Results: Totally, 282 embryos from 62 couples were evaluated. The chromosomes were normal in 199 (70.57%) embryos and abnormal in 83 (29.43%) embryos. There was no significant association between the quality of embryos and numerical chromosomal abnormality (P=0.67). Conclusions: Embryo quality is not significantly correlated with its genetic status. Hence, the quality of embryos determined by morphological parameters is not an appropriate method for choosing embryos without these abnormalities.
Keywords	assisted reproductive technology ; preimplantation genetic screening ; aneuploidy ; fluorescence insitu hybridization ; chromosomal abnormalities ; embryo quality ; blastomere ; blastocyst ; Medicine ; R
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Heat-killed Saccharomyces cerevisiae on Growth Rate and Apoptosis in Colorectal Cancer Cells

Jalal Abdolalizadeh / Roshanak Sambrani / Leila Kohan / Behboud Jafari

Journal of Mazandaran University of Medical Sciences, Vol 30, Iss 189, Pp 133-

2020 Volume 139

Abstract: Background and purpose: Colorectal cancer ( CRC ) is highly prevalent and conventional therapies are associated with side effects, therefore, application of novel complementary treatment such as probiotics (especially Saccharomyces cerevisiae) is ... ...

Abstract	Background and purpose: Colorectal cancer ( CRC ) is highly prevalent and conventional therapies are associated with side effects, therefore, application of novel complementary treatment such as probiotics (especially Saccharomyces cerevisiae) is necessary. The aim of this study was to investigate the effect of heat-killed form of S.cerevisiae on growing rate and apoptosis (expression levels of PTEN and RelA) in colon cancer cell line HT29. Materials and methods: In this experimental study, the cytotoxic effects of heat-killed form of S.cerevisiae and Fluorouracil (5-FU), as positive control, were tested by MTT assay. Apoptosis induction was investigated by determining the PTEN and RelA expression levels using qRT-PCR. Data were analyzed in GraphPad Prism Software. Results: Heat killed form of S.cerevisiae showed anti-proliferative and apoptotic effect by decreasing the expression levels of RelA and increasing PTEN expression levels in HT-29 cells. The expression levels were found to be significantly different between the intervention groups and controls. Conclusion: The yeast probiotics could decrease the growth rate of colorectal cancer cells and play key role in induction of apoptosis via regulation of RelA and PTEN.
Keywords	saccharomyces cerevisiae ; apoptosis ; colorectal cancer ; probiotics ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of UCP2 45bp ins/del Gene Polymorphism with Idiopathic Male Infertility

Arezoo Ghaderi / Leila Kohan / Zahra Anvar

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 26, Iss 5, Pp 189-

2019 Volume 195

Abstract: Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of ... ...

Abstract	Introduction: Infertility is a reproductive issue that has influenced couples worldwide and caused them psychiatric and emotional troubles. It is believed that mitochondrial proteins play a major role in male infertility. One of the most important of these proteins is UCP2, which consists of more than 10% of mitochondria’s inner membrane proteins. The purpose of this study was to investigate the association of UCP2 45bp ins/del polymorphism with idiopathic male infertility. Materials & Methods: In this case-control study, UCP2 polymorphism was investigated in 196 individuals with idiopathic infertility and 278 healthy individuals. UCP2 45bp ins/del genotypes were identified by the polymerase chain reaction (PCR) technique. Also, genotype and allele frequencies in cases and controls were assessed by logistic regression analysis. Findings: No association was observed between UCP2 45bp ins/del polymorphism genotypes and risk of idiopathic male infertility, but there was a marginal difference between cases and controls regarding II genotype frequency (P=0.08). Moreover, data analysis showed that I allele had protective effect against idiopathic male infertility (OR: 0.729, 95%CI: 0.54-0.985, P=0.039). Discussion & Conclusions: In this study, for the first time, we found that the I allele in UCP2 45bp ins/del polymorphism has protective effects against idiopathic male infertility. Further studies with larger sample sizes and different ethnicities are needed to confirm these results.
Keywords	Idiopathic ; Male infertility ; UCP2 ; Polymorphism ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	590
Language	Persian
Publishing date	2019-01-01T00:00:00Z
Publisher	Ilam University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Role of rs2227956 HSPA1L Gene Polymorphism in Idiopathic Male Infertility

Leila Kohan / Omid Tabiee

Journal of Fasa University of Medical Sciences, Vol 6, Iss 2, Pp 188-

2016 Volume 193

Abstract: Background & objective: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Despite the methodological advancements, the possible causes of infertility are still unknown for more than ...

