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  1. AU="Leire Martin-Souto"
  2. AU="Wu, Ji-Chun"
  3. AU="M S Siddiqui"
  4. AU="Gabriel A. Martos-Moreno"
  5. AU="Warburton, W K"
  6. AU="Abbaspour, Faeze"
  7. AU="González-Montalvo, Juan Ignacio"
  8. AU="Emery H Bresnick"
  9. AU="McManus, R J"
  10. AU="Mahmoudi, Hamid Reza"
  11. AU="Lee, Dongil"
  12. AU="T Oni"
  13. AU="Diego R. Pérez-Salicrup"
  14. AU="Verhaaren, Benjamin F J"
  15. AU="Gamoudi, Gamoudi Amor"
  16. AU="Fonseca, Barbara F."
  17. AU="Rubio García, Rafael"
  18. AU="Jiménez-Solano, A"
  19. AU=Mai Huynh Kim
  20. AU=Ellis R J
  21. AU="Carvalho, Aline Carla Araújo"
  22. AU=Gleeson Sarah
  23. AU="Lozier, Alan P."
  24. AU="Perrin, Elodie"
  25. AU="Chung, Haniee"
  26. AU="Jendernalik, Kamila"
  27. AU="Naveira, Horacio F"
  28. AU="Heyliger, Jamie"
  29. AU="García-Fernández, Ciara"
  30. AU="Lee, Mi-Ock"
  31. AU="Pouraliakbar, Hamidreza"
  32. AU="Raina, Hema"
  33. AU="Rosenbaum, David P"
  34. AU="Paulus, Markus"
  35. AU="Nguyen, David Truong"
  36. AU="Khazanchi, Rakesh Kumar"
  37. AU="Agrò, Felice E"
  38. AU="Bücker, Bettina"
  39. AU="Steussy, Bryan W"

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  1. Artikel ; Online: The Host Immune Response to Scedosporium / Lomentospora

    Idoia Buldain / Leire Martin-Souto / Aitziber Antoran / Maialen Areitio / Leire Aparicio-Fernandez / Aitor Rementeria / Fernando L. Hernando / Andoni Ramirez-Garcia

    Journal of Fungi, Vol 7, Iss 2, p

    2021  Band 75

    Abstract: Infections caused by the opportunistic pathogens Scedosporium / Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against ... ...

    Abstract Infections caused by the opportunistic pathogens Scedosporium / Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium / Lomentospora cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dectin-1 and through receptors that are yet unknown. After recognition, cytokine synthesis and antifungal activity of different phagocytes and epithelial cells is species-specific, highlighting the poor response by microglial cells against L. prolificans . Moreover, a great number of Scedosporium / Lomentospora antigens have been identified, most notably catalase, PRM and Hsp70 for their potential medical applicability. Against host immune response, these fungi contain evasion mechanisms, inducing host non-protective response, masking fungal molecular patterns, destructing host defense proteins and decreasing oxidative killing. In conclusion, although many advances have been made, many aspects remain to be elucidated and more research is necessary to shed light on the immune response to Scedosporium / Lomentospora .
    Schlagwörter Scedosporium ; Lomentospora ; immune response ; cytokine ; macrophage ; lymphocyte ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The monoclonal antibody Ca37, developed against Candida albicans alcohol dehydrogenase, inhibits the yeast in vitro and in vivo

    Aitziber Antoran / Leire Aparicio-Fernandez / Aize Pellon / Idoia Buldain / Leire Martin-Souto / Aitor Rementeria / Mahmoud A. Ghannoum / Beth Burgwyn Fuchs / Eleftherios Mylonakis / Fernando L. Hernando / Andoni Ramirez-Garcia

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 12

    Abstract: Abstract Candida albicans is a commensal yeast able to cause life threatening invasive infections particularly in immunocompromised patients. Despite the availability of antifungal treatments, mortality rates are still unacceptably high and drug ... ...

    Abstract Abstract Candida albicans is a commensal yeast able to cause life threatening invasive infections particularly in immunocompromised patients. Despite the availability of antifungal treatments, mortality rates are still unacceptably high and drug resistance is increasing. We, therefore, generated the Ca37 monoclonal antibody against the C. albicans alcohol dehydrogenase (Adh) 1. Our data showed that Ca37 was able to detect C. albicans cells, and it bound to Adh1 in yeast and Adh2 in hyphae among the cell wall-associated proteins. Moreover, Ca37 was able to inhibit candidal growth following 18 h incubation time and reduced the minimal inhibitory concentration of amphotericin B or fluconazole when used in combination with those antifungals. In addition, the antibody prolonged the survival of C. albicans infected-Galleria mellonella larvae, when C. albicans was exposed to antibody prior to inoculating G. mellonella or by direct application as a therapeutic agent on infected larvae. In conclusion, the Ca37 monoclonal antibody proved to be effective against C. albicans, both in vitro and in vivo, and to act together with antifungal drugs, suggesting Adh proteins could be interesting therapeutic targets against this pathogen.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Pathobiology of lomentospora prolificans: could this species serve as a model of primary antifungal resistance?

    Pellon, Aize / Andoni Ramirez-Garcia / Idoia Buldain / Aitziber Antoran / Leire Martin-Souto / Aitor Rementeria / Fernando L. Hernando

    International Journal of Antimicrobial Agents. 2017,

    2017  

    Abstract: The number of fungal isolates resistant to antifungal drugs has increased dramatically over the last few years and has become an important concern for clinicians. Among these isolates, fungi showing multidrug resistance are especially worrying because of ...

    Abstract The number of fungal isolates resistant to antifungal drugs has increased dramatically over the last few years and has become an important concern for clinicians. Among these isolates, fungi showing multidrug resistance are especially worrying because of the difficulties associated with their treatment. These factors hamper the successful recovery of patients and drastically raise mortality rates. Therefore, since it is well known that antifungal resistance is multifactorial and several mechanisms in different fungi have been described, there is a need to study these processes in depth. However, the study of antifungal drug resistance separately for each and every individual species makes progress in the field very slow and tedious. So, the selection of a multi-resistant microorganism as a model for understanding resistance mechanisms and extrapolating the results to other species could help in the search for a solution. In this mini-review we describe the pathobiology of Lomentospora (Scedosporium) prolificans, paying special attention to its intrinsic resistance to all currently available antifungal agents. The characteristics of L. prolificans offer several advantages: the possibility of using a single microorganism for the study of resistance to different drugs, even cases of double and triple resistance, it is biologically safe for society in general as no new genetically modified strains are needed for the experiments, along with its homology with other fungal species, and the repetitiveness between different strains. In conclusion, we propose L. prolificans as a candidate for consideration as a fungal model for the study of resistance mechanisms against antifungal agents.
    Schlagwörter Scedosporium ; antifungal agents ; drugs ; fungi ; models ; mortality ; multiple drug resistance ; patients ; resistance mechanisms ; society
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2017.06.009
    Datenquelle NAL Katalog (AGRICOLA)

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