Abstract	Background & objective: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Despite the methodological advancements, the possible causes of infertility are still unknown for more than 25 percent of cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1L rs2227956 gene polymorphism in the idiopathic infertility in males. Material & methods: This case control study was conducted on 342 subjects consisted of 143 patients with idiopathic male infertility and 199 control subjects. Followed by the DNA extraction from the peripheral blood, genotype determination was done by PCR-restriction fragment length polymorphism method. The logistic regression analysis was used to estimate the association between the polymorphism and male infertility. Results: A significant difference was observed in the genotype distributions between the cases and controls. The results showed that the individuals with TC and CC genotype had an increased risk of male infertility. In addition, there was a significant association between C allele and male infertility. Conclusion: HSPA1L rs2227956 polymorphism is associated with the idiopathic male infertility risk
Keywords	Male Infertility ; Idiopathic ; Polymorphism ; HSP ; Medicine (General) ; R5-920
Subject code	590
Language	Persian
Publishing date	2016-09-01T00:00:00Z
Publisher	Fasa University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacogenetic variation of SLC47A1 gene and metformin response in type2 diabetes patients

Saeedeh Mousavi / Leila Kohan / Majid Yavarian / Asadollah Habib

Molecular Biology Research Communications, Vol 6, Iss 2, Pp 91-

2017 Volume 94

Abstract: Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the ... ...

Abstract	Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes related to the pharmacokinetics of metformin were associated with glucose-lowering effect of metformin. The aim of this study was to evaluate pharmacogenetic variation in SLC47A1 (rs2289669) and metformin response in type 2 diabetes patients. Seventy one patients with type 2 diabetes were included in the study. The genotypes were determined by Tetra–ARMS–PCR method. There was a significant association between the study polymorphism and the response to metformin treatment with the highest HbA1C reduction in AG genotype. In the dominant model for A allele (AA+AG vs GG), patients with A allele had highest HbA1C reduction in response to metformin.
Keywords	Diabetes; Pharmacogenetics; SLC47A1; Polymorphism ; Biology (General) ; QH301-705.5 ; Science ; Q
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Shiraz University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of HSPA1B rs6457452 Genetic Variant with Idiopathic Male Infertility

Elahe Kohan / Leila Kohan / Maryam Maghbol

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, Vol 20, Iss 8, Pp 94-

2017 Volume 101

Abstract: Abstract Background: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic Failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs) are ... ...

Abstract	Abstract Background: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic Failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1B rs6457452 genetic variants in male infertility. Material and Methods: This case control study was conducted on 516 subjects consisted of 308 patients with idiopathic male infertility and 208 control subjects. After DNA extraction from peripheral blood, genotype determination was done by Tetra-ARMS PCR method. Logistic regression analysis was used to estimate the association between the polymorphism and male infertility. Results: A significant difference was observed in genotype distributions between cases and controls. Results showed individuals with TC (OR=1.552, 95%CI: 1.032-2.334, p=0.035) and TT (OR=2.746, 95%CI: 1.153-6.545, p=0.023) genotype had an increased risk of male infertility. Also, there was a significant association between T allele (OR=1.695, 95%CI: 1.220-2.355, p<0.001) and male infertility. Conclusion: This study showed for the first time that HSPA1B rs6457452 polymorphism is associated with infertility risk in Iranian men and the T allele may act as a dominant allele for increasing the risk of male infertility.
Keywords	Heat shock protein ; Idiopathic ; Male infertility ; Polymorphism ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616 ; 590
Language	Persian
Publishing date	2017-11-01T00:00:00Z
Publisher	Arak Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome

Zahra Rezaei / Leila Kohan / Majid Yavarian

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 24, Iss 11, Pp 861-

2017 Volume 867

Abstract: Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this study was to ... ...

Abstract	Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this study was to assess the role of SIRT-1 rs7895833 polymorphism in the susceptibility of PCOS. Methods: This case-control study was done on 456 Iranian women from March to February 2015. Blood samples were collected from 274 women with PCOS and 182 age matched (±5) healthy women at Shiraz Ghadir Mother and Child Hospital. After DNA extraction, SIRT1 rs7895833 genotype determination was done by Tetra-ARMS PCR. Data analysis was performed by SPSS version 18. Results: In the dominant model for G allele (AG+GG vs. AA), AG+GG genotypes in SIRT1 rs7895833 gene polymorphism was associated with the increased risk of PCOS (OR: 2.01, CI:1.32-3.24, P=0.002). Moreover, there was a significant association between the G allele and PCOS (OR: 1.45, CI:1.10-1.91, P=0.008). Conclusion: The results showed a possible association between SIRT1 rs7895833 gene polymorphism and susceptibility to PCOS.
Keywords	Polycystic Ovary Syndrome ; SIRT1 ; Obesity ; Polymorphism ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2017-02-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome

Samira Heidarpanah / Leila Kohan / Seyedeh Sara Hashemi

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, Vol 19, Iss 10, Pp 9-

2017 Volume 16

Abstract: Abstract Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory ... ...

Abstract	Abstract Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of Fas in ovarian apoptosis. The present study is the first investigation to examine the possible association of Fas rs1800682gene polymorphism with PCOS risk in Iranian women. Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The Fas rs1800682 gene polymorphism genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk. Results: There was a significant association between A allele and susceptibility to PCOS(OR =1.4, CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index(OR=1.6, CI=1.02-2.51, p=0.041). Conclusion: For the first time, this study showed that Fas rs1800682 polymorphism is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS.
Keywords	Fas ; Polycystic ovary syndrome ; Polymorphism ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2017-01-01T00:00:00Z
Publisher	Arak Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